Covalent modification of reduced flavin mononucleotide in type-2 isopentenyl diphosphate isomerase by active-site-directed inhibitors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 51, 2011, Pages 20461-20466

  Nagai, Takuya ^a   Unno, Hideaki ^b   Janczak, Matthew Walter ^c   Yoshimura, Tohru ^a   Poulter, C Dale ^c   Hemmi, Hisashi ^a  

^a NAGOYA UNIVERSITY   (Japan)

^b NAGASAKI UNIVERSITY   (Japan)

^c UNIVERSITY OF UTAH   (United States)

Author keywords

Enzyme structure; Mechanism of action

Indexed keywords

3 METHYLENE 4 PENTEN 1 YL DIPHOSPHATE; 3 OXIRANYL 3 BUTEN 1 YL DIPHOSPHATE; DIMETHYLALLYL DIPHOSPHATE; FLAVINE MONONUCLEOTIDE; ISOPENTENYL DIPHOSPHATE; ISOPENTENYL DIPHOSPHATE DELTA ISOMERASE; ISOPENTENYL DIPHOSPHATE ISOMERASE TYPE 2; ISOPRENOID; PYROPHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CATALYSIS; CHEMICAL MODIFICATION; COVALENT BOND; CRYSTAL STRUCTURE; ISOMERIZATION; KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTON TRANSPORT; ULTRAVIOLET SPECTROSCOPY; X RAY CRYSTALLOGRAPHY;

CARBON-CARBON DOUBLE BOND ISOMERASES; CATALYSIS; CATALYTIC DOMAIN; CATIONS; ELECTRONS; ENZYME INHIBITORS; FLAVIN MONONUCLEOTIDE; KINETICS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTONS; SPECTROPHOTOMETRY, ULTRAVIOLET; SULFOLOBUS;

EID: 84855501578     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1115749108     Document Type: Article

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