Expression of cdc2 and p27(KIP1) phosphorylation in mitotic cells of the human retinoblastoma

International Journal of Molecular Medicine

Volumn 17, Issue 3, 2006, Pages 465-468

  Kase, Satoru ^a   Yoshida, Kazuhiko ^a   Ohgami, Kazuhiro ^a   Shiratori, Kenji ^a   Suzuki, Yukari ^a   Nakayama, Keiichi I ^b   Ohno, Shigeaki ^a  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

cdc2; Mitosis; p27(KIP1); Phosphorylation; Retinoblastoma

Indexed keywords

CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; THREONINE;

ARTICLE; ENZYMOLOGY; FEMALE; HUMAN; METABOLISM; MITOSIS; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN BINDING; RETINOBLASTOMA; TUMOR CELL LINE;

CDC2 PROTEIN KINASE; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P27; FEMALE; HUMANS; MITOSIS; PHOSPHORYLATION; PROTEIN BINDING; RETINOBLASTOMA; THREONINE;

EID: 33644932621     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.17.3.465     Document Type: Article

References (17)

1. Albert DM: Historic review of retinoblastoma. Ophthalmology 94: 654-662, 1987.
2. Knudson AG Jr: Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci USA 68: 820-823, 1971.
3. Sherr CJ and Roberts JM: Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev 9: 1149-1163, 1995.
4. Nourse J, Firpo E, Flanagan WM, Coats S, Polyak K, Lee MH, et al: Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin. Nature 372: 570-573, 1994.
5. Reynisdottir I, Polyak K, Iavarone A and Massague J: Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta. Genes Dev 9: 1831-1845, 1995.
6. Coats S, Flanagan WM, Nourse J and Roberts JM: Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle. Science 272: 877-880, 1996.
7. Hirai A, Nakamura S, Noguchi Y, Yasuda T, Kitagawa M, Tatsuno I, et al: Geranylgeranylated rho small GTPase(s) are essential for the degradation of p27Kip1 and facilitate the progression from G1 to S phase in growth-stimulated rat FRTL-5 cells. J Biol Chem 272: 13-16, 1997.
8. Carrano AC, Eytan E, Hershko A and Pagano M: SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat Cell Biol 1: 193-199, 1999.
9. Tsvetkov LM, Yeh KH, Lee SJ, Sun H and Zhang H: p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27. Curr Biol 9: 661-664, 1999.
10. Skowyra D, Craig KL, Tyers M, Elledge SJ and Harper JW: F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell 91: 209-219, 1997.
11. Vlach J, Hennecke S and Amati B: Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27. EMBO J 16: 5334-5344, 1997.
12. Ji P, Jiang H, Rekhtman K, Bloom J, Ichetovkin M, Pagano M, et al: An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant. Mol Cell 16: 47-58, 2004.
13. Nakayama K, Nagahama H, Minamishima YA, Miyake S, Ishida N, Hatakeyama S, et al: Skp2-mediated degradation of p27 regulates progression into mitosis. Dev Cell 6: 661-672, 2004.
14. Sutterluty H, Chatelain E, Marti A, Wirbelauer C, Senften M, Muller U, et al: p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells. Nat Cell Biol 1: 207-214, 1999.
15. Kase S, Yoshida K, Nakayama KI, Nakayama K, Ikeda H, Harada T, et al: Phosphorylation of p27(KIP1) in the developing retina and retinoblastoma. Int J Mol Med 16: 257-262, 2005.
16. Gartner L and Hiatt J: Color Textbook of Histology. W.B. Saunders Co., 1997.
17. Kase S, Yoshida K, Ohgami K, Shiratori K, Harada T and Ohno S: Expression of p27(KIP1) and cell proliferation in human retina and retinoblastoma. Anticancer Res 25: 3843-3846, 2005.