Sequence variants at the myostatin gene locus influence the body composition ofthoroughbred horses

Journal of Veterinary Medical Science

Volumn 73, Issue 12, 2011, Pages 1617-1624

  Tozaki, Teruaki ^a   Sato, Fumio ^b   Hill, Emmeline W ^c   Miyake, Takeshi ^d   Endo, Yoshiro ^b   Kakoi, Hironaga ^a   Gawahara, Hitoshi ^a   Hirota, Kei ichi ^a   Nakano, Yasuko ^e   Nambo, Yasuo ^b   Kurosawa, Masahiko ^a  

^a LABORATORY OF RACING CHEMISTRY   (Japan)

^b EQUINE RESEARCH INSTITUTE   (Japan)

^c UNIVERSITY COLLEGE DUBLIN   (Ireland)

^d KYOTO UNIVERSITY   (Japan)

^e SHOWA UNIVERSITY   (Japan)

Author keywords

Body composition; Myostatin; Racing performance; Thoroughbred

Indexed keywords

MYOSTATIN;

ANIMAL; ANIMAL EXPERIMENT; ARTICLE; BODY COMPOSITION; FEMALE; GENETICS; GENOTYPE; HORSE; MALE; METABOLISM; PHYSIOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM;

ANIMALS; BODY COMPOSITION; FEMALE; GENOTYPE; HORSES; MALE; MYOSTATIN; PHYSICAL CONDITIONING, ANIMAL; POLYMORPHISM, SINGLE NUCLEOTIDE;

EQUIDAE;

EID: 84855460559     PISSN: 09167250     EISSN: 13477439     Source Type: Journal    
DOI: 10.1292/jvms.11-0295     Document Type: Article

References (26)

1. Bellinge, R. H. S., Liberles, D. A., Iaschi, S. P. A., O'Brien, P. A. and Tay, G. K. 2005. Myostatin and its implications on animal breeding: a review. Anim. Genet. 36: 1-6
2. Binns, M. M., Boehler, D. A. and Lambert, D. H. 2010. Identification of the myostatin locus (MSTN) as having a major effect on optimum racing distance in the Thoroughbred horse in the USA. Anim. Genet. 41: 154-158.
3. Bower, M., Campana, M., Whitten, C., Edwards, C., Jones, H., Barrett, E., Cassidy, R., Nisbet, R. E., Hill, E. W., Howe, C. and Binns, M. 2011. The cosmopolitan maternal heritage of the Thoroughbred racehorse breed shows a significant contribution from British and Irish Native mares. Biol. Lett. 7: 316-320.
4. Carroll, C. L. and Huntington, P. J. 1988. Body condition scoring and weight estimation of horses. Equine Vet. J. 20: 41-45.
5. Cunningham, E. P., Dooley, J. J., Splan, R. K. and Bradley, D. G. 2001. Microsatellite diversity, pedigree relatedness and the contributions of founder lineages to thoroughbred horses. Anim. Genet. 32: 360-364.
6. Dall'Olio, S., Fontanesi, L., Costa, L. N., Tassinari, M., Minieri, L. and Falaschini, A. 2010. Analysis of Horse Myostatin Gene and Identification of Single Nucleotide Polymorphisms in Breeds of Different Morphological Types. J. Biomed. Biotechnol. Article ID 542945.
7. Grobet, L., Martin, L. J., Poncelet, D., Pirottin, D., Brouwers, B., Riquet, J., Schoeberlein, A., Dunner, S., Ménissier, F., Massabanda, J., Fries, R., Hanset, R. and Georges, M. 1997. A deletion in the bovine myostatin gene causes the double-muscled phenotype in cattle. Nat. Genet. 17: 71-74.
8. Gu, J., Orr, N., Park, S. D., Katz, L. M., Sulimova, G., MacHugh, D. E. and Hill, E. W. 2009. A genome scan for positive selection in thoroughbred horses. PLoS One 4: e5767.
9. Gu, J., MacHugh, D. E., McGivney, B. A., Park, S. D. E., Katz, L. M. and Hill, E. W. 2010. Association of sequence variants in CKM (creatine kinase, muscle) and COX4I2 (cytochrome c oxidase, subunit 4, isoform 2) genes with racing performance in Thoroughbred horses. Equine Vet. J. 42: 569-575.
10. Gunn, H. M. 1987. Muscle, bone and fat productions and muscle distribution of thoroughbreds and quarter horses. In: Equine exercise physiology 2: Proceedings of the Second International Conference on Equine Exercise Physiology; August 7-11 1986; San Diego, California, United States [cited 2011 June 17]. Available from http://www.iceep.org/pdf/iceep2/_1129101114_001.pdf.
11. Henneke, D. R., Potter, G. D., Kreider, J. L. and Yeates, B. F. 1983. Relationship between condition score, physical measurements and body fat percentage in mares. Equine Vet. J. 15: 371-372.
12. Hill, E. W., Bradley, D. G., Al-Barody, M., Ertugrul, O., Splan, R. K., Zakharov, I. and Cunningham, E. P. 2002. History and integrity of thoroughbred dam lines revealed in equine mtDNA variation. Anim. Genet. 33: 287-294.
13. Hill, E. W., Gu, J., Eivers, S. S., Fonseca, R. G., McGivney, B. A., Govindarajan, P., Orr, N., Katz, L. M. and MacHugh, D. E. 2010a. A sequence polymorphism in MSTN predicts sprinting ability and racing stamina in thoroughbred horses. PLoS ONE 5: e8645.
14. Hill, E. W., McGivney, B. A., Gu, J., Whiston, R. and MacHugh, D. E. 2010. A genome-wide SNP-association study confirms a sequence variant (g.66493737C>T) in the equine myostatin (MSTN) gene as the most powerful predictor of optimum racing distance for Thoroughbred racehorses. BMC Genomics 11: 552.
15. Hill, E. W., Gu, J., McGivney, B. A. and MacHugh, D. E. 2010. Targets of selection in the Thoroughbred genome contain exercise-relevant gene SNPs associated with elite racecourse performance. Anim. Genet. 41: 56-63.
16. Jones, J. H. and Lindstedt, S. L. 1993. Limits to maximal performance. Annu. Rev. Physiol. 55: 547-569.
17. Jones, J. H., Longworth, K. E., Lindholm, A., Conley, K. E., Karas, R. H., Kayar, S. R. and Taylor, C. R. 1989. Oxygen transport during exercise in large mammals. I. Adaptive variation in oxygen demand. J. Appl. Physiol. 67: 862-870.
18. McGivney, B. A., Browne, J. A., Fonseca, R. G., Katz, L. M., MacHugh, D. E., Whiston, R. and Hill, E. W. 2011. MSTN genotypes in Thoroughbred horses influence skeletal muscle gene expression and racetrack performance. Anim. Genet. (in press).
19. McPherron, A. C. and Lee, S. J. 1997. Double muscling in cattle due to mutations in the myostatin gene. Proc. Natl. Acad. Sci. U.S.A. 94: 12457-12461.
20. McPherron, A. C., Lawler, A. M. and Lee, S. J. 1997. Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature 387: 83-90.
21. Mosher, D. S., Quignon, P., Bustamante, C. D., Sutter, N. B., Mellersh, C. S., Parker, H. G. and Ostrander, E. A. 2007. A mutation in the myostatin gene increases muscle mass and enhances racing performance in heterozygote dogs. PloS Genet. 3: e79.
22. Rodgers, B. D. and Garikipati, D. K. 2008. Clinical, agricultural, and evolutionary biology of myostatin: a comparative review. Endocr. Rev. 29: 513-534.
23. Tozaki, T., Miyake, T., Kakoi, H., Gawahara, H., Sugita, S., Hasegawa, T., Ishida, N., Hirora, K. and Nakano, Y. 2010. A genome-wide association study for racing performances in Thoroughbreds clarifies a candidate region near the MSTN gene. Anim. Genet. 41: 28-35.
24. Tozaki, T., Hill, E. W., Hirota, K., Kakoi, H., Gawahara, H., Miyake, T., Sugita, S., Hasegawa, T., Ishida, N., Nakano, Y. and Kurosawa, M. 2011. A cohort study of racing performance in Japanese Thoroughbred racehorses using genome information on ECA18. Anim. Genet. (in press).
25. Wade, C. M., Giulotto, E., Sigurdsson, S., Zoli, M., Gnerre, S., Imsland, F., Lear, T. L., Adelson, D. L., Bailey, E., Bellone, R. R., Blöcker, H., Distl, O., Edgar, R. C., Garber, M., Leeb, T., Mauceli, E., MacLeod, J. N., Penedo, M. C., Raison, J. M., Sharpe, T., Vogel, J., Andersson, L., Antczak, D. F., Biagi, T., Binns, M. M., Chowdhary, B. P., Coleman, S. J., Della Valle, G., Fryc, S., Guérin, G., Hasegawa, T., Hill, E. W., Jurka, J., Kiialainen, A., Lindgren, G., Liu, J., Magnani, E., Mickelson, J. R., Murray, J., Nergadze, S. G., Onofrio, R., Pedroni, S., Piras, M. F., Raudsepp, T., Rocchi, M., Røed, K. H., Ryder, O. A., Searle, S., Skow, L., Swinburne, J. E., Syvänen, A. C., Tozaki, T., Valberg, S. J., Vaudin, M., White, J. R., Zody, M. C., Broad Institute Genome Sequencing Platform, Broad Institute Whole Genome Assembly Team, Lander E. S. and Lindblad- Toh, K. 2009. Genome sequence, comparative analysis, and population genetics of the domestic horse. Science 326: 865-867.
26. Young, L. E., Marlin, D. J., Deaton, C., Brown-Feltner, H., Roberts, C. A. and Wood, J. L. 2002. Heart size estimated by echocardiography correlates with maximal oxygen uptake. Equine Vet. J. Suppl. 34: 467-471.