5-((4-Aminopiperidin-1-yl)methyl)pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 17, 2007, Pages 4947-4954

  Mastalerz, Harold ^a   Chang, Ming ^a   Chen, Ping ^a   Fink, Brian E ^a   Gavai, Ashvinikumar ^a   Han, Wen Ching ^a   Johnson, Walter ^a   Langley, David ^a   Lee, Francis Y ^a   Leavitt, Kenneth ^a   Marathe, Punit ^a   Norris, Derek ^a   Oppenheimer, Simone ^a   Sleczka, Bogdan ^a   Tarrant, James ^a   Tokarski, John S ^a   Vite, Gregory D ^a   Vyas, Dolatrai M ^a   Wong, Henry ^a   Wong, Tai W ^a   Zhang, Hongjian ^a   Zhang, Guifen ^a   more..

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

EGFR; HER2; Kinase inhibitor; Pyrrolotriazine

Indexed keywords

5 [(4 AMINOPIPERIDIN 1 YL)METHYL)PYRROLOTRIAZINE DUAL INHIBITOR; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; X RAY CRYSTALLOGRAPHY;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; INSECTS; MODELS, CHEMICAL; NEOPLASM TRANSPLANTATION; NEOPLASMS; PIPERIDINES; PYRROLES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; TRIAZINES;

EID: 34547611405     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.06.019     Document Type: Article

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