Pharmacokinetic and pharmacodynamic profiles of recombinant human erythropoietin-loaded poly(lactic-co-glycolic acid) microspheres in rats

Acta Pharmacologica Sinica

Volumn 33, Issue 1, 2012, Pages 137-144

  Zhou, Xiang Lian ^a   He, Jin Tian ^a   Du, Hui Juan ^a   Fan, Yang Yang ^a   Wang, Ying ^b   Zhang, Hong Xia ^b   Jiang, Yang ^b  

^a HEBEI NORMAL UNIVERSITY   (China)

^b NCPC GeneTech Biotechnology Development Co Ltd   (China)

Author keywords

microspheres; pharmacodynamics; pharmacokinetics; poly(lactic co glycolic acid); recombinant human erythropoietin

Indexed keywords

ERYTHROPOIETIN ANTIBODY; HEMOGLOBIN; MICROSPHERE; OIL; POLYGLACTIN; RECOMBINANT ERYTHROPOIETIN; WATER;

ANIMAL EXPERIMENT; ANTIBODY BLOOD LEVEL; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG RELEASE; DRUG SOLUBILITY; ENZYME LINKED IMMUNOSORBENT ASSAY; ERYTHROCYTE COUNT; FEMALE; IMMUNOGENICITY; IN VITRO STUDY; IN VIVO STUDY; MALE; MICROEMULSION; MICROENCAPSULATION; NONHUMAN; RAT; SOLID; STEADY STATE;

ANIMALS; EMULSIONS; ERYTHROPOIETIN; HUMANS; LACTIC ACID; MALE; MICROSPHERES; PARTICLE SIZE; POLYGLYCOLIC ACID; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS;

EID: 84855433463     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2011.157     Document Type: Article

References (23)

1. Davis JM, Aralkawas T, Strickland TW, Yphantis DA. Characterization of recombinant human erythropoietin produced in Chinese hamster ovary cells. Biochemistry 1987; 26: 2633-8. (Pubitemid 17081496)
2. Eschbach JW, Egrie JC, Downing MR, Browne JK, Adamson JW. Correction of the anemia of end-stage renal disease with recombinant human erythropoietin. N Engl J Med 1987; 316: 73-8.
3. Markham A, Bryson H, Epoetin A. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in non-renal applications. Drugs 1995; 49: 232-54.
4. Mundargi RC, Babu VR, Rangaswamy V, Patel P, Aminabhavi TM. Nano/micro technologies for delivering macromolecular therapeutics using poly(D,L-lactide-co-glycolide) and its derivatives. J Control Release 2008; 125: 193-209.
5. Pisal DS, Kosloski MP, Balu-Iyer SV. Delivery of therapeutic proteins. J Pharm Sci 2010; 99: 2557-75.
6. Morlock M, Koll H, Winter G, Kissel T. Microencapsulation of rh-erythropoietin, using biodegradable poly(DL,-lactide-co-glycolide): protein stability and the effects of stabilizing excipients. Eur J Pharm Biopharm 1997; 43: 29-36. (Pubitemid 28298807)
7. Morlock M, Kissel T, Li YX, Koll H, Winter G. Erythropoietin loaded micro spheres prepared from biodegradable LPLG-PEO-LPLG triblock copolymers: protein stabilization and in-vitro release properties. J Control Release 1998; 56: 105-15. (Pubitemid 28511131)
8. Pistel KF, Bittner B, Koll H, Winter G, Kissel T. Biodegradable recom-binant human erythropoietin loaded microspheres prepared from linear and star-branched block copolymers: Infuence of encapsulation technique and polymer composition on particle characteristics. J Control Release 1999; 59: 309-25. (Pubitemid 29238175)
9. Geng Y, Yuan W, Wu F, Chen J, He M, Jin T. Formulating erythropoietin-loaded sustained-release PLGA microspheres without protein. J Control Release 2008; 130: 259-65.
10. Morita T, Horikiri Y, Yamahara H, Suzuki T, Yoshino H. Formation and isolation of spherical fne protein microparticles through lyophilization of protein-poly(ethylene glycol) aqueous mixture. Pharm Res 2000; 17: 1367-73. (Pubitemid 32109488)
11. Morita T, Sakamura Y, Horikiri Y, Suzuki T, Yoshino H. Protein encapsula tion into biodegradable microspheres by a novel s/o/w emulsion method using poly(ethylene glycol) as a protein micro-nization adjuvant. J Control Release 2000; 69: 435-44.
12. Zhu G, Mallery SR, Schwendeman SP. Stabilization of proteins encapsulated in injectable poly(lactide-co-glycolide). Nat Biotechnol 2000; 18: 52-7. (Pubitemid 30041172)
13. El-Sayed YM, Niazy EM, Khidr SH. In vivo evaluation of sustained-release microspheres of metoclopramide hydrochloride in beagle dogs. Int J Pharm 1995; 123: 113-8.
14. He J, Feng M, Zhou X, Ma Sh, Jiang Y, Wang Y, et al. Stabilization and encapsulation of recombinant human erythropoietin into PLGA micro-spheres using human serum albumin as a stabilizer. Int J Pharm 2011; 416: 69-76.
15. Wischke C, Schwendeman SP. Principles of encapsulating hydro-phobic drugs in PLA/PLGA microparticles. Int J Pharm 2008; 364: 298-327.
16. Sun Y, Wang J, Zhang X, Zhang Z, Zheng Y, Chen D, et al. Synchronic release of two hormonal contraceptives for about one month from the PLGA microspheres: in vitro and in vivo studies. J Control Release 2008; 129: 192-9.
17. Cohen S, Yoshioka T, Lucarelli M, Hwang LH, Langer R. Controlled delivery systems for proteins based on poly(lactic/glycolic acid) microspheres. Pharm Res 1991; 8: 713-20.
18. Zolnik BS, Burgess DJ. Evaluation of in vivo-in vitro release of dexa-methasone from PLGA microspheres. J Control Release 2008; 127: 137-45.
19. Chu DF, Fu XQ, Liu WH, Liu K, Li YX. Pharmacokinetics and in vitro and in vivo correlation of huperzine A loaded poly(lactic-co-glycolic acid) microspheres in dogs. Int J Pharm 2006; 325: 116-23. (Pubitemid 44573702)
20. 14C-methylated lysozyme release from poly(ether-ester) microspheres. Pharm Res 2004; 21: 484-91. (Pubitemid 38338984)
21. Tamber H, Johansen P, Merkle HP, Gander B. Formulation aspects of bio degradable polymeric microspheres for antigen delivery. Adv Drug Deliv Rev 2005; 57: 357-76. (Pubitemid 39555502)
22. Nagao M, Suga H, Okano M, Masuda S, Narita H, Ikura K, et al. Nucleotide sequence of rat erythropoietin. Biochim Biophys Acta 1992; 1171; 99-102.
23. Lee HJ, Riley G, Johnson O, Cleland JL, Kim N, Charnis M, et al. In vivo characterization of sustained-release formulations of human growth hormone. J Pharmacol Exp Ther 1997; 281: 1431-9. (Pubitemid 27258404)