Influence of preoperative 7.5% hypertonic saline on neutrophil activation after reamed intramedullary nailing of femur shaft fractures: A prospective randomized pilot study

Journal of Orthopaedic Trauma

Volumn 26, Issue 2, 2012, Pages 86-91

  Agudelo, Juan F ^a   Flierl, Michael A ^a   Smith, Wade R ^b   Moore, Ernest E ^a   Williams, Allison E ^c   Eckels, Philip C ^a   Morgan, Steven J ^a   Stahel, Philip F ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b GEISINGER MEDICAL CENTER   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

femur shaft fracture; hypertonic saline; intramedullary nailing; neutrophil

Indexed keywords

CD11B ANTIGEN; L SELECTIN; SODIUM CHLORIDE;

AGED; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD ANALYSIS; BLOOD SAMPLING; CELL SURFACE; CLINICAL ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; FEMUR SHAFT FRACTURE; FLOW CYTOMETRY; HUMAN; IMMUNOMODULATION; INTRAMEDULLARY NAILING; LEUKOCYTE ACTIVATION; MALE; PREOPERATIVE CARE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; DOUBLE-BLIND METHOD; FEMALE; FEMORAL FRACTURES; FRACTURE FIXATION, INTRAMEDULLARY; HUMANS; INFLAMMATION; MALE; MIDDLE AGED; NEUTROPHIL ACTIVATION; PREMEDICATION; PREOPERATIVE CARE; PROSPECTIVE STUDIES; SALINE SOLUTION, HYPERTONIC; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84855826102     PISSN: 08905339     EISSN: 15312291     Source Type: Journal    
DOI: 10.1097/BOT.0b013e31821cfd2a     Document Type: Article

References (66)

1. Wolinsky PR, McCarty E, Shyr Y, et al. Reamed intramedullary nailing of the femur: 551 cases. J Trauma. 1999;46:392-399. (Pubitemid 29144332)
2. Rudloff MI, Smith WR. Intramedullary nailing of the femur: current concepts concerning reaming. J Orthop Trauma. 2009;23:S12-S17.
3. Goris RJ, Gimbrere JS, van Niekerk JL, et al. Early osteosynthesis and prophylactic mechanical ventilation in the multitrauma patient. J Trauma. 1982;22:895-903. (Pubitemid 13250886)
4. Johnson KD, Cadambi A, Seibert GB. Incidence of adult respiratory distress syndrome in patients with multiple musculoskeletal injuries: effect of early operative stabilization of fractures. J Trauma. 1985;25:375-384. (Pubitemid 15009543)
5. Bone LB, Johnson KD, Weigelt J, et al. Early versus delayed stabilization of femoral fractures. A prospective randomized study. J Bone Joint Surg Am. 1989;71:336-340. (Pubitemid 19116683)
6. Pape HC, Hildebrand F, Pertschy S, et al. Changes in the management of femoral shaft fractures in polytrauma patients: from early total care to damage control orthopedic surgery. J Trauma. 2002;53:452-461.
7. Pape HC, Grimme K, Van Griensven M, et al. Impact of intramedullary instrumentation versus damage control for femoral fractures on immunoinflammatory parameters: prospective randomized analysis by the EPOFF Study Group. J Trauma. 2003;55:7-13. (Pubitemid 36919229)
8. Giannoudis PV, Abbott C, Stone M, et al. Fatal systemic inflammatory response syndrome following early bilateral femoral nailing. Intensive Care Med. 1998;24:641-642. (Pubitemid 28344772)
9. Giannoudis PV, Pape HC, Cohen AP, et al. Review: systemic effects of femoral nailing: from Kuntscher to the immune reactivity era. Clin Orthop Relat Res. 2002;404:378-386. (Pubitemid 35351094)
10. Pape HC. Effects of changing strategies of fracture fixation on immunologic changes and systemic complications after multiple trauma: damage control orthopedic surgery. J Orthop Res. 2008;26:1478-1484.
11. Gebhard F, Huber-Lang M. Polytrauma-pathophysiology and management principles. Langenbecks Arch Surg. 2008;393:825-831.
12. Keel M, Trentz O. Pathophysiology of polytrauma. Injury. 2005;36:691-709. (Pubitemid 40732303)
13. Stahel PF, Smith WR, Moore EE. Current trends in resuscitation strategy for the multiply injured patient. Injury. 2009;40(Suppl 4):S27-S35.
14. Stahel PF, Smith WR, Moore EE. Role of biological modifiers regulating the immune response after trauma. Injury. 2007;38:1409-1422. (Pubitemid 350192403)
15. Weiss SJ. Tissue destruction by neutrophils. N Engl J Med. 1989;320: 365-376. (Pubitemid 19106873)
16. Waydhas C, Nast-Kolb D, Trupka A, et al. Posttraumatic inflammatory response, secondary operations, and late multiple organ failure. J Trauma. 1996;40:624-630. (Pubitemid 126425014)
17. Gonzalez RJ, Moore EE, Ciesla DJ, et al. Post-hemorrhagic shock mesenteric lymph lipids prime neutrophils for enhanced cytotoxicity via phospholipase A2. Shock. 2001;16:218-222. (Pubitemid 33598200)
18. Moore FA, Moore EE. Evolving concepts in the pathogenesis of postinjury multiple organ failure. Surg Clin North Am. 1995;75:257-277.
19. Rivkind AI, Siegel JH, Littleton M, et al. Neutrophil oxidative burst activation and the pattern of respiratory physiologic abnormalities in the fulminant post-traumatic adult respiratory distress syndrome. Circ Shock. 1991;33:48-62.
20. Windsor AC, Mullen PG, Fowler AA, et al. Role of the neutrophil in adult respiratory distress syndrome. Br J Surg. 1993;80:10-17. (Pubitemid 23071465)
21. Aldridge AJ. Role of the neutrophil in septic shock and the adult respiratory distress syndrome. Eur J Surg. 2002;168:204-214. (Pubitemid 34879391)
22. Moraes TJ, Zurawska JH, Downey GP. Neutrophil granule contents in the pathogenesis of lung injury. Curr Opin Hematol. 2006;13:21-27.
23. Botha AJ, Moore FA, Moore EE, et al. Postinjury neutrophil priming and activation: an early vulnerable window. Surgery. 1995;118:358-364.
24. Botha AJ, Moore FA, Moore EE, et al. Early neutrophil sequestration after injury: a pathogenic mechanism for multiple organ failure. J Trauma. 1995;39:411-417.
25. Gago LA, Moore EE, Partrick DA, et al. Secretory phospholipase A2 cleavage of intravasated bone marrow primes human neutrophils. J Trauma. 1998;44:660-664. (Pubitemid 28173604)
26. Meldrum DR, Cleveland JC Jr, Moore EE, et al. Adaptive and maladaptive mechanisms of cellular priming. Ann Surg. 1997;226:587-598. (Pubitemid 28049654)
27. Sauaia A, Moore FA, Moore EE, et al. Early risk factors for postinjury multiple organ failure. World J Surg. 1996;20:392-400. (Pubitemid 26138584)
28. de Felippe J Jr, Timoner J, Velasco IT, et al. Treatment of refractory hypovolaemic shock by 7.5% sodium chloride injections. Lancet. 1980;2: 1002-1004. (Pubitemid 10025072)
29. Poli-de-Figueiredo LF, Cruz RJ Jr, Sannomiya P, et al. Mechanisms of action of hypertonic saline resuscitation in severe sepsis and septic shock. Endocr Metab Immune Disord Drug Targets. 2006;6:201-206. (Pubitemid 43881033)
30. Deitch EA, Shi HP, Feketeova E, et al. Hypertonic saline resuscitation limits neutrophil activation after trauma-hemorrhagic shock. Shock. 2003; 19:328-333.
31. Rizoli SB, Kapus A, Fan J, et al. Immunomodulatory effects of hypertonic resuscitation on the development of lung inflammation following hemorrhagic shock. J Immunol. 1998;161:6288-6296. (Pubitemid 28536004)
32. Homma H, Deitch EA, Feketeova E, et al. Small volume resuscitation with hypertonic saline is more effective in ameliorating trauma-hemorrhagic shock-induced lung injury, neutrophil activation and red blood cell dysfunction than pancreatitic protease inhibition. J Trauma. 2005;59:266-272. (Pubitemid 41639985)
33. Deree J, Martins JO, Leedom A, et al. Hypertonic saline and pentoxifyl-line reduces hemorrhagic shock resuscitation-induced pulmonary inflammation through attenuation of neutrophil degranulation and proinflammatory mediator synthesis. J Trauma. 2007;62:104-111. (Pubitemid 46102839)
34. Gonzalez RJ, Moore EE, Ciesla DJ, et al. Hyperosmolarity abrogates neutrophil cytotoxicity provoked by post-shock mesenteric lymph. Shock. 2002;18:29-32.
35. Ciesla DJ, Moore EE, Musters RJ, et al. Hypertonic saline alteration of the PMN cytoskeleton: implications for signal transduction and the cytotoxic response. J Trauma. 2001;50:206-212. (Pubitemid 32230140)
36. Ciesla DJ, Moore EE, Zallen G, et al. Hypertonic saline attenuation of polymorphonuclear neutrophil cytotoxicity: timing is everything. J Trauma. 2000;48:388-395. (Pubitemid 30183097)
37. Ciesla DJ, Moore EE, Biffl WL, et al. Hypertonic saline attenuation of the neutrophil cytotoxic response is reversed upon restoration of normoto-nicity and reestablished by repeated hypertonic challenge. Surgery. 2001; 129:567-575. (Pubitemid 32374988)
38. Ciesla DJ, Moore EE, Gonzalez RJ, et al. Hypertonic saline inhibits neutrophil (PMN) priming via attenuation of p38 MAPK signaling. Shock. 2000;14:265-269.
39. Bahrami S, Zimmermann K, Szelenyi Z, et al. Small-volume fluid resuscitation with hypertonic saline prevents inflammation but not mortality in a rat model of hemorrhagic shock. Shock. 2006;25: 283-289.
40. Powers KA, Woo J, Khadaroo RG, et al. Hypertonic resuscitation of hemorrhagic shock upregulates the anti-inflammatory response by alveolar macrophages. Surgery. 2003;134:312-318. (Pubitemid 37070355)
41. Bulger EM, Cuschieri J, Warner K, et al. Hypertonic resuscitation modulates the inflammatory response in patients with traumatic hemorrhagic shock. Ann Surg. 2007;245:635-641. (Pubitemid 46555669)
42. Bulger EM, Jurkovich GJ, Nathens AB, et al. Hypertonic resuscitation of hypovolemic shock after blunt trauma: a randomized controlled trial. Arch Surg. 2008;143:139-148; discussion 149. (Pubitemid 351281617)
43. Mattox KL, Maningas PA, Moore EE, et al. Prehospital hypertonic saline/Dextran infusion for post-traumatic hypotension. The USA Multicenter Trial. Ann Surg. 1991;213:482-491.
44. Rizoli SB, Rhind SG, Shek PN, et al. The immunomodulatory effects of hypertonic saline resuscitation in patients sustaining traumatic hemor-rhagic shock: a randomized, controlled, double-blinded trial. Ann Surg. 2006;243:47-57. (Pubitemid 43054054)
45. Ziran BH, Smith WR, Zlotolow DA, et al. Clinical evaluation of a true percutaneous technique for antegrade femoral nailing. Orthopedics. 2005; 28:1182-1186. (Pubitemid 41582110)
46. Velasco IT, Pontieri V, Rocha e Silva M Jr, et al. Hyperosmotic NaCl and severe hemorrhagic shock. Am J Physiol. 1980;239:H664-673. (Pubitemid 11241496)
47. Fracture and Dislocation Classification Compendium- 2007: Orthopaedic Trauma Association Classification, Database and Outcomes Committee. Femur. J Orthop Trauma. 2007;21:S31-S42.
48. Gustilo RB, Anderson JT. Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. J Bone Joint Surg Am. 1976;58:453-458.
49. Gustilo RB, Mendoza RM, Williams DN. Problems in the management of type III (severe) open fractures: a new classification of type III open fractures. J Trauma. 1984;24:742-746. (Pubitemid 14069063)
50. Bernard GR, Artigas A, Brigham KL, et al. The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med. 1994;149:818-824. (Pubitemid 24082248)
51. Sauaia A, Moore EE, Johnson JL, et al. Validation of postinjury multiple organ failure scores. Shock. 2009;31:438-447.
52. Pallister I, Bhatia R, Katpalli G, et al. Alteration of polymorphonuclear neutrophil surface receptor expression and migratory activity after isolation: comparison of whole blood and isolated PMN preparations from normal and postfracture trauma patients. J Trauma. 2006;60:844-850.
53. Pallister I, Topley N. Chemiluminescence: comparison of whole blood with isolated polymorphonuclear leukocytes after major trauma. J Trauma. 2004;57:347-351. (Pubitemid 39166790)
54. Rosen SD. Ligands for L-selectin: homing, inflammation, and beyond. Annu Rev Immunol. 2004;22:129-156. (Pubitemid 38680420)
55. Barkhausen T, Krettek C, van Griensven M. L-selectin: adhesion, signalling and its importance in pathologic posttraumatic endotoxemia and non-septic inflammation. Exp Toxicol Pathol. 2005;57:39-52. (Pubitemid 40922622)
56. Kerner T, Ahlers O, Spielmann S, et al. L-selectin in trauma patients: a marker for organ dysfunction and outcome? Eur J Clin Invest. 1999;29: 1077-1086.
57. McGill SN, Ahmed NA, Hu F, et al. Shedding of L-selectin as a mechanism for reduced polymorphonuclear neutrophil exudation in patients with the systemic inflammatory response syndrome. Arch Surg. 1996;131:1141-1146.
58. Stewart M, Thiel M, Hogg N. Leukocyte integrins. Curr Opin Cell Biol. 1995;7:690-696.
59. Arnaout MA, Todd RF, Dana N, et al. Inhibition of phagocytosis of complement C3- or immunoglobulin G-coated particles and of C3bi binding by monoclonal antibodies to a monocyte-granulocyte membrane glycoprotein (Mol). J Clin Invest. 1983;72:171-179. (Pubitemid 13026640)
60. Bhatia R, Dent C, Topley N, et al. Neutrophil priming for elastase release in adult blunt trauma patients. J Trauma. 2006;60:590-596.
61. Maekawa K, Futami S, Nishida M, et al. Effects of trauma and sepsis on soluble L-selectin and cell surface expression of L-selectin and CD11b. J Trauma. 1998;44:460-468. (Pubitemid 28153095)
62. Oliveira RP, Velasco I, Soriano F, et al. Clinical review: Hypertonic saline resuscitation in sepsis. Crit Care. 2002;6:418-423.
63. Catrambone JE, He W, Prestigiacomo CJ, et al. The use of hypertonic saline in the treatment of post-traumatic cerebral edema: a review. Eur J Trauma Emerg Surg. 2008;34:397-409.
64. Pascual JL, Maloney-Wilensky E, Reilly PM, et al. Resuscitation of hypotensive head-injured patients: is hypertonic saline the answer? Am Surg. 2008;74:253-259. (Pubitemid 351323710)
65. Brasel KJ, Bulger E, Cook AJ, et al. Hypertonic resuscitation: design and implementation of a prehospital intervention trial. J Am Coll Surg. 2008; 206:220-232.
66. Ciesla DJ, Moore EE, Johnson JL, et al. Decreased progression of postinjury lung dysfunction to the acute respiratory distress syndrome and multiple organ failure. Surgery. 2006;140:640-647.