Homozygosity for the NOD2 p.Leu1007fsX1008 variant is the main genetic predictor for fibrostenotic Crohn's disease

Inflammatory Bowel Diseases

Volumn 18, Issue 2, 2012, Pages 393-394

  Brand, Stephan ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CROHN DISEASE; FIBROSIS; GENE; GENE MUTATION; GENETIC VARIABILITY; HOMOZYGOSITY; HUMAN; INTESTINE FISTULA; INTESTINE STENOSIS; LETTER; NOD2 GENE; PHENOTYPE; PREDICTIVE VALUE; PRIORITY JOURNAL; RISK FACTOR; SENSITIVITY AND SPECIFICITY;

CROHN DISEASE; FIBROSIS; HUMANS;

EID: 84855665333     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1002/ibd.21914     Document Type: Letter

References (8)

1. Rieder F, Lawrance IC, Leite A, et al. Predictors of fibrostenotic Crohn's disease. Inflamm Bowel Dis. 2011; 17: 2000-2007.
2. Figueroa CD, Cleynen I, Franke A, et al. Genetic factors conferring an increased susceptibility to develop Crohn's disease also influence disease phenotype, but do not predict it. Results from the IBDChip European Project. Gastroenterology. 2010; 138:(suppl 1): S677.
3. Adler J, Rangwalla SC, Dwamena BA, et al. The prognostic power of the NOD2 genotype for complicated Crohn's disease: a meta-analysis. Am J Gastroenterol. 2011; 106: 699-712.
4. Glas J, Seiderer J, Tillack C, et al. The NOD2 single nucleotide polymorphisms rs2066843 and rs2076756 are novel and common Crohn's disease susceptibility gene variants. PLoS One. 2010; 5: e14466.
5. Schnitzler F, Brand S, Staudinger T, et al. Eight novel CARD15 variants detected by DNA sequence analysis of the CARD15 gene in 111 patients with inflammatory bowel disease. Immunogenetics. 2006; 58: 99-106.
6. Seiderer J, Schnitzler F, Brand S, et al. Homozygosity for the CARD15 frameshift mutation 1007fs is predictive of early onset of Crohn's disease with ileal stenosis, entero-enteral fistulas, and frequent need for surgical intervention with high risk of re-stenosis. Scand J Gastroenterol. 2006; 41: 1421-1432. (Pubitemid 44767495)
7. Seiderer J, Brand S, Herrmann KA, et al. Predictive value of the CARD15 variant 1007fs for the diagnosis of intestinal stenoses and the need for surgery in Crohn's disease in clinical practice: results of a prospective study. Inflamm Bowel Dis. 2006; 12: 1114-1121. (Pubitemid 44847468)
8. Jürgens M, Brand S, Laubender RP, et al. The presence of fistulas and NOD2 homozygosity strongly predict intestinal stenosis in Crohn's disease independent of the IL23R genotype. J Gastroenterol. 2010; 45: 721-731.