The effect of Ginkgo biloba extract (EGb 761) on parameters of oxidative stress in different regions of aging rat brains after acute hypoxia

Aging Clinical and Experimental Research

Volumn 23, Issue 4, 2011, Pages 255-263

  Martin, Rosemarie ^a   Mozet, Christian ^a   Martin, Hans ^a   Welt, Klaus ^a   Engel, Christoph ^a   Fitzl, Günther ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Acute hypoxia; Aging; Brain regions; CK; Ginkgo biloba extract (EGb761); Oxidative stress

Indexed keywords

CREATINE KINASE; GINKGO BILOBA EXTRACT; GLUTATHIONE; MALONALDEHYDE; REACTIVE OXYGEN METABOLITE; SCAVENGER; SUPEROXIDE DISMUTASE;

ADAPTATION; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN BIOPSY; BRAIN HYPOXIA; BRAIN REGION; BRAIN STEM; CEREBELLUM; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVITY; FRONTAL CORTEX; MALE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; RAT; TEMPORAL CORTEX;

AGING; ANIMALS; ANOXIA; BRAIN; CREATINE KINASE; GINKGO BILOBA; GLUTATHIONE; MALE; OXIDATIVE STRESS; PLANT EXTRACTS; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE;

GINKGO BILOBA; RATTUS; RATTUS NORVEGICUS;

EID: 84855445646     PISSN: 15940667     EISSN: 17208319     Source Type: Journal    
DOI: 10.3275/7229     Document Type: Article

References (38)

1. Harman D. Free-radical theory of aging. Ann NY Acad Sci 1994; 717: 1-15.
2. Diamond BJ, Shiflett SC, Feiwel N et al. Ginkgo biloba extract: Mechanisms and clinical indications. Arch Phys Med Rehabil 2000; 81: 668-78. (Pubitemid 30257692)
3. Sastre J, Pallardó, Viña J. Mitochondrial oxidative stress plays a key role in aging and apoptosis. IUBMB Life 2000; 49: 427-35. (Pubitemid 30436178)
4. Ilyin SE, Sonti G, Molloy G, Plata-Salamán CR. Creatine kinase-B mRNA levels in brain regions from male and female rats. Mol Brain Res 1996; 41: 50-6. (Pubitemid 26288143)
5. Candelario-Jalil E, Mhadu NH, Al-Dalain SM, Martinez G, León OS. Time course of oxidative damage in different brain regions following transient cerebral ischemia in gerbils. Neurosci Res 2001; 41: 233-41. (Pubitemid 32988398)
6. Sakamoto S, Ishii K. Low cerebral glucose extraction rates in the human medial temporal cortex and cerebellum. J Neurol Sci 2000; 172: 41-8. (Pubitemid 30006980)
7. Wallimann T, Wyss M, Brdiczka D, Nicolay K, Eppenberger HM. Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands. Biochem J 1992; 281: 21-40.
8. Mozet C, Martin R, Welt K, Fitzl G. Cardioprotective effect of EGb 761 on myocardial ultrastructure of young and old rat heart and antioxidant status during acute hypoxia. Aging Clin Exp Res 2009: 21: 14-21.
9. Uchiyama M, Mihara M. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem 1978; 86: 271-8. (Pubitemid 9050395)
10. Flohé L, Otting F. Superoxide dismutase assays. Methods Enzymol 1984; 105: 93-104. (Pubitemid 14165376)
11. Herder M, Elser RC, Gerhardt M. Approved recommendation on IFCC methods for the measurement of catalytic concentration of enzymes. Part 7. IFCC Method for creatine kinase. Eur J Clin Chem Clin Biochem 1991; 29: 435-56.
12. Burton K. A study of the condition and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. Biochem J 1956; 62: 315-22.
13. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193: 265-75.
14. Bohman R, Tamura CT, Doolittle MH, Cascarano J. Growth and aging in the rat: changes in total protein, cellularity, and polyploidy in various organs. J Exp Zool 1985; 233: 385-96. (Pubitemid 15130476)
15. DiCiero Miranda M, De Bruin VM, Vale MR, Viana GS. Lipid peroxidation and nitrite plus nitrate levels in brain tissue from patients with Alzheimer's disease. Gerontology 2000; 46: 179-84. (Pubitemid 30422221)
16. Martin R, Fitzl G, Mozet C, Martin H, Welt K, Wieland E. Can antioxidants influence the life span? In Sames K, Sethe S, Stoizing A, Eds. Extending the life span. Medizin and Gesellschaft. LIT Verlag Münster 2005; 12: 107-15.
17. Siqueira IR, Fochesatto C, De Andrade A, et al. Total antioxidant capacity is impaired in different structures from aged rat brain. Int J Dev Neurosci 2005; 23: 663-71. (Pubitemid 41674505)
18. Devi SA, Kiran TR. Regional responses in antioxidant system to exercise training and dietary Vitamin E in aging rat brain. Neurobiol Aging 2004; 25: 501-8. (Pubitemid 38317348)
19. Murali G, Paneerselvam C. Age-associated oxidative macro-molecular damages in rat brain regions: Role of glutathione monoesters. J Gerontol Biol Sci 2007; 62A: 824-30. (Pubitemid 350131665)
20. Martinez-Romero R, Cañuelo A, Martinez-Lara E et al. Aging affects but does not eliminate the enzymatic antioxidative response to hypoxia/reoxygenation in cerebral cortex. Exp Gerontol 2006; 41: 25-31. (Pubitemid 43031364)
21. Gamier P, Demougeot C, Bertrand N, Prigent-Tessier A, Marie C, Beley A. Stress response to hypoxia in gerbil brain: HO-1 and Mn SOD expression and glial activation. Brain Res 2001; 893: 301-9. (Pubitemid 32171926)
22. Arthur PG, Lim SCC, Meloni BP, Munns SE, Chan A, Knuckey NW. The protective effect of hypoxic preconditioning on cortical neuronal cultures is associated with increases in the activity of several antioxidant enzymes. Brain Res 2004; 1017: 146-54. (Pubitemid 38917154)
23. Sastre J, Lloret A, Borrás C et al. Ginkgo biloba extract EGb 761 protects against mitochondrial aging in the brain and in the liver. Cell Mol Biol 2002; 48: 685-92.
24. Brunetti L, Orlando G, Menghini L, Ferrante C, Chiavarolli A, Vacca M. Ginkgo biloba leaf extract reverses amyloid β-peptide-induced isoprostane production in rat brain in vitro. Planta Med 2006; 72: 1296-9. (Pubitemid 44862030)
25. Santiago LA, Osato JA, Liu J, Mori A. Age-related increase in su-peroxide dismutase activity and thiobarbiturate acid-reactive substances: effect of biocatalyser in aged rat brain. Neurochem Res 1993; 18: 711-7.
26. Aksenova MV, Aksenov MY, Carney JM, Butterfield DA. Protein oxidation and enzyme activity decline in old brown Norway rats are reduced by dietary reduction. Mech Ageing Dev 1998; 100: 157-68. (Pubitemid 28101686)
27. Aksenov M, Aksenova M, Butterfield DA, Markesbery WR. Oxidative modification of creatine kinase BB in Alzheimer's disease brain. J Neurochem 2000; 74: 2520-7. (Pubitemid 30314229)
28. Manos P, Bryan GK, Edmond J. Creatine kinase activity in postnatal rat brain development and in cultured neurons, astrocytes, and oligodendrocytes. J Neurochem 1991; 56: 2101-7.
29. Ramirez O, Jiménez E. Sexual dimorphism in rat cerebrum and cerebellum: different patterns of catalytically active creatine kinase isoenzymes during postnatal development and aging. Int J Dev Neurosci 2002; 20: 627-39. (Pubitemid 36071283)
30. Cervós-Navarro J, Diemer NH. Selective vulnerability in brain hypoxia. Crit Rev Neurobiol 1991; 6: 149-82.
31. Canese R, Fortuna S, Lorenzini, P, Podo F, Michalek H. Transient global ischemia in young and aged rats: differences in severity and progression, but not localisation, of lesions evaluated by magnetic resonance imaging. Magnetic Resonance Materials in Physics, Biology and Medicine 1998; 7: 28-34. (Pubitemid 29014254)
32. Macdonald RL, Stoodley M. Pathophysiology of cerebral ischemia. Neurol Med Chir (Tokyo) 1998; 38: 1-11. (Pubitemid 28071102)
33. Balu M, Sangeetha P, Murali G, Panneerselvam C. Age-related oxidative protein damages in central nervous system of rats: modulatory role of grape seed extract. Int J Dev Neurosci 2005; 23: 501-7. (Pubitemid 41138141)
34. Jolitha AB, Subramanyam MVV, Asha Devi SA. Modification by vitamin E and exercise of oxidative stress in regions of aging rat brain: Studies on superoxide dismutase isoenzymes and protein oxidation status. Exp Gerontol 2006; 41: 753-63. (Pubitemid 44223891)
35. Mizuno Y, Ohta K. Regional distributions of thiobarbituric acid-reactive products, activities of enzymes regulating the metabolism of oxygen free radicals, and some of the related enzymes in adult and aged rat brains. J Neurochem 1986; 46: 1344-52. (Pubitemid 16062529)
36. Singh A, Naidu P, Kulkarni S. Reversal of aging and chronic ethanol-induced cognitive dysfunction by quercetin, a bioflavonoid. Free Rad Res 2003; 37: 1245-52. (Pubitemid 37322203)
37. Nagata H, Takekoshi S, Honma T, Watanable K. Antioxidative action of flavonoids, quercetin and catechin, mediated by the activation of glutathione peroxidase. Tokai J Exp Clin Med 1999; 24: 1-11. (Pubitemid 29403853)
38. Dringen R, Pawlowski PG, Hirrlinger J. Peroxide detoxification by brain cell. J Neurosci Res 2005; 79: 157-65.