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Volumn 47, Issue 1, 2012, Pages 351-359

Structure based drug design, synthesis and evaluation of 4-(benzyloxy)-1-phenylbut-2-yn-1-ol derivatives as 5-lipoxygenase inhibitors

(6) Reddy, Nimmanapalli P a Chandramohan Reddy, T a Aparoy, Polamarasetty a Achari, Chandrani a Sridhar, P Ramu a Reddanna, Pallu a

a UNIVERSITY OF HYDERABAD (India)

Author keywords

4 (Benzyloxy) 1 phenylbut 2 yn 1 ol derivatives; 5 LOX; Acute lung injury; Carcinoma cell line; In silico prediction; Site point connection method

Indexed keywords

4 (BENZYLOXY) 1 PHENYLBUT 2 YN 1 OL DERIVATIVE; CELECOXIB; LIPOPOLYSACCHARIDE; LIPOXYGENASE INHIBITOR; UNCLASSIFIED DRUG;

ACUTE LUNG INJURY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING SITE; CANCER CELL CULTURE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOTOXICITY; DRUG DESIGN; DRUG EFFECT; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROPHOBICITY; IC 50; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN;

ACUTE LUNG INJURY; ANIMALS; ARACHIDONATE 5-LIPOXYGENASE; BENZYL COMPOUNDS; BUTANOLS; CATALYTIC DOMAIN; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; LIPOPOLYSACCHARIDES; LIPOXYGENASE INHIBITORS; MICE; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84855784789 PISSN: 02235234 EISSN: 17683254 Source Type: Journal
DOI: 10.1016/j.ejmech.2011.11.003 Document Type: Article

Times cited : (17)

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