Identification of tumorigenic retinal stem-like cells in human solid retinoblastomas

International Journal of Cancer

Volumn 121, Issue 10, 2007, Pages 2125-2131

  Zhong, Xiufeng ^a   Li, Yongping ^a   Peng, Fuhua ^b   Huang, Bing ^a   Lin, Jianxian ^a   Zhang, Wenxin ^a   Zheng, Jianliang ^a   Jiang, Ruzhang ^a   Song, Ge ^a   Ge, Jian ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

Retinal stem cell; Retinoblastoma; Tumor stem cell; Tumorigenesis

Indexed keywords

CD133 ANTIGEN; NESTIN; PROTEIN; PROTEIN BMI 1; PROTEIN CHX10; PROTEIN RX; TRANSCRIPTION FACTOR PAX6; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPHENOTYPING; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RETINA CELL; RETINA DEVELOPMENT; RETINOBLASTOMA; SCID MOUSE; STEM CELL;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; CHILD; CHILD, PRESCHOOL; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INFANT; MALE; MICE; RETINA; RETINOBLASTOMA; STEM CELLS; TUMOR MARKERS, BIOLOGICAL; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 35348922996     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.22880     Document Type: Article

References (44)

1. Abramson DH, Schefler AC. Update on retinoblastoma. Retina 2004;24:828-48.
2. Handoff M, Fine BS. Ocular pathology, 4th ed. London: Mosby, 1996.
3. Dyer MA, Bremner R. The search for the retinoblastoma cell of origin. Nat Rev Cancer 2005;5:91-101.
4. Knudson AG, Jr, Hethcote HW, Brown BW. Mutation and childhood cancer: a probabilistic model for the incidence of retinoblastoma. Proc Natl Acad Sci USA 1975;72:5116-20.
5. Friend SH, Bernards R, Rogelj S, Weinberg RA, Rapaport JM, Albert DM, Dryja TP. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature 1986;323:643-6.
6. Gallie BL, Campbell C, Devlin H, Duckett A, Squire JA. Developmental basis of retinal-specific induction of cancer by RB mutation. Cancer Res 1999;59 (7 Suppl): 1731s-5s.
7. Kyritsis AP, Tsokos M, Triche TJ, Chader GJ. Retinoblastoma - origin from a primitive neuroectodermal tumor cell? Nature 1984;307:471-3.
8. Nork TM, Schwartz TL, Doshi HM, Millecchia LL. Retinoblastoma. Cell of origin. Arch Ophthalmol 1995;113:791-802.
9. Tso MO, Fine BS, Zimmerman LE. The nature of retinoblastoma. II. Photoreceptor differentiation: an electron microscopic study. Am J Ophthalmol 1970;69:350-9.
10. Perentes E, Herbort CP, Rubinstein LJ, Herman MM, Uffer S, Donoso LA, Collins VP. Immunohistochemical characterization of human retinoblastomas in situ with multiple markers. Am J Ophthalmol 1987;103:647-58.
11. Rodrigues MM, Wiggert B, Shields J, Donoso L, Bardenstein D, Katz N, Friendly D, Chader G. Retinoblastoma: immunohistochemistry and cell differentiation. Ophthalmology 1987;94:378-87.
12. Tarlton JF, Easty DL. Immunohistological characterisation of retinoblastoma and related ocular tissue. Br J Ophthalmol 1990;74:144-9.
13. Antunez JR, Couce M, Fraga M, Garcia-Caballero T, Beiras A, Perez-Becerra E, Forteza J. Immunohistochemical demonstration of neuronal and astrocytic markers and oncofoetal antigens in retinoblastomas. Histol Histopathol 1991;6:241-6.
14. He W, Hashimoto H, Tsuneyoshi M, Enjoji M, Inomata H. A reassessment of histologic classification and an immunohistochemical study of 88 retinoblastomas: a special reference to the advent of bipolar-like cells. Cancer 1992;70:2901-8.
15. Tsuji M, Goto M, Uehara F, Kaneko A, Sawai J, Yonezawa S, Ohba N. Photoreceptor cell differentiation in retinoblastoma demonstrated by a new immunohistochemical marker mucin-like glycoprotein associated with photoreceptor cells (MLGAPC). Histopathology 2002;40:180-6.
16. Fassina G, Aluigi MG, Gentleman S, Wong P, Cai T, Albini A, Noonan DM. the cAMP analog 8-C1-cAMP inhibits growth and induces differentiation and apoptosis in retinoblastoma cells. Int J Cancer 1997;72:1088-94.
17. Galli R, Binda E, Orfanelli U, Cipelletti B, Gritti A, Vitis SD, Fiocco R, Foroni C, Dimeco F, Vescovi A. Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res 2004;64:7011-21.
18. Singh SK, Clarke ID, Terasaki M, Bonn VE, Hawkins C, Squire J, Dirks PB. Identification of a cancer stem cell in human brain tumors. Cancer Res 2003;63:5821-28.
19. Hemmati HD, Nakano I, Lazareff JA, Masterman-Smith M, Geschwind DH, Bronner-Fraser M, Kornblum HI. Cancerous stem cells can arise from pediatric brain tumors. Proc Natl Acad Sci USA 2003;100:15178-83.
20. Seigel GM, Campbell LM, Narayan M, Gonzalez-Fernandez F. Cancer stem cell characteristics in retinoblastoma. Mol Vision 2005;11:729-37.
21. Coles BLK, Nieux BA, Inoue T, Rio-Tsonis KD, Spence JR, McInnes RR, Arsenijevic Y, Kooy DVD. Facile isolation and the characterization of human retinal stem cells. Proc Natl Acad Sci USA 2004;101:15772-7.
22. Zhong X, Li Y, Ge J, Huang B, Peng F, Du J, Lin J, Wu Z, Liu J. Isolation and culture of tumor stem cells in human retinoblastomas. Chin J Pathophysiol 2006;22:1177-81.
23. Geschwind DH, Ou J, Easterday MC, Dougherty JD, Jackson RL, Chen Z, Antoine H, Terskikh A, Weissman IL, Nelson SF, Kornblum HI. A genetic analysis of neural progenitor differentiation. Neuron 2001;29:325-39.
24. Groszer M, Erickson R, Scripture-Adams DD, Lesche R, Trumpp A, Zack JA, Kornblum HI, Liu X, Wu H. Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo. Science 2001;294:2186-9.
25. Galli R, Fiocco R, De Filippis L, Muzio L, Gritti A, Mercurio S, Broccoli V, Pellegrini M, Mallamaci A, Vescovi AL. Emx2 regulates the proliferation of stem cells of the adult mammalian central nervous system. Development 2002;129:1633-44.
26. Tropepe V, Coles BLK, Chiasson BJ, Horsford DJ, Elia AJ, McInnes RR, Kooy D. Retinal stem cells in the adult mammalian eye. Science 2000;287:2032-6.
27. Yang P, Seiler MJ, Aramant RB, Whittemore SR. In vitro isolation and expansion of human retinal progenitor cells. Exp Neurol 2002;177:326-31.
28. Mathers PH, Jamrich M. Regulation of eye formation by the Rx and pax6 homeobox genes. Cell Mol Life Sci 2000;57:186-94.
29. Belecky-Adams T, Tomarev S, Li HS, Ploder L, McInnes RR, Sundin O, Adler R. Pax-6, Prox1, and Chx10 homeobox gene expression correlates with phenotypic fate of retinal precursor cells. Invest Ophthalmol Vis Sci 1997;38:1293-303.
30. Uchida N, Buck DW, He D, Reitsma MJ, Masek M, Phan TV, Tsukamoto AS, Gage FH, Weissman IL. Direct isolation of human central nervous system stem cells. Proc Natl Acad Sci USA 2000;97:14720-5.
31. Lessard J, Sauvageau G. Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature 2003;423:255-60.
32. Kummermehr J. Tumour stem cells. In: Potten C, eds. Stem cells. London: Academic Press, 1997. 363-99.
33. Galderisi U, Cipollaro M, Giordano A. Stem cells and brain cancer. Cell Death Differ 2006;13:5-11.
34. Kopper L, Hajdu M. Tumor stem cells. Pathol Oncol Res 2004;10:69-73.
35. Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 1997;7:3730-7.
36. Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 2003;10:3983-8.
37. Ponti D, Costa A, Zaffaroni N, Pratesi G, Petrangolini G, Coradini D, Pilotti S, Pierotti MA, Daidone MG. Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties. Cancer Res 2005;65:5506-11.
38. Bertolesi GE, Walia Da Silva R, Jollimore CAB, Shi C, Barnes S, Kelly MEM. Ca(v)3.1 splice variant expression during neuronal differentiation of Y-79 retinoblastoma cells. Neuroscience 2006;141:259-68.
39. Lemieux N, Leung TK, Michaud J, Milot J, Richer CL. Neuronal and photoreceptor differentiation of retinoblastoma in culture. Ophthalmic Paediatr Genet 1990;11:109-20.
40. Tombran-Tink J, Johnson LV. Neuronal differentiation of retinoblastoma cells induced by medium conditioned by human RPE cells. Invest Ophthalmol Vis Sci 1989;30:1700-7.
41. Kyritsis AP, Tsokos M, Triche TJ, Chader GJ. Retinoblastoma: a primitive tumor with multipotential characteristics. Invest Ophthalmol Vis Sci 1986;27:1760-3.
42. Gonzalez-Fernandez F, Lopes MB, Garcia-Femandez JM, Foster RG, De Grip WJ, Rosemberg S, Newman SA, VandenBerg SR. Expression of developmentally defined retinal phenotypes in the histogenesis of retinoblastoma. Am J Pathol 1992;141:363-75.
43. Bogenmann E, Lochrie MA, Simon MI. Cone cell-specific genes expressed in retinoblastoma. Science 1988;240:76-8.
44. Mohan A, Kandalam M, Ramkumar HL, Gopal L, Krishnakumar S. Stem cell markers: ABCG2 and MCM2 expression in retinoblastoma. Br J Ophthalmol 2006;90:889-93.