A genome-wide association study for racing performances in Thoroughbreds clarifies a candidate region near the MSTN gene

Animal Genetics

Volumn 41, Issue SUPPL. 2, 2010, Pages 28-35

  Tozaki, T ^a   Miyake, T ^b   Kakoi, H ^a   Gawahara, H ^a   Sugita, S ^c   Hasegawa, T ^c   Ishida, N ^c   Hirota, K ^a   Nakano, Y ^d  

^a LABORATORY OF RACING CHEMISTRY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c EQUINE RESEARCH INSTITUTE   (Japan)

^d SHOWA UNIVERSITY   (Japan)

Author keywords

GWAS; Heritability; Horse; Racing performance; Thoroughbred

Indexed keywords

CONGIOPODIDAE; EQUIDAE;

MICROSATELLITE DNA; MYOSTATIN;

ANIMAL; GENETIC ASSOCIATION; GENETICS; HORSE; PHYSIOLOGY;

ANIMALS; GENOME-WIDE ASSOCIATION STUDY; HORSES; MICROSATELLITE REPEATS; MYOSTATIN;

EID: 78449275602     PISSN: 02689146     EISSN: 13652052     Source Type: Journal    
DOI: 10.1111/j.1365-2052.2010.02095.x     Document Type: Conference Paper

References (25)

1. Boldman K.G., Kriese L.A., Van Vleck L.D., Van Tassell C.P., &, Kachman S.D., (1995) A Manual for Use of MTDFREML. A Set of Programs to Obtain Estimates of Variances and Covariances [DRAFT]. ARS-USDA, Washington, DC.
2. Cunningham E.P., Dooley J.J., Splan R.K., &, Bradley D.G., (2001) Microsatellite diversity, pedigree relatedness and the contributions of founder lineages to thoroughbred horses. Animal Genetics 32, 360-4.
3. Gaffney B., &, Cunningham E.P., (1988) Estimation of genetic trend in racing performance of Thoroughbred horses. Nature 332, 722-3.
4. Grobet L., Martin L.J., Poncelet D., etal. (1997) A deletion in the bovine myostatin gene causes the double-muscled phenotype in cattle. Nature Genetics 17, 71-4.
5. Gu J., Orr N., Park S.D., Katz L.M., Sulimova G., MacHugh D.E., &, Hill E.W., (2009) A genome scan for positive selection in thoroughbred horses. PLoS ONE 4, e5767.
6. Gunn H.M., (1987) Muscle, bone and fat proportions and muscle distribution of thoroughbreds and quarter horses. In: Equine Exercise Physiology 2: Proceedings of the Second International Conference on Equine Exercise Physiology; August 7-11 1986; San Diego, California, United States. Available:.
7. Henderson C.R., (1973) Sire evaluation and genetic trends. In: Proceeding of Animal Breeding and Genetics Symposium in Honor of Lush J.L. ASAS and ADSA (Ed. by, L.V. Cundiff,), pp. 10-28. Champaign, IL.
8. Hill E.W., Bradley D.G., Al-Barody M., Ertugrul O., Splan R.K., Zakharov I., &, Cunningham E.P., (2002) History and integrity of thoroughbred dam lines revealed in equine mtDNA variation. Animal Genetics 33, 287-94.
9. Hill E.W., Gu J., Eivers S.S., Fonseca R.G., McGivney B.A., Govindarajan P., Orr N., Katz L.M., &, MacHugh D., (2010) A sequence polymorphism in MSTN predicts sprinting ability and racing stamina in thoroughbred horses. PLoS 5, e8645.
10. Miyake T., Oki H., Nishiura A., Ibi T., &, Sasaki Y., (1999) Computer Program for Genetic Analysis with Gibbs Sampling for Threshold Models, GSTM. Computer Program Library No. 38, Animal Breeding and Genetics, Agriculture, Kyoto University, Sakyo, Kyoto, Japan.
11. Mosher D.S., Quignon P., Bustamante C.D., Sutter N.B., Mellersh C.S., Parker H.G., &, Ostrander E.A., (2007) A mutation in the myostatin gene increases muscle mass and enhances racing performance in heterozygote dogs. PloS Genetics 3, e79.
12. Mota M.D., Abrahão A.R., &, Oliveira H.N., (2005) Genetic and environmental parameters for racing time at different distances in Brazilian Thoroughbreds. Journal of Animal Breeding and Genetics 122, 393-9.
13. Oki H., Sasaki Y., &, Willham R.L., (1995) Genetic parameter estimates for racing time by restricted maximum likelihood in the thoroughbred horse of Japan. Journal of Animal Breeding and Genetics 112, 146-50.
14. Penedo M.C., Millon L.V., Bernoco D., etal. (2005) International equine gene mapping workshop report: a comprehensive linkage map constructed with data from new markers and by merging four mapping resources. Cytogenetics and Genome Research 111, 5-15.
15. Raudsepp T., Gustafson-Seabury A., Durkin K., etal. (2008) A 4,103 marker integrated physical and comparative map of the horse genome. Cytogenetics and Genome Research 122, 28-36.
16. SAS Institute Inc. (2000) SAS/STAT User's Guide, Version 8, Vol. 2. SAS Institute Inc., Cary, NC.
17. Sobczynska M., (2006) Genetic correlation between racing performance at different racing distances in Thoroughbreds and Arab horses. Czechoslovak Journal of Animal Science 51, 523-8.
18. Swinburne J.E., Boursnell M., Hill G., etal. (2006) Single linkage group per chromosome genetic linkage map for the horse, based on two-three-generation, full-sibling, crossbred horse reference families. Genomics 87, 1-29.
19. Tolley E.S., Notter D.R., &, Marlowe T.J., (1985) A review of the inheritance of racing performance in horses. Animal Breeding Abstracts 53, 163-85.
20. Tozaki T., Mashima S., Hirota K., Miura N., Choi-Miura N.H., &, Tomita M., (2001) Characterization of equine microsatellites and microsatellite-linked repetitive elements (eMLREs) by efficient cloning and genotyping methods. DNA Research 8, 33-45.
21. Tozaki T., Hirota K., Hasegawa T., Tomita M., &, Kurosawa M., (2005) Prospects for whole genome linkage disequilibrium mapping in thoroughbreds. Gene 14, 127-32.
22. Tozaki T., Swinburne J., Hirota K., Hasegawa T., Ishida N., &, Tobe T., (2007a) Improved resolution of the comparative horse-human map: investigating markers with in silico and linkage mapping approaches. Gene 392, 181-6.
23. Tozaki T., Hirota K., Hasegawa T., Ishida N., &, Tobe T., (2007b) Whole-genome linkage disequilibrium screening for complex traits in horses. Molecular genetics and genomics 277, 663-72.
24. Wade C.M., Giulotto E., Sigurdsson S., etal. (2009) Genome sequence, comparative analysis, and population genetics of the domestic horse. Science 326, 865-7.
25. Williamson S.A., &, Beilharz R.G., (1998) The inheritance of speed, stamina and other racing performance characteristics in the Australian thoroughbred. Journal of Animal Breeding and Genetics 115, 1-16.