Serotonergic and BDNF genes associated with depression 1 week and 1 year after mastectomy for breast cancer

Psychosomatic Medicine

Volumn 74, Issue 1, 2012, Pages 8-15

  Kim, Jae Min ^a,b   Kim, Sung Wan ^a,b   Stewart, Robert ^f   Kim, Seon Young ^c   Shin, Il Seon ^a,b   Park, Min Ho ^c   Yoon, Jung Han ^c   Lee, Ji Shin ^a   Park, Sung Woo ^d,e   Kim, Young Hoon ^d,e   Yoon, Jin Sang ^a,b  

^a Chonnam National University Medical School   (South Korea)

^b Chonnam National University Medical School   (South Korea)

^c Chonnam National University Hwasun Hospital and Medical School   (South Korea)

^d Inje University College of Medicine   (South Korea)

^e Inje University   (South Korea)

^f KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

brain derived neurotrophic factor; breast cancer; depression; genetic association study; serotonin receptor; serotonin transporter

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; SCATTER FACTOR RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN TRANSPORTER;

ARTICLE; BREAST CANCER; CONTROLLED STUDY; DEPRESSION; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; FEMALE; FOLLOW UP; GENE INTERACTION; GENETIC ASSOCIATION; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MASTECTOMY; MINI MENTAL STATE EXAMINATION; POSTOPERATIVE PERIOD; PREVALENCE; PRIORITY JOURNAL; SEROTONINERGIC SYSTEM; VARIABLE NUMBER OF TANDEM REPEAT;

EID: 84855697949     PISSN: 00333174     EISSN: 15347796     Source Type: Journal    
DOI: 10.1097/PSY.0b013e318241530c     Document Type: Article

References (50)

1. Ferlay J, Shin HR, Bray F, Forman D. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010;127:2893-917.
2. Jemal A, Siegel R, Xu J, Ward E. Cancer statistics. CA Cancer J Clin 2010;60:277-300.
3. Bower J. Behavioral symptoms in patients with breast cancer and survivors. J Clin Oncol 2008;26:768-77. (Pubitemid 351264390)
4. Massie MJ. Prevalence of depression in patients with cancer. J Natl Cancer Inst Monogr 2004;32:57-71.
5. Shim EJ, Shin YW, Jeon HJ, Hahm BJ. Distress and its correlates in Korean cancer patients: pilot use of the distress thermometer and the problem list. Psychooncology 2008;17:548-55.
6. Giese-Davis J, Collie K, Rancourt KM, Neri E, Kraemer HC, Spiegel D. Decrease in depression symptoms is associated with longer survival in patients with metastatic breast cancer: a secondary analysis. J Clin Oncol 2011;29:413-20.
7. Fann JR, Thomas-Rich AM, Katon WJ, Cowley D, Pepping M, McGregor BA, Gralow J. Major depression after breast cancer: a review of epidemiology and treatment. Gen Hosp Psychiatry 2008;30:112-26. (Pubitemid 351248974)
8. Reich M, Lesur A, Perdrizet-Chevallier C. Depression, quality of life and breast cancer: a review of the literature. Breast Cancer Res Treat 2008;110:9-17. (Pubitemid 351793862)
9. Caspi A, Hariri AR, Holmes A, Uher R, Moffitt TE. Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. Am J Psychiatry 2010;167: 509-27.
10. Mossner R, Henneberg A, Schmitt A, Syagailo YV, Grassle M, Hennig T, Simantov R, Gerlach M, Riederer P, Lesch KP. Allelic variation of serotonin transporter expression is associated with depression in Parkinson's disease. Mol Psychiatry 2001;6:350-2. (Pubitemid 32275685)
11. Lenze EJ, Munin MC, Ferrell RE, Pollock BG, Skidmore E, Lotrich F, Rogers JC, Quear T, Houck P, Reynolds CF 3rd. Association of the serotonin transporter geneYlinked polymorphic region (5-HTTLPR) genotype with depression in elderly persons after hip fracture. Am J Geriatr Psychiatry 2005;13:428-32. (Pubitemid 40617488)
12. Otte C, McCaffery J, Ali S, Whooley MA. Association of a serotonin transporter polymorphism (5-HTTLPR) with depression, perceived stress, and norepinephrine in patients with coronary disease: The Heart and Soul Study. Am J Psychiatry 2007;164:1379-84. (Pubitemid 47461138)
13. Kohen R, Cain KC, Mitchell PH, Becker K, Buzaitis A, Millard SP, Navaja GP, Teri L, Tirschwell D, Veith R. Association of serotonin transporter gene polymorphisms with poststroke depression. Arch Gen Psychiatry 2008;65: 1296-302.
14. Kim JM, Stewart R, Kim SW, Yang SJ, Shin IS, Yoon JS. Modification by two genes of associations between general somatic health and incident depressive syndrome in older people. Psychosom Med 2009;71:286-91.
15. Jarrett ME, Kohen R, Cain KC, Burr RL, Poppe A, Navaja GP, Heitkemper MM. Relationship of SERT polymorphisms to depressive and anxiety symptoms in irritable bowel syndrome. Biol Res Nurs 2007;9:161-9.
16. Enoch MA, Goldman D, Barnett R, Sher L, Mazzanti CM, Rosenthal NE. Association between seasonal affective disorder and the 5-HT2A promoter polymorphism, j1438G/A. Mol Psychiatry 1999;4:89-92. (Pubitemid 29050208)
17. Bonnier B, Gorwood P, Hamon M, Sarfati Y, Boni C, Hardy-Bayle MC. Association of 5-HT(2A) receptor gene polymorphism with major affective disorder: the case of a subgroup of bipolar disorder with low suicide risk. Biol Psychiatry 2002;51:762-5. (Pubitemid 34450812)
18. Zhang HY, Ishigaki T, Tani K, Chen K, Shih JC, Miyasato K, Ohara K, Ohara K. Serotonin-2A receptor gene polymorphism in mood disorders. Biol Psychiatry 1997;41:768-73. (Pubitemid 27146214)
19. Du L, Bakish D, Lapierre YD, Ravindran AV, Hrdina PD. Association of polymorphism of serotonin 2A receptor gene with suicidal ideation in major depressive disorder. Am J Med Genet 2000;97:56-60. (Pubitemid 30077651)
20. Kim JM, Stewart R, Kim SW, Yang SJ, Shin IS, Kim YH, Yoon JS. BDNF genotype potentially modifying the association between incident stroke and depression. Neurobiol Aging 2008;29:789-92. (Pubitemid 351400826)
21. Bozzini S, Gambelli P, Boiocchi C, Schirinzi S, Falcone R, Buzzi P, Storti C, Falcone C. Coronary artery disease and depression: possible role of brain-derived neurotrophic factor and serotonin transporter gene polymorphisms. Int J Mol Med 2009;24:813-8.
22. Gilbert J, Hamann K, Yarbrough WG, Dietrich MS, Chung CH, Cmelak AJ, Pham M, Muldowney N, Blakely RD, Murphy BA. Head and neck cancer (HNC), depression, and genetic polymorphism. J Clin Oncol 2008;26:6017.
23. Grassi L, Rossi E, Cobianchi M, Aguiari L, Capozzo M, Martinis E, Nanni MG, Lelli G, Schillani G, Biancosino B, Giraldi T. Depression and serotonin transporter (5-HTTLPR) polymorphism in breast cancer patients. J Affect Disord 2010;124:346-50.
24. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed.Washington, DC:American Psychiatric Press; 1994.
25. American Joint Committee on Cancer. AJCC Cancer Staging Handbook From the AJCC Cancer Staging Manual. 6th ed. New York, NY: Springer-Verlag; 2002:257-81.
26. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC. The Mini-International Neuropsychiatric Interview (M.I.N.I): the development and validation of a structured diagnostic psychiatric interview for DSM-VI and ICD-10. J Clin Psychiatry 1988;59:22-33.
27. Yoo SW, Kim YS, Noh JS, Oh KS, Kim CH, Namkoong K, Chae JH, Lee GC, Jeon SI, Min KJ, Oh DJ, Joo EJ, Park HJ, Choi YH, Kim SJ. Validity of Korean version of the Mini-International Neuropsychiatric Interview. Anxiety Mood 2006;2:50-5.
28. Lou XY, Chen GB, Yan L, Ma JZ, Zhu J, Elston RC, Li MD. A generalized combinational approach for detecting gene-by-gene and gene-byenvironment interactionswith application to nicotine dependence.AmJ Hum Genet 2007;80:1125-37. (Pubitemid 47579348)
29. Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, Zaitsev E, Gold B, Goldman D, Dean M, Lu B, Weinberger DR. The BDNF Val66Met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 2003;112: 257-69. (Pubitemid 36144114)
30. Manji HK, Drevets WC, Charney DS. The cellular neurobiology of depression. Nat Genet 2001;7:541-7. (Pubitemid 32448319)
31. De Villiers N, Burger AP, Smith H, Szeinfeld D. Homeostatic derangement in the CBA rodent host during the growth of the CaNT tumor. Cancer Biochem Biophys 1993;13:255-64. (Pubitemid 2013357)
32. Kaynar H, Meral M, Turhan H, Keles M, Selik G, Akcay F. Glutathione peroxidase, glutathione-S-transferase, catalase, xanthine oxidase, Cu-Zn superoxide dismutase activities, total glutathione, nitric oxide, and malondialdehyde levels in erythrocytes of patients with small cell and nonsmall cell lung cancer. Cancer Lett 2005;227:133-9. (Pubitemid 41169926)
33. Qi H, Ma J, Liu YM, Yang L, Peng L,Wang H, Chen HZ. Allostatic tumorburden induces depression-associated changes in hepatoma-bearing mice. J Neurooncol 2009;94:367-72.
34. Kaufman J, Yang B-Z, Douglas-Palumberi H, Grasso D, Lipschitz D, Houshyar S, Krystal JH, Gelernter J. Brain-derived neurotrophic factorY5-HTTLPR gene interactions and environmental modifiers of depression in children. Biol Psychiatry 2006;59:673-80.
35. Kim JM, Stewart R, Kim SW, Yang SJ, Shin IS, Kim YH, Yoon JS. Interactions between life stressors and susceptibility genes (5-HTTLPR and BDNF) on depression in Korean elders. Biol Psychiatry 2007;62:423-8. (Pubitemid 47284032)
36. Gatt JM, Nemeroff CB, Dobson-Stone C, Paul RH, Bryant RA, Schofield PR, Gordon E, Kemp AH, Williams LM. Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety. Mol Psychiatry 2009;14: 681-95.
37. Kunugi H, Iijima Y, Tatsumi M, Yoshida M, Hashimoto R, Kato T, Sakamoto K, Fukunaga T, Inada T, Suzuki T, Iwata N, Ozaki N, Yamada K, Yoshikawa T. No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population: a multicenter study. Biol Psychiatry 2004;56:376-8. (Pubitemid 39164523)
38. Caspi A, Sugden K, Moffitt TE, Talyor A, Craig IW, Harrington H, McClay J, Mill J, Martin J, Braithwaite A, Poulton R. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 2003;301:386-9. (Pubitemid 36877077)
39. Kendler KS, Kuhn JW, Vittum J, Prescott CA, Riley B. The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression. Arch Gen Psychiatry 2005;62: 529-35. (Pubitemid 40628882)
40. Gillespie N, Whitfield JB, Williams B, Heath AC, Martin NG. The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression. Psychol Med 2005;35:101-11. (Pubitemid 40201920)
41. Araya R, Hu X, Heron J, Enoch MA, Evans J, Lewis G, Nutt D, Goldman D. Effects of stressful life events, maternal depression and 5-HTTLPR genotype on emotional symptoms in pre-adolescent children. Am J Med Genet B Neuropsychiatr Genet 2009;150B:670-82.
42. Power T, Stewart R, Ancelin ML, Jaussent I, Malafosse A, Ritchie K. 5-HTTLPR genotype, stressful life events and late-life depression: no evidence of interaction in a French population. Neurobiol Aging 2010;31: 886-7.
43. McCaffery JM, Duan QL, Frasure-Smith N, Barhdadi A, Lespérance F, Théroux P, Rouleau GA, Dubé MP. Genetic predictors of depressive symptoms in cardiac patients. Am J Med Genet B Neuropsychiatr Genet 2009;150B:381-8.
44. Jansson M, Gatz M, Berg S, Johansson B, Malmberg B, McClearn GE, Schalling M, Pedersen NL. Association between depressed mood in the elderly and a 5-HTR2A gene variant. Am J Med Genet 2003;120:79-84. (Pubitemid 37059382)
45. Serretti A, Lorenzi C, Lilli R, Smeraldi E. Serotonin receptor 2A, 2C, 1A genes and response to lithium prophylaxis in mood disorders. J Psychiatr Res 2000;34:89-98. (Pubitemid 30176115)
46. Minov C, Baghai TC, Schule C, Zwanzger P, Schwarz MJ, Zill P, Rupprecht R, Bondy B. Serotonin-2AYreceptor and Ytransporter polymorphisms: lack of association in patients with major depression. Neurosci Lett 2001;303:119-22. (Pubitemid 32320019)
47. Wendland JR, Martin BJ, Kruse MR, Lesch KP, Murphy DL. Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531. Mol Psychiatry 2006;11:224-6.
48. Ono H, Shirakawa O, Nishiguchi N, Nishmura A, Nushida H, Ueno Y, Maeda K. Serotonin 2A receptor gene polymorphism is not associated with completed suicide. J Psychiatr Res 2001;35:173-6. (Pubitemid 32674108)
49. Duman RS, Heninger GR, Nestler EJ. A molecular and cellular theory of depression. Arch Gen Psychiatry 1997;54:597-606. (Pubitemid 27306570)
50. Cho MJ, Kim J, Jeon HJ, Suh T, Chung I, Hong JP, Bae J, Lee D, Park J, Cho S, Lee CJ, Hahm B. Lifetime and 12-month prevalence of DSM-IV psychiatric disorders among Korean adults. J Nerv Ment Dis 2007;195: 203-10. (Pubitemid 46673540)