Blood clot formation under flow: The importance of factor XI depends strongly on platelet count

Biophysical Journal

Volumn 102, Issue 1, 2012, Pages 10-18

  Fogelson, Aaron L ^a,b   Hussain, Yasmeen H ^a   Leiderman, Karin ^c  

^a UNIVERSITY OF UTAH   (United States)

^b University of Utah   (United States)

^c DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 11; THROMBIN;

ANIMAL; ARTERY; ARTICLE; BIOLOGICAL MODEL; BLOOD CLOTTING; COMPUTER SIMULATION; CYTOLOGY; HUMAN; METABOLISM; PHYSIOLOGY; SHEAR STRENGTH; THROMBOCYTE; THROMBOCYTE COUNT;

ANIMALS; ARTERIES; BLOOD COAGULATION; BLOOD PLATELETS; COMPUTER SIMULATION; FACTOR XI; HUMANS; MODELS, CARDIOVASCULAR; PLATELET COUNT; SHEAR STRENGTH; THROMBIN;

EID: 84855464236     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2011.10.048     Document Type: Article

References (48)

1. A.L. Fogelson, and N. Tania Coagulation under flow: the influence of flow-mediated transport on the initiation and inhibition of coagulation Pathophysiol. Haemost. Thromb. 34 2005 91 108
2. A.L. Kuharsky, and A.L. Fogelson Surface-mediated control of blood coagulation: the role of binding site densities and platelet deposition Biophys. J. 80 2001 1050 1074 (Pubitemid 32182136)
3. B. Savage, and Z. Ruggeri Platelet thrombus formation in flowing blood A. Michelson, Platelets 2007 Elsevier New York 359 376
4. Y. Nemerson The tissue factor pathway of blood coagulation Semin. Hematol. 29 1992 170 176
5. K.G. Mann, and M.E. Nesheim S. Krishnaswamy Surface-dependent reactions of the vitamin K-dependent enzyme complexes Blood 76 1990 1 16 (Pubitemid 20220784)
6. B. Blombäck Fibrinogen structure, activation, polymerization and fibrin gel structure Thromb. Res. 75 1994 327 328 (Pubitemid 24241965)
7. P. Lollar, G.J. Knutson, and D.N. Fass Activation of porcine factor VIII:C by thrombin and factor Xa Biochemistry 24 1985 8056 8064 (Pubitemid 16102834)
8. D.D. Monkovic, and P.B. Tracy Activation of human factor V by factor Xa and thrombin Biochemistry 29 1990 1118 1128 (Pubitemid 20053831)
9. C. van 't Veer, and K.G. Mann Regulation of tissue factor initiated thrombin generation by the stoichiometric inhibitors tissue factor pathway inhibitor, antithrombin-III, and heparin cofactor-II J. Biol. Chem. 272 1997 4367 4377 (Pubitemid 27078512)
10. C.T. Esmon The roles of protein C and thrombomodulin in the regulation of blood coagulation J. Biol. Chem. 264 1989 4743 4746 (Pubitemid 19092874)
11. J.J. Hathcock, and Y. Nemerson Platelet deposition inhibits tissue factor activity: in vitro clots are impermeable to factor Xa Blood 104 2004 123 127 (Pubitemid 38879847)
12. B.N. Bouma, and J.H. Griffin Human blood coagulation factor XI. Purification, properties, and mechanism of activation by activated factor XII J. Biol. Chem. 252 1977 6432 6437 (Pubitemid 8193790)
13. P.A. von dem Borne, J.C. Meijers, and B.N. Bouma Feedback activation of factor XI by thrombin in plasma results in additional formation of thrombin that protects fibrin clots from fibrinolysis Blood 86 1995 3035 3042
14. R. Asakai, and D.W. Chung U. Seligsohn Factor XI deficiency in Ashkenazi Jews in Israel N. Engl. J. Med. 325 1991 153 158
15. D. Gailani, and G.J. Broze Jr. Factor XI activation in a revised model of blood coagulation Science 253 1991 909 912 (Pubitemid 21917236)
16. K. Naito, and K. Fujikawa Activation of human blood coagulation factor XI independent of factor XII. Factor XI is activated by thrombin and factor XIa in the presence of negatively charged surfaces J. Biol. Chem. 266 1991 7353 7358 (Pubitemid 21906372)
17. D. Gailani, and T. Renné Intrinsic pathway of coagulation and arterial thrombosis Arterioscler. Thromb. Vasc. Biol. 27 2007 2507 2513 (Pubitemid 350158899)
18. T.R. Baird, and P.N. Walsh The interaction of factor XIa with activated platelets but not endothelial cells promotes the activation of factor IX in the consolidation phase of blood coagulation J. Biol. Chem. 277 2002 38462 38467 (Pubitemid 35154704)
19. J.A. Oliver, and D.M. Monroe M. Hoffman Thrombin activates factor XI on activated platelets in the absence of factor XII Arterioscler. Thromb. Vasc. Biol. 19 1999 170 177 (Pubitemid 29031926)
20. K.M. Cawthern, and C. van 't Veer K.G. Mann Blood coagulation in hemophilia A and hemophilia C Blood 91 1998 4581 4592 (Pubitemid 28270306)
21. I.M. Keularts, and A. Zivelin S. Béguin The role of factor XI in thrombin generation induced by low concentrations of tissue factor Thromb. Haemost. 85 2001 1060 1065 (Pubitemid 32573760)
22. P.A. von dem Borne, L.M. Cox, and B.N. Bouma Factor XI enhances fibrin generation and inhibits fibrinolysis in a coagulation model initiated by surface-coated tissue factor Blood Coagul. Fibrinolysis 17 2006 251 257
23. S. Butenas, C. van 't Veer, and K.G. Mann Evaluation of the initiation phase of blood coagulation using ultrasensitive assays for serine proteases J. Biol. Chem. 272 1997 21527 21533 (Pubitemid 27374027)
24. E.I. Tucker, and U.M. Marzec S.R. Hanson Prevention of vascular graft occlusion and thrombus-associated thrombin generation by inhibition of factor XI Blood 113 2009 936 944
25. U.M. Okorie, and W.S. Denney S.L. Diamond Determination of surface tissue factor thresholds that trigger coagulation at venous and arterial shear rates: amplification of 100 fM circulating tissue factor requires flow Blood 111 2008 3507 3513
26. M.S. Chatterjee, and W.S. Denney S.L. Diamond Systems biology of coagulation initiation: kinetics of thrombin generation in resting and activated human blood PLOS Comput. Biol. 6 2010 9
27. A.W. Tilles, and E.C. Eckstein The near-wall excess of platelet-sized particles in blood flow: its dependence on hematocrit and wall shear rate Microvasc. Res. 33 1987 211 223 (Pubitemid 17065260)
28. B. Woldhuis, and G.J. Tangelder R.S. Reneman Concentration profile of blood platelets differs in arterioles and venules Am. J. Physiol. 262 1992 H1217 H1223
29. P. Kamath, and S. Krishnaswamy Fate of membrane-bound reactants and products during the activation of human prothrombin by prothrombinase J. Biol. Chem. 283 2008 30164 30173
30. D. Gailani, and D. Ho P.N. Walsh Model for a factor IX activation complex on blood platelets: dimeric conformation of factor XIa is essential Blood 97 2001 3117 3122
31. W. Wu, and D. Sinha P.N. Walsh Factor XI homodimer structure is essential for normal proteolytic activation by factor XIIa, thrombin, and factor XIa J. Biol. Chem. 283 2008 18655 18664
32. J. Emsley, P.A. McEwan, and D. Gailani Structure and function of factor XI Blood 115 2010 2569 2577
33. S.B. Smith, and I.M. Verhamme D. Gailani Characterization of novel forms of coagulation factor XIa: independence of factor XIa subunits in factor IX activation J. Biol. Chem. 283 2008 6696 6705
34. F.A. Baglia, B.A. Jameson, and P.N. Walsh Identification and characterization of a binding site for platelets in the Apple 3 domain of coagulation factor XI J. Biol. Chem. 270 1995 6734 6740
35. 542) in factor XIa mediates binding to a site on activated platelets Biochemistry 46 2007 14450 14460 (Pubitemid 350276352)
36. P.N. Walsh, and D. Sinha H. Bradford Functional characterization of platelet-bound factor XIa: retention of factor XIa activity on the platelet surface Blood 68 1986 225 230 (Pubitemid 16033634)
37. J.S. Greengard, and M.J. Heeb J.H. Griffin Binding of coagulation factor XI to washed human platelets Biochemistry 25 1986 3884 3890 (Pubitemid 16042517)
38. A. Hindmarsh ODEPACK, a systematized collection of ODE solvers R.S. Stepleman, Scientific Computing, Vol. 1, IMACS Transactions on Scientific Computation 1983 North-Holland Amsterdam, The Netherlands 55 65
39. J.M. Scandura, and Y. Zhang P.N. Walsh Progress curve analysis of the kinetics with which blood coagulation factor XIa is inhibited by protease nexin-2 Biochemistry 36 1997 412 420 (Pubitemid 27043477)
40. P.N. Walsh Roles of platelets and factor XI in the initiation of blood coagulation by thrombin Thromb. Haemost. 86 2001 75 82 (Pubitemid 32663939)
41. U. Seligsohn Factor XI deficiency in humans J. Thromb. Haemost. 7 Suppl 1 2009 84 87
42. O. Salomon, and D.M. Steinberg U. Seligsohn Patients with severe factor XI deficiency have a reduced incidence of deep-vein thrombosis Thromb. Haemost. 105 2011 269 273
43. J.C. Meijers, and W.L. Tekelenburg F.R. Rosendaal High levels of coagulation factor XI as a risk factor for venous thrombosis N. Engl. J. Med. 342 2000 696 701 (Pubitemid 30131422)
44. C.J. Doggen, F.R. Rosendaal, and J.C. Meijers Levels of intrinsic coagulation factors and the risk of myocardial infarction among men: opposite and synergistic effects of factors XI and XII Blood 108 2006 4045 4051 (Pubitemid 44913273)
45. N. Mackman, R.E. Tilley, and N.S. Key Role of the extrinsic pathway of blood coagulation in hemostasis and thrombosis Arterioscler. Thromb. Vasc. Biol. 27 2007 1687 1693 (Pubitemid 47207163)
46. A. Brill, and T.A. Fuchs D.D. Wagner von Willebrand factor-mediated platelet adhesion is critical for deep vein thrombosis in mouse models Blood 117 2011 1400 1407
47. W.A. Schumacher, and J.M. Luettgen D.A. Seiffert Inhibition of factor XIa as a new approach to anticoagulation Arterioscler. Thromb. Vasc. Biol. 30 2010 388 392
48. K. Leiderman, and A.L. Fogelson Grow with the flow: a spatial-temporal model of platelet deposition and blood coagulation under flow Math. Med. Biol. 28 2011 47 84