An alpha 2 collagen VIII transgenic knock-in mouse model of Fuchs endothelial corneal dystrophy shows early endothelial cell unfolded protein response and apoptosis

Human Molecular Genetics

Volumn 21, Issue 2, 2012, Pages 384-393

  Jun, Albert S ^a   Meng, Huan ^a   Ramanan, Naren ^c   Matthaei, Mario ^a   Chakravarti, Shukti ^a,b   Bonshek, Richard ^d   Black, Graeme C M ^d   Grebe, Rhonda ^a   Kimos, Martha ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b DEPARTMENT OF PATHOLOGY   (United States)

^c WASHINGTON UNIVERSITY   (United States)

^d MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 COLLAGEN TYPE 8; COLLAGEN TYPE 8; GLUTAMINE; LYSINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BASEMENT MEMBRANE; CELL LOSS; CELL STRUCTURE; CLINICAL FEATURE; CONGENITAL CORNEA DYSTROPHY; CORNEA ENDOTHELIUM; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENDOTHELIUM CELL; GENE TARGETING; HOMOZYGOTE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MOUSE; MOUSE MUTANT; NICK END LABELING; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; POINT MUTATION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE; ULTRASTRUCTURE ANALYSIS AND ELECTRON MICROSCOPY; UNFOLDED PROTEIN RESPONSE; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; COLLAGEN TYPE VIII; DISEASE MODELS, ANIMAL; ENDOTHELIUM, CORNEAL; FUCHS' ENDOTHELIAL DYSTROPHY; MICE; MICE, TRANSGENIC; MICROSCOPY, ELECTRON; MUTATION; PROTEIN DENATURATION;

MUS;

EID: 84855381762     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddr473     Document Type: Article

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