The epidemiology of sarcopenia in community living older adults: What role does lifestyle play?

Journal of Cachexia, Sarcopenia and Muscle

Volumn 2, Issue 3, 2011, Pages 125-134

  Scott, David ^a   Blizzard, Leigh ^b   Fell, James ^c   Jones, Graeme ^b  

^a CENTRAL QUEENSLAND UNIVERSITY   (Australia)

^b UNIVERSITY OF TASMANIA   (Australia)

^c UNIVERSITY OF TASMANIA   (Australia)

Author keywords

Chronic disease; Diet; Epidemiology; Physical activity; Sarcopenia; Vitamin D

Indexed keywords

ANTIDEPRESSANT AGENT; BENZODIAZEPINE; CALCIUM CHANNEL BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FIBRIC ACID DERIVATIVE; FUROSEMIDE; NITRATE; PLACEBO; VITAMIN D;

AGING; CHRONIC DISEASE; COMMUNITY LIVING; DIETARY INTAKE; DISEASE COURSE; DISEASE EXACERBATION; ENVIRONMENTAL FACTOR; FALLING; GERIATRICS; HAND GRIP; HUMAN; INFORMATION RETRIEVAL; LIFESTYLE MODIFICATION; LOWER LIMB MUSCLE STRENGTH; MUSCLE ATROPHY; MUSCLE FATIGUE; MUSCLE MASS; MYALGIA; MYOPATHY; PHYSICAL ACTIVITY; PRESCRIPTION; PRIORITY JOURNAL; REVIEW; SIDE EFFECT; SUN EXPOSURE;

EID: 84855795806     PISSN: 21905991     EISSN: 21906009     Source Type: Journal    
DOI: 10.1007/s13539-011-0036-4     Document Type: Review

References (146)

1. Rosenberg IH. Summary comments. Am J Clin Nutr. 1989; 50: 1231-3.
2. Rosenberg IH. Sarcopenia: origins and clinical relevance. J Nutr. 1997; 127: 990-1.
3. Abellan van Kan G. Epidemiology and consequences of sarcopenia. J Nutr Health Aging. 2009; 13: 708-12.
4. Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, et al. Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People. Age Ageing. 2010; 39: 412-23.
5. Fielding RA, Vellas B, Evans WJ, Bhasin S, Morley JE, Newman AB, et al. Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International Working Group on Sarcopenia. J Am Med Dir Assoc. 2011; 12: 249-56.
6. Muscaritoli M, Anker SD, Argilés J, Aversa Z, Bauer JM, Biolo G, et al. Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) "cachexia-anorexia in chronic wasting diseases" and "nutrition in geriatrics". Clin Nutr. 2010; 29: 154-9.
7. Marcell TJ. Sarcopenia: causes, consequences, and preventions. J Gerontol A Biol Sci Med Sci. 2003; 58: 911-6.
8. Waters DL, Baumgartner RN, Garry PJ. Sarcopenia: current perspectives. J Nutr Health Aging. 2000; 4: 133-9.
9. Aniansson A, Hedberg M, Henning GB, Grimby G. Muscle morphology, enzymatic activity, and muscle strength in elderly men: a follow-up study. Muscle Nerve. 1986; 9: 585-91.
10. Frontera WR, Hughes VA, Fielding RA, Fiatarone MA, Evans WJ, Roubenoff R. Aging of skeletal muscle: a 12-yr longitudinal study. J Appl Physiol. 2000; 88: 1321-6.
11. Frontera WR, Reid KF, Phillips EM, Krivickas LS, Hughes VA, Roubenoff R, et al. Muscle fiber size and function in elderly humans: a longitudinal study. J Appl Physiol. 2008; 105: 637-42.
12. Delmonico MJ, Harris TB, Visser M, Park SW, Conroy MB, Velasquez-Mieyer P, et al. Longitudinal study of muscle strength, quality, and adipose tissue infiltration. Am J Clin Nutr. 2009; 90: 1579-85.
13. Hughes VA, Frontera WR, Wood M, Evans WJ, Dallal GE, Roubenoff R, et al. Longitudinal muscle strength changes in older adults: influence of muscle mass, physical activity, and health. J Gerontol A Biol Sci Med Sci. 2001; 56: 209-17.
14. Bassey EJ, Harries UJ. Normal values for handgrip strength in 920 men and women aged over 65 years, and longitudinal changes over 4 years in 620 survivors. Clin Sci. 1993; 84: 331-7.
15. Rantanen T, Masaki K, Foley D, Izmirlian G, White L, Guralnik JM. Grip strength changes over 27 yr in Japanese-American men. J Appl Physiol. 1998; 85: 2047-53.
16. Winegard KJ, Hicks AL, Sale DG, Vandervoort AA. A 12-year follow-up study of ankle muscle function in older adults. J Gerontol A Biol Sci Med Sci. 1996; 51: 202-7.
17. Goodpaster BH, Park SW, Harris TB, Kritchevsky SB, Nevitt M, Schwartz AV, et al. The loss of skeletal muscle strength, mass, and quality in older adults: the health, aging and body composition study. J Gerontol A Biol Sci Med Sci. 2006; 61: 1059-64.
18. Dutta C, Hadley EC, Lexell J. Sarcopenia and physical performance in old age: overview. Muscle Nerve. 1997; 5: 5-9.
19. Stenholm S, Harris TB, Rantanen T, Visser M, Kritchevsky SB, Ferrucci L. Sarcopenic obesity-definition, etiology and consequences. Curr Opin Clin Nutr Metab Care. 2008; 11: 693-700.
20. Doherty TJ. Invited review: aging and sarcopenia. J Appl Physiol. 2003; 95: 1717-27.
21. Zhai G, Ding C, Stankovich J, Cicuttini F, Jones G. The genetic contribution to longitudinal changes in knee structure and muscle strength: a sibpair study. Arthritis Rheum. 2005; 52: 2830-4.
22. Arden NK, Spector TD. Genetic influences on muscle strength, lean body mass, and bone mineral density: a twin study. J Bone Miner Res. 1997; 12: 2076-81.
23. Tiainen K, Sipila S, Alen M, Heikkinen E, Kaprio J, Koskenvuo M, et al. Heritability of maximal isometric muscle strength in older female twins. J Appl Physiol. 2004; 96: 173-80.
24. Carmelli D, Kelly-Hayes M, Wolf PA, Swan GE, Jack LM, Reed T, et al. The contribution of genetic influences to measures of lower-extremity function in older male twins. J Gerontol A Biol Sci Med Sci. 2000; 55: 49-53.
25. Reed T, Fabsitz RR, Selby JV, Carmelli D. Genetic influences and grip strength norms in the NHLBI twin study males aged 59-69. Ann Hum Biol. 1991; 18: 425-32.
26. Huygens W, Thomis MAI, Peeters MW, Aerssens J, Vlietinck R, Beunen GP. Quantitative trait loci for human muscle strength: linkage analysis of myostatin pathway genes. Physiol Genomics. 2005; 22: 390-7.
27. Sayer AA, Syddall HE, Dennison EM, Gilbody HJ, Duggleby SL, Cooper C, et al. Birth weight, weight at 1 y of age, and body composition in older men: findings from the Hertfordshire Cohort Study. Am J Clin Nutr. 2004; 80: 199-203.
28. Sayer AA, Dennison EM, Syddall HE, Jameson K, Martin HJ, Cooper C. The developmental origins of sarcopenia: using peripheral quantitative computed tomography to assess muscle size in older people. J Gerontol A Biol Sci Med Sci. 2008; 63: 835-40.
29. Sayer AA, Syddall HE, Gilbody HJ, Dennison EM, Cooper C. Does sarcopenia originate in early life? Findings from the Hertfordshire Cohort Study. J Gerontol A Biol Sci Med Sci. 2004; 59: 930-4.
30. Sayer AA, Syddall HE, Martin HJ, Dennison EM, Anderson FH, Cooper C. Falls, sarcopenia, and growth in early life: findings from the Hertfordshire Cohort Study. Am J Epidemiol. 2006; 164: 665-71.
31. Kuh D, Bassey J, Hardy R, Sayer AA, Wadsworth M, Cooper C. Birth weight, childhood size, and muscle strength in adult life: evidence from a birth cohort study. Am J Epidemiol. 2002; 156: 627-33.
32. Kuh D, Hardy R, Butterworth S, Okell L, Richards M, Wadsworth M, et al. Developmental origins of midlife physical performance: evidence from a British birth cohort. Am J Epidemiol. 2006; 164: 110-21.
33. Gale CR, Martyn CN, Kellingray S, Eastell R, Cooper C. Intrauterine programming of adult body composition. J Clin Endocrinol Metab. 2001; 86: 267-72.
34. Ylihärsilä H, Kajantie E, Osmond C, Forsen T, Barker DJP, Eriksson JG. Birth size, adult body composition and muscle strength in later life. Int J Obes. 2007; 31: 1392-9.
35. Woo J, Leung JCS, Wong SYS. Impact of childhood experience of famine on late life health. J Nutr Health Aging. 2010; 14: 91-5.
36. Chodzko-Zajko WJ, Proctor DN, Fiatarone Singh M, Minson CT, Nigg CR, Salem GJ, et al. Exercise and physical activity for older adults. Med Sci Sports Exerc. 2009; 41: 1510-30.
37. Lenk K, Schuler G, Adams V. Skeletal muscle wasting in cachexia and sarcopenia: molecular pathophysiology and impact of exercise training. J Cachexia Sarcopenia Muscle. 2010; 1: 9-21.
38. Kostka T, Bonnefoy M, Arsac LM, Berthouze SE, Belli A, Lacour JR. Habitual physical activity and peak anaerobic power in elderly women. Eur J Appl Physiol. 1997; 76: 81-7.
39. van Heuvelen MJ, Kempen GI, Ormel J, Rispens P. Physical fitness related to age and physical activity in older persons. Med Sci Sports Exerc. 1998; 30: 434-41.
40. Baumgartner RN, Waters DL, Gallagher D, Morley JE, Garry PJ. Predictors of skeletal muscle mass in elderly men and women. Mech Ageing Dev. 1999; 107: 123-36.
41. Szulc P, Duboeuf F, Marchand F, Delmas PD. Hormonal and lifestyle determinants of appendicular skeletal muscle mass in men: the MINOS study. Am J Clin Nutr. 2004; 80: 496-503.
42. Iannuzzi-Sucich M, Prestwood KM, Kenny AM. Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women. J Gerontol A Biol Sci Med Sci. 2002; 57: 772-7.
43. Janssen I, Heymsfield SB, Ross R. Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr Soc. 2002; 50: 889-96.
44. Baumgartner RN, Romero L, Garry PJ, Heymsfield SB, Koehler KM, Gallagher D, et al. Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol. 1998; 147: 755-63.
45. Hughes VA, Frontera WR, Evans WJ, Roubenoff R, Wood M, Fiatarone Singh MA. Anthropometric assessment of 10-y changes in body composition in the elderly. Am J Clin Nutr. 2004; 80: 475-82.
46. DiPietro L. Physical activity in aging. J Gerontol A Biol Sci Med Sci. 2001; 56: 13-22.
47. Australian Sports Commission. Participation in Exercise, recreation and sport survey: 2008 annual report. Canberra: Australian Sports Commission; 2009.
48. Bassett DR. Validity and reliability issues in objective monitoring of physical activity. Res Q Exerc Sport. 2000; 71: S30-6.
49. Bassey EJ, Bendall MJ, Pearson M. Muscle strength in the triceps surae and objectively measured customary walking activity in men and women over 65 years of age. Clin Sci. 1988; 74: 85-9.
50. Tudor-Locke CE, Ainsworth BE, Whitt MC, Thompson RW, Addy CL, Jones DA. The relationship between pedometer-determined ambulatory activity and body composition variables. Int J Obes. 2001; 25: 1571-8.
51. Chan CB, Spangler E, Valcour J, Tudor-Locke CE. Cross-sectional relationship of pedometer-determined ambulatory activity to indicators of health. Obes Res. 2003; 11: 1563-70.
52. Thompson DL, Rakow J, Perdue SM. Relationship between accumulated walking and body composition in middle-aged women. Med Sci Sports Exerc. 2004; 36: 911-4.
53. Roubenoff R. Sarcopenic obesity: does muscle loss cause fat gain? Lessons from rheumatoid arthritis and osteoarthritis. Ann N Y Acad Sci. 2000; 904: 553-7.
54. Scott D, Blizzard L, Fell J, Jones G. Ambulatory activity, body composition, and lower-limb muscle strength in older adults. Med Sci Sports Exer. 2009; 41: 383-9.
55. Scott D, Blizzard L, Fell J, Jones G. Prospective associations between ambulatory activity, body composition and muscle function in older adults. Scand J Med Sci Sports. 2010. doi: 10. 1111/j. 600-0838. 2010. 01229. x.
56. Proctor DN, O'Brien PC, Atkinson EJ, Nair KS. Comparison of techniques to estimate total body skeletal muscle mass in people of different age groups. Am J Physiol Endocrinol Metab. 1999; 277: 489-95.
57. Wakimoto P, Block G. Dietary intake, dietary patterns, and changes with age: an epidemiological perspective. J Gerontol A Biol Sci Med Sci. 2001; 56: 65-80.
58. Baumgartner RN, Koehler KM, Romero L, Garry PJ. Serum albumin is associated with skeletal muscle in elderly men and women. Am J Clin Nutr. 1996; 64: 552-8.
59. Scott D, Blizzard L, Fell J, Giles G, Jones G. Associations between dietary nutrient intake and muscle mass and strength in community-dwelling older adults: the Tasmanian Older Adult Cohort study. J Am Geriatr Soc. 2010; 58: 2129-34.
60. Mitchell D, Haan MN, Steinberg FM, Visser M. Body composition in the elderly: the influence of nutritional factors and physical activity. J Nutr Health Aging. 2003; 7: 130-9.
61. Starling RD, Ades PA, Poehlman ET. Physical activity, protein intake, and appendicular skeletal muscle mass in older men. Am J Clin Nutr. 1999; 70: 91-6.
62. Stookey JD, Adair L, Stevens J, Popkin BM. Patterns of long-term change in body composition are associated with diet, activity, income and urban residence among older adults in China. J Nutr. 2001; 131: 2433-40.
63. Houston DK, Nicklas BJ, Ding J, Harris TB, Tylavsky FA, Newman AB, et al. Dietary protein intake is associated with lean mass change in older, community-dwelling adults: the Health, Aging, and Body Composition (Health ABC) Study. Am J Clin Nutr. 2008; 87: 150-5.
64. Meng X, Zhu K, Devine A, Kerr DA, Binns CW, Prince RL. A 5-year cohort study of the effects of high protein intake on lean mass and bone mineral content in elderly postmenopausal women. J Bone Miner Res. 2009; 24: 1827-34.
65. Semba RD, Lauretani F, Ferrucci L. Carotenoids as protection against sarcopenia in older adults. Arch Biochem Biophys. 2007; 458: 141-5.
66. Chaput JP, Lord C, Cloutier M, Aubertin Leheudre M, Goulet ED, Rousseau S, et al. Relationship between antioxidant intakes and class I sarcopenia in elderly men and women. J Nutr Health Aging. 2007; 11: 363-9.
67. Robinson SM, Jameson KA, Batelaan SF, Martin HJ, Syddall HE, Dennison EM, et al. Diet and its relationship with grip strength in community-dwelling older men and women: the Hertfordshire Cohort Study. J Am Geriatr Soc. 2008; 56: 84-90.
68. Semba RD, Blaum C, Guralnik JM, Moncrief DT, Ricks MO, Fried LP. Carotenoid and vitamin E status are associated with indicators of sarcopenia among older women living in the community. Aging Clin Exp Res. 2003; 15: 482-7.
69. Michelon E, Blaum C, Semba RD, Xue Q-L, Ricks MO, Fried LP. Vitamin and carotenoid status in older women: associations with the frailty syndrome. J Gerontol A Biol Sci Med Sci. 2006; 61: 600-7.
70. Semba RD, Bartali B, Zhou J, Blaum C, Ko C-W, Fried LP. Low serum micronutrient concentrations predict frailty among older women living in the community. J Gerontol A Biol Sci Med Sci. 2006; 61: 594-9.
71. Semba RD, Varadhan R, Bartali B, Ferrucci L, Ricks MO, Blaum C, et al. Low serum carotenoids and development of severe walking disability among older women living in the community: the women's health and aging study I. Age Ageing. 2007; 36: 62-7.
72. Alipanah N, Varadhan R, Sun K, Ferrucci L, Fried LP, Semba RD. Low serum carotenoids are associated with a decline in walking speed in older women. J Nutr Health Aging. 2009; 13: 170-5.
73. Bartali B, Semba RD, Frongillo EA, Varadhan R, Ricks MO, Blaum CS, et al. Low micronutrient levels as a predictor of incident disability in older women. Arch Intern Med. 2006; 166: 2335-40.
74. Cesari M, Pahor M, Bartali B, Cherubini A, Penninx BWJH, Williams GR, et al. Antioxidants and physical performance in elderly persons: the Invecchiare in Chianti (InCHIANTI) study. Am J Clin Nutr. 2004; 79: 289-94.
75. Lauretani F, Semba RD, Bandinelli S, Ray AL, Guralnik JM, Ferrucci L. Association of low plasma selenium concentrations with poor muscle strength in older community-dwelling adults: the InCHIANTI Study. Am J Clin Nutr. 2007; 86: 347-52.
76. Lauretani F, Semba RD, Bandinelli S, Dayhoff-Brannigan M, Giacomini V, Corsi AM, et al. Low plasma carotenoids and skeletal muscle strength decline over 6 years. J Gerontol A Biol Sci Med Sci. 2008; 63: 376-83.
77. Lauretani F, Semba RD, Bandinelli S, Dayhoff-Brannigan M, Corsi AM, Guralnik JM, et al. Carotenoids as protection against disability in older persons. Rejuvenation Res. 2008; 11: 557-63.
78. Dawson-Hughes B, Harris SS, Ceglia L. Alkaline diets favor lean tissue mass in older adults. Am J Clin Nutr. 2008; 87: 662-5.
79. Fiatarone MA, Marks EC, Ryan ND, Meredith CN, Lipsitz LA, Evans WJ. High-intensity strength training in nonagenarians. Effects on skeletal muscle. J Am Med Assoc. 1990; 263: 3029-34.
80. Dominguez LJ, Barbagallo M, Lauretani F, Bandinelli S, Bos A, Corsi AM, et al. Magnesium and muscle performance in older persons: The InCHIANTI study. Am J Clin Nutr. 2006; 84: 419-26.
81. Adams JS, Hewison M. Update in vitamin D. J Clin Endocrinol Metab. 2010; 95: 471-8.
82. van der Mei IAF, Ponsonby AL, Engelsen O, Pasco JA, McGrath JJ, Eyles DW, et al. The high prevalence of vitamin D insufficiency across Australian populations is only partly explained by season and latitude. Environ Health Perspect. 2007; 115: 1132-9.
83. Bischoff-Ferrari HA, Borchers M, Gudat F, Dürmüller U, Stähelin HB, Dick W. Vitamin D receptor expression in human muscle tissue decreases with age. J Bone Miner Res. 2004; 19: 265-9.
84. Roth SM, Zmuda JM, Cauley JA, Shea PR, Ferrell RE. Vitamin D receptor genotype is asscociated with fat-free mass and sarcopenia in elderly men. J Gerontol A Biol Sci Med Sci. 2004; 59: 10-5.
85. Geusens P, Vandevyver C, Vanhoof J, Cassiman JJ, Boonen S, Raus J. Quadriceps and grip strength are related to vitamin D receptor genotype in elderly nonobese women. J Bone Miner Res. 1997; 12: 2082-8.
86. Visser M, Deeg DJH, Lips P. Low vitamin D and high parathyroid hormone levels as determinants of loss of muscle strength and muscle mass (sarcopenia): the longitudinal aging study Amsterdam. J Clin Endocrinol Metab. 2003; 88: 5766-72.
87. Scott D, Blizzard L, Fell J, Ding C, Winzenberg T, Jones G. A prospective study of the associations between 25-hydroxyvitamin D, sarcopenia progression, and physical activity in older adults. Clin Endocrinol (Oxf). 2010; 73: 581-7.
88. Pfeifer M, Begerow B, Minne HW, Schlotthauer T, Pospeschill M, Scholz M, et al. Vitamin D status, trunk muscle strength, body sway, falls, and fractures among 237 postmenopausal women with osteoporosis. Exp Clin Endocrinol Diabetes. 2001; 109: 87-92.
89. Gerdhem P, Ringsberg KAM, Obrant KJ, Akesson K. Association between 25-hydroxy vitamin D levels, physical activity, muscle strength and fractures in the prospective population-based OPRA Study of Elderly Women. Osteoporos Int. 2005; 16: 1425-31.
90. Mowe M, Haug E, Bøhmer T. Low serum calcidiol concentration in older adults with reduced muscular function. J Am Geriatr Soc. 1999; 47: 220-6.
91. Flicker L, Mead K, MacInnis RJ, Nowson C, Scherer S, Stein MS, et al. Serum vitamin D and falls in older women in residential care in Australia. J Am Geriatr Soc. 2003; 51: 1533-8.
92. Snijder MB, van Schoor NM, Pluijm SMF, van Dam RM, Visser M, Lips P. Vitamin D status in relation to one-year risk of recurrent falling in older men and women. J Clin Endocrinol Metab. 2006; 91: 2980-5.
93. Shardell M, Hicks GE, Miller RR, Kritchevsky S, Andersen D, Bandinelli S, et al. Association of low vitamin D levels with the frailty syndrome in men and women. J Gerontol A Biol Sci Med Sci. 2009; 64: 69-75.
94. Visser M, Deeg DJH, Puts MTE, Seidell JC, Lips P. Low serum concentrations of 25-hydroxyvitamin D in older persons and the risk of nursing home admission. Am J Clin Nutr. 2006; 84: 616-22.
95. Bischoff-Ferrari HA, Dietrich T, Orav EJ, Hu FB, Zhang Y, Karlson EW, et al. Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged & or =60 y. Am J Clin Nutr. 2004; 80: 752-8.
96. Houston DK, Cesari M, Ferrucci L, Cherubini A, Maggio D, Bartali B, et al. Association between vitamin D status and physical performance: the InCHIANTI Study. J Gerontol A Biol Sci Med Sci. 2007; 62: 440-6.
97. Zamboni M, Zoico E, Tosoni P, Zivelonghi A, Bortolani A, Maggi S, et al. Relation between vitamin D, physical performance, and disability in elderly persons. J Gerontol A Biol Sci Med Sci. 2002; 57: 7-11.
98. Annweiler C, Beauchet O, Berrut G, Fantino B, Bonnefoy M, Herrmann FR, et al. Is there an association between serum 25-hydroxyvitamin D concentration and muscle strength among older women? Results from baseline assessment of the EPIDOS study. J Nutr Health Aging. 2009; 13: 90-5.
99. Annweiler C, Schott AM, Berrut G, Kressig RW, Herrmann FR, Beauchet O. Vitamin D deficiency-related quadriceps weakness: results of the EPIDOS cohort. J Am Geriatr Soc. 2009; 57: 368-9.
100. Verreault R, Semba RD, Volpato S, Ferrucci L, Fried LP, Guralnik JM. Low serum vitamin D does not predict new disability or loss of muscle strength in older women. J Am Geriatr Soc. 2002; 50: 912-7.
101. Wolff JL, Starfield B, Anderson G. Prevalence, expenditures, and complications of multiple chronic conditions in the elderly. Arch Intern Med. 2002; 162: 2269-76.
102. Fearon K, Evans W, Anker S. Myopenia-a new universal term for muscle wasting. J Cachexia Sarcopenia Muscle. 2011; 2: 1-3.
103. Lee JSW, Auyeung TW, Kwok T, Lau EMC, Leung PC, Woo J. Associated factors and health impact of sarcopenia in older Chinese men and women: a cross-sectional study. Gerontology. 2007; 53: 404-10.
104. Scherbakov N, Doehner W. Sarcopenia in stroke-facts and numbers on muscle loss accounting for disability after stroke. J Cachexia Sarcopenia Muscle. 2011; 2: 5-8.
105. Burns JM, Johnson DK, Watts A, Swerdlow RH, Brooks WM. Reduced lean mass in early Alzheimer disease and its association with brain atrophy. Arch Neurol. 2010; 67: 428-33.
106. Karasik D, Kiel DP. Evidence for pleiotropic factors in genetics of the musculoskeletal system. Bone. 2010; 46: 1226-37.
107. Burr DB. Muscle strength, bone mass, and age-related bone loss. J Bone Miner Res. 1997; 12: 1547-51.
108. Brandt KD, Dieppe P, Radin EL. Etiopathogenesis of osteoarthritis. Rheum Dis Clin North Am. 2008; 34: 531-59.
109. March LM, Bagga H. Epidemiology of osteoarthritis in Australia. Med J Aust. 2004; 180: S6-S10.
110. March LM, Bachmeier CJ. Economics of osteoarthritis: a global perspective. Baillieres Clin Rheumatol. 1997; 11: 817-34.
111. Arokoski MH, Arokoski JP, Haara M, Kankaanpaa M, Vesterinen M, Niemitukia LH, et al. Hip muscle strength and muscle cross sectional area in men with and without hip osteoarthritis. J Rheumatol. 2002; 29: 2185-95.
112. Toda Y, Segal N, Toda T, Kato A, Toda F. A decline in lower extremity lean body mass per body weight is characteristic of women with early phase osteoarthritis of the knee. J Rheumatol. 2000; 27: 2449-54.
113. Zhai G, Blizzard L, Srikanth V, Ding C, Cooley H, Cicuttini F, et al. Correlates of knee pain in older adults: Tasmanian older adult Cohort study. Arthritis Rheum. 2006; 55: 264-71.
114. O'Reilly SC, Jones A, Muir KR, Doherty M. Quadriceps weakness in knee osteoarthritis: the effect on pain and disability. Ann Rheum Dis. 1998; 57: 588-94.
115. Nevitt MC, Cummings SR, Kidd S, Black D. Risk factors for recurrent nonsyncopal falls: a prospective study. J Am Med Assoc. 1989; 261: 2663-8.
116. Slemenda C, Brandt KD, Heilman DK, Mazzuca S, Braunstein EM, Katz BP, et al. Quadriceps weakness and osteoarthritis of the knee. Ann Intern Med. 1997; 127: 97-104.
117. Guccione AA, Felson DT, Anderson JJ. Defining arthritis and measuring functional status in elders: methodological issues in the study of disease and physical disability. Am J Public Health. 1990; 80: 945-9.
118. Baker KR, Xu L, Zhang Y, Nevitt M, Niu J, Aliabadi P, et al. Quadriceps weakness and its relationship to tibiofemoral and patellofemoral knee osteoarthritis in Chinese: the Beijing osteoarthritis study. Arthritis Care Res. 2004; 50: 1815-21.
119. Miller ME, Rejeski WJ, Messier SP, Loeser RF. Modifiers of change in physical functioning in older adults with knee pain: the Observational Arthritis Study in Seniors (OASIS). Arthritis Rheum. 2001; 45: 331-9.
120. Scott D, Blizzard L, Fell J, Jones G. A prospective study of the associations between self-reported pain, radiographic osteoarthritis and sarcopenia in community-dwelling older adults. Arthritis Care Res 2011; (in press).
121. Kaufman DW, Kelly JP, Rosenberg L, Anderson TE, Mitchell AA. Recent patterns of medication use in the ambulatory adult population of the United States: the slone survey. J Am Med Assoc. 2002; 287: 337-44.
122. Ashfield TA, Syddall HE, Martin HJ, Dennison EM, Cooper C, Aihie Sayer A. Grip strength and cardiovascular drug use in older people: findings from the Hertfordshire Cohort Study. Age Ageing. 2010; 39: 185-91.
123. Campbell AJ, Borrie MJ, Spears GF. Risk factors for falls in a community-based prospective study of people 70 years and older. J Gerontol. 1989; 44: M112-7.
124. Blake AJ, Morgan K, Bendall MJ, Dallosso H, Ebrahim SBJ, Arie THD, et al. Falls by elderly people at home: prevalence and associated factors. Age Ageing. 1988; 17: 365-72.
125. Lawlor DA, Patel R, Ebrahim S. Association between falls in elderly women and chronic diseases and drug use: cross sectional study. Br Med J. 2003; 327: 712-7.
126. Gray SL, LaCroix AZ, Hanlon JT, Penninx B, Blough DK, Leveille SG, et al. Benzodiazepine use and physical disability in community-dwelling older adults. J Am Geriatr Soc. 2006; 54: 224-30.
127. Lord SR, Anstey KJ, Williams P, Ward JA. Psychoactive medication use, sensori-motor function and falls in older women. Br J Clin Pharmacol. 1995; 39: 227-34.
128. Vescovo G, Dalla Libera L, Serafini F, Leprotti C, Facchin L, Volterrani M, et al. Improved exercise tolerance after losartan and enalapril in heart failure: correlation with changes in skeletal muscle myosin heavy chain composition. Circulation. 1998; 98: 1742-9.
129. Onder G, Penninx B, Balkrishnan R, Fried LP, Chaves PHM, Williamson J, et al. Relation between use of angiotensin-converting enzyme inhibitors and muscle strength and physical function in older women: an observational study. Lancet. 2002; 359: 926-30.
130. Qato DM, Alexander GC, Conti RM, Johnson M, Schumm P, Lindau ST. Use of prescription and over-the-counter medications and dietary supplements among older adults in the United States. J Am Med Assoc. 2008; 300: 2867-78.
131. ATPIII. Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults. J Am Med Assoc. 2001; 285: 2486-97.
132. Bruckert E, Hayem G, Dejager S, Yau C, Begaud B. Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients-the PRIMO study. Cardiovasc Drugs Ther. 2005; 19: 403-14.
133. Thompson PD, Clarkson PM, Rosenson RS. An assessment of statin safety by muscle experts. Am J Cardiol. 2006; 97: S69-76.
134. Graham DJ, Staffa JA, Shatin D, Andrade SE, Schech SD, La Grenade L, et al. Incidence of hospitalized rhabdomyolysis in patients treated with lipid-lowering drugs. J Am Med Assoc. 2004; 292: 2585-90.
135. Thompson PD, Clarkson P, Karas RH. Statin-associated myopathy. J Am Med Assoc. 2003; 289: 1681-90.
136. Krishnan GM, Thompson PD. The effects of statins on skeletal muscle strength and exercise performance. Curr Opin Lipidol. 2010; 21: 324-8.
137. Agostini JV, Tinetti ME, Han L, McAvay G, Foody JM, Concato J. Effects of statin use on muscle strength, cognition, and depressive symptoms in older adults. J Am Geriatr Soc. 2007; 55: 420-5.
138. McDermott MM, Guralnik JM, Greenland P, Pearce WH, Criqui MH, Liu K, et al. Statin use and leg functioning in patients with and without lower-extremity peripheral arterial disease. Circulation. 2003; 107: 757-61.
139. Giri J, McDermott MM, Greenland P, Guralnik JM, Criqui MH, Liu K, et al. Statin use and functional decline in patients with and without peripheral arterial disease. J Am Coll Cardiol. 2006; 47: 998-1004.
140. LaCroix AZ, Gray SL, Aragaki A, Cochrane BB, Newman AB, Kooperberg CL, et al. Statin use and incident frailty in women aged 65 years or older: prospective findings from the women's health initiative observational study. J Gerontol A Biol Sci Med Sci. 2008; 63: 369-75.
141. Traustadóttir T, Stock AA, Harman SM. High-dose statin use does not impair aerobic capacity or skeletal muscle function in older adults. Age. 2008; 30: 283-91.
142. Thompson PD, Zmuda JM, Domalik LJ, Zimet RJ, Staggers J, Guyton JR. Lovastatin increases exercise-induced skeletal muscle injury. Metabolism. 1997; 46: 1206-10.
143. Phillips PS, Haas RH, Bannykh S, Hathaway S, Gray NL, Kimura BJ, et al. Statin-associated myopathy with normal creatine kinase levels. Ann Intern Med. 2002; 137: 581-5.
144. Scott D, Blizzard L, Fell J, Jones G. Statin therapy, muscle function and falls risk in community-dwelling older adults. QJM. 2009; 102: 625-33.
145. von Haehling S, Morley J, Anker S. An overview of sarcopenia: facts and numbers on prevalence and clinical impact. J Cachexia Sarcopenia Muscle. 2010; 1: 129-33.
146. von Haehling S, Morley JE, Coats AJS, Anker SD. Ethical guidelines for authorship and publishing in the Journal of Cachexia, Sarcopenia and Muscle. J Cachexia Sarcopenia Muscle. 2010; 1: 7-8.