Anxiety in anorexia nervosa and its management using family-based treatment

European Eating Disorders Review

Volumn 20, Issue 1, 2012, Pages

  Hildebrandt, Tom ^a   Bacow, Terri ^a   Markella, Mariana ^a   Loeb, Katharine L ^a,b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b FAIRLEIGH DICKINSON UNIVERSITY   (United States)

Author keywords

adolescents; anorexia nervosa; exposure therapy; family based treatment; fear; worry

Indexed keywords

ANOREXIA NERVOSA; ANXIETY DISORDER; ARTICLE; AVOIDANCE BEHAVIOR; COGNITIVE THERAPY; COMORBIDITY; EMOTIONAL DISORDER; EXPOSURE; EXPOSURE THERAPY; FAMILY BASED TREATMENT; FEAR; FOOD INTAKE; GENERALIZED ANXIETY DISORDER; HERITABILITY; HUMAN; HUMAN RELATION; OBSESSIVE COMPULSIVE DISORDER; PERSONALITY DISORDER; PHENOMENOLOGY; PSYCHIATRIC TREATMENT; PSYCHOTHERAPY; SOCIAL PHOBIA; TEMPERAMENT; WEIGHT GAIN;

ANOREXIA NERVOSA; ANXIETY; ANXIETY DISORDERS; COMORBIDITY; DISEASE MANAGEMENT; FAMILY THERAPY; HUMANS; IMPLOSIVE THERAPY;

EID: 84855471674     PISSN: 10724133     EISSN: 10990968     Source Type: Journal    
DOI: 10.1002/erv.1071     Document Type: Article

References (82)

1. Antony, M. M., &, Barlow, D. H., (2002). Specific phobias. In, D. H. Barlow, (Ed.), Anxiety and its disorders: The nature and treatment of anxiety and panic (pp. 380-417). New York, NY: Guilford Press.
2. Behar, E., DiMarco, I. D., Hekler, E. B., Mohlman, J., &, Staples, A. M., (2009). Current theoretical models of generalized anxiety disorder (GAD): Conceptual review and treatment implications. Journal of Anxiety Disorders, 23, 1011-1023.
3. Boelen, P. A., &, Reijntjes, A., (2009). Intolerance of uncertainty and social anxiety. Journal of Anxiety Disorders, 23, 130-135.
4. Borkovec, T. D., Alcaine, O. M., &, Behar, E., (2004). Avoidance theory of worry and generalized anxiety disorder. In, R. G. Heimberg, C. L. Turk, &, D. S. Mennin, (Eds.), Generalized anxiety disorder: Advances in research and practice (pp. 77-108). New York, NY: Guilford Press.
5. Buhr, K., &, Dugas, M. J., (2009). The role of fear of anxiety and intolerance of uncertainty in worry: An experimental manipulation. Behavior Research and Therapy, 47, 215-223.
6. Bulik, C. M., Hebebrand, J., Keski-Rahkonen, A., Klump, K. L., Reichborn-Kjennerud, T., Mazzeo, S. E., et al. (2007). Genetic epidemiology, endophenotypes, and eating disorder classification. International Journal of Eating Disorders, 40, S52-S60. (Pubitemid 47608520)
7. Bulik, C. M., Sullivan, P. F., Fear, J. L., &, Joyce, P. R., (1997). Eating disorders and antecedent anxiety disorders: A controlled study. Acta Psychiatrica Scandinavica, 96, 101-107. (Pubitemid 27345268)
8. Bulik, C. M., Sullivan, P. F., Joyce, P. R., &, Carter, F. A., (1995). Temperament, character, and personality disorder in bulimia nervosa. The Journal of Nervous and Mental Disease, 183, 593-598.
9. Chu, B. C., &, Harrison, T. L., (2007). Disorder-specific effects of CBT for anxious and depressed youth: A meta-analysis of candidate mediators of change. Clinical Child and Family Psychology Review, 10, 352-372.
10. Collier, D. A., &, Treasure, J. L., (2004). The aetiology of eating disorders. The British Journal of Psychiatry, 185, 363-365. (Pubitemid 39482070)
11. Craske, M. G., (1999). Anxiety disorders: Psychological approaches to theory and treatment. Boulder, CO: Westview Press.
12. Eisler, I., Dare, C., Hodes, M., Russell, G., Dodge, E., &, Le Grange, D., (2000). Family therapy for adolescent anorexia nervosa: The results of a controlled comparison of two family interventions. Journal of Child Psychology and Psychiatry, 41, 727-736.
13. Eisler, I., Dare, C., Russell, G. F., Szmukler, G., Le Grange, D., &, Dodge, E., (1997). Family and individual therapy in anorexia nervosa: A 5-year follow-up. Archives of General Psychiatry, 54, 1025-1030. (Pubitemid 27476098)
14. Eisler, I., Simic, M., Russell, G. F., &, Dare, C., (2007). A randomised controlled treatment trial of two forms of family therapy in adolescent anorexia nervosa: A five-year follow-up. Journal of Child Psychology and Psychiatry, 48, 552-560. (Pubitemid 46902325)
15. Epstein, L. H., Leddy, J. J., Temple, J. L., &, Faith, M. S., (2007). Food reinforcement and eating: A multilevel analysis. Psychological Bulletin, 133, 884-906.
16. Fairburn, C. G., (2008). Cognitive behavior therapy and eating disorders. New York: the Guilford Press.
17. Fairburn, C. G., Cooper, Z., Doll, H. A., &, Welch, S. L., (1999). Risk factors for anorexia nervosa: Three integrated case-control comparisons. Archives of General Psychiatry, 56, 468-476. (Pubitemid 29215436)
18. Fassino, S., Abbate-Daga, G., Amianto, F., Leombruni, P., Boggio, S., &, Rovera, G. G., (2002). Temperament and character profile of eating disorders: A controlled study with the Temperament and Character Inventory. International Journal of Eating Disorders, 32, 412-425. (Pubitemid 35253496)
19. Friedrich, H. C., Kumari, V., Uher, R., Riga, M., Schmidt, U., Campbell, I., et al. (2006). Motivational responses to food, body image and emotional cues in eating disorders-a startle reflex paradigm. Psychological Medicine, 36, 1327-1335. (Pubitemid 44184710)
20. Godart, N. T., Flament, M. F., Curt, F., Perdereau, F., Lang, F., Venisse, J. L., et al. (2003). Anxiety disorders in subjects seeking treatment for eating disorders: A DSM-IV controlled study. Psychiatry Research, 117, 245-258. (Pubitemid 36398500)
21. Godart, N. T., Flament, M. F., Perdereau, F., &, Jeammet, P., (2002). Comorbidity between eating disorders and anxiety disorders: A review. International Journal of Eating Disorders, 32, 253-270. (Pubitemid 34951499)
22. Goldfarb, L. A., Fuhr, R., Tsujimoto, R. N., &, Fischman, S. E., (1987). Systematic desensitization and relaxation as adjuncts in the treatment of anorexia nervosa: A preliminary study. Psychological Reports, 60, 511-518.
23. Halmi, Sunday, S. R., Klump, K. L., Strober, M., Leckman, J. F., Fichter, M., et al. (2003). Obsessions and compulsions in anorexia nervosa subtypes. International Journal of Eating Disorders, 33, 308-319. (Pubitemid 36457068)
24. Halmi, K. A., Tozzi, F., Thornton, L. M., Crow, S., Fichter, M. M., Kaplan, A. S., et al. (2005). The relation among perfectionism, obsessive-compulsive personality disorder and obsessive-compulsive disorder in individuals with eating disorders. International Journal of Eating Disorders, 38, 371-374. (Pubitemid 41785855)
25. Hazlett, R. L., McLeod, D. R., &, Hoehn-Saric, R., (1994). Muscle tension in generalized anxiety disorder: Elevated muscle tonus or agitated movement ? Psychophysiology, 31, 189-195. (Pubitemid 24077068)
26. Hoenig, K., Hochrein, A., Quednow, B. B., Maier, W., &, Wagner, M., (2005). Impaired prepulse inhibition of acoustic startle in obsessive-compulsive disorder. Biological Psychiatry, 15, 1153-1158. (Pubitemid 40615777)
27. Holaway, R. M., Heimberg, R. G., &, Coles, M. E., (2006). A comparison of intolerance of uncertainty in analogue obsessive-compulsive disorder and generalized anxiety disorder. Journal of Anxiety Disorders, 20, 158-174. (Pubitemid 43197800)
28. Hoyer, J., Beesdo, K., Gloster, A. T., Runge, J., Hofler, M., &, Becker, E. S., (2009). Worry exposure versus applied relaxation in the treatment of generalized anxiety disorder. Psychotherapy and Psychosomatics, 78, 106-115.
29. Jacobs, M. J., Roesch, S., Wonderlich, S. A., Crosby, R., Thornton, L., Wilfley, D. E., et al. (2009). Anorexia nervosa trios: Behavioral profiles of individuals with anorexia nervosa and their parents. Psychological Medicine, 39, 451-461.
30. Jimenez-Murcia, S., Fernandez-Aranda, F., Raich, R. M., Alonso, P., Krug, I., Jaurrieta, N., et al. (2007). Obsessive-compulsive and eating disorders: Comparison of clinical and personality features. Psychiatry Clinical Neuroscience, 61, 385-391. (Pubitemid 47019907)
31. Khanna, M. S., &, Kendall, P. C., (2009). Exploring the role of parent-training in the treatment of childhood anxiety. Journal of Consulting and Clinical Psychology, 77, 981-986.
32. Karwautz, A., Troop, N. A., Rabe-Hesketh, S., Collier, D. A., &, Treasure, J. L., (2003). Personality disorders and personality dimensions in anorexia nervosa. Journal of Personality Disorders, 17, 73-85. (Pubitemid 36343241)
33. Kaye, W. H., Barbarich, N. C., Putnam, K., Gendall, K. A., Fernstrom, J., Fernstrom, M., et al. (2003). Anxiolytic effects of acute tryptophan depletion in anorexia nervosa. International Journal of Eating Disorders, 33, 257-267. (Pubitemid 36457061)
34. Kaye, W. H., Bulik, C. M., Plotnicov, K., Thornton, L., Devlin, B., Fichter, M. M., et al. (2008). The genetics of anorexia nervosa collaborative study: Methods and sample description. International Journal of Eating Disorders, 41, 289-300. (Pubitemid 351581389)
35. Kaye, W. H., Bulik, C. M., Thornton, L., Barbarich, N., &, Masters, K., (2004). Comorbidity of anxiety disorders with anorexia and bulimia nervosa. American Journal of Psychiatry, 161, 2215-2221. (Pubitemid 39587286)
36. Keel, P. K., Klump, K. L., Miller, K. B., McGue, M., &, Iacono, W. G., (2005). Shared transmission of eating disorders and anxiety disorders. International Journal of Eating Disorders, 38, 99-105. (Pubitemid 41262772)
37. Kendall, P. C., Flannery-Schroeder, E., Panichelli-Mindel, S. M., Southam-Gerow, M., Henin, A., &, Warman, M., (1997). Therapy for youths with anxiety disorders: A second randomized clinical trial. Journal of Consulting and Clinical Psychology, 65, 366-380. (Pubitemid 27246778)
38. Kendler, K. S., Walters, E. E., Neale, M. C., Kessler, R. C., Heath, A. C., &, Eaves, L. J., (1995). The structure of the genetic and environmental risk factors for six major psychiatric disorders in women. Phobia, generalized anxiety disorder, panic disorder, bulimia, major depression, and alcoholism. Archives of General Psychiatry, 52, 374-383.
39. Klump, K. L., Bulik, C. M., Pollice, C., Halmi, K. A., Fichter, M. M., Berrettini, W. H., et al. (2000). Temperament and character in women with anorexia nervosa. The Journal of Nervous and Mental Disease, 188, 559-567.
40. Ladouceur, R., Gosselin, P., &, Dugas, M. J., (2000). Experimental manipulation of intolerance of uncertainty: A study of a theoretical model of worry. Behavior Research and Therapy, 38, 933-941. (Pubitemid 30336427)
41. Le Grange, D., Crosby, R. D., Rathouz, P. J., &, Leventhal, B. L., (2007). A randomized controlled comparison of family-based treatment and supportive psychotherapy for adolescent bulimia nervosa. Archives of General Psychiatry, 64, 1049-1056. (Pubitemid 47360850)
42. Le Grange, D., Eisler, I., Dare, C., &, Hodes, M., (1992b). Family criticism and self-starvation: A study of expressed emotion. Journal of Family Therapy, 14, 177-192.
43. Le Grange, D., Eisler, I., Dare, C., &, Russell, G. F., (1992). Evaluation of family treatments in adolescent anorexia nervosa: A pilot study. International Journal of Eating Disorders, 12, 347-357.
44. Le Grange, D., &, Lock, J., (2007). Treating bulimia in adolescents: A family-based approach. New York, NY: The Guilford Press.
45. Lee, J. K., Orsillo, S. M., Roemer, L., &, Allen, L. B., (2009). Distress and avoidance in generalized anxiety disorder: Exploring the relationships with intolerance of uncertainty and worry. Cognitive Behavior Therapy, 391, 126-136.
46. Lock, J., Agras, W. S., Bryson, S., &, Kraemer, H. C., (2005). A comparison of short- and long-term family therapy for adolescent anorexia nervosa. Journal of the American Academy of Child and Adolescent Psychiatry, 44, 632-639. (Pubitemid 40875357)
47. Lock, J., Couturier, J., &, Agras, W., (2006). Comparison of long-term outcomes in adolescents with anorexia nervosa treated with family therapy. Journal of the American Academy of Child & Adolescent Psychiatry, 45, 666-672. (Pubitemid 43833099)
48. Lock, J., Le Grange, D., Agras, W. S., &, Dare, C., (2001). Treatment manual for anorexia nervosa: A family-based approach. New York: The Guilford Press.
49. Lock, J., Le Grange, D., Forsberg, S., &, Hewell, K., (2006). Is family therapy useful for treating children with anorexia nervosa? Results of a case series. Journal of the American Academy of Child & Adolescent Psychiatry, 45, 1323-1328. (Pubitemid 44665449)
50. Loeb, K. L., &, Le Grange, D., (2009). Family-based treatment for adolescent eating disorders: Current status, new applications, and future directions. International Journal of Child and Adolescent Health, 2, 243-253.
51. Loeb, K. L., Le Grange, D., &, Lock, J., (2005). Family-based treatment for the prevention of anorexia nervosa. New York, Mount Sinai School of Medicine (unpublished manual).
52. Loeb, K. L., Lock, J., Greif, R., &, Le Grange, D., (2010). Transdiagnostic theory and application of family-based treatment for youth with eating disorders. Cognitive and Behaviorial Practice, Available online 20 November [Epub ahead of print].
53. Loeb Walsh, B. T., Lock, J., Le Grange, D., Jones, J., Marcus, S., et al. (2007). Open trial of family-based treatment for full and partial anorexia nervosa in adolescence: Evidence of successful dissemination. Journal of the American Academy of Child & Adolescent Psychiatry, 46, 792-800. (Pubitemid 46975916)
54. March, J. S., &, Muller, K., (1998). OCD in children and adolescents: A cognitive-behavioral treatment manual. New York, NY: The Guilford Press.
55. Mineka, S., &, Thomas, C., (1999). Mechanisms of change in exposure therapy for anxiety disorders. In, T. Dalgleish, &, M. J. Power, (Eds.), Handbook of cognition and emotion. Chichester, New York: Wiley.
56. Minuchin, S., Rosman, B. L., &, Baker, L., (1978). Psychosomatic families, anorexia nervosa in context. Cambridge, MA: Harvard University Press.
57. Moscovitch, D. A., Antony, M. M., &, Swinson, R. P., (2009). Exposure-based treatments for anxiety disorders: Theory and process. In, M. M. Antony, &, M. B. Stein, (Eds.), Handbook of anxiety and related disorders. Oxford: Oxford University Press.
58. O'Doherty, J. P., Buchanan, T. W., Seymour, B., &, Dolan, R. J., (2006). Predictive neural coding of reward preference involves dissociable responses in human ventral midbrain and ventral striatum. Neuron, 49, 157-166. (Pubitemid 43017193)
59. Olmstead, M. P., McFarlane, T. L., Carter, J. C., Trottier, K., Woodside, B. W., &, Dimitropoulous, D., (2010). Inpatient and day hospital treatment for anorexia nervosa. In, C. G. Grilo, &, J. G. Mitchell, (Eds.), The treatment of eating disorders: A clinical handbook. New York: The Guilford Press.
60. Pallister, E., &, Waller, G., (2008). Anxiety in the eating disorders: Understanding the overlap. Clinical Psychology Review, 28, 366-386. (Pubitemid 351308098)
61. Prins, P. J., &, Ollendick, T. H., (2003). Cognitive change and enhanced coping: Missing mediational links in cognitive behavior therapy with anxiety-disordered children. Clinical Child and Family Psychology Review, 6, 87-105. (Pubitemid 38979776)
62. Roemer, L., Orsillo, S. M., &, Barlow, D. H., (2002). Generalized anxiety disorder. In, D. H. Barlow, (Ed.), Anxiety and its disorders: The nature and treatment of anxiety and panic (second edition). New York, NY: The Guilford Press.
63. Rowe, M. K., &, Craske, M. G., (1998). Effects of an expanding-spaced vs. massed exposure schedule on fear reduction and return of fear. Behavior Research and Therapy, 36, 701-717. (Pubitemid 28339790)
64. Russell, G. F., Szmukler, G. I., Dare, C., &, Eisler, I., (1987). An evaluation of family therapy in anorexia nervosa and bulimia nervosa. Archives of General Psychiatry, 44, 1047-1056. (Pubitemid 18003467)
65. Silverman, W. K., Kurtines, W. M., Ginsburg, G. S., Weems, C. F., Rabian, B., &, Serafini, L. T., (1999). Contingency management, self-control, and education support in the treatment of childhood phobic disorders: A randomized clinical trial. Journal of Consulting and Clinical Psychology, 67, 675-687. (Pubitemid 29491679)
66. Smukler, G. I., Eisler, I., Russell, G. F., &, Dare, C., (1985). Anorexia nervosa, parental 'expressed emotion' and dropping out of treatment. British Journal of Psychiatry, 147, 265-271. (Pubitemid 16255916)
67. Sohlberg, S., &, Strober, M., (1994). Personality in anorexia nervosa: An update and a theoretical integration. Acta Psychiatrica Scandinavica, 378, 1-15. (Pubitemid 24106064)
68. Steinglass, J., Sysko, R., Schebendach, J., Broft, A., Strober, M., &, Walsh, B. T., (2007). The application of exposure therapy and D-cycloserine to the treatment of anorexia nervosa: A preliminary trial. Journal of Psychiatric Practice, 13, 238-245. (Pubitemid 47222146)
69. Steinglass, J., Sysko, R., Glasofer, D., Albano, A. M., Simpson, H. B., &, Walsh, B. T., (2010). Rationale for the application of exposure and response prevention to the treatment of anorexia nervosa. International Journal of Eating Disorders, 2 Available online February 2, 2010.
70. Steinglass, J., &, Walsh, B. T., (2006). Habit learning and anorexia nervosa: A cognitive neuroscience hypothesis. International Journal of Eating Disorders, 39, 267-275.
71. Steketee, G., &, Barlow, D. H., (2002). Obsessive-compulsive disorder. In, D. H. Barlow, (Ed.), Anxiety and its disorders: The nature and treatment of anxiety and panic (pp. 516-550). New York, NY: Guilford Press.
72. Strober, M., (2004). Pathologic fear conditioning and anorexia nervosa: On the search for novel paradigms. International Journal of Eating Disorders, 35, 504-508. (Pubitemid 38552822)
73. Swinbourne, J. M., &, Touyz, S. W., (2007). The co-morbidity of eating disorders and anxiety disorders: A review. European Eating Disorders Review, 15, 253-274. (Pubitemid 47062399)
74. Sysko, R., Walsh, B. T., Schebendach, J., &, Wilson, G. T., (2005). Eating behavior among women with anorexia nervosa. The American Journal of Clinical Nutrition, 82, 296-301.
75. Thayer, J. F., Friedman, B. H., &, Borkovec, T. D., (1996). Autonomic characteristics of generalized anxiety disorder and worry. Biological Psychiatry, 39, 255-266. (Pubitemid 26083149)
76. Uehara, T., Kawashima, Y., Goto, M., Tasaki, S., &, Someya, T., (2001). Psychoeducation for the families of patients with eating disorders and changes in expressed emotion: A preliminary study. Comprehensive Psychiatry, 42, 132-138. (Pubitemid 32207248)
77. Walters, E. E., &, Kendler, K. S., (1995). Anorexia nervosa and anorexic-like syndromes in a population-based female twin sample. American Journal of Psychiatry, 152, 64-71.
78. Wells, A., &, Carter, K., (1999). Preliminary tests of a cognitive model of generalized anxiety disorder. Behaviour Research and Therapy, 37, 585-594. (Pubitemid 29225210)
79. Wildes, J. E., Ringham, R. M., &, Marcus, M. D., (2010). Emotion avoidance in patients with anorexia nervosa: Initial test of a functional model. International Journal of Eating Disorders, 43, 398-404.
80. Wilson, G. T., Grilo, C. M., &, Vitousek, K. M., (2007). Psychological treatment of Eating Disorders. American Psychologist, 62, 199-216.
81. Woodside, D. B., Bulik, C. M., Halmi, K. A., Fichter, M. M., Kaplan, A., Berrettini, W. H., et al. (2002). Personality, perfectionism, and attitudes toward eating in parents of individuals with eating disorders. International Journal of Eating Disorders, 31, 290-299. (Pubitemid 34260725)
82. Zinbarg, R. E., Craske, M. G., &, Barlow, D. H., (1993). Therapists Guide for the Mastery of Your Anxiety and Worry. San Antonio, TX: Psychological Corporation/Graywind Publications Incorporated.