Targeting sialic acid dependent and independent pathways of invasion in Plasmodium falciparum

PLoS ONE

Volumn 7, Issue 1, 2012, Pages

  Ord, Rosalynn Louise ^a   Rodriguez, Marilis ^a   Yamasaki, Tsutomu ^b   Takeo, Satoru ^b   Tsuboi, Takafumi ^b   Lobo, Cheryl A ^a  

^a NEW YORK BLOOD CENTER   (United States)

^b EHIME UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EBA 175 VACCINE; HYBRID PROTEIN; MALARIA VACCINE; RECOMBINANT PROTEIN; RECOMBINANT RETICULOCYTE BINDING HOMOLOG 5; SIALIC ACID; UNCLASSIFIED DRUG; N ACETYLNEURAMINIC ACID; PARASITE ANTIGEN; PROTOZOAL PROTEIN; PROTOZOON ANTIBODY; SIALIDASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY SPECIFICITY; ANTIGEN EXPRESSION; ANTIGEN RECOGNITION; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG POTENTIATION; DRUG TARGETING; GROWTH INHIBITION; IMMUNE RESPONSE; MALARIA FALCIPARUM; MOUSE; NONHUMAN; PARASITE INVASION; PARASITE PHENOMENA AND FUNCTIONS; PLASMODIUM FALCIPARUM; PROTEIN BINDING; VACCINATION; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; DRUG EFFECT; ERYTHROCYTE; HUMAN; IMMUNOLOGY; ISOLATION AND PURIFICATION; METABOLISM; PARASITE; PARASITOLOGY; PHYSIOLOGY; PROTEIN CONFORMATION; REPRODUCIBILITY; SIGNAL TRANSDUCTION;

MUS; PICHIA PASTORIS; PLASMODIUM FALCIPARUM; TRITICUM AESTIVUM;

ANIMALS; ANTIBODIES, PROTOZOAN; ANTIGENS, PROTOZOAN; ERYTHROCYTES; HUMANS; MICE; MODELS, BIOLOGICAL; N-ACETYLNEURAMINIC ACID; NEURAMINIDASE; PARASITES; PLASMODIUM FALCIPARUM; PROTEIN CONFORMATION; PROTOZOAN PROTEINS; RECOMBINANT PROTEINS; REPRODUCIBILITY OF RESULTS; SIGNAL TRANSDUCTION;

EID: 84855794722     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0030251     Document Type: Article

References (44)

1. Miller LH, Baruch DI, Marsh K, Doumbo OK, (2002) The pathogenic basis of malaria. Nature 415: 673-679.
2. Cowman AF, Crabb BS, (2006) Invasion of red blood cells by malaria parasites. Cell 124: 755-766.
3. Hadley TJ, Klotz FW, Pasvol G, Haynes JD, McGinniss MH, et al. (1987) Falciparum malaria parasites invade erythrocytes that lack glycophorin A and B (MkMk). Strain differences indicate receptor heterogeneity and two pathways for invasion. J Clin Invest 80: 1190-1193.
4. Camus D, Hadley TJ, (1985) A Plasmodium falciparum antigen that binds to host erythrocytes and merozoites. Science 230: 553-556.
5. Adams JH, Blair PL, Kaneko O, Peterson DS, (2001) An expanding ebl family of Plasmodium falciparum. Trends Parasitol 17: 297-299.
6. Maier AG, Duraisingh MT, Reeder JC, Patel SS, Kazura JW, et al. (2003) Plasmodium falciparum erythrocyte invasion through glycophorin C and selection for Gerbich negativity in human populations. Nat Med 9: 87-92.
7. Gilberger TW, Thompson JK, Triglia T, Good RT, Duraisingh MT, et al. (2003) A novel erythrocyte binding antigen-175 paralogue from Plasmodium falciparum defines a new trypsin-resistant receptor on human erythrocytes. J Biol Chem 278: 14480-14486.
8. Mayer DC, Mu JB, Kaneko O, Duan J, Su XZ, et al. (2004) Polymorphism in the Plasmodium falciparum erythrocyte-binding ligand JESEBL/EBA-181 alters its receptor specificity. Proc Natl Acad Sci U S A 101: 2518-2523.
9. Peterson DS, Wellems TE, (2000) EBL-1, a putative erythrocyte binding protein of Plasmodium falciparum, maps within a favored linkage group in two genetic crosses. Mol Biochem Parasitol 105: 105-113.
10. Sim BK, Chitnis CE, Wasniowska K, Hadley TJ, Miller LH, (1994) Receptor and ligand domains for invasion of erythrocytes by Plasmodium falciparum. Science 264: 1941-1944.
11. Dolan SA, Proctor JL, Alling DW, Okubo Y, Wellems TE, et al. (1994) Glycophorin B as an EBA-175 independent Plasmodium falciparum receptor of human erythrocytes. Mol Biochem Parasitol 64: 55-63.
12. Mayer DC, Cofie J, Jiang L, Hartl DL, Tracy E, et al. (2009) Glycophorin B is the erythrocyte receptor of Plasmodium falciparum erythrocyte-binding ligand, EBL-1. Proc Natl Acad Sci U S A 106: 5348-5352.
13. Lobo CA, Rodriguez M, Reid M, Lustigman S, (2003) Glycophorin C is the receptor for the Plasmodium falciparum erythrocyte binding ligand PfEBP-2 (baebl). Blood 101: 4628-4631.
14. Duraisingh MT, Maier AG, Triglia T, Cowman AF, (2003) Erythrocyte-binding antigen 175 mediates invasion in Plasmodium falciparum utilizing sialic acid-dependent and-independent pathways. Proc Natl Acad Sci U S A 100: 4796-4801.
15. Gaur D, Singh S, Singh S, Jiang L, Diouf A, et al. (2007) Recombinant Plasmodium falciparum reticulocyte homology protein 4 binds to erythrocytes and blocks invasion. Proc Natl Acad Sci U S A 104: 17789-17794.
16. Rodriguez M, Lustigman S, Montero E, Oksov Y, Lobo CA, (2008) PfRH5: a novel reticulocyte-binding family homolog of plasmodium falciparum that binds to the erythrocyte, and an investigation of its receptor. PLoS One 3: e3300.
17. Rayner JC, Vargas-Serrato E, Huber CS, Galinski MR, Barnwell JW, (2001) A Plasmodium falciparum homologue of Plasmodium vivax reticulocyte binding protein (PvRBP1) defines a trypsin-resistant erythrocyte invasion pathway. J Exp Med 194: 1571-1581.
18. Spadafora C, Awandare GA, Kopydlowski KM, Czege J, Moch JK, et al. (2011) Complement receptor 1 is a sialic acid-independent erythrocyte receptor of Plasmodium falciparum. PLoS Pathog 6: e1000968.
19. Sim BK, (1998) Delineation of functional regions on Plasmodium falciparum EBA-175 by antibodies eluted from immune complexes. Mol Biochem Parasitol 95: 183-192.
20. Dolan SA, Miller LH, Wellems TE, (1990) Evidence for a switching mechanism in the invasion of erythrocytes by Plasmodium falciparum. J Clin Invest 86: 618-624.
21. Duraisingh MT, Triglia T, Ralph SA, Rayner JC, Barnwell JW, et al. (2003) Phenotypic variation of Plasmodium falciparum merozoite proteins directs receptor targeting for invasion of human erythrocytes. Embo J 22: 1047-1057.
22. Reed MB, Caruana SR, Batchelor AH, Thompson JK, Crabb BS, et al. (2000) Targeted disruption of an erythrocyte binding antigen in Plasmodium falciparum is associated with a switch toward a sialic acid-independent pathway of invasion. Proc Natl Acad Sci U S A 97: 7509-7514.
23. Sim BK, Carter JM, Deal CD, Holland C, Haynes JD, et al. (1994) Plasmodium falciparum: further characterization of a functionally active region of the merozoite invasion ligand EBA-175. Exp Parasitol 78: 259-268.
24. Narum DL, Haynes JD, Fuhrmann S, Moch K, Liang H, et al. (2000) Antibodies against the Plasmodium falciparum receptor binding domain of EBA-175 block invasion pathways that do not involve sialic acids. Infect Immun 68: 1964-1966.
25. Jones TR, Narum DL, Gozalo AS, Aguiar J, Fuhrmann SR, et al. (2001) Protection of Aotus monkeys by Plasmodium falciparum EBA-175 region II DNA prime-protein boost immunization regimen. J Infect Dis 183: 303-312.
26. Sim BK, Narum DL, Liang H, Fuhrmann SR, Obaldia N 3rd, et al. (2001) Induction of biologically active antibodies in mice, rabbits, and monkeys by Plasmodium falciparum EBA-175 region II DNA vaccine. Mol Med 7: 247-254.
27. Jiang L, Gaur D, Mu J, Zhou H, Long CA, et al. (2011) Evidence for erythrocyte-binding antigen 175 as a component of a ligand-blocking blood-stage malaria vaccine. Proc Natl Acad Sci U S A 108: 7553-7558.
28. Hayton K, Gaur D, Liu A, Takahashi J, Henschen B, et al. (2008) Erythrocyte binding protein PfRH5 polymorphisms determine species-specific pathways of Plasmodium falciparum invasion. Cell Host Microbe 4: 40-51.
29. Baum J, Chen L, Healer J, Lopaticki S, Boyle M, et al. (2009) Reticulocyte-binding protein homologue 5- an essential adhesin involved in invasion of human erythrocytes by Plasmodium falciparum. Int J Parasitol 39: 371-380.
30. Tsuboi T, Takeo S, Arumugam TU, Otsuki H, Torii M, (2010) The wheat germ cell-free protein synthesis system: a key tool for novel malaria vaccine candidate discovery. Acta Trop 114: 171-176.
31. Tsuboi T, Takeo S, Sawasaki T, Torii M, Endo Y, (2010) An efficient approach to the production of vaccines against the malaria parasite. Methods Mol Biol 607: 73-83.
32. Zhang D, Pan W, (2005) Evaluation of three Pichia pastoris-expressed Plasmodium falciparum merozoite proteins as a combination vaccine against infection with blood-stage parasites. Infect Immun 73: 6530-6536.
33. Sim BK, (1990) Sequence conservation of a functional domain of erythrocyte binding antigen 175 in Plasmodium falciparum. Mol Biochem Parasitol 41: 293-295.
34. El Sahly HM, Patel SM, Atmar RL, Lanford TA, Dube T, et al. (2010) Safety and immunogenicity of a recombinant nonglycosylated erythrocyte binding antigen 175 Region II malaria vaccine in healthy adults living in an area where malaria is not endemic. Clin Vaccine Immunol 17: 1552-1559.
35. Gaur D, Furuya T, Mu J, Jiang LB, Su XZ, et al. (2006) Upregulation of expression of the reticulocyte homology gene 4 in the Plasmodium falciparum clone Dd2 is associated with a switch in the erythrocyte invasion pathway. Mol Biochem Parasitol 145: 205-215.
36. Stubbs J, Simpson KM, Triglia T, Plouffe D, Tonkin CJ, et al. (2005) Molecular mechanism for switching of P. falciparum invasion pathways into human erythrocytes. Science 309: 1384-1387.
37. Lopaticki S, Maier AG, Thompson J, Wilson DW, Tham WH, et al. (2011) Reticulocyte and erythrocyte binding-like proteins function cooperatively in invasion of human erythrocytes by malaria parasites. Infect Immun 79: 1107-1117.
38. Miura K, Perera S, Brockley S, Zhou H, Aebig JA, et al. (2011) Non-apical membrane antigen 1 (AMA1) IgGs from Malian children interfere with functional activity of AMA1 IgGs as judged by growth inhibition assay. PLoS One 6: e20947.
39. Pandey KC, Singh S, Pattnaik P, Pillai CR, Pillai U, et al. (2002) Bacterially expressed and refolded receptor binding domain of Plasmodium falciparum EBA-175 elicits invasion inhibitory antibodies. Mol Biochem Parasitol 123: 23-33.
40. Trager W, Jensen JB, (1976) Human malaria parasites in continuous culture. Science 193: 673-675.
41. Su XZ, Carucci DJ, Wellems TE, (1998) Plasmodium falciparum: parasite typing by using a multicopy microsatellite marker, PfRRM. Exp Parasitol 89: 262-265.
42. Peek LJ, Brandau DT, Jones LS, Joshi SB, Middaugh CR, (2006) A systematic approach to stabilizing EBA-175 RII-NG for use as a malaria vaccine. Vaccine 24: 5839-5851.
43. Tsuboi T, Takeo S, Iriko H, Jin L, Tsuchimochi M, et al. (2008) Wheat germ cell-free system-based production of malaria proteins for discovery of novel vaccine candidates. Infect Immun 76: 1702-1708.
44. Wahlgren M, Berzins K, Perlmann P, Bjorkman A, (1983) Characterization of the humoral immune response in Plasmodium falciparum malaria. I. Estimation of antibodies to P. falciparum or human erythrocytes by means of microELISA. Clinical and experimental immunology 54: 127-134.