Brain metastases as the primary site of relapse in two randomized phase III pemetrexed trials in advanced nonsmall-cell lung cancer

Clinical Lung Cancer

Volumn 13, Issue 1, 2012, Pages 24-30

  Ortuzar, Waldo ^a   Hanna, Nasser ^b   Pennella, Eduardo ^a   Peng, Guangbin ^a   Langer, Corey ^c   Monberg, Matthew ^a   Scagliotti, Giorgio ^d  

^a ELI LILLY AND COMPANY   (United States)

^b INDIANA UNIVERSITY   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d UNIVERSITY OF TURIN   (Italy)

Author keywords

Brain metastases; Nonsmall cell lung cancer; Pemetrexed; Symptomatic

Indexed keywords

CISPLATIN; CYANOCOBALAMIN; DEXAMETHASONE; DOCETAXEL; FOLIC ACID; GEMCITABINE; PEMETREXED;

ADVANCED CANCER; ARTICLE; BRAIN METASTASIS; CANCER RELAPSE; HISTOLOGY; HUMAN; INCIDENCE; LUNG NON SMALL CELL CANCER; MULTIPLE CYCLE TREATMENT; PHASE 3 CLINICAL TRIAL (TOPIC); RANDOMIZED CONTROLLED TRIAL (TOPIC); RETROSPECTIVE STUDY;

AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BRAIN NEOPLASMS; CARCINOMA, NON-SMALL-CELL LUNG; CARCINOMA, SQUAMOUS CELL; CISPLATIN; DEOXYCYTIDINE; FEMALE; FOLLOW-UP STUDIES; GLUTAMATES; GUANINE; HUMANS; LUNG NEOPLASMS; MALE; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; RETROSPECTIVE STUDIES; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 84855709286     PISSN: 15257304     EISSN: 19380690     Source Type: Journal    
DOI: 10.1016/j.cllc.2011.05.007     Document Type: Article

References (55)

1. A. Jemal, R. Siegel, E. Ward Cancer statistics, 2009 CA Cancer J Clin 59 2009 225 249
2. Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomised clinical trials Non-small Cell Lung Cancer Collaborative Group BMJ 311 1995 899 909
3. R. Grilli, A.D. Oxman, J.A. Julian Chemotherapy for advanced non-small-cell lung cancer: how much benefit is enough? J Clin Oncol 11 1993 1866 1872 (Pubitemid 23304609)
4. P. Marino, S. Pampallona, A. Preatoni Chemotherapy vs supportive care in advanced non-small-cell lung cancer Results of a meta-analysis of the literature Chest 106 1994 861 865 (Pubitemid 24278896)
5. P.J. Souquet, F. Chauvin, J.P. Boissel Polychemotherapy in advanced non small cell lung cancer: a meta-analysis Lancet 342 1993 19 21 (Pubitemid 23183916)
6. A. Rajeswaran, A. Trojan, B. Burnand Efficacy and side effects of cisplatin- and carboplatin-based doublet chemotherapeutic regimens versus non-platinum-based doublet chemotherapeutic regimens as first line treatment of metastatic non-small cell lung carcinoma: a systematic review of randomized controlled trials Lung Cancer 59 2008 1 11
7. G. D'Addario, M. Pintilie, N.B. Leighl Platinum-based versus non-platinum-based chemotherapy in advanced non-small-cell lung cancer: a meta-analysis of the published literature J Clin Oncol 23 2005 2926 2936 (Pubitemid 46224111)
8. P. Davey Brain metastases: treatment options to improve outcomes CNS Drugs 16 2002 325 338 (Pubitemid 34548200)
9. L. Gaspar, C. Scott, M. Rotman Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials Int J Radiat Oncol Biol Phys 37 1997 745 751 (Pubitemid 27181303)
10. J.B. Posner Management of brain metastases Rev Neurol (Paris) 148 1992 477 487
11. P.Y. Wen, J.S. Loeffler Management of brain metastases Oncology (Williston Park) 13 1999 941 954 957-61; discussion 961-2, 969
12. A. Bajard, V. Westeel, A. Dubiez Multivariate analysis of factors predictive of brain metastases in localised non-small cell lung carcinoma Lung Cancer (Amsterdam, Netherlands) 45 2004 317 323 (Pubitemid 39037713)
13. R.A. Figlin, S. Piantadosi, R. Feld Intracranial recurrence of carcinoma after complete surgical resection of stage I, II, and III non-small-cell lung cancer N Engl J Med 318 1988 1300 1305
14. L.E. Gaspar, K. Chansky, K.S. Albain Time from treatment to subsequent diagnosis of brain metastases in stage III non-small-cell lung cancer: a retrospective review by the Southwest Oncology Group J Clin Oncol 23 2005 2955 2961 (Pubitemid 46224114)
15. C.A. Perez, T.F. Pajak, P. Rubin Long-term observations of the patterns of failure in patients with unresectable non-oat cell carcinoma of the lung treated with definitive radiotherapy Report by the Radiation Therapy Oncology Group Cancer 59 1987 1874 1881 (Pubitemid 17072411)
16. A. Charloux, E. Quoix, N. Wolkove The increasing incidence of lung adenocarcinoma: reality or artifact? A review of the epidemiology of lung adenocarcinoma Int J Epidemiol 26 1997 14 23 (Pubitemid 27129564)
17. M.M. Hochstenbag, A. Twijnstra, P. Hofman MR-imaging of the brain of neurologic asymptomatic patients with large cell or adenocarcinoma of the lung Does it influence prognosis and treatment? Lung Cancer (Amsterdam, Netherlands) 42 2003 189 193 (Pubitemid 37268029)
18. B.P. O'Neill, N.J. Iturria, M.J. Link A comparison of surgical resection and stereotactic radiosurgery in the treatment of solitary brain metastases Int J Radiat Oncol Biol Physics 55 2003 1169 1176 (Pubitemid 36338280)
19. Y. Oh, D.J. Stewart Systemic therapy for lung cancer brain metastases: a rationale for clinical trials Oncology (Williston Park) 22 2008 168 178
20. W. Schuette Treatment of brain metastases from lung cancer: chemotherapy Lung Cancer (Amsterdam, Netherlands) 45 suppl 2 2004 S253 S257
21. E.R. Gerstner, R.L. Fine Increased permeability of the blood-brain barrier to chemotherapy in metastatic brain tumors: establishing a treatment paradigm J Clin Oncol 25 2007 2306 2312
22. J.E. Chang, H.I. Robins, M.P. Mehta Therapeutic advances in the treatment of brain metastases Clin Adv Hematol Oncol 5 2007 54 64 (Pubitemid 46336328)
23. G. Robinet, P. Thomas, J.L. Breton Results of a phase III study of early versus delayed whole brain radiotherapy with concurrent cisplatin and vinorelbine combination in inoperable brain metastasis of non-small-cell lung cancer: Groupe Francais de Pneumo-Cancerologie (GFPC) Protocol 95-1 Ann Oncol 12 2001 59 67 (Pubitemid 32162449)
24. C.J. Langer, M.P. Mehta Current management of brain metastases, with a focus on systemic options J Clin Oncol 23 2005 6207 6219
25. J. Cortes, J. Rodriguez, J.M. Aramendia Front-line paclitaxel/cisplatin- based chemotherapy in brain metastases from non-small-cell lung cancer Oncology 64 2003 28 35 (Pubitemid 35477952)
26. V. Franciosi, G. Cocconi, M. Michiara Front-line chemotherapy with cisplatin and etoposide for patients with brain metastases from breast carcinoma, nonsmall cell lung carcinoma, or malignant melanoma: a prospective study Cancer 85 1999 1599 1605 (Pubitemid 29152834)
27. A. Fujita, S. Fukuoka, H. Takabatake Combination chemotherapy of cisplatin, ifosfamide, and irinotecan with rhG-CSF support in patients with brain metastases from non-small cell lung cancer Oncology 59 2000 291 295
28. V. Minotti, L. Crino, M.L. Meacci Chemotherapy with cisplatin and teniposide for cerebral metastases in non-small cell lung cancer Lung Cancer (Amsterdam, Netherlands) 20 1998 93 98 (Pubitemid 28345190)
29. L.G. Mendelsohn, C. Shih, V.J. Chen Enzyme inhibition, polyglutamation, and the effect of LY231514 (MTA) on purine biosynthesis Semin Oncol 26 suppl 6 1999 42 47 (Pubitemid 29218027)
30. R.M. Schultz, V.J. Chen, J.R. Bewley Biological activity of the multitargeted antifolate, MTA (LY231514), in human cell lines with different resistance mechanisms to antifolate drugs Semin Oncol 26 suppl 6 1999 68 73 (Pubitemid 29218031)
31. C. Cripps, M. Burnell, J. Jolivet Phase II study of first-line LY231514 (multi-targeted antifolate) in patients with locally advanced or metastatic colorectal cancer: an NCIC Clinical Trials Group study Ann Oncol 10 1999 1175 1179 (Pubitemid 29533566)
32. H.L. Kindler Pemetrexed in pancreatic cancer Semin Oncol 29 suppl 18 2002 49 53 (Pubitemid 36176675)
33. J.A. O'Shaughnessy, R.S. Clark, J.L. Blum Phase II study of pemetrexed in patients pretreated with an anthracycline, a taxane, and capecitabine for advanced breast cancer Clin Breast Cancer 6 2005 143 149 (Pubitemid 40975610)
34. L. Paz-Ares, E. Ciruelos, R. Garcia-Carbonero Pemetrexed in bladder, head and neck, and cervical cancers Semin Oncol 29 suppl 18 2002 69 75 (Pubitemid 36176679)
35. M. Spielmann, M. Martin, M. Namer Activity of pemetrexed (ALIMTA, multitargeted antifolate, LY231514) in metastatic breast cancer patients previously treated with an anthracycline and a taxane: an interim analysis Clin Breast Cancer 2 2001 47 51 (Pubitemid 32440423)
36. R. Thodtmann, T. Sauter, S. Weinknecht A phase II trial of pemetrexed in patients with metastatic renal cancer Invest New Drugs 21 2003 353 358 (Pubitemid 37486336)
37. N. Hanna, F.A. Shepherd, F.V. Fossella Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy J Clin Oncol 22 2004 1589 1597 (Pubitemid 41079796)
38. G.V. Scagliotti, P. Parikh, J. von Pawel Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer J Clin Oncol 26 2008 3543 3551
39. I. Fleming, J. Cooper, D. Henson American Joint Committee on Cancer Staging Manual 5th ed. 1998 Lippincott-Raven Philadelphia, PA
40. M.M. Oken, R.H. Creech, D.C. Tormey Toxicity and response criteria of the Eastern Cooperative Oncology Group Am J Clin Oncol 5 1982 649 655 (Pubitemid 13149996)
41. E. Kaplan, P. Meier Nonparametric estimation of incomplete observations J Am Stat Assoc 53 1958 457 481
42. D. Cox, E. Snell Analysis of Binary Data 2nd ed. 1989 Chapman & Hall London
43. K.J. Rothman, S. Greenland, T.L. Lash Modern Epidemiology 3rd ed. 2008 Lippincott Williams & Wilkins Philadelphia
44. G. Scagliotti, N. Hanna, F. Fossella The differential efficacy of pemetrexed according to NSCLC histology: a review of two phase III studies Oncologist 14 2009 253 263
45. A.M. Omuro, M.G. Kris, V.A. Miller High incidence of disease recurrence in the brain and leptomeninges in patients with nonsmall cell lung carcinoma after response to gefitinib Cancer 103 2005 2344 2348 (Pubitemid 40686581)
46. F. Barlesi, R. Gervais, H. Lena Pemetrexed and cisplatin as first-line chemotherapy for advanced non-small-cell lung cancer (NSCLC) with asymptomatic inoperable brain metastases: a multicenter phase II trial (GFPC 07-01) Ann Oncol February 14, 2011 [Epub ahead of print]
47. G. Robinet, F. Barlesi, R. Gervais Pemetrexed and cisplatin as first line chemotherapy for advanced non-small-cell lung cancer (NSCLC) with measurable asymptomatic inoperable brain metastases (BM) A multicenter phase II trial (GFPC 07-01) J Clin Oncol 28 suppl 2010 15s (abstract 7595)
48. L. Kepka, E. Cieslak, K. Bujko Results of the whole-brain radiotherapy for patients with brain metastases from lung cancer: the RTOG RPA intra-classes analysis Acta Oncol 44 2005 389 398 (Pubitemid 41021044)
49. A. Bearz, I. Garassino, M. Tiseo Activity of pemetrexed on brain metastases from non-small cell lung cancer Lung Cancer (Amsterdam, Netherlands) 68 2010 264 268
50. Phase II Trial of Bevacizumab in Combination With Pemetrexed as 2nd Line Therapy in Patients With Stable Brain Metastases From Non-small Cell Lung Cancer ClinicalTrials.gov [Web site] http://www.clinicaltrials.gov/ct2/show/ NCT00227019 Accessed: July 7, 2011
51. H. Dai, Y. Chen, W.F. Elmquist Distribution of the novel antifolate pemetrexed to the brain J Pharmacol Exp Ther 315 2005 222 229 (Pubitemid 41380515)
52. S.L. Stapleton, J.M. Reid, P.A. Thompson Plasma and cerebrospinal fluid pharmacokinetics of pemetrexed after intravenous administration in non-human primates Cancer Chemother Pharmacol 59 2007 461 466 (Pubitemid 46122324)
53. S. Motl, Y. Zhuang, C.M. Waters Pharmacokinetic considerations in the treatment of CNS tumours Clin Pharmacokinet 45 2006 871 903 (Pubitemid 44313694)
54. H. Hasegawa, Y. Ushio, T. Hayakawa Changes of the blood-brain barrier in experimental metastatic brain tumors J Neurosurg 59 1983 304 310 (Pubitemid 13029212)
55. R.D. Zhang, J.E. Price, T. Fujimaki Differential permeability of the blood-brain barrier in experimental brain metastases produced by human neoplasms implanted into nude mice Am J Pathol 141 1992 1115 1124