Knockdown of vascular endothelial cell growth factor expression sensitizes U251 glioma cells to liposomal paclitaxel and radiation treatment in vitro

Experimental and Therapeutic Medicine

Volumn 3, Issue 2, 2012, Pages 181-186

  Yu, Yang ^a   Feng, Jianguo ^a   Zong, Xiangyun ^a   Yang, Hongjian ^a   Zou, Dehong ^a   He, Xiangming ^a  

^a ZHEJIANG CANCER HOSPITAL   (China)

Author keywords

Chemotherapy; Gene therapy; Glioblastoma; Liposomal paclitaxel; Radiation; Vascular endothelial growth factor

Indexed keywords

PACLITAXEL; SHORT HAIRPIN RNA; VASCULOTROPIN;

APOPTOSIS; ARTICLE; CANCER GENE THERAPY; CELL STRUCTURE; CELL VIABILITY; CHEMORADIOTHERAPY; COLONY FORMATION; CONTROLLED STUDY; GLIOBLASTOMA; GLIOMA CELL; IN VITRO STUDY; PROTEIN EXPRESSION;

EID: 84855392272     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2011.379     Document Type: Article

References (24)

1. Jemal A, Murray T, Ward E, et al: Cancer statistics. CA Cancer J Clin 55: 10-30, 2005.
2. Behin A, Hoang-Xuan K, Carpentier AF, et al: Primary brain tumours in adults. Lancet 361: 323-331, 2003.
3. Meyer MA: Malignant gliomas in adults. N Engl J Med 359: 1850, 2007.
4. Furnari FB, Fenton T, Bachoo RM, et al: Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes Dev 21: 2683-2710, 2007.
5. De Witt Hamer PC: Small molecule kinase inhibitors in glioblastoma: a systematic review of clinical studies. Neuro Oncol 12: 304-316, 2010.
6. Lo HW: EGFR-targeted therapy in malignant glioma: novel aspects and mechanisms of drug resistance. Curr Mol Pharmacol 3: 37-52, 2010.
7. Machein M and de Miguel LS: Angiogenesis in gliomas. Recent Results Cancer Res 171: 193-215, 2009.
8. Jain RK, di Tomaso E, Duda DG, et al: Angiogenesis in brain tumours. Nat Rev Neurosci 8: 610-622, 2007.
9. Lin MI and Sessa WC: Antiangiogenic therapy: creating a unique 'window' of opportunity. Cancer Cell 6: 529-531, 2004.
10. Said HM, Hagemann C, Staab A, et al: Expression patterns of the hypoxia-related genes osteopontin, CA9, erythropoietin, VEGF and HIF-1alpha in human glioma in vitro and in vivo. Radiother Oncol 83: 398-405, 2007.
11. Damiano V, Melisi D, Bianco C, et al: Cooperative antitumor effect of multitargeted kinase inhibitor ZD6474 and ionizing radiation in glioblastoma. Clin Cancer Res 11: 5639-5644, 2005.
12. Abdollahi A, Lipson KE, Sckell A, et al: Combined therapy with direct and indirect angiogenesis inhibition results in enhanced antiangiogenic and antitumor effects. Cancer Res 63: 8890-8898, 2003.
13. Kamoun WS, Ley CD, Farrar CT, et al: Edema control by cediranib, a vascular endothelial growth factor receptor-targeted kinase inhibitor, prolongs survival despite persistent brain tumor growth in mice. J Clin Oncol 27: 2542-2552, 2009.
14. Tabatabai G, Frank B, Wick A, et al: Synergistic antiglioma activity of radiotherapy and enzastaurin. Ann Neurol 61: 153-161, 2007.
15. Wachsberger PR, Burd R, Cardi C, et al: VEGF trap in combination with radiotherapy improves tumor control in u87 glioblastoma. Int J Radiat Oncol Biol Phys 67: 1526-1537, 2007.
16. Winkler F, Kozin SV, Tong RT, et al: Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases. Cancer Cell 6: 553-563, 2004.
17. Hovinga KE, Stalpers LJ, van Bree C, et al: Radiation-enhanced vascular endothelial growth factor (VEGF) secretion in glioblastoma multiforme cell lines - a clue to radioresistance? J Neurooncol 74: 99-103, 2005.
18. Fountzilas G, Karkavelas G, Kalogera-Fountzila A, et al: Post-operative combined radiation and chemotherapy with temozolomide and irinotecan in patients with high-grade astrocytic tumors. A phase II study with biomarker evaluation. Anticancer Res 26: 4675-4686, 2006.
19. Kesari S, Schiff D, Henson JW, et al: Phase II study of temozolomide, thalidomide, and celecoxib for newly diagnosed glioblastoma in adults. Neuro Oncol 10: 300-308, 2008.
20. Matsumura Y and Maeda A: A new concept for macromolecular therapies in cancer chemotherapy: mechanisms of tumortropic accumulation of proteins and the antitumor agents smancs. Cancer Res 46: 6387-6392, 1986.
21. Harrington KJ, Mohammadtaghi S, Uster PS, et al: Effective targeting of solid tumors in patients with locally advanced cancers by radiolabeled pegylated liposomes. Clin Cancer Res 7: 243-254, 2001.
22. Noble CO, Kirpotin DB, Hayes ME, et al: Development of ligand targeted liposomes for cancer therapy. Expert Opin Ther Targets 8: 335-353, 2004.
23. Aoki H, Kakinuma K, Morita K, et al: Therapeutic efficacy of targeting chemotherapy using local hyperthermia and thermosensitive liposome: evaluation of drug distribution in a rat glioma model. Int J Hypertherm 20: 595-605, 2005.
24. Mamot C, Nguyen JB, Pourdehnad M, et al: Extensive distribution of liposomes in rodent brains and brain tumors following convection-enhanced delivery. J Neurooncol 68: 1-9, 2004.