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Volumn 5, Issue 1, 2012, Pages 23-30

Prucalopride: Safety, efficacy and potential applications

Author keywords

Colonic motilty; Constipation; Irritable bowel syndrome; Prokinetic; Prucalopride

Indexed keywords

PLACEBO; PRUCALOPRIDE;

EID: 84855541533     PISSN: 1756283X     EISSN: 17562648     Source Type: Journal    
DOI: 10.1177/1756283X11423706     Document Type: Review
Times cited : (64)

References (48)
  • 1
    • 0036143629 scopus 로고    scopus 로고
    • Treatment of GI dysmotility in scleroderma with the new enterokinetic agent prucalopride
    • Boeckxstaens G.E. Bartelsman J.F. Lauwers L. Tytgat G.N. (2002) Treatment of GI dysmotility in scleroderma with the new enterokinetic agent prucalopride. Am J Gastroenterol 97: 194–197.
    • (2002) Am J Gastroenterol , vol.97 , pp. 194-197
    • Boeckxstaens, G.E.1    Bartelsman, J.F.2    Lauwers, L.3    Tytgat, G.N.4
  • 2
    • 0036079899 scopus 로고    scopus 로고
    • Rectal distension testing in patients with the irritable bowel syndrome: sensitivity, specificity, and predictive values of pain sensory thresholds
    • Bouin M. Plourde V. Boivin M. Riberdy M. Lupien F. Laganière M. et al. (2002) Rectal distension testing in patients with the irritable bowel syndrome: sensitivity, specificity, and predictive values of pain sensory thresholds. Gastroenterology 122: 1771–1777.
    • (2002) Gastroenterology , vol.122 , pp. 1771-1777
    • Bouin, M.1    Plourde, V.2    Boivin, M.3    Riberdy, M.4    Lupien, F.5    Laganière, M.6
  • 3
    • 0033005188 scopus 로고    scopus 로고
    • Selective stimulation of colonic transit by the benzofuran 5HT4 agonist, prucalopride, in healthy humans
    • Bouras E.P. Camilleri M. Burton D.D. McKinzie S. (1999) Selective stimulation of colonic transit by the benzofuran 5HT4 agonist, prucalopride, in healthy humans. Gut 44: 682–686.
    • (1999) Gut , vol.44 , pp. 682-686
    • Bouras, E.P.1    Camilleri, M.2    Burton, D.D.3    McKinzie, S.4
  • 4
    • 0035121508 scopus 로고    scopus 로고
    • Prucalopride accelerates gastrointestinal and colonic transit in patients with constipation without a rectal evacuation disorder
    • Bouras E.P. Camilleri M. Burton D.D. Thomforde G. McKinzie S. Zinsmeister A.R. (2001) Prucalopride accelerates gastrointestinal and colonic transit in patients with constipation without a rectal evacuation disorder. Gastroenterology 120: 354–360.
    • (2001) Gastroenterology , vol.120 , pp. 354-360
    • Bouras, E.P.1    Camilleri, M.2    Burton, D.D.3    Thomforde, G.4    McKinzie, S.5    Zinsmeister, A.R.6
  • 5
    • 72449142246 scopus 로고    scopus 로고
    • Cardiovascular safety of prucalopride in healthy subjects: results from two randomized, double-blind, placebo-controlled, cross-over trials [abstract]
    • Boyce M. Kerstens R. Beyens G. Ausma J. Vandeplassche L. (2009) Cardiovascular safety of prucalopride in healthy subjects: results from two randomized, double-blind, placebo-controlled, cross-over trials [abstract]. Gastroenterology 136(Suppl. 1): T1265.
    • (2009) Gastroenterology , vol.136 , Issue.Suppl. 1 , pp. T1265
    • Boyce, M.1    Kerstens, R.2    Beyens, G.3    Ausma, J.4    Vandeplassche, L.5
  • 8
    • 72049090263 scopus 로고    scopus 로고
    • Safety assessment of prucalopride in elderly patients with constipation: a double-blind, placebo-controlled study
    • Camilleri M. Beyens G. Kerstens R. Robinson P. Vandeplassche L. (2009) Safety assessment of prucalopride in elderly patients with constipation: a double-blind, placebo-controlled study. Neurogastroenterol Motil 21: e1256–e117.
    • (2009) Neurogastroenterol Motil , vol.21 , pp. e1256-e117
    • Camilleri, M.1    Beyens, G.2    Kerstens, R.3    Robinson, P.4    Vandeplassche, L.5
  • 9
    • 56549111183 scopus 로고    scopus 로고
    • American Neurogastroenterology and Motility Society consensus statement on intraluminal measurement of gastrointestinal and colonic motility in clinical practice
    • Camilleri M. Bharucha A.E. di Lorenzo C. Hasler W.L. Prather C.M. Rao S.S. et al. (2008 a) American Neurogastroenterology and Motility Society consensus statement on intraluminal measurement of gastrointestinal and colonic motility in clinical practice. Neurogastroenterol Motil 20: 1269–1282.
    • (2008) Neurogastroenterol Motil , vol.20 , pp. 1269-1282
    • Camilleri, M.1    Bharucha, A.E.2    di Lorenzo, C.3    Hasler, W.L.4    Prather, C.M.5    Rao, S.S.6
  • 11
    • 44349130441 scopus 로고    scopus 로고
    • A placebo-controlled trial of prucalopride for severe chronic constipation
    • Camilleri M. Kerstens R. Rykx A. Vandeplassche L. (2008 b) A placebo-controlled trial of prucalopride for severe chronic constipation. N Engl J Med 358: 2344–2354.
    • (2008) N Engl J Med , vol.358 , pp. 2344-2354
    • Camilleri, M.1    Kerstens, R.2    Rykx, A.3    Vandeplassche, L.4
  • 12
    • 78649484435 scopus 로고    scopus 로고
    • Clinical trial: the efficacy of open-label prucalopride treatment in patients with chronic constipation - follow-up of patients from the pivotal studies
    • Camilleri M. van Outryve M.J. Beyens G. Kerstens R. Robinson P. Vandeplassche L. (2010) Clinical trial: the efficacy of open-label prucalopride treatment in patients with chronic constipation - follow-up of patients from the pivotal studies. Aliment Pharmacol Ther 32: 1113–1123.
    • (2010) Aliment Pharmacol Ther , vol.32 , pp. 1113-1123
    • Camilleri, M.1    van Outryve, M.J.2    Beyens, G.3    Kerstens, R.4    Robinson, P.5    Vandeplassche, L.6
  • 13
    • 69749097048 scopus 로고    scopus 로고
    • Functional characterization of contractions to tegaserod in human isolated proximal and distal coronary arteries
    • Chan K.Y. de Vries R. Leijten F.P. Pfannkuche H.J. van den Bogaerdt A.J. Danser A.H. et al. (2009) Functional characterization of contractions to tegaserod in human isolated proximal and distal coronary arteries. Eur J Pharmacol 619: 61–67.
    • (2009) Eur J Pharmacol , vol.619 , pp. 61-67
    • Chan, K.Y.1    de Vries, R.2    Leijten, F.P.3    Pfannkuche, H.J.4    van den Bogaerdt, A.J.5    Danser, A.H.6
  • 14
    • 0037540068 scopus 로고    scopus 로고
    • Prucalopride is effective in patients with severe chronic constipation in whom laxatives fail to provide adequate relief. Results of a double-blind, placebo-controlled clinical trial
    • Coremans G. Kerstens R. de Pauw M. Stevens M. (2003) Prucalopride is effective in patients with severe chronic constipation in whom laxatives fail to provide adequate relief. Results of a double-blind, placebo-controlled clinical trial. Digestion 67: 82–89.
    • (2003) Digestion , vol.67 , pp. 82-89
    • Coremans, G.1    Kerstens, R.2    de Pauw, M.3    Stevens, M.4
  • 16
    • 34548139322 scopus 로고    scopus 로고
    • A randomized, multicenter comparison of polyethylene glycol laxative and tegaserod in treatment of patients with chronic constipation
    • Di Palma J.A. Cleveland M.V. McGowan J. Herrera J.L. (2007) A randomized, multicenter comparison of polyethylene glycol laxative and tegaserod in treatment of patients with chronic constipation. Am J Gastroenterol 102: 1964–1971.
    • (2007) Am J Gastroenterol , vol.102 , pp. 1964-1971
    • Di Palma, J.A.1    Cleveland, M.V.2    McGowan, J.3    Herrera, J.L.4
  • 17
    • 0027185528 scopus 로고
    • US householder survey of functional gastrointestinal disorders. Prevalence, sociodemography and health impact
    • Drossman D.A. Li Z. Andruzzi E. Temple R.D. Talley N.J. Thompson W.G. et al. (1993) US householder survey of functional gastrointestinal disorders. Prevalence, sociodemography and health impact. Dig Dis Sci 38: 1569–1580.
    • (1993) Dig Dis Sci , vol.38 , pp. 1569-1580
    • Drossman, D.A.1    Li, Z.2    Andruzzi, E.3    Temple, R.D.4    Talley, N.J.5    Thompson, W.G.6
  • 18
    • 58149103805 scopus 로고    scopus 로고
    • Clinical trial: lubiprostone in patients with constipation-associated irritable bowel syndrome – results of two randomized, placebo-controlled studies
    • Drossman D.A. Chey W.D. Johanson J.F. Fass R. Scott C. Panas R. et al. (2009) Clinical trial: lubiprostone in patients with constipation-associated irritable bowel syndrome – results of two randomized, placebo-controlled studies. Aliment Pharmacol Ther 29: 329–341.
    • (2009) Aliment Pharmacol Ther , vol.29 , pp. 329-341
    • Drossman, D.A.1    Chey, W.D.2    Johanson, J.F.3    Fass, R.4    Scott, C.5    Panas, R.6
  • 19
    • 74549216986 scopus 로고    scopus 로고
    • Psychometric performance and clinical meaningfulness of the Patient Assessment of Constipation-Quality of Life questionnaire in prucalopride (RESOLOR) trials for chronic constipation
    • Dubois D. Gilet H. Viala-Danten M. Tack J. (2010) Psychometric performance and clinical meaningfulness of the Patient Assessment of Constipation-Quality of Life questionnaire in prucalopride (RESOLOR) trials for chronic constipation. Neurogastroenterol Motil 22: e54–e63.
    • (2010) Neurogastroenterol Motil , vol.22 , pp. e54-e63
    • Dubois, D.1    Gilet, H.2    Viala-Danten, M.3    Tack, J.4
  • 20
    • 0031950380 scopus 로고    scopus 로고
    • Effect of a novel prokinetic drug, R093877, on gastrointestinal transit in healthy volunteers
    • Emmanuel A.V. Kamm M.A. Roy A.J. Antonelli K. (1998) Effect of a novel prokinetic drug, R093877, on gastrointestinal transit in healthy volunteers. Gut 42: 511–516.
    • (1998) Gut , vol.42 , pp. 511-516
    • Emmanuel, A.V.1    Kamm, M.A.2    Roy, A.J.3    Antonelli, K.4
  • 21
    • 0036024222 scopus 로고    scopus 로고
    • Prucalopride, a systemic enterokinetic, for the treatment of constipation
    • Emmanuel A.V. Roy A.J. Nicholls T.J. Kamm M.A. (2002) Prucalopride, a systemic enterokinetic, for the treatment of constipation. Aliment Pharmacol Ther 16: 1347–1356.
    • (2002) Aliment Pharmacol Ther , vol.16 , pp. 1347-1356
    • Emmanuel, A.V.1    Roy, A.J.2    Nicholls, T.J.3    Kamm, M.A.4
  • 23
    • 40949131857 scopus 로고    scopus 로고
    • Clinical trial: phase 2 study of lubiprostone for irritable bowel syndrome with constipation
    • Johanson J.F. Drossman D.A. Panas R. Wahle A. Ueno R. (2008 a) Clinical trial: phase 2 study of lubiprostone for irritable bowel syndrome with constipation. Aliment Pharmacol Ther 27: 685–696.
    • (2008) Aliment Pharmacol Ther , vol.27 , pp. 685-696
    • Johanson, J.F.1    Drossman, D.A.2    Panas, R.3    Wahle, A.4    Ueno, R.5
  • 24
    • 37849024665 scopus 로고    scopus 로고
    • Multicenter, 4-week, double-blind, randomized, placebo-controlled trial of lubiprostone, a locally-acting type-2 chloride channel activator, in patients with chronic constipation
    • Johanson J.F. Morton D. Geenen J. Ueno R. (2008 b) Multicenter, 4-week, double-blind, randomized, placebo-controlled trial of lubiprostone, a locally-acting type-2 chloride channel activator, in patients with chronic constipation. Am J Gastroenterol 103: 170–177.
    • (2008) Am J Gastroenterol , vol.103 , pp. 170-177
    • Johanson, J.F.1    Morton, D.2    Geenen, J.3    Ueno, R.4
  • 25
    • 78649690668 scopus 로고    scopus 로고
    • Linaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome with constipation
    • Johnston J.M. Kurtz C.B. Macdougall J.E. Lavins B.J. Currie M.G. Fitch D.A. et al. (2010) Linaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome with constipation. Gastroenterology 139: 1877–1886.
    • (2010) Gastroenterology , vol.139 , pp. 1877-1886
    • Johnston, J.M.1    Kurtz, C.B.2    Macdougall, J.E.3    Lavins, B.J.4    Currie, M.G.5    Fitch, D.A.6
  • 26
    • 0036212168 scopus 로고    scopus 로고
    • Efficacy and tolerability of prucalopride in patients with constipation due to spinal cord injury
    • Krogh K. Jensen M.B. Gandrup P. Laurberg S. Nilsson J. Kerstens R. et al. (2002) Efficacy and tolerability of prucalopride in patients with constipation due to spinal cord injury. Scand J Gastroenterol 37: 431–436.
    • (2002) Scand J Gastroenterol , vol.37 , pp. 431-436
    • Krogh, K.1    Jensen, M.B.2    Gandrup, P.3    Laurberg, S.4    Nilsson, J.5    Kerstens, R.6
  • 29
    • 84993805714 scopus 로고    scopus 로고
    • World Gastroenterology Organisation Global Guidelines. Constipation: a global perspective
    • http://www.worldgastroenterology.org/assets/export/userfiles/05_constipation.pdf (accessed 11 July 2011).
    • Lindberg G. Hamid S. Malfertheiner P. Thomsen O. Bustos Fernandez L. Garisch J. et al. (2011) World Gastroenterology Organisation Global Guidelines. Constipation: a global perspective. http://www.worldgastroenterology.org/assets/export/userfiles/05_constipation.pdf (accessed 11 July 2011).
    • (2011)
    • Lindberg, G.1    Hamid, S.2    Malfertheiner, P.3    Thomsen, O.4    Bustos Fernandez, L.5    Garisch, J.6
  • 31
    • 0027385325 scopus 로고
    • Intestinal motility in irritable bowel syndrome: is IBS a motility disorder? Part 1: Definition of IBS and colonic motility
    • McKee D.P. Quigley E.M.M. (1993) Intestinal motility in irritable bowel syndrome: is IBS a motility disorder? Part 1: Definition of IBS and colonic motility. Dig Dis Sci 38: 1761–1772.
    • (1993) Dig Dis Sci , vol.38 , pp. 1761-1772
    • McKee, D.P.1    Quigley, E.M.M.2
  • 32
    • 77955493094 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled study of prucalopride in elderly patients with chronic constipation
    • Müller-Lissner S. Rykx A. Kerstens R. Vandeplassche L. (2010) A double-blind, placebo-controlled study of prucalopride in elderly patients with chronic constipation. Neurogastroenterol Motil 22: 991–998.
    • (2010) Neurogastroenterol Motil , vol.22 , pp. 991-998
    • Müller-Lissner, S.1    Rykx, A.2    Kerstens, R.3    Vandeplassche, L.4
  • 33
    • 63049140085 scopus 로고    scopus 로고
    • Selected interventions in nuclear medicine: gastrointestinal motor functions
    • Odunsi S.T. Camilleri M. (2009) Selected interventions in nuclear medicine: gastrointestinal motor functions. Semin Nucl Med 39: 186–194.
    • (2009) Semin Nucl Med , vol.39 , pp. 186-194
    • Odunsi, S.T.1    Camilleri, M.2
  • 34
    • 0032589966 scopus 로고    scopus 로고
    • Effect of prucalopride, a new enterokinetic agent, on gastrointestinal transit and anorectal function in healthy volunteers
    • Poen A.C. Felt-Bersma R.J. van Dongen P.A. Meuwissen S.G. (1999) Effect of prucalopride, a new enterokinetic agent, on gastrointestinal transit and anorectal function in healthy volunteers. Aliment Pharmacol Ther 13: 1493–1497.
    • (1999) Aliment Pharmacol Ther , vol.13 , pp. 1493-1497
    • Poen, A.C.1    Felt-Bersma, R.J.2    van Dongen, P.A.3    Meuwissen, S.G.4
  • 35
    • 0035197735 scopus 로고    scopus 로고
    • Gastrointestinal prokinetic drugs have different affinity for the human cardiac human ether-a-gogo K. (+) channel
    • Potet F. Bouyssou T. Escande D. Baro I. (2001) Gastrointestinal prokinetic drugs have different affinity for the human cardiac human ether-a-gogo K(+) channel. J Pharmacol Exp Ther 299: 1007–1012.
    • (2001) J Pharmacol Exp Ther , vol.299 , pp. 1007-1012
    • Potet, F.1    Bouyssou, T.2    Escande, D.3    Baro, I.4
  • 36
    • 0037613276 scopus 로고    scopus 로고
    • Current concepts of the irritable bowel syndrome
    • Quigley E.M. (2003) Current concepts of the irritable bowel syndrome. Scand J Gastroenterol Suppl 237: 1–8.
    • (2003) Scand J Gastroenterol Suppl , vol.237 , pp. 1-8
    • Quigley, E.M.1
  • 37
    • 79957611296 scopus 로고    scopus 로고
    • Cisapride. What can we learn from the rise and fall of a prokinetic?
    • Quigley E.M.M. (2011) Cisapride. What can we learn from the rise and fall of a prokinetic?. J Dig Dis 12: 147–156.
    • (2011) J Dig Dis , vol.12 , pp. 147-156
    • Quigley, E.M.M.1
  • 39
    • 58149084950 scopus 로고    scopus 로고
    • Clinical trial: the efficacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation–a 12-week, randomized, double-blind, placebo-controlled study
    • Quigley E.M. Vandeplassche L. Kerstens R. Ausma J. (2009) Clinical trial: the efficacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation–a 12-week, randomized, double-blind, placebo-controlled study. Aliment Pharmacol Ther 29: 315–328.
    • (2009) Aliment Pharmacol Ther , vol.29 , pp. 315-328
    • Quigley, E.M.1    Vandeplassche, L.2    Kerstens, R.3    Ausma, J.4
  • 40
    • 78650734005 scopus 로고    scopus 로고
    • Constipation, IBS and the 5-HT4 receptor: what role for prucalopride?
    • Sanger G.J. Quigley E.M.M. (2010) Constipation, IBS and the 5-HT4 receptor: what role for prucalopride?. Clin Med Insights: Gastroenterology 3: 21–33.
    • (2010) Clin Med Insights: Gastroenterology , vol.3 , pp. 21-33
    • Sanger, G.J.1    Quigley, E.M.M.2
  • 41
    • 0036109163 scopus 로고    scopus 로고
    • Effects of prucalopride on colonic transit, anorectal function and bowel habits in patients with chronic constipation
    • Sloots C.E. Poen A.C. Kerstens R. Stevens M. de Pauw M. van Oene J.C. et al. (2002) Effects of prucalopride on colonic transit, anorectal function and bowel habits in patients with chronic constipation. Aliment Pharmacol Ther 16: 759–767.
    • (2002) Aliment Pharmacol Ther , vol.16 , pp. 759-767
    • Sloots, C.E.1    Poen, A.C.2    Kerstens, R.3    Stevens, M.4    de Pauw, M.5    van Oene, J.C.6
  • 42
    • 77957924970 scopus 로고    scopus 로고
    • Efficacy and safety of prucalopride in patients with chronic noncancer pain suffering from opioid-induced constipation
    • Sloots C.E. Rykx A. Cools M. Kerstens R. de Pauw M. (2010) Efficacy and safety of prucalopride in patients with chronic noncancer pain suffering from opioid-induced constipation. Dig Dis Sci 55: 2912–2921.
    • (2010) Dig Dis Sci , vol.55 , pp. 2912-2921
    • Sloots, C.E.1    Rykx, A.2    Cools, M.3    Kerstens, R.4    de Pauw, M.5
  • 43
    • 0024478044 scopus 로고
    • Physician visits in the United States for constipation: 1958 to 1986
    • Sonnenberg A. Koch T.R. (1989) Physician visits in the United States for constipation: 1958 to 1986. Dig Dis Sci 34: 606–611.
    • (1989) Dig Dis Sci , vol.34 , pp. 606-611
    • Sonnenberg, A.1    Koch, T.R.2
  • 44
    • 59149091346 scopus 로고    scopus 로고
    • Safety and tolerability of prucalopride (Resolor®) in patients with chronic constipation: pooled data from three pivotal phase III studies [abstract]
    • Tack J. Ausma J. Kerstens R. Vandeplassche L. (2008) Safety and tolerability of prucalopride (Resolor®) in patients with chronic constipation: pooled data from three pivotal phase III studies [abstract]. Gastroenterology 134: A530–A531.
    • (2008) Gastroenterology , vol.134 , pp. A530-A531
    • Tack, J.1    Ausma, J.2    Kerstens, R.3    Vandeplassche, L.4
  • 46
    • 61649119045 scopus 로고    scopus 로고
    • Prucalopride (Resolor) in the treatment of severe chronic constipation in patients dissatisfied with laxatives
    • Tack J. van Outryve M. Beyens G. Kerstens R. Vandeplassche L. (2009) Prucalopride (Resolor) in the treatment of severe chronic constipation in patients dissatisfied with laxatives. Gut 58: 357–365.
    • (2009) Gut , vol.58 , pp. 357-365
    • Tack, J.1    van Outryve, M.2    Beyens, G.3    Kerstens, R.4    Vandeplassche, L.5
  • 47
    • 0026567833 scopus 로고
    • Prevalence of gastrointestinal symptoms in the elderly: a population-based study
    • Talley N.J. O'Keefe E.A. Zinsmeister A.R. Melton L.J. 3rd (1992) Prevalence of gastrointestinal symptoms in the elderly: a population-based study. Gastroenterology 102: 895–901.
    • (1992) Gastroenterology , vol.102 , pp. 895-901
    • Talley, N.J.1    O'Keefe, E.A.2    Zinsmeister, A.R.3    Melton, L.J.4
  • 48
    • 0026469867 scopus 로고
    • Measurement of small bowel and colonic transit: indications and methods
    • von der Ohe M.R. Camilleri M. (1992) Measurement of small bowel and colonic transit: indications and methods. Mayo Clin Proc 67: 1169–1179.
    • (1992) Mayo Clin Proc , vol.67 , pp. 1169-1179
    • von der Ohe, M.R.1    Camilleri, M.2


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