Colocalization of increased Transforming Growth Factor-β-Induced protein (TGFBIp) and clusterin in fuchs endothelial corneal dystrophy

Investigative Ophthalmology and Visual Science

Volumn 50, Issue 3, 2009, Pages 1129-1136

  Jurkunas, Ula V ^a,b,c   Bitar, Maya ^b,c   Rawe, Ian ^b  

^a MASSACHUSETTS EYE AND EAR INFIRMARY   (United States)

^b SCHEPENS EYE RESEARCH INSTITUTE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLUSTERIN; ISOPROTEIN; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA; BETAIG H3 PROTEIN; BETAIG-H3 PROTEIN; CLU PROTEIN, HUMAN; SCLEROPROTEIN;

ADULT; AGE; AGED; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONFOCAL MICROSCOPY; CONGENITAL CORNEA DYSTROPHY; CONTROLLED STUDY; CORNEA ENDOTHELIUM; DESCEMET MEMBRANE; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEOMICS; TWO DIMENSIONAL GEL ELECTROPHORESIS; WESTERN BLOTTING; ADOLESCENT; GENETICS; METABOLISM; MIDDLE AGED; PRESCHOOL CHILD; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADOLESCENT; AGED; AGED, 80 AND OVER; BLOTTING, WESTERN; CHILD, PRESCHOOL; CLUSTERIN; DESCEMET MEMBRANE; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; ENDOTHELIUM, CORNEAL; EXTRACELLULAR MATRIX PROTEINS; FEMALE; FUCHS' ENDOTHELIAL DYSTROPHY; HUMANS; MALE; MICROSCOPY, CONFOCAL; MIDDLE AGED; PROTEOMICS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA;

EID: 62649086642     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.08-2525     Document Type: Article

References (26)

1. Waring GO 3rd, Bourne WM, Edelhauser HF, Kenyon KR. The corneal endothelium: normal and pathologic structure and function. Ophthalmology. 1982;89:531-590.
2. Borderie VM, Baudrimont M, Vallee A, Ereau TL, Gray F, Laroche L. Corneal endothelial cell apoptosis in patients with Fuchs' dystrophy. Invest Ophthalmol Vis Sci. 2000;41:2501-2505.
3. Jurkunas UV, Bitar MS, Rawe I, Harris DL, Colby K, Joyce NC. Increased clusterin expression in Fuchs' endothelial dystrophy. Invest Ophthalmol Vis Sci. 2008;49:2946-2955.
4. Jurkunas UV, Rawe I, Bitar MS, et al. Decreased expression of peroxiredoxins in Fuchs' endothelial dystrophy. Invest Ophthalmol Vis Sci. 2008;49:2956-2963.
5. Schwochau GB, Nath KA, Rosenberg ME. Clusterin protects against oxidative stress in vitro through aggregative and nonaggregative properties. Kidney Int. 1998;53:1647-1653.
6. Runager K, Enghild JJ, Klintworth GK. Focus on molecules: transforming growth factor beta induced protein (TGFBIp). Exp Eye Res. 2008;87(4):298-9.
7. Hashimoto K, Noshiro M, Ohno S, et al. Characterization of a cartilage-derived 66-kDa protein (RGD-CAP/beta ig-h3) that binds to collagen. Biochim Biophys Acta. 1997;1355:303-314.
8. Billings PC, Whitbeck JC, Adams CS, et al. The transforming growth factor-beta-inducible matrix protein (beta)ig-h3 interacts with fibronectin. J Biol Chem. 2002;277:28003-28009.
9. LeBaron RG, Bezverkov KI, Zimber MP, Pavelec R, Skonier J, Purchio AF. Beta IG-H3, a novel secretory protein inducible by transforming growth factor-beta, is present in normal skin and promotes the adhesion and spreading of dermal fibroblasts in vitro. J Invest Dermatol. 1995;104:844-849.
10. Kim JE, Kim SJ, Lee BH, Park RW, Kim KS, Kim IS. Identification of motifs for cell adhesion within the repeated domains of transforming growth factor-beta-induced gene, betaig-h3. J Biol Chem. 2000; 275:30907-30915.
11. Skonier J, Neubauer M, Madisen L, Bennett K, Plowman GD, Purchio AF. cDNA cloning and sequence analysis of beta ig-h3, a novel gene induced in a human adenocarcinoma cell line after treatment with transforming growth factor-beta. DNA Cell Biol. 1992;11:511-522.
12. Munier FL, Korvatska E, Djemai A, et al. Kerato-epithelin mutations in four 5q31-linked corneal dystrophies. Nat Genet. 1997;15:247-251.
13. Zhao XC, Nakamura H, Subramanyam S, et al. Spontaneous and inheritable R555Q mutation in the TGFBI/BIGH3 gene in two unrelated families exhibiting Bowman's layer corneal dystrophy. Ophthalmology. 2007;114:e39-e46.
14. Okada M, Yamamoto S, Tsujikawa M, et al. Two distinct keratoepithelin mutations in Reis-Bucklers corneal dystrophy. Am J Ophthalmol. 1998;126:535-542.
15. Yamamoto S, Okada M, Tsujikawa M, et al. The spectrum of beta ig-h3 gene mutations in Japanese patients with corneal dystrophy. Cornea. 2000;19:S21-S23.
16. Korvatska E, Henry H, Mashima Y, et al. Amyloid and non-amyloid forms of 5q31-linked corneal dystrophy resulting from keratoepithelin mutations at Arg-124 are associated with abnormal turnover of the protein. J Biol Chem. 2000;275:11465-11469.
17. Rawe IM, Zhan Q, Burrows R, Bennett K, Cintron C. Beta-ig: molecular cloning and in situ hybridization in corneal tissues. Invest Ophthalmol Vis Sci. 1997;38:893-900.
18. El-Shabrawi Y, Kublin CL, Cintron C. mRNA levels of alpha1(VI) collagen, alpha1(XII) collagen, and beta ig in rabbit cornea during normal development and healing. Invest Ophthalmol Vis Sci. 1998;39:36-44.
19. Takacs L, Csutak A, Balazs E, Berta A. Immunohistochemical detection of betaIG-H3 in scarring human corneas. Graefes Arch Clin Exp Ophthalmol. 1999;237:529-534.
20. Leung EW, Rife L, Smith RE, Kay EP. Extracellular matrix components in retrocorneal fibrous membrane in comparison to corneal endothelium and Descemet's membrane. Mol Vis. 2000;6:15-23.
21. Hirano K, Klintworth GK, Zhan Q, Bennett K, Cintron C. Beta ig-h3 is synthesized by corneal epithelium and perhaps endothelium in Fuchs' dystrophic corneas. Curr Eye Res. 1996;15:965-972.
22. Akhtar S, Bron AJ, Hawksworth NR, Bonshek RE, Meek KM. Ultra-structural morphology and expression of proteoglycans, betaig-h3, tenascin-C, fibrillin-1, and fibronectin in bullous keratopathy. Br J Ophthalmol. 2001;85:720-731.
23. Streeten BW, Qi Y, Klintworth GK, Eagle RC Jr, Strauss JA, Bennett K. Immunolocalization of beta ig-h3 protein in 5q31-linked corneal dystrophies and normal corneas. Arch Ophthalmol. 1999;117:67-75.
24. Korvatska E, Munier FL, Chaubert P, et al. On the role of keratoepithelin in the pathogenesis of 5q31-linked corneal dystrophies. Invest Ophthalmol Vis Sci. 1999;40:2213-2219.
25. Silkensen JR, Skubitz KM, Skubitz AP, et al. Clusterin promotes the aggregation and adhesion of renal porcine epithelial cells. J Clin Invest. 1995;96:2646-2653.
26. Tung PS, Burdzy K, Wong K, Fritz IB. Competition between cellsubstratum interactions and cell-cell interactions. J Cell Physiol. 1992;152:410-421.