Targets of selection in the Thoroughbred genome contain exercise-relevant gene SNPs associated with elite racecourse performance

Animal Genetics

Volumn 41, Issue SUPPL. 2, 2010, Pages 56-63

  Hill, E W ^a   Gu, J ^a   McGivney, B A ^a   MacHugh, D E ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

Association test; Exercise; Gene; SNP; Thoroughbred

Indexed keywords

CONGIOPODIDAE; EQUIDAE;

ANIMAL; ANIMAL EXPERIMENT; CASE CONTROL STUDY; GENETICS; GENOME; HORSE; PHYSIOLOGY; QUANTITATIVE TRAIT LOCUS; SINGLE NUCLEOTIDE POLYMORPHISM;

ANIMALS; CASE-CONTROL STUDIES; GENOME; HORSES; PHYSICAL CONDITIONING, ANIMAL; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI;

EID: 78249285496     PISSN: 02689146     EISSN: 13652052     Source Type: Journal    
DOI: 10.1111/j.1365-2052.2010.02104.x     Document Type: Conference Paper

References (25)

1. Akey J.M., (2009) Constructing genomic maps of positive selection in humans: where do we go from here? Genome Research 19, 711-22.
2. Arany Z., (2008) PGC-1 coactivators and skeletal muscle adaptations in health and disease. Current Opinion in Genetics and Development 18, 426-34.
3. Bray M.S., Hagberg J.M., Perusse L., Rankinen T., Roth S.M., Wolfarth B., &, Bouchard C., (2009) The human gene map for performance and health-related fitness phenotypes: the 2006-2007 update. Medicine and Science in Sports and Exercise 41, 35-73.
4. Chinsomboon J., Ruas J., Gupta R.K., Thom R., Shoag J., Rowe G.C., Sawada N., Raghuram S., &, Arany Z., (2009) The transcriptional coactivator PGC-1alpha mediates exercise-induced angiogenesis in skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America 106, 21401-6.
5. Constantinopol M., Jones J.H., Weibel E.R., Taylor C.R., Lindholm A., &, Karas R.H., (1989) Oxygen transport during exercise in large mammals. II. Oxygen uptake by the pulmonary gas exchanger. Journal of Applied Physiology 67, 871-8.
6. Eivers S.S., McGivney B.A., Fonseca R.G., MacHugh D.E., Menson K., Park S.D., Rivero J.L., Taylor C.T., Katz L.M., &, Hill E.W., (2009) Alterations in oxidative gene expression in equine skeletal muscle following exercise and training. Physiological Genomics 40, 83-93.
7. Evans D.L., Harris R.C., &, Snow D.H., (1993) Correlation of racing performance with blood lactate and heart rate after exercise in thoroughbred horses. Equine Veterinary Journal 25, 441-5.
8. Gaffney B., &, Cunningham E.P., (1988) Estimation of genetic trend in racing performance of thoroughbred horses. Nature 332, 722-4.
9. Gu J., Orr N., Park S.D., Katz L.M., Sulimova G., MacHugh D.E., &, Hill E.W., (2009) A genome scan for positive selection in thoroughbred horses. PLoS ONE 4, e5767.
10. Harrison S.P., &, Turrion-Gomez J.L., (2006) Mitochondrial DNA: an important female contribution to thoroughbred racehorse performance. Mitochondrion 6, 53-63.
11. Hill E.W., Gu J., Eivers S.S., Fonseca R.G., McGivney B.A., Govindarajan P., Orr N., Katz L.M., &, MacHugh D., (2010) A sequence polymorphism in MSTN predicts sprinting ability and racing stamina in thoroughbred horses. PLoS ONE 5, e8645.
12. Hinchcliff K.W., Kaneps A.J., &, Geor R.J., (2008) Equine Exercise Physiology: The Science of Exercise in the Athletic Horse. Elsevier Saunders, Edinburgh.
13. Indecon (2004) An assessment of the economic contribution of the Thoroughbred breeding and horse racing industry in Ireland (A final report for the Irish Thoroughbred Breeders' Association, European Breeders' Fund, and Horse Racing Ireland). Available at:.
14. Jones J.H., Longworth K.E., Lindholm A., Conley K.E., Karas R.H., Kayar S.R., &, Taylor C.R., (1989) Oxygen transport during exercise in large mammals. I. Adaptive variation in oxygen demand. Journal of Applied Physiology 67, 862-70.
15. Jurinke C., Oeth P., &, Van Den Boom D., (2004) MALDI-TOF mass spectrometry: a versatile tool for high-performance DNA analysis. Molecular Biotechnology 26, 147-64.
16. McGivney B.A., Eivers S.S., MacHugh D.E., MacLeod J.N., O'Gorman G.M., Park S.D., Katz L.M., &, Hill E.W., (2009) Transcriptional adaptations following exercise in thoroughbred horse skeletal muscle highlights molecular mechanisms that lead to muscle hypertrophy. BMC Genomics 10, 638.
17. Oleksyk T.K., Smith M.W., &, O'Brien S.J., (2010) Genome-wide scans for footprints of natural selection. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 365, 185-205.
18. Pilegaard H., &, Neufer P.D., (2004) Transcriptional regulation of pyruvate dehydrogenase kinase 4 in skeletal muscle during and after exercise. Proceedings of the Nutrition Society 63, 221-6.
19. Pritchard J.K., Pickrell J.K., &, Coop G., (2010) The genetics of human adaptation: hard sweeps, soft sweeps, and polygenic adaptation. Current Biology 20, R208-15.
20. Purcell S., Neale B., Todd-Brown K., etal. (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. American Journal of Human Genetics 81, 559-75.
21. Sambrook J., &, Russell D.W., (2001) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
22. Scarpulla R.C., (2008) Nuclear control of respiratory chain expression by nuclear respiratory factors and PGC-1-related coactivator. Annals of the New York Academy of Sciences 1147, 321-34.
23. Wade C.M., Giulotto E., Sigurdsson S., etal. (2009) Genome sequence, comparative analysis, and population genetics of the domestic horse. Science 326, 865-7.
24. Wende A.R., Huss J.M., Schaeffer P.J., Giguere V., &, Kelly D.P., (2005) PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: a mechanism for transcriptional control of muscle glucose metabolism. Molecular and Cellular Biology 25, 10684-94.
25. Wigginton J.E., Cutler D.J., &, Abecasis G.R., (2005) A note on exact tests of Hardy-Weinberg equilibrium. American Journal of Human Genetics 76, 887-93.