A once-per-day, drug-in-food protocol for prolonged administration of antiepileptic drugs in animal models

Epilepsia

Volumn 53, Issue 1, 2012, Pages 199-206

  Ali, Atif ^a   Dua, Yashomati ^a   Constance, Jonathan E ^b   Franklin, Michael R ^b   Dudek, F Edward ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH   (United States)

Author keywords

Antiepileptic drugs; Convulsion; Drug treatment; Kainic acid

Indexed keywords

CARBAMAZEPINE; KAINIC ACID;

ANIMAL EXPERIMENT; ANIMAL FOOD; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ANTICONVULSANT THERAPY; ARTICLE; CALORIC INTAKE; CIRCADIAN RHYTHM; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG FATALITY; DRUG RESPONSE; EPILEPTIC STATE; FOOD INTAKE; LIGHT DARK CYCLE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECURRENT DISEASE; SEIZURE;

ANIMALS; ANTICONVULSANTS; CARBAMAZEPINE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EPILEPSY; FOOD, FORMULATED; KAINIC ACID; MALE; PHARMACEUTICAL PREPARATIONS; RATS; SEIZURES; STATUS EPILEPTICUS; TIME FACTORS; TREATMENT OUTCOME;

EID: 84855440864     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2011.03314.x     Document Type: Article

References (23)

1. Bastlund JF, Jennum P, Mohapel P, Penschuck S, Watson WP,. (2005) Spontaneous epileptic rats show changes in sleep architecture and hypothalamic pathology. Epilepsia 46: 934-938. (Pubitemid 40847361)
2. Bealer SL, Johnson AK,. (1980) Preoptic-hypothalamic periventricular lesions after food-associated drinking and circadian rhythms. J Comp Physiol Psychol 94: 547-555. (Pubitemid 10000024)
3. Bertram EH, Williamson J, Johnson M, Edelbroek P,. (2005) Testing drugs for antiepileptic efficacy in a rat model of chronic limbic epilepsy (abstract). Epilepsia 46 (Suppl. 8): 281-282.
4. Carl GF, Smith ML,. (1989) Chronic carbamazepine treatment in the rat: efficacy, toxicity, and effect on plasma and tissue folate concentrations. Epilepsia 30: 217-224. (Pubitemid 19095113)
5. Chakir A, Fabene PF, Ouazzani R, Bentivoglio M,. (2006) Drug resistance and hippocampal damage after delayed treatment of pilocarpine-induced epilepsy in the rat. Brain Res Bull 71: 127-138. (Pubitemid 44750429)
6. de Castro JM, Stoerzinger A, Barkmeier D, Ellen P,. (1978) Medial septal lesions: disruptions of microregulatory patterns and circadian rhythmicity in rats. J Comp Physiol Psychol 92: 71-84. (Pubitemid 8274388)
7. Dudek FE, Clark S, Williams PA, Grabenstatter HL,. (2006) Kainate-induced status epilepticus: a chronic model of acquired epilepsy. In, Pitkänen A, Schwartzkroin PA, Moshé SL, (Eds) Models of seizures and epilepsy. Elsevier BV, Amsterdam, pp. 415-432.
8. Fitzsimons TJ, Le Magnen J,. (1969) Eating as a regulatory control of drinking in the rat. J Comp Physiol Psychol 67: 273-283.
9. Glien M, Brandt C, Potschka H, Loscher W,. (2002) Effects of the novel antiepileptic drug levetiracetam on spontaneous recurrent seizures in the rat pilocarpine model of temporal lobe epilepsy. Epilepsia 43: 350-357. (Pubitemid 34297172)
10. Grabenstatter HL, Clark S, Dudek FE,. (2007) Anticonvulsant effects of carbamazepine on spontaneous seizures in rats with kainate-induced epilepsy: comparison of intraperitoneal injections with drug-in-food protocols. Epilepsia 48: 2287-2295. (Pubitemid 350243413)
11. Hellier JL, Dudek FE,. (2005) Chemoconvulsant model of chronic spontaneous seizures. In, Crawley J, (Ed.) Current protocols on neuroscience: models of chronic spontaneous seizures. Wiley & Sons, Inc, Hoboken, NJ, pp. 10053-10064.
12. Honack D, Loscher W,. (1989) Amygdala-kindling as a model for chronic efficacy studies on antiepileptic drugs: experiments with carbamazepine. Neuropharmacology 28: 599-610. (Pubitemid 19169502)
13. Hvidberg EF,. (1985) Monitoring antiepileptic drug levels. In, Frey HH, Janz D, (Eds) Handbook of experimental pharmacology. Springer, Berlin, pp. 725-764.
14. Joëls M,. (2009) Stress, the hippocampus, and epilepsy. Epilepsia 50: 586-597.
15. Jones PJ, Merrick EC, Batts TW, Hargus NJ, Wang Y, Stables JP, Bertram EH, Brown ML, Patel MK,. (2009) Modulation of sodium channel inactivation gating by a novel lactam: implications for seizure suppression in chronic limbic epilepsy. J Pharmacol Exp Ther 328: 201-212.
16. Leite JP, Cavalheiro EA,. (1995) Effects of conventional antiepileptic drugs in a model of spontaneous recurrent seizures in rats. Epilepsy Res 20: 93-104.
17. Loscher W,. (2007) The pharmacokinetics of antiepileptic drugs in rats: consequences for maintaining effective drug levels during prolonged drug administration in rat models of epilepsy. Epilepsia 48: 1245-1258. (Pubitemid 47063087)
18. Loscher W, Honack D,. (1997) Intravenous carbamazepine: comparison of different parenteral formulations in a mouse model of convulsive status epilepticus. Epilepsia 38: 106-113. (Pubitemid 27057488)
19. Loscher W, Schmidt D,. (1988) Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations. Epilepsy Res 2: 145-181.
20. Nissinen J, Pitkanen A,. (2007) Effect of antiepileptic drugs on spontaneous seizures in epileptic rats. Epilepsy Res 73: 181-191. (Pubitemid 46329332)
21. Quigg M, Straume M, Smith T, Menaker M, Bertram EH,. (2001) Seizures induce phase shifts of rat circadian rhythms. Brain Res 913: 165-169. (Pubitemid 32817061)
22. Raol YH, Meti BL,. (1998) Sleep-wakefulness alterations in amygdala-kindled rats. Epilepsia 39: 1133-1137. (Pubitemid 28516024)
23. Zucker I,. (1971) Light-dark rhythms in rat eating and drinking behavior. Physiol Behav 6: 115-126.