Upregulation of BAD, a pro-apoptotic protein of the BCL2 family, in vascular smooth muscle cells exposed to uremic conditions

Biochemical and Biophysical Research Communications

Volumn 417, Issue 1, 2012, Pages 479-483

  Trécherel, Eric ^a   Godin, Corinne ^a   Louandre, Christophe ^b   Benchitrit, Joyce ^a   Poirot, Sabrina ^a   Mazière, Jean Claude ^a,b   Massy, Ziad A ^a,b   Galmiche, Antoine ^a,b  

^a INSERM   (France)

^b AMIENS UNIVERSITY HOSPITAL   (France)

Author keywords

Apoptosis; BCL2; Chronic kidney disease; Uremic toxins; Vascular smooth muscle cells

Indexed keywords

PROTEIN BAD;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; SENSITIZATION; SMOOTH MUSCLE FIBER; UPREGULATION; UREMIA; VASCULAR SMOOTH MUSCLE;

ANIMALS; APOPTOSIS; BCL-ASSOCIATED DEATH PROTEIN; CELLS, CULTURED; CREATINE; HUMANS; KIDNEY FAILURE, CHRONIC; MICE; MICE, INBRED C57BL; MUSCLE, SMOOTH, VASCULAR; UREA; UREMIA;

MUS;

EID: 84855756808     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.11.144     Document Type: Article

References (27)

1. W.G. Couser, G. Remuzzi, S. Mendis, M. Tonelli. The contribution of chronic kidney disease to the global burden of major noncommunicable diseases. Kidney Int. 2011 [Epub ahead of print].
2. Keith D.S., Nichols G.A., Gullion C.M., Brown J.B., Smith D.H. Longitudinal follow-up and outcomes among a population with chronic kidney disease in a large managed care organization. Arch. Intern. Med. 2004, 164:659-663.
3. Wen C.P., Cheng T.Y., Tsai M.K., Chang Y.C., Chan H.T., Tsai S.P., et al. All-cause mortality attributable to chronic kidney disease: a prospective cohort study based on 462,293 adults in Taiwan. Lancet 2008, 371:2173-2182.
4. Drüeke T.B., Massy Z.A. Atherosclerosis in CKD: differences from the general population. Nat. Rev. Nephrol. 2010, 12:723-735.
5. Swaminathan S., Shah S.V. Novel inflammatory mechanisms of accelerated atherosclerosis in kidney disease. Kidney Int. 2011, 80:453-463.
6. Libby P., Ridker P.M., Hansson G.K. Progress and challenges in translating the biology of atherosclerosis. Nature 2011, 473:317-325.
7. Vanholder R., De Smet R., Glorieux G., et al. Review on uremic toxins: classification, concentration, and interindividual variability. Kidney Int. 2003, 63:1934-1943.
8. Bennett M.R., Evan G.I., Schwartz S.M. Apoptosis of human vascular smooth muscle cells derived from normal vessels and coronary atherosclerotic plaques. J. Clin. Invest. 1995, 95:2266-2274.
9. Bennett M.R. Life and death in the atherosclerotic plaque. Curr. Opin. Lipidol. 2010, 21:422-426.
10. Tabas I. Apoptosis and plaque destabilization in atherosclerosis: the role of macrophage apoptosis induced by cholesterol. Cell Death Differ. 2004, 11:S12-S16.
11. Seimon T., Tabas I. Mechanisms and consequences of macrophage apoptosis in atherosclerosis. J. Lipid Res. 2009, 50(Suppl):S382-S387.
12. Clarke M.C., Figg N., Maguire J.J., Davenport A.P., Goddard M., Littlewood T.D., Bennett M.R. Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis. Nat. Med. 2006, 12:1075-1080.
13. Clarke M.C., Littlewood T.D., Figg N., Maguire J.J., Davenport A.P., Goddard M., Bennett M.R. Chronic apoptosis of vascular smooth muscle cells accelerates atherosclerosis and promotes calcification and medial degeneration. Circ. Res. 2008, 102:1529-1538.
14. Shroff R.C., McNair R., Figg N., Skepper J.N., Schurgers L., Gupta A., et al. Dialysis accelerates medial vascular calcification in part by triggering smooth muscle cell apoptosis. Circulation 2008, 118:1748-1757.
15. Martinou J.C., Youle R.J. Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics. Dev. Cell. 2011, 21:92-101.
16. Massy Z.A., Ivanovski O., Nguyen-Khoa T., Angulo J., Szumilak D., Mothu N., et al. Uremia accelerates both atherosclerosis and arterial calcification in apolipoprotein E knockout mice. J. Am. Soc. Nephrol. 2005, 16:109-116.
17. Ezzoukhry Z., Louandre C., François C., Saidak Z., Godin C., Mazière J.C., Galmiche A. The Bcl-2 homology domain 3 (BH3) mimetic ABT-737 reveals the dynamic regulation of Bad, a proapoptotic protein of the Bcl-2 family, by Bcl-xL. Mol. Pharmacol. 2011, 79:997-1004.
18. Danial N.N. BAD: undertaker by night, candyman by day. Oncogene 2008, 27:S53-S70.
19. Ying W.Z., Zhang H.G., Sanders P.W. EGF receptor activity modulates apoptosis induced by inhibition of the proteasome of vascular smooth muscle cells. J. Am. Soc. Nephrol. 2007, 18:131-142.
20. Fueller J., Becker M., Sienerth A.R., Fischer A., Hotz C., Galmiche A. C-RAF activation promotes BAD poly-ubiquitylation and turn-over by the proteasome. Biochem. Biophys. Res. Commun. 2008, 370:552-556.
21. Massy Z.A., Stenvinkel P., Drueke T.B. The role of oxidative stress in chronic kidney disease. Semin. Dial. 2009, 22:405-408.
22. Salvayre R., Auge N., Benoist H., Negre-Salvayre A. Oxidized low-density lipoprotein-induced apoptosis. Biochim. Biophys. Acta. 2002, 1585:213-221.
23. Oltersdorf T., Elmore S.W., Shoemaker A.R., Armstrong R.C., Augeri D.J., Belli B.A., et al. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 2005, 435:677-681.
24. Galmiche A., Ezzoukhry Z., François C., Louandre C., Sabbagh C., Nguyen-Khac E., et al. BAD, a proapoptotic member of the BCL2 family, is a potential therapeutic target in hepatocellular carcinoma. Mol. Cancer Res. 2010, 8:1116-1125.
25. D'Apolito M., Du X., Zong H., Catucci A., Maiuri L., Trivisano T., et al. Urea-induced ROS generation causes insulin resistance in mice with chronic renal failure. J. Clin. Invest. 2010, 120:203-213.
26. Danial N.N., Gramm C.F., Scorrano L., Zhang C.Y., Krauss S., Ranger A.M., et al. BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Nature 2003, 424:952-956.
27. Danial N.N., Walensky L.D., Zhang C.Y., Choi C.S., Fisher J.K., Molina A.J., et al. Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nat. Med. 2008, 14:144-153.