Synthesis and evaluation of substrate analogues as mechanism-based inhibitors of type II isopentenyl diphosphate isomerase

Journal of Organic Chemistry

Volumn 73, Issue 2, 2008, Pages 726-729

  Walker, Joel R ^a,b   Rothman, Steven C ^a,c   Poulter, C Dale ^a  

^a UNIVERSITY OF UTAH   (United States)

^b ALBANY MOLECULAR RESEARCH INC   (United States)

^c DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; SUBSTRATES; SYNTHESIS (CHEMICAL);

INHIBITORS; ISOPENTENYL DIPHOSPHATE ISOMERASE; SUBSTRATE ANALOGUES;

ENZYME ACTIVITY;

ISOPENTENYL DIPHOSPHATE DELTA ISOMERASE; CYCLOPROPANE DERIVATIVE; EPOXIDE; ISOMERASE; ISOPENTENYLDIPHOSPHATE DELTA-ISOMERASE; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ADDITION REACTION; AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; CHEMICAL REACTION; CHEMICAL STRUCTURE; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE; ENZYME SYNTHESIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PROTON TRANSPORT; THERMUS THERMOPHILUS; BINDING SITE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; ENZYME ACTIVATION; PROTEIN TERTIARY STRUCTURE; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

BINDING SITES; CARBON-CARBON DOUBLE BOND ISOMERASES; CYCLOPROPANES; DRUG EVALUATION, PRECLINICAL; ENZYME ACTIVATION; EPOXY COMPOUNDS; MOLECULAR STRUCTURE; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 40949160085     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo702061d     Document Type: Article

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