-
1
-
-
2642551603
-
Development of the proteasome inhibitor Velcade (Bortezomib)
-
Adams J, Kauffman M. Development of the proteasome inhibitor Velcade (Bortezomib). Cancer Invest 2004;22:304-11.
-
(2004)
Cancer Invest
, vol.22
, pp. 304-311
-
-
Adams, J.1
Kauffman, M.2
-
2
-
-
0036144763
-
Regulatory functions of ubiquitination in the immune system
-
Ben-Neriah Y. Regulatory functions of ubiquitination in the immune system. Nat Immunol 2002;3:20-6.
-
(2002)
Nat Immunol
, vol.3
, pp. 20-26
-
-
Ben-Neriah, Y.1
-
3
-
-
33746160660
-
Proteasome inhibitor bortezomib for the treatment of multiple myeloma
-
Cavo M. Proteasome inhibitor bortezomib for the treatment of multiple myeloma. Leukemia 2006;20:1341-52.
-
(2006)
Leukemia
, vol.20
, pp. 1341-1352
-
-
Cavo, M.1
-
4
-
-
0242468166
-
Proteasome inhibitors potentiate leukemic cell apoptosis induced by the cyclin-dependent kinase inhibitor flavopiridol through a SAPK/JNK and NF-κB dependent process
-
Dai Y, Rahman M, Grant S. Proteasome inhibitors potentiate leukemic cell apoptosis induced by the cyclin-dependent kinase inhibitor flavopiridol through a SAPK/JNK and NF-κB dependent process. Oncogene 2003;22:7103-22.
-
(2003)
Oncogene
, vol.22
, pp. 7103-7122
-
-
Dai, Y.1
Rahman, M.2
Grant, S.3
-
5
-
-
0032905030
-
Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB
-
Wang CY, Cusack JC, Liu R, Baldwin A Jr. Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB. Nat Med 1999;5:412-7.
-
(1999)
Nat Med
, vol.5
, pp. 412-417
-
-
Wang, C.Y.1
Cusack, J.C.2
Liu, R.3
Baldwin Jr, A.4
-
6
-
-
3843061181
-
The bortezomib-induced mitochondrial damage is mediated by accumulation of active protein kinase C-delta
-
Durrant D, Liu J, Yang HS, Lee RM. The bortezomib-induced mitochondrial damage is mediated by accumulation of active protein kinase C-delta. Biochem Biophys Res Commun 2004;321:905-8.
-
(2004)
Biochem Biophys Res Commun
, vol.321
, pp. 905-908
-
-
Durrant, D.1
Liu, J.2
Yang, H.S.3
Lee, R.M.4
-
7
-
-
43749098729
-
Proteasome inhibition suppresses essential immune functions of human CD4+T cells
-
Berges C, Haberstock H, Fuchs D et al. Proteasome inhibition suppresses essential immune functions of human CD4+T cells. Immunology 2008;124:234-46.
-
(2008)
Immunology
, vol.124
, pp. 234-246
-
-
Berges, C.1
Haberstock, H.2
Fuchs, D.3
-
8
-
-
2542599273
-
Inhibition of acute graft-versus-host disease with retention of graft versus-tumor effects by proteasome inhibitor bortezomib
-
Sun K, Welniak LA, Panoskaltsis-Mortari A et al. Inhibition of acute graft-versus-host disease with retention of graft versus-tumor effects by proteasome inhibitor bortezomib. Proc Natl Acad Sci USA 2004;101:8120-5.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 8120-8125
-
-
Sun, K.1
Welniak, L.A.2
Panoskaltsis-Mortari, A.3
-
9
-
-
46749088320
-
The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis
-
Neubert K, Meister S, Moser K et al. The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis. Nat Med 2008;14:748-55.
-
(2008)
Nat Med
, vol.14
, pp. 748-755
-
-
Neubert, K.1
Meister, S.2
Moser, K.3
-
10
-
-
63049137443
-
The proteasome inhibitor bortezomib inhibits the release of NFkappaB-inducible cytokines and induces apoptosis of activated T cells from rheumatoid arthritis patients
-
van der Heijden JW, Oerlemans R, Lems WF, Scherper RJ, Dijkmans BA, Jansen G. The proteasome inhibitor bortezomib inhibits the release of NFkappaB-inducible cytokines and induces apoptosis of activated T cells from rheumatoid arthritis patients. Clin Exp Rheumatol 2009;27:92-8.
-
(2009)
Clin Exp Rheumatol
, vol.27
, pp. 92-98
-
-
van der Heijden, J.W.1
Oerlemans, R.2
Lems, W.F.3
Scherper, R.J.4
Dijkmans, B.A.5
Jansen, G.6
-
11
-
-
78049497262
-
The proteasome inhibitor bortezomib drastically affects inflammation and bone disease in adjuvant-induced arthritis in rats
-
Yannaki E, Papadopoulou A, Athanasiou E et al. The proteasome inhibitor bortezomib drastically affects inflammation and bone disease in adjuvant-induced arthritis in rats. Arthritis Rheum 2010;62:3277-88.
-
(2010)
Arthritis Rheum
, vol.62
, pp. 3277-3288
-
-
Yannaki, E.1
Papadopoulou, A.2
Athanasiou, E.3
-
12
-
-
33845713350
-
Systems biology in systemic lupus erythematosus: integrating genes, biology and immune function
-
Kyttaris VC, Krishnan S, Tsokos GS. Systems biology in systemic lupus erythematosus: integrating genes, biology and immune function. Autoimmunity 2006;39:705-9.
-
(2006)
Autoimmunity
, vol.39
, pp. 705-709
-
-
Kyttaris, V.C.1
Krishnan, S.2
Tsokos, G.S.3
-
13
-
-
75749095952
-
Pathogenic mechanisms in systemic lupus erythematosus
-
Perl A. Pathogenic mechanisms in systemic lupus erythematosus. Autoimmunity 2010;43:1-6.
-
(2010)
Autoimmunity
, vol.43
, pp. 1-6
-
-
Perl, A.1
-
14
-
-
0037653244
-
Increased ubiquitination and reduced expression of LCK in T lymphocytes from patients with systemic lupus erythematosus
-
Jury EC, Kabouridis PS, Abba A, Mageed RA, Isenberg DA. Increased ubiquitination and reduced expression of LCK in T lymphocytes from patients with systemic lupus erythematosus. Arthritis Rheum 2003;48:1343-54.
-
(2003)
Arthritis Rheum
, vol.48
, pp. 1343-1354
-
-
Jury, E.C.1
Kabouridis, P.S.2
Abba, A.3
Mageed, R.A.4
Isenberg, D.A.5
-
15
-
-
53749090207
-
Novel therapies in lupus - focus on nephritis
-
Cordeiro AC, Isenberg DA. Novel therapies in lupus - focus on nephritis. Acta Rheumatol Port 2008;33:157-69.
-
(2008)
Acta Rheumatol Port
, vol.33
, pp. 157-169
-
-
Cordeiro, A.C.1
Isenberg, D.A.2
-
16
-
-
77956044827
-
Therapeutic opportunities in systemic lupus erythematosus: state of the art and prospects for the new decade
-
Bertsias GK, Salmon JE, Boumpas DT. Therapeutic opportunities in systemic lupus erythematosus: state of the art and prospects for the new decade. Ann Rheum Dis 2010;99:1603-11.
-
(2010)
Ann Rheum Dis
, vol.99
, pp. 1603-1611
-
-
Bertsias, G.K.1
Salmon, J.E.2
Boumpas, D.T.3
-
17
-
-
79953035759
-
The genetics of systemic lupus erythematosus and implications for targeted therapy
-
Sestak AL, Fürnrohr BG, Harley JB, Merrill JT, Namjou B. The genetics of systemic lupus erythematosus and implications for targeted therapy. Ann Rheum Dis 2011;70 (Suppl. 1):i37-43.
-
(2011)
Ann Rheum Dis
, vol.70
, Issue.SUPPL. 1
-
-
Sestak, A.L.1
Fürnrohr, B.G.2
Harley, J.B.3
Merrill, J.T.4
Namjou, B.5
-
18
-
-
4944221618
-
Abnormal cell-specific expressions of certain protein kinase C isoenzymes in peripheral mononuclear cells of patients with systemic lupus erythematosus: effect of corticosteroid application
-
Bíró T, Griger Z, Kiss E et al. Abnormal cell-specific expressions of certain protein kinase C isoenzymes in peripheral mononuclear cells of patients with systemic lupus erythematosus: effect of corticosteroid application. Scand J Immunol 2004;60:421-8.
-
(2004)
Scand J Immunol
, vol.60
, pp. 421-428
-
-
Bíró, T.1
Griger, Z.2
Kiss, E.3
-
19
-
-
18844473151
-
PKC theta is required for TCR-induced NF-kappa B activation in mature but not immature T lymphocytes
-
Sun Z, Arendt CW, Ellmeier CW, Schaeffer EM, Sunshine MJ, Gandhi L. PKC theta is required for TCR-induced NF-kappa B activation in mature but not immature T lymphocytes. Nature 2000;404:402-7.
-
(2000)
Nature
, vol.404
, pp. 402-407
-
-
Sun, Z.1
Arendt, C.W.2
Ellmeier, C.W.3
Schaeffer, E.M.4
Sunshine, M.J.5
Gandhi, L.6
-
20
-
-
33646421393
-
Bortezomib induces selective depletion of alloreactive T lymphocytes and decreases the production of Th1 cytokines
-
Blanco B, Pérez-Simón JA, Sánchez-Abarca LI, Carvajal-Vergaga X, Mateos J, Vidriales B. Bortezomib induces selective depletion of alloreactive T lymphocytes and decreases the production of Th1 cytokines. Blood 2006;107:3575-83.
-
(2006)
Blood
, vol.107
, pp. 3575-3583
-
-
Blanco, B.1
Pérez-Simón, J.A.2
Sánchez-Abarca, L.I.3
Carvajal-Vergaga, X.4
Mateos, J.5
Vidriales, B.6
-
21
-
-
36749025313
-
Protein kinase C delta and apoptosis
-
Reyland ME. Protein kinase C delta and apoptosis. Biochem Soc Trans 2007;35:1001-4.
-
(2007)
Biochem Soc Trans
, vol.35
, pp. 1001-1004
-
-
Reyland, M.E.1
-
22
-
-
36148993630
-
Protein kinase C-zeta (PKC-zeta) regulates Kupffer cell apoptosis during experimental sepsis
-
Peng Y, Sigua CA, Karsonovich C, Murr MM. Protein kinase C-zeta (PKC-zeta) regulates Kupffer cell apoptosis during experimental sepsis. J Gastrointest Surg 2007;11:1712-21.
-
(2007)
J Gastrointest Surg
, vol.11
, pp. 1712-1721
-
-
Peng, Y.1
Sigua, C.A.2
Karsonovich, C.3
Murr, M.M.4
-
23
-
-
77954677747
-
The proteasome inhibitor bortezomib inhibits T cell-dependent inflammatory responses
-
Yanaba K, Yoshazaki A, Muroi E et al. The proteasome inhibitor bortezomib inhibits T cell-dependent inflammatory responses. J Leukoc Biol 2010;88:117-22.
-
(2010)
J Leukoc Biol
, vol.88
, pp. 117-122
-
-
Yanaba, K.1
Yoshazaki, A.2
Muroi, E.3
-
24
-
-
77955853897
-
Systemic lupus erythematosus and increased risk to develop B cell malignancies: role of the p200-family proteins
-
Veeranki S, Choubey D. Systemic lupus erythematosus and increased risk to develop B cell malignancies: role of the p200-family proteins. Immunol Lett 2010;133:1-5.
-
(2010)
Immunol Lett
, vol.133
, pp. 1-5
-
-
Veeranki, S.1
Choubey, D.2
-
25
-
-
78049450649
-
Apoptosis in Jurkat cells induced by bortezomib combined with adriamycin
-
Chen JF, Jin J. Apoptosis in Jurkat cells induced by bortezomib combined with adriamycin. Zhonghua Zhong Liu Za Zhi 2009;31:890-3.
-
(2009)
Zhonghua Zhong Liu Za Zhi
, vol.31
, pp. 890-893
-
-
Chen, J.F.1
Jin, J.2
-
26
-
-
77956238948
-
D1 and D2 dopamine receptor-mediated inhibition of activated normal T cell proliferation is lost in Jurkat T leukemic cells
-
Basu B, Sarkar C, Chakroborty D et al. D1 and D2 dopamine receptor-mediated inhibition of activated normal T cell proliferation is lost in Jurkat T leukemic cells. J Biol Chem 2010;285:27026-32.
-
(2010)
J Biol Chem
, vol.285
, pp. 27026-27032
-
-
Basu, B.1
Sarkar, C.2
Chakroborty, D.3
-
27
-
-
78751483373
-
Bortezomib sensitizes malignant human glioma cells to TRAIL, mediated by inhibition of the NF-(kappa)B signaling pathway
-
Jane EP, Premkumar DR, Pollack IF. Bortezomib sensitizes malignant human glioma cells to TRAIL, mediated by inhibition of the NF-(kappa)B signaling pathway. Mol Cancer Ther 2011;10:198-208.
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 198-208
-
-
Jane, E.P.1
Premkumar, D.R.2
Pollack, I.F.3
-
28
-
-
65549124475
-
Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus
-
Jakob CO, Zhu J, Armstrong DL et al. Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus. Proc Natl Acad Sci USA 2009;106:6256-61.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 6256-6261
-
-
Jakob, C.O.1
Zhu, J.2
Armstrong, D.L.3
-
29
-
-
70350496589
-
Identification of critical residues of the MyD88 death domain involved in the recruitment of downstream kinases
-
Loiarro M, Gallo G, Fanto N et al. Identification of critical residues of the MyD88 death domain involved in the recruitment of downstream kinases. J Biol Chem 2009;284:28093-103.
-
(2009)
J Biol Chem
, vol.284
, pp. 28093-28103
-
-
Loiarro, M.1
Gallo, G.2
Fanto, N.3
|