A microfluidic device with passive air-bubble valves for real-time measurement of dose-dependent drug cytotoxicity through impedance sensing

Biosensors and Bioelectronics

Volumn 32, Issue 1, 2012, Pages 300-304

  Xu, Youchun ^a,b   Lv, Yi ^a,b   Wang, Lei ^b   Xing, Wanli ^a,b   Cheng, Jing ^a,b  

^a TSINGHUA UNIVERSITY   (China)

^b NATIONAL ENGINEERING RESEARCH CENTER FOR BEIJING BIOCHIP TECHNOLOGY   (China)

Author keywords

Air bubble valve; Concentration gradient generator; Cytotoxicity; ECIS

Indexed keywords

AIR-BUBBLE VALVE; ANTICANCER DRUG; AUTOMATED ANALYSIS; AUTOMATIC CLOSURE; BIOLOGICAL STUDIES; CANCER CELL LINES; CELL BEHAVIORS; CELL SUBSTRATES; CIS-PLATIN; CONCENTRATION GRADIENT GENERATOR; CONCENTRATION GRADIENTS; DIFFUSIBLE MOLECULES; DOSE-DEPENDENT; DRUG DISCOVERY; DRUG RESPONSE; DRUG SCREENING; ECIS; IMPEDANCE SENSING; IN-VITRO; MICRO-FLUIDIC DEVICES; POLYDIMETHYLSILOXANE PDMS; PROOF OF CONCEPT; QUANTITATIVE MEASUREMENT; REAL TIME MEASUREMENTS; REAL TIME MONITORING; THREE COMPONENT;

CELL CULTURE; CELL DEATH; CYTOTOXICITY; DRUG DOSAGE; FLUIDIC DEVICES; MICROFLUIDICS; MONITORING; PLATINUM COMPOUNDS; SILICONES;

ELECTRIC SENSING DEVICES;

CISPLATIN; DIMETICONE;

AIR; AIR BUBBLE VALVE; APOPTOSIS; ARTICLE; AUTOMATION; CANCER CELL CULTURE; CELL CULTURE; CONTROLLED STUDY; DENSITY GRADIENT; DOSE RESPONSE; DRUG CYTOTOXICITY; DYNAMICS; ELECTRIC CELL SUBSTRATE IMPEDANCE SENSING; ELECTRODE; GENETIC PROCEDURES; IMPEDANCE; MICROFLUIDIC ANALYSIS; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CISPLATIN; DRUG EVALUATION, PRECLINICAL; ELECTRIC IMPEDANCE; EQUIPMENT DESIGN; HUMANS; MICROFLUIDIC ANALYTICAL TECHNIQUES; NEOPLASMS;

EID: 84855787999     PISSN: 09565663     EISSN: 18734235     Source Type: Journal    
DOI: 10.1016/j.bios.2011.12.009     Document Type: Article

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