Spin tagging for hyperpolarized 13C metabolic studies

Journal of Magnetic Resonance

Volumn 214, Issue , 2012, Pages 319-323

  Chen, Albert P ^a   Hurd, Ralph E ^b   Cunningham, Charles H ^c,d  

^a GE HEALTHCARE   (Canada)

^b GE HEALTHCARE   (United States)

^c UNIVERSITY OF TORONTO   (Canada)

^d SUNNYBROOK RESEARCH INSTITUTE   (Canada)

Author keywords

Hyperpolarized 13C; Spin tagging

Indexed keywords

EXCHANGE RATES; EXTRACELLULAR; HYPERPOLARIZED; IN-VIVO; INTRACELLULAR SPACES; LONGITUDINAL MAGNETIZATION; METABOLIC ACTIVITY; METABOLIC FLUX; METABOLIC PRODUCTS; PULSE SEQUENCE; RF PULSE; SPIN-TAGGING;

ENZYME ACTIVITY; MAGNETIZATION; METABOLITES; SUBSTRATES;

METABOLISM;

CARBON; PYRUVIC ACID;

ANIMAL; ARTICLE; HEART MUSCLE; KIDNEY; METABOLIC CLEARANCE RATE; METABOLISM; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUDE RAT; RAT; SPIN LABELING;

ANIMALS; CARBON ISOTOPES; KIDNEY; MAGNETIC RESONANCE SPECTROSCOPY; METABOLIC CLEARANCE RATE; MYOCARDIUM; PYRUVIC ACID; RATS; RATS, NUDE; SPIN LABELS;

EID: 84855685679     PISSN: 10907807     EISSN: 10960856     Source Type: Journal    
DOI: 10.1016/j.jmr.2011.10.007     Document Type: Article

References (16)

1. K. Golman, R. Zandt, and M. Thaning Real-time metabolic imaging PNAS 103 2006 11270 11275 (Pubitemid 44156508)
2. S.E. Day, M.I. Kettunen, F.A. Gallagher, D. Hu, M. Lerche, J. Wolber, K. Golman, J.H. Ardenkjaer-Larsen, and K.M. Brindle Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy Nat. Med. 13 2007 1382 1387 (Pubitemid 350073590)
3. M. Albers, R. Bok, A.P. Chen, C.H. Cunningham, M.L. Zierhut, V.Y. Zhang, S.J. Kohler, J. Tropp, R.E. Hurd, Y. Yen, S.J. Nelson, D.B. Vigneron, and J. Kurhanewicz Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading Cancer Res. 68 2007 8607 8615
4. M.A. Schroeder, L.E. Cochlin, L.C. Heather, K. Clark, G.K. Radda, and D.J. Tyler In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance PNAS 105 2008 12051 12056
5. J. Frahm, K.D. Merboldt, W. Hanicke, and A. Haase Stimulated echo imaging J. Magn. Reson. 64 1985 81 93
6. C.H. Cunningham, A.P. Chen, M. Lustig, B.A. Hargreaves, J. Lupo, D. Xu, J. Kurhanewicz, R.E. Hurd, J.M. Pauly, S.J. Nelson, and D.B. Vigneron Pulse sequence for dynamic volumetric imaging of hyperpolarized metabolic products J. Magn. Reson. 193 2008 139 146
7. J.H. Ardenkjaer-Larsen, B. Fridlund, A. Gram, G. Hansson, L. Hansson, M.H. Lerche, R. Servin, M. Thaning, and K. Golman Increase in signal-to-noise ratio of >10,000 times in liquid-state NMR Proc. Natl Acad. Sci. USA 100 2003 10158 10163 (Pubitemid 37071849)
8. S.J. Kohler, Y. Yen, J. Wolber, A.P. Chen, M.J. Albers, R. Bok, V. Zhang, J. Tropp, S. Nelson, D.B. Vigneron, J. Kurhanewicz, and R.E. Hurd In vivo 13 carbon metabolic imaging at 3T with hyperpolarized 13C-1-pyruvate Magn. Reson. Med. 58 2007 65 69 (Pubitemid 47229918)
9. M.L. Zierhut, Y.F. Yen, A.P. Chen, R. Bok, M.J. Albers, V. Zhang, J. Tropp, I. Park, D.B. Vigneron, J. Kurhanewicz, R.E. Hurd, and S.J. Nelson Kinetic modeling of hyperpolarized 13C1-pyruvate metabolism in normal rats and TRAMP mice J. Magn. Reson. 202 2010 85 92
10. R.E. Hurd, Y.-F. Yen, J. Tropp, A. Pfefferbaum, D.M. Spielman, and D. Mayer Cerebral dynamics and metabolism of hyperpolarized [1-13C]pyruvate using time-resolved MR spectroscopic imaging J. Cereb. Blood Flow Metab.: Official J. Int. Soc. Cereb. Blood Flow Metab. 30 2010 1734 1741
11. A.P. Chen, K. Leung, W. Lam, R.E. Hurd, D.B. Vigneron, and C.H. Cunningham Design of spectral-spatial outer volume suppression RF pulses for tissue specific metabolic characterization with hyperpolarized 13C pyruvate J. Magn. Reson. 200 2009 344 348
12. T. Xu, D. Mayer, M. Gu, Y.-F. Yen, E. Johansson, J. Tropp, R. Hurd, D. Spielman, Measuring michaelis-menten kinetics of hyperpolarized 13C1-pyruvate metabolism in a single bolus injection, in: ISMRM 19th Annual Meeting and Exhibition, Honolulu, Hawaii, 2009.
13. P.E. Larson, A.B. Kerr, J.M. Pauly, D.B. Vigneron, Hyperpolarized C-13 metabolic activity decomposition with stimulated-echoes, in: ISMRM 19th Annual Meeting and Exhibition, Montreal, Canada, 2011, pp. 655.
14. C.H. Cunningham, A.P. Chen, M.J. Albers, J. Kurhanewicz, R.E. Hurd, Y. Yen, S.J. Nelson, and D.B. Vigneron Double spin-echo sequence for rapid spectroscopic imaging of hyperpolarized 13C J. Magn. Reson. 287 2007 357 362 (Pubitemid 47069025)
15. Y.F. Yen, P. Le Roux, D. Mayer, R. King, D. Spielman, J. Tropp, K. Butts Pauly, A. Pfefferbaum, S. Vasanawala, and R. Hurd T(2) relaxation times of (13)C metabolites in a rat hepatocellular carcinoma model measured in vivo using (13)C-MRS of hyperpolarized [1-(13)C]pyruvate NMR Biomed. 23 2010 414 423
16. K.-D. Merboldt, W. Hanicke, and J. Frahm Self-diffusion NMR imaging using stimulated echoes J. Magn. Reson. 64 1985 479 486