Evidence for elevated cerebrospinal fluid ERK1/2 levels in Alzheimer dementia

International Journal of Alzheimer's Disease

Volumn , Issue , 2011, Pages

  Spitzer, Philipp ^a,b   Schieb, Heinke ^a   Kamrowski Kruck, Heike ^a   Otto, Markus ^c   Chiasserini, Davide ^d   Parnetti, Lucilla ^d   Herukka, Sanna Kaisa ^e   Schuchhardt, Johannes ^f   Wiltfang, Jens ^a   Klafki, Hans Wolfgang ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c UNIVERSITY OF ULM   (Germany)

^d UNIVERSITY OF PERUGIA   (Italy)

^e UNIVERSITY OF EASTERN FINLAND   (Finland)

^f MICRODISCOVERY GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; TAU PROTEIN;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CEREBROSPINAL FLUID LEVEL; CONTROLLED STUDY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MILD COGNITIVE IMPAIRMENT; PRIORITY JOURNAL;

EID: 84855531476     PISSN: None     EISSN: 20900252     Source Type: Journal    
DOI: 10.4061/2011/739847     Document Type: Article

References (30)

1. Nussbaum R. L., Ellis C. E., Alzheimer's disease and Parkinson's disease New England Journal of Medicine 2003 348 14 1356 1364 (Pubitemid 36384104)
2. Blennow K., Zetterberg H., Cerebrospinal fluid biomarkers for Alzheimer's disease Journal of Alzheimer's Disease 2009 18 2 413 417
3. Lewczuk P., Wiltfang J., Neurochemical dementia diagnostics: state of the art and research perspectives Proteomics 2008 8 6 1292 1301 (Pubitemid 351462934)
4. Hansson O., Zetterberg H., Buchhave P., Londos E., Blennow K., Minthon L., Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study Lancet Neurology 2006 5 3 228 234 (Pubitemid 43238346)
5. Braak H., Braak E., Staging of Alzheimer's disease-related neurofibrillary changes Neurobiology of Aging 1995 16 3 271 278
6. Buée L., Bussire T., Buée-Scherrer V., Delacourte A., Hof P. R., Tau protein isoforms, phosphorylation and role in neurodegenerative disorders Brain Research Reviews 2000 33 1 95 130
7. Klafki H. W., Staufenbiel M., Kornhuber J., Wiltfang J., Therapeutic approaches to Alzheimer's disease Brain 2006 129 11 2840 2855 (Pubitemid 44684507)
8. Klafki H.-W., Lewczuk P., Kamrowski-Kruck H., Maler J. M., Mller K., Peters O., Heuser I., Jessen F., Popp J., Frlich L., Wolf S., Prinz B., Luckhaus C., Schrder J., Pantel J., Gertz H.-J., Klsch H., Mller B. W., Esselmann H., Bibl M., Kornhuber J., Wiltfang J., Measurement of ERK 1/2 in CSF from patients with neuropsychiatric disorders and evidence for the presence of the activated form Journal of Alzheimer's Disease 2009 18 3 613 622
9. McKhann G., Drachman D., Folstein M., Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease Neurology 1984 34 7 939 944 (Pubitemid 14076461)
10. Petersen R. C., Negash S., Mild cognitive impairment: an overview CNS Spectrums 2008 13 1 45 53 (Pubitemid 351224282)
11. Folstein M. F., Folstein S. E., McHugh P. R., 'Mini mental state'. A practical method for grading the cognitive state of patients for the clinician Journal of Psychiatric Research 1975 12 3 189 198
12. Brazzelli M., Capitani E., Della Sala S., Spinnler H., Zuffi M., A neuropsychological instrument adding to the description of patients with suspected cortical dementia: the Milan overall dementia assessment Journal of Neurology Neurosurgery and Psychiatry 1994 57 12 1510 1517
13. Herukka S. K., Helisalmi S., Hallikainen M., Tervo S., Soininen H., Pirttila T., CSF Abeta42, Tau and phosphorylated Tau, APOE epsilon4 allele and MCI type in progressive MCI Neurobiology of Aging 2007 28 4 507 514
14. Teunissen C. E., Petzold A., Bennett J. L., Berven F. S., Brundin L., Comabella M., Franciotta D., Frederiksen J. L., Fleming J. O., Furlan R., Hintzen R. Q., Hughes S. G., Johnson M. H., Krasulova E., Kuhle J., Magnone M. C., Rajda C., Rejdak K., Schmidt H. K., van Pesch V., Waubant E., Wolf C., Giovannoni G., Hemmer B., Tumani H., Deisenhammer F., A consensus protocol for the standardization of cerebrospinal fluid collection and biobanking Neurology 2009 73 22 1914 1922
15. Spitzer P., Klafki H. W., Blennow K., Buée L., Esselmann H., Herruka S. K., Jimenez C., Klivenyi P., Lewczuk P., Maler J. M., Markus K., Meyer H. E., Morris C., Mller T., Otto M., Parnetti L., Soininen H., Schraen S., Teunissen C., Vecsei L., Zetterberg H., Wiltfang J., CNEUPRO: novel biomarkers for neurodegenerative diseases International Journal of Alzheimer's Disease 2010 2010 12
16. Tapiola T., Alafuzoff I., Herukka S.-K., Parkkinen L., Hartikainen P., Soininen H., Pirttil T., Cerebrospinal fluid -amyloid 42 and tau proteins as biomarkers of Alzheimer-type pathologic changes in the brain Archives of Neurology 2009 66 3 382 389
17. Lanari A., Parnetti L., Cerebrospinal fluid biomarkers and prediction of conversion in patients with mild cognitive impairment: 4-Year follow-up in a routine clinical setting The Scientific World Journal 2009 9 961 966
18. Parnetti L., Lanari A., Silvestrelli G., Saggese E., Reboldi P., Diagnosing prodromal Alzheimer's disease: role of CSF biochemical markers Mechanisms of Ageing and Development 2006 127 2 129 132 (Pubitemid 43165611)
19. Laemmli U. K., Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Nature 1970 227 5259 680 685
20. Towbin H., Staehelin T., Gordon J., Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications Proceedings of the National Academy of Sciences of the United States of America 1979 76 9 4350 4354 (Pubitemid 9256559)
21. Verwey N. A., van der Flier W. M., Blennow K., Clark C., Sokolow S., de Deyn P. P., Galasko D., Hampel H., Hartmann T., Kapaki E., Lannfelt L., Mehta P. D., Parnetti L., Petzold A., Pirttila T., Saleh L., Skinningsrud A., V Swieten J. C., Verbeek M. M., Wiltfang J., Younkin S., Scheltens P., Blankenstein M. A., A worldwide multicentre comparison of assays for cerebrospinal fluid biomarkers in Alzheimer's disease Annals of Clinical Biochemistry 2009 46 3 235 240
22. Shaw L. M., Vanderstichele H., Knapik-Czajka M., Clark C. M., Aisen P. S., Petersen R. C., Blennow K., Soares H., Simon A., Lewczuk P., Dean R., Siemers E., Potter W., Lee V. M. Y., Trojanowski J. Q., Cerebrospinal fluid biomarker signature in alzheimer's disease neuroimaging initiative subjects Annals of Neurology 2009 65 4 403 413
23. Steinacker P., Klafki H., Lehnert S., Jesse S., Arnim C. A., Tumani H., Pabst A., Kretzschmar H. A., Wiltfang J., Otto M., ERK2 is increased in cerebrospinal fluid of Creutzfeldt-Jakob disease patients Journal of Alzheimer's Disease 2010 22 1 119 128
24. Cobb M. H., Goldsmith E. J., How MAP kinases are regulated Journal of Biological Chemistry 1995 270 25 14843 14846
25. Cheung E. C., Slack R. S., Emerging role for ERK as a key regulator of neuronal apoptosis Science's STKE 2004 2004 251 pe45
26. Adams J. P., Roberson E. D., English J. D., Selcher J. C., Sweatt J. D., MAPK regulation of gene expression in the central nervous system Acta Neurobiologiae Experimentalis 2000 60 3 377 394 (Pubitemid 30659915)
27. Grewal S. S., York R. D., Stork P. J. S., Extracellular-signal-regulated kinase signalling in neurons Current Opinion in Neurobiology 1999 9 5 544 553 (Pubitemid 29484377)
28. David Sweatt J., The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory Journal of Neurochemistry 2001 76 1 1 10 (Pubitemid 32044362)
29. Zhu X., Lee H. G., Raina A. K., Perry G., Smith M. A., The role of mitogen-activated protein kinase pathways in Alzheimer's disease NeuroSignals 2002 11 5 270 281 (Pubitemid 37494394)
30. Ortiz J., Harris H. W., Guitart X., Terwilliger R. Z., Haycock J. W., Nestler E. J., Extracellular signal-regulated protein kinases (ERKs) and ERK kinase (MEK) in brain: regional distribution and regulation by chronic morphine Journal of Neuroscience 1995 15 2 1285 1297