Oxicam structure in non-steroidal anti-inflammatory drugs is essential to exhibit Akt-mediated neuroprotection against 1-methyl-4-phenyl pyridinium-induced cytotoxicity

European Journal of Pharmacology

Volumn 676, Issue 1-3, 2012, Pages 57-63

  Tasaki, Yoshikazu ^a   Yamamoto, Joe ^a   Omura, Tomohiro ^a   Noda, Toshihiro ^a   Kamiyama, Naoya ^a   Yoshida, Koichi ^a   Satomi, MacHiko ^a   Sakaguchi, Tomoki ^a   Asari, Masaru ^a   Ohkubo, Tomoko ^a   Shimizu, Keiko ^a   Matsubara, Kazuo ^a  

^a ASAHIKAWA MEDICAL COLLEGE   (Japan)

Author keywords

1 methyl 4 phenyl pyridinium; Akt; Neuroprotection; Non steroidal anti inflammatory drug; Oxicam; Parkinson's disease

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; 5 (4 FLUOROPHENYL) 1 [(4 METHYLSULFONYL)PHENYL] 3 TRIFLUOROMETHYLPYRAZOLE; ACETYLSALICYLIC ACID; AMPIROXICAM; CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; LICOFELONE; MELOXICAM; PHOSPHATIDYLINOSITOL 3 KINASE; PIROXICAM; PROTEIN KINASE B; RESVERATROL; TENOXICAM; VALDECOXIB;

ARTICLE; CELL LEVEL; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; HUMAN; HUMAN CELL; NERVE CELL NECROSIS; NEUROBLASTOMA CELL; NEUROPROTECTION; NEUROTOXICITY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

1-METHYL-4-PHENYLPYRIDINIUM; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL DEATH; CELL LINE, TUMOR; CYTOTOXINS; HUMANS; NEURONS; NEUROPROTECTIVE AGENTS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 84855614639     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.11.046     Document Type: Article

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