Ozone induces synthesis of systemic prostacyclin by cyclooxygenase-2 dependent mechanism in vivo

Biochemical Pharmacology

Volumn 83, Issue 4, 2012, Pages 506-513

  Schulz, Siegfried ^b   Ninke, Simone ^a   Watzer, Bernhard ^b   Nüsing, Rolf Michael ^a  

^a GOETHE UNIVERSITY   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Cyclooxygenase; Insufflation; Isoprostanes; Oxidative stress; Ozone; Prostanoids

Indexed keywords

2,3 DINOR 6 OXOPROSTAGLANDIN F1 ALPHA; CYCLOOXYGENASE 2; ISOPROSTANE DERIVATIVE; MESSENGER RNA; OZONE; PROSTACYCLIN; PROSTACYCLIN SYNTHASE; PROSTAGLANDIN E2; PROSTAGLANDIN F1 ALPHA; PROSTANOID; REACTIVE OXYGEN METABOLITE; THROMBOXANE; THROMBOXANE B2;

AMINO ACID URINE LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME MECHANISM; IN VIVO STUDY; MOUSE; NONHUMAN; OXIDATIVE STRESS; OXYGEN THERAPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SENSITIVITY ANALYSIS;

ANIMALS; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYTOCHROME P-450 ENZYME SYSTEM; EPOPROSTENOL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; INTRAMOLECULAR OXIDOREDUCTASES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OZONE; RABBITS; RATS; RATS, WISTAR; RNA, MESSENGER;

EID: 84855819202     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.11.025     Document Type: Article

References (53)

1. D.M. Amron, and R.L. Moy Stratospheric ozone depletion and its relationship to skin cancer J Dermatol Surg Oncol 17 1991 370 372
2. W.A. Pryor, B. Das, and D.F. Church The ozonation of unsaturated fatty acids: aldehydes and hydrogen peroxide as products and possible mediators of ozone toxicity Chem Res Toxicol 4 1991 341 348
3. B.D. Goldstein The pulmonary and extrapulmonary effects of ozone Ciba Found Symp 1978 295 319
4. C. Hassett, M.G. Mustafa, W.F. Coulson, and R.M. Elashoff Splenomegaly in mice following exposure to ambient levels of ozone Toxicol Lett 26 1985 139 144 (Pubitemid 16251051)
5. B.M. Babior, C. Takeuchi, J. Ruedi, A. Gutierrez, and P. Wentworth Jr. Investigating antibody-catalyzed ozone generation by human neutrophils Proc Natl Acad Sci U S A 100 2003 3031 3034 (Pubitemid 36358199)
6. P. Wentworth, L.H. Jones Jr., A.D. Wentworth, X. Zhu, N.A. Larsen, and I.A. Wilson Antibody catalysis of the oxidation of water Science 293 2001 1806 1811 (Pubitemid 32845773)
7. V. Bocci, I. Zanardi, and V. Travagli Ozone: a new therapeutic agent in vascular diseases Am J Cardiovasc Drugs 11 2011 73 82
8. V.A. Bocci, I. Zanardi, and V. Travagli Ozone acting on human blood yields a hormetic dose-response relationship J Transl Med 9 2011 66
9. F Bocci V.A. Scientific and medical aspects of ozone therapy. State of the art Arch Med Res 37 2006 425 435
10. Z.Z. Rodriguez, D. Guanche, R.G. Alvarez, F.H. Rosales, Y. Alonso, and S. Schulz Preconditioning with ozone/oxygen mixture induces reversion of some indicators of oxidative stress and prevents organic damage in rats with fecal peritonitis Inflamm Res 58 2010 371 375
11. S. Schulz, Z.Z. Rodriguez, R. Mutters, S. Menendez, and M. Bette Repetitive pneumoperitoneum with ozonized oxygen as a preventive in lethal polymicrobial sepsis in rats Eur Surg Res 35 2003 26 34 (Pubitemid 36098769)
12. S. Schulz, U. Haussler, R. Mandic, J.T. Heverhagen, A. Neubauer, and A.A. Dunne Treatment with ozone/oxygen-pneumoperitoneum results in complete remission of rabbit squamous cell carcinomas Int J Cancer 122 2008 2360 2367 (Pubitemid 351542343)
13. M. Bette, R.M. Nusing, R. Mutters, Z.B. Zamora, S. Menendez, and S. Schulz Efficiency of tazobactam/piperacillin in lethal peritonitis is enhanced after preconditioning of rats with O3/O2-pneumoperitoneum Shock 25 2006 23 29
14. J.M. Fouke, R.A. DeLemos, M.J. Dunn, and E.R. McFadden Jr. Effects of ozone on cyclooxygenase metabolites in the baboon tracheobronchial tree J Appl Physiol 69 1990 245 250 (Pubitemid 20230968)
15. J.M. Fouke, A.D. Wolin, and E.R. McFadden Jr. Effects of ozone on lung mechanics and cyclooxygenase metabolites in dogs Prostaglandins 42 1991 343 353
16. G.D. Leikauf, Q. Zhao, S. Zhou, and J. Santrock Ozonolysis products of membrane fatty acids activate eicosanoid metabolism in human airway epithelial cells Am J Respir Cell Molecul Biol 9 1993 594 602 (Pubitemid 2028740)
17. P.D. Miller, D. Ainsworth, H.F. Lam, and M.O. Amdur Effect of ozone exposure on lung functions and plasma prostaglandin and thromboxane concentrations in guinea pigs Toxicol Appl Pharmacol 88 1987 132 140 (Pubitemid 17058754)
18. W. Smith Prostanoid biosynthesis and mechanism of action Am J Physiol 263 1992 F181 F191
19. W.L. Smith, D.L. DeWitt, and R.M. Garavito Cyclooxygenases: structural, cellular, and molecular biology Annu Rev Biochem 69 2000 145 182
20. J.D. Morrow, K.E. Hill, R.F. Burk, T.M. Nammour, K.F. Badr, and L.J.d. Roberts A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism Proc Natl Acad Sci U S A 87 1990 9383 9387 (Pubitemid 120030630)
21. J.D. Morrow, and L.J. Roberts The isoprostanes: unique bioactive products of lipid peroxidation Prog Lipid Res 36 1997 1 21 (Pubitemid 27387112)
22. S.G. Morham, R. Langenbach, C.D. Loftin, H.F. Tiano, N. Vouloumanos, and J.C. Jennette Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse Cell 83 1995 473 482
23. T. Klein, F. Reutter, H. Schweer, H.W. Seyberth, and R.M. Nüsing Generation of the isoprostane 8-epi-prostaglandin F-2 alpha in vitro and in vivo via the cyclooxygenases J Pharmacol Exp Ther 282 1997 1658 1665 (Pubitemid 27408353)
24. H. Schweer, B. Watzer, and H.W. Seyberth Determination of seven prostanoids in 1 ml of urine by gas chromatography-negative ion chemical ionization triple stage quadrupole mass spectrometry J Chromatogr 652 1994 221 227 (Pubitemid 24081329)
25. H. Schweer, B. Watzer, H.W. Seyberth, and R.M. Nusing Improved quantification of 8-epi-prostaglandin F2 alpha and F2-isoprostanes by gas chromatography/triple-stage quadrupole mass spectrometry: partial cyclooxygenase-dependent formation of 8-epi- prostaglandin F2 alpha in humans J Mass Spectrom 32 1997 1362 1370
26. R. Nüsing, M. Goerig, A.J. Habenicht, and V. Ullrich Selective eicosanoid formation during HL-60 macrophage differentiation. Regulation of thromboxane synthase Eur J Biochem 212 1993 371 376 (Pubitemid 23076103)
27. A. Bachi, R. Brambilla, R. Fanelli, R. Bianchi, E. Zuccato, and C. Chiabrando Reduction of urinary 8-epi-prostaglandin F-2 alpha during cyclooxygenase inhibition in rats but not in man Br J Pharmacol 121 1997 1770 1774 (Pubitemid 27343409)
28. A. Olliges, S. Wimmer, and R.M. Nusing Defects in mouse nephrogenesis induced by selective and non-selective cyclooxygenase-2 inhibitors Br J Pharmacol 163 2011 927 936
29. A. Tanaka, H. Araki, S. Hase, Y. Komoike, and K. Takeuchi Up-regulation of COX-2 by inhibition of COX-1 in the rat: a key to NSAID-induced gastric injury Aliment Pharmacol Therap 16 Suppl. 2 2002 90 101 (Pubitemid 41771467)
30. T.D. Schmittgen, and B.A. Zakrajsek Effect of experimental treatment on housekeeping gene expression: validation by real-time, quantitative RT-PCR J Biochem Biophys Methods 46 2000 69 81
31. B.F. McAdam, F. Catella-Lawson, I.A. Mardini, S. Kapoor, J.A. Lawson, and G.A. FitzGerald Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2 Proc Natl Acad Sci U S A 96 1999 272 277 (Pubitemid 29036089)
32. J.I. Fann, P.D. Cahill, R.S. Mitchell, and D.C. Miller Regional variability of prostacyclin biosynthesis Arteriosclerosis 9 1989 368 373 (Pubitemid 19139872)
33. A.R. Johnson Human pulmonary endothelial cells in culture. Activities of cells from arteries and cells from veins J Clin Invest 65 1980 841 850 (Pubitemid 10144058)
34. N.A. Flavahan Balancing prostanoid activity in the human vascular system Trends Pharmacol Sci 28 2007 106 110 (Pubitemid 46283588)
35. K.K. Mubarak A review of prostaglandin analogs in the management of patients with pulmonary arterial hypertension Respir Med 104 2010 9 21
36. Z. Safdar Treatment of pulmonary arterial hypertension: the role of prostacyclin and prostaglandin analogs Respir Med 105 2011 818 827
37. L.J. Roberts, and J.D. Morrow Measurement of F(2)-isoprostanes as an index of oxidative stress in vivo Free Radic Biol Med 28 2000 505 513 (Pubitemid 30136031)
38. W.A. Pryor, G.L. Squadrito, and M. Friedman The cascade mechanism to explain ozone toxicity: the role of lipid ozonation products Free Radic Biol Med 19 1995 935 941
39. P. Montuschi, J.A. Nightingale, S.A. Kharitonov, and P.J. Barnes Ozone-induced increase in exhaled 8-isoprostane in healthy subjects is resistant to inhaled budesonide Free Radic Biol Med 33 2002 1403 1408 (Pubitemid 35284923)
40. G.A. FitzGerald, and C. Patrono The coxibs, selective inhibitors of cyclooxygenase-2 N Engl J Med 345 2001 433 442 (Pubitemid 32747607)
41. L.H. Smith, O. Boutaud, M. Breyer, J.D. Morrow, J.A. Oates, and D.E. Vaughan Cyclooxygenase-2-dependent prostacyclin formation is regulated by low density lipoprotein cholesterol in vitro Arterioscler Thromb Vasc Biol 22 2002 983 988 (Pubitemid 34655227)
42. R.J. Gryglewski Prostacyclin among prostanoids Pharmacol Rep 60 2008 3 11 (Pubitemid 351586537)
43. M.A. Iniguez, C. Cacheiro-Llaguno, N. Cuesta, M.D. Diaz-Munoz, and M. Fresno Prostanoid function and cardiovascular disease Arch Physiol Biochem 114 2008 201 209 (Pubitemid 352009306)
44. A. Sakai, M. Yajima, and S. Nishio Cytoprotective effect of TRK-100, a prostacyclin analogue, against chemical injuries in cultured human vascular endothelial cells Life Sci 47 1990 711 719 (Pubitemid 20262153)
45. G.A. Fitzgerald Coxibs and cardiovascular disease N Engl J Med 351 2004 1709 1711
46. M.J. Tisdale Role of prostaglandins in metastatic dissemination of cancer. Minireview on cancer research Exp Cell Biol 51 1983 250 256 (Pubitemid 13019804)
47. W. Zhou, T.S. Blackwell, K. Goleniewska, J.F. O'Neal, G.A. Fitzgerald, and M. Lucitt Prostaglandin I2 analogs inhibit Th1 and Th2 effector cytokine production by CD4T cells J Leukoc Biol 81 2007 809 817 (Pubitemid 46393559)
48. W. Zhou, K. Hashimoto, K. Goleniewska, J.F. O'Neal, S. Ji, and T.S. Blackwell Prostaglandin I2 analogs inhibit proinflammatory cytokine production and T cell stimulatory function of dendritic cells J Immunol 178 2007 702 710 (Pubitemid 46095142)
49. A. Guven, G. Gundogdu, S. Sadir, T. Topal, E. Erdogan, and A. Korkmaz The efficacy of ozone therapy in experimental caustic esophageal burn J Pediatr Surg 43 2008 1679 1684
50. P. Madej, A. Plewka, J.A. Madej, M. Nowak, D. Plewka, and G. Franik Ozonotherapy in an induced septic shock. I. Effect of ozonotherapy on rat organs in evaluation of free radical reactions and selected enzymatic systems Inflammation 30 2007 52 58 (Pubitemid 46438048)
51. P. Madej, A. Plewka, J.A. Madej, D. Plewka, W. Mroczka, and K. Wilk Ozone therapy in induced endotoxemic shock. II. The effect of ozone therapy upon selected histochemical reactions in organs of rats in endotoxemic shock Inflammation 30 2007 69 86 (Pubitemid 46985772)
52. Z.B. Zamora, A. Borrego, O.Y. Lopez, R. Delgado, R. Gonzalez, and S. Menendez Effects of ozone oxidative preconditioning on TNF-alpha release and antioxidant-prooxidant intracellular balance in mice during endotoxic shock Mediat Inflamm 2005 2005 16 22 (Pubitemid 40942906)
53. T.H. Stadlbauer, A. Eisele, M.C. Heidt, H.H. Tillmanns, and S. Schulz Preconditioning with ozone abrogates acute rejection and prolongs cardiac allograft survival in rats Transplant Proc 40 2008 974 977 (Pubitemid 351794291)