Two randomized, controlled, comparative studies of the stratum corneum integrity benefits of two cosmetic niacinamide/glycerin body moisturizers vs. conventional body moisturizers

Journal of Drugs in Dermatology

Volumn 11, Issue 1, 2012, Pages 22-29

  Christman, Jeremy C ^a   Fix, Deborah K ^b   Lucus, Sawanna C ^a   Watson, Debrah ^a   Desmier, Emma ^a   Johnson Wilkerson, Rolanda J ^a   Fixler, Charles ^b  

^a PROCTER AND GAMBLE COMPANY   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BODY MOISTURIZER; DERMATOLOGICAL AGENT; GLYCEROL; MINERAL OIL; NICOTINAMIDE; PETROLATUM; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CLINICAL ASSESSMENT TOOL; CONTROLLED STUDY; CUTANEOUS PARAMETERS; DRY SKIN; FEMALE; HUMAN; MAJOR CLINICAL STUDY; RANDOMIZED CONTROLLED TRIAL; SKIN FUNCTION; SKIN HYDRATION; SKIN WATER LOSS; STRATUM CORNEUM; XEROSIS;

ADMINISTRATION, TOPICAL; ADOLESCENT; ADULT; AGED; CHEMISTRY, PHARMACEUTICAL; COSMETICS; DOUBLE-BLIND METHOD; DRUG COMBINATIONS; EMOLLIENTS; EPIDERMIS; FEMALE; GLYCEROL; HUMANS; MIDDLE AGED; NIACINAMIDE; YOUNG ADULT;

EID: 84855399538     PISSN: 15459616     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Rawlings AV, Matts PJ. Stratum corneum moisturization at the molecular level: An update in relation to the dry skin cycle. J Invest Dermatol. 2005;124(6):1099-1110. (Pubitemid 40847395)
2. Loden M. The clinical benefit of moisturizers. J Eur Acad Dermatol Venereol. 2005;19(6):672-688. (Pubitemid 41743319)
3. Buraczewska I, Berne B, Lindberg M, Torma H, Loden M. Changes in skin barrier function following long-term treatment with moisturizers, a randomized controlled trial. 2007;156(3):492-498.
4. Loden M. Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders. Am J Clin Dermatol. 2003;4(11):771-788. (Pubitemid 37452637)
5. Barany E, Lindberg M, Loden M. Unexpected skin barrier influence from nonionic emulsifiers. Int J Pharm. 2000;195(1-2):189-195. (Pubitemid 30089503)
6. Crowther JM, Sieg A, Blenkiron P, Marcottt C, Matts PJ, Kaczvinsky JR, Rawlings AV. Measuring the effects of topical moisturizers on changes in stratum corneum thickness, water gradients and hydration in vivo. Br J Dermatol. 2008;159(3):567-577. Epub July 4, 2008.
7. Ertel K, Rodriguez VR, Bacon R, Farris R, Hartwig. Protocol to predict the dry skin benefit from the unique in-shower body lotion product form. J Cosmet Sci. 2008;59(4):253-262.
8. Huber, PJ. Robust Statistics. New York: John Wiley & Sons, Inc; 1981.
9. Draelos ZD, Ertel K, Berge C. Niacinamide-containing facial moisturizer improves skin barrier and benefits subjects with rosacea. Cutis. 2005;76(2):135-141. (Pubitemid 41290900)
10. Bissett DL, Miyamoto K, Sun P, et al. Topical niacinamide reduces yellowing, wrinkling, red blotchiness, and hyperpigmented spots in aging facial skin. Int J Cosmet Sci. 2004;26(5):231-238. (Pubitemid 39389251)
11. Matts PJ, Oblong JE, Bissett DL. A review of the range of effects of niacinamide in human skin. IFSCC Mag. 2002;50(4):285-290.
12. Crowther JM, Sieg A, Blenkiron P, Marcott C, Matts PJ, Kaczvinsky JR, Rawlings AV. Measuring the effects of topical moisturizers on changes in stratum corneum thickness, water gradients and hydration in vivo. Br J Dermatol. 2008;159(3):567-577. Epub July 4, 2008.
13. Tanno O, Ota Y, Kitamura N, Katsube T, Inoue S. Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier. Br J Dermatol. 2000;143(3):524-531.
14. Kraft JN, Lynde CW. Moisturizers: What they are and a practical approach to product selection. Skin Therapy Lett. 2005;10(5):1-8.
15. Stamates, GN, de Sterke J, Hauser M, von Stetten O, van der Pol A. Lipid uptake and skin occlusion following topical application of oils on adult and infant skin. J Dermatol Sci. 2008;50(2):135-142. Epub March 4, 2008.