DHA induces apoptosis and differentiation in human melanoma cells in vitro: Involvement of hur-mediated COX-2 mRNA stabilization and β-catenin nuclear translocation

Carcinogenesis

Volumn 33, Issue 1, 2012, Pages 164-173

  Serini, Simona ^a   Fasano, Elena ^a   Piccioni, Elisabetta ^a   Monego, Giovanni ^a   Cittadini, Achille R M ^a   Celleno, Leonardo ^a   Ranelletti, Franco O ^a   Calviello, Gabriella ^a  

^a CATHOLIC UNIVERSITY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CYCLOOXYGENASE 2; DOCOSAHEXAENOIC ACID; HUR PROTEIN; ICOSAPENTAENOIC ACID; LINOLEIC ACID; MESSENGER RNA; OLEIC ACID;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BASAL CELL; CANCER CELL CULTURE; CANCER INHIBITION; CELL DIFFERENTIATION; CELL NUCLEUS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOPLASM; CYTOSOL; DRUG EFFECT; DRUG SPECIFICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRACELLULAR SIGNALING; MELANOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN STABILITY;

EID: 84855375288     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgr240     Document Type: Article

References (54)

1. Jemal,A. et al. (2009) Cancer statistics, 2009. CACancer J. Clin., 59, 225-249.
2. Kvaskoff,M. et al. (2010) Are some melanomas caused by artificial light? Med. Hypotheses, 75, 305-311.
3. Yang,J. et al. (2010) Conditional ablation of Ikkb inhibits melanoma tumor development in mice. J. Clin. Invest., 120, 2563-2574.
4. Ivanov,V.N. et al. (2011) Suppression of the proinflammatory response of metastatic melanoma cells increases TRAIL-induced apoptosis. J. Cell. Biochem., 112, 463-475.
5. Chakraborti,A.K. et al. (2010) Progress in COX-2 inhibitors: a journey so far. Curr. Med. Chem., 17, 1563-1593.
6. Wang,M.T. et al. (2007) Cyclooxygenases, prostanoids, and tumor progression. Cancer Metastasis Rev., 26, 525-534.
7. Denkert,C. et al. (2001) Expression of cyclooxygenase-2 in human malignant melanoma. Cancer Res., 61, 303-308.
8. Trifan,O.C. et al. (2003) Cyclooxygenase-2 modulates cellular growth and promotes tumorigenesis. J. Cell. Mol. Med., 7, 207-222.
9. Goulet,A.C. et al. (2003) Analysis of cyclooxygenase 2 (COX-2) expression during malignant melanoma progression. Cancer Biol. Ther., 2, 713-718.
10. Liao,Z. et al. (2007) Cyclo-oxygenase-2 and its inhibition in cancer: is there a role? Drugs, 67, 821-845.
11. Chwirot,B.W. et al. (2007) Cyclooxygenase-2 (COX-2): first immunohistochemical marker distinguishing early cutaneous melanomas from benign melanocytic skin tumours. Melanoma Res., 17, 139-145.
12. Becker,M.R. et al. (2009) Impressive regression of visceral and cerebral melanoma metastases under combination treatment including dacarbacine, radiotherapy and celecoxib. Int. J. Dermatol., 48, 207-209.
13. Khan,M.N. et al. (2011) Cyclooxygenase inhibitors: scope of their use and development in cancer chemotherapy. Med. Res. Rev., 31, 161-201.
14. Tabolacci,C. et al. (2010) Similar antineoplastic effects of nimesulide, a selective COX-2 inhibitor, and prostaglandin E1 on B16-F10 murine melanoma cells. Melanoma Res., 20, 273-279.
15. Scuderi,M.R. et al. (2008) Expression of Ca(2+)-independent and Ca(2+)-dependent phospholipases A(2) and cyclooxygenases in human melanocytes and malignant melanoma cell lines. Biochim. Biophys. Acta, 1781, 635-642.
16. Bhatt,R.S. et al. (2010) A phase 2 pilot trial of low-dose, continuous infusion, or "metronomic" paclitaxel and oral celecoxib in patients with metastatic melanoma. Cancer, 116, 1751-1756.
17. Moore,R.A. et al. (2007) Cyclo-oxygenase-2 selective inhibitors and nonsteroidal anti-inflammatory drugs: balancing gastrointestinal and cardiovascular risk. BMC Musculoskelet. Disord., 8, 73.
18. Lim,K. et al. (2009) Omega-3 polyunsaturated fatty acids inhibit hepatocellular carcinoma cell growth through blocking beta-catenin and cyclooxygenase- Mol. Cancer Ther., 8, 3046-3055.
19. Kelavkar,U.P. et al. (2009) Prostate tumor growth can be modulated by dietarily targeting the 15-lipoxygenase-1 and cyclooxygenase-2 enzymes. Neoplasia, 11, 692-699.
20. Calviello,G. et al. (2004) n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and -2 and HIF-1alpha induction pathway. Carcinogenesis, 25, 2303-2310.
21. Calviello,G. et al. (2007) Docosahexaenoic acid induces proteasomedependent degradation of beta-catenin, down-regulation of survivin and apoptosis in human colorectal cancer cells not expressing COX-2. Carcinogenesis, 28, 1202-1209.
22. Calviello,G. et al. (2007) n-3 polyunsaturated fatty acids and the prevention of colorectal cancer: molecular mechanisms involved. Curr. Med. Chem., 14, 3059-3069.
23. Serini,S. et al. (2009) Dietary n-3 PUFA vascular targeting and the prevention of tumor growth and age-related macular degeneration. Curr. Med. Chem., 16, 4511-4526.
24. Serini,S. et al. (2009) Dietary polyunsaturated fatty acids as inducers of apoptosis: implications for cancer. Apoptosis, 14, 135-152.
25. Albino,A.P. et al. (2000) Cellcycle arrest and apoptosis of melanoma cells by docosahexaenoic acid: association with decreased pRb phosphorylation. Cancer Res., 60, 4139-4145.
26. Chiu,L.C. et al. (2005) Cytostatic and cytotoxic effects of cyclooxygenase inhibitors and their synergy with docosahexaenoic acid on the growth of human skin melanoma A-375 cells. Biomed. Pharmacother., 59, S293-S297.
27. Denkins,Y. et al. (2005) Role of omega-3 polyunsaturated fatty acids on cyclooxygenase-2 metabolism in brain-metastatic melanoma. J. Lipid Res., 46, 1278-1284.
28. Serini,S. et al. (2010) Docosahexaenoic acid reverts resistance to UVinduced apoptosis in human keratinocytes: involvement of COX-2 and HuR. J. Nutr. Biochem., 22, 874-885.
29. Zhang,J. et al. (2008) UVB irradiation regulates Cox-2 mRNA stability through AMPK and HuR in human keratinocytes. Mol. Carcinog., 47, 974-983.
30. Dixon,D.A. et al. (2001) Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells. J. Clin. Invest., 108, 1657-1665.
31. Do,S.I. et al. (2008) Correlation between cyclooxygenase-2 expression and HuR cytoplasmic translocation of breast cancer. Korean J. Pathol., 42, 75-80.
32. Denkert,C. et al. (2004) Overexpression of the embryonic-lethal abnormal vision-like protein HuR in ovarian carcinoma is a prognostic factor and is associated with increased cyclooxygenase 2 expression. Cancer Res., 64, 189-195.
33. Mrena,J. et al. (2005) Cyclooxygenase-2 is an independent prognostic factor in gastric cancer and its expression is regulated by the messenger RNA stability factor HuR. Clin. Cancer Res., 11, 7362-7368.
34. Abdelmohsen,K. et al. (2007) Posttranscriptional orchestration of an antiapoptotic program by HuR. Cell Cycle, 6, 1288-1292.
35. Lee,H.K. et al. (2006) Beta-Catenin stabilizes cyclooxygenase-2 mRNA by interacting with AU-rich elements of 3#-UTR. Nucleic Acids Res., 34, 5705-5714.
36. GormanA. et al. (1996) In Cotter, T.G. and Martin, S.J. (eds) Techniques in Apoptosis: Morphological assessment of apoptosis. Portland Press Ltd, London, UK, pp. 7-9.
37. Peritz,T. et al. (2006) Immunoprecipitation of mRNA-protein complexes. Nat. Protoc., 1, 577-580.
38. Slominski,A. et al. (1988) Positive regulation of melanin pigmentation by two key substrates of the melanogenic pathway, L-tyrosine and L-dopa. J. Cell Sci., 3, 287-296.
39. Rouzer,C.A. et al. (2009) Cyclooxygenases: structural and functional insights. J. Lipid Res., 50, S29-S34.
40. Koistinen,P. et al. (2004) alphaV integrin promotes in vitro and in vivo survival of cells in metastatic melanoma. Int. J. Cancer, 112, 61-70.
41. Trimmer,C. et al. (2010) Of swords and ploughshares: immunosurveillance and inflammation in melanoma. Pigment Cell Melanoma Res., 23, 727-728.
42. Calviello,G. et al. (2006) n-3 polyunsaturated fatty acids as signal transduction modulators and therapeutical agents in cancer. Curr. Signal Transd. Ther., 1, 255-271.
43. Dai,D.L. et al. (2004) Reduced Apaf-1 expression in human cutaneous melanomas. Br. J. Cancer, 91, 1089-1095.
44. Denkert,C. et al. (2006) Expression of the ELAV-like protein HuR in human colon cancer: association with tumor stage and cyclooxygenase-2. Mod. Pathol., 19, 1261-1269.
45. Denkert,C. et al. (2004) Expression of the ELAV-like protein HuR is associated with higher tumor grade and increased cyclooxygenase-2 expression in human breast carcinoma. Clin. Cancer Res., 10, 5580-5586.
46. Xiao,J. et al. (2010) A new cyclooxygenase-2 inhibitor, (1E,4E)-1,5-bis(2-bromophenyl)penta-1,4-dien-3-one (GL63) suppresses cyclooxygenase-2 gene expression in human lung epithelial cancer cells: coupled mRNA stabilization and posttranscriptional inhibition. Biol. Pharm. Bull., 33, 1170-1175.
47. Lim,S.J. et al. (2007) Expression of HuR is associated with increased cyclooxygenase-2 expression in uterine cervical carcinoma. Int. J. Gynecol. Pathol., 26, 229-234.
48. Cho,N.P. et al. (2007) Cytoplasmic HuR over-expression is associated with increased cyclooxygenase-2 expression in laryngeal squamous cell carcinomas. Pathology, 39, 545-550.
49. Fischer,S.M. et al. (2007) Cyclooxygenase-2 expression is critical for chronic UV-induced murine skin carcinogenesis. Mol. Carcinog., 46, 363-371.
50. Hecht,A. et al. (2000) Curbing the nuclear activities of beta-catenin. Control over Wnt target gene expression. EMBO Rep., 1, 24-28.
51. Bachmann,I.M. et al. (2005) Importance of P-cadherin, beta-catenin, and Wnt5a/frizzled for progression of melanocytic tumors and prognosis in cutaneous melanoma. Clin. Cancer Res., 11, 8606-8614.
52. Chien,A.J. et al. (2009) Activated Wnt/beta-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model. Proc. Natl Acad. Sci. USA, 106, 1193-1198.
53. Finstad,H.S. et al. (1994) Effect of n-3 and n-6 fatty acids on proliferation and differentiation of promyelocytic leukemic HL-60 cells. Blood, 84, 3799-3809.
54. Suzuki,K. et al. (2009) Docosahexaenoic acid induces adipose differentiation-related protein through activation of retinoid x receptor in human choriocarcinoma BeWo cells. Biol. Pharm. Bull., 32, 1177-1182.