Depletion of b2 but not b1a b cells in baff receptor-deficient apoe -/- mice attenuates atherosclerosis by potently ameliorating arterial inflammation

PLoS ONE

Volumn 7, Issue 1, 2012, Pages

  Kyaw, Tin ^a,b   Tay, Christopher ^a,b   Hosseini, Hamid ^a,b   Kanellakis, Peter ^a   Gadowski, Tahlia ^a   MacKay, Fabeinne ^b   Tipping, Peter ^b   Bobik, Alex ^a   Toh, Ban Hock ^b  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^b MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; B CELL ACTIVATING FACTOR RECEPTOR; CD4 ANTIGEN; CD68 ANTIGEN; CD8 ANTIGEN; CHOLESTEROL; CYTOKINE; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN M; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1; AUTACOID; CCL2 PROTEIN, MOUSE; MONOCYTE CHEMOTACTIC PROTEIN 1; TNFRSF13C PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; AORTA ATHEROSCLEROSIS; ARTICLE; B LYMPHOCYTE; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DENDRITIC CELL; IMMUNOGLOBULIN DEPOSITION; LIPID DIET; LYMPH NODE; LYMPHOCYTIC INFILTRATION; MACROPHAGE; MOUSE; NONHUMAN; PERITONEAL FLUID; SPLEEN; ANIMAL; ARTERITIS; ARTERY; ATHEROSCLEROSIS; C57BL MOUSE; CELL PROTECTION; CLASSIFICATION; CYTOLOGY; DOWN REGULATION; ENDOTHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; MALE; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY;

MUS;

ANIMALS; APOLIPOPROTEINS E; ARTERIES; ARTERITIS; ATHEROSCLEROSIS; B-CELL ACTIVATION FACTOR RECEPTOR; CHEMOKINE CCL2; CYTOKINES; CYTOPROTECTION; DOWN-REGULATION; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; INFLAMMATION MEDIATORS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT;

EID: 84855369823     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0029371     Document Type: Article

References (45)

1. Ridker PM, (2009) Testing the inflammatory hypothesis of atherothrombosis: scientific rationale for the cardiovascular inflammation reduction trial (CIRT). J Thromb Haemost 7 (Suppl 1): 332-339.
2. Ridker PM, Danielson E, Fonseca FA, Genest J, Gotto AM Jr, et al. (2008) Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med 359: 2195-2207.
3. Caligiuri G, Nicoletti A, Poirier B, Hansson GK, (2002) Protective immunity against atherosclerosis carried by B cells of hypercholesterolemic mice. J Clin Invest 109: 745-753.
4. Major AS, Fazio S, Linton MF, (2002) B-lymphocyte deficiency increases atherosclerosis in LDL receptor-null mice. Arterioscler Thromb Vasc Biol 22: 1892-1898.
5. Kyaw T, Tay C, Khan A, Dumouchel V, Cao A, et al. (2010) Conventional B2 B cell depletion ameliorates whereas its adoptive transfer aggravates atherosclerosis. J Immunol 185: 4410-4419.
6. Ait-Oufella H, Herbin O, Bouaziz JD, Binder CJ, Uyttenhove C, et al. (2010) B cell depletion reduces the development of atherosclerosis in mice. J Exp Med 207: 1579-1587.
7. Kyaw T, Tay C, Krishnamurthi S, Kanellakis P, Agrotis A, et al. (2011) B1a B Lymphocytes Are Atheroprotective by Secreting Natural IgM That Increases IgM Deposits and Reduces Necrotic Cores in Atherosclerotic Lesions. Circ Res.
8. Kyaw T, Tipping P, Toh BH, Bobik A, (2011) Current understanding of the role of B cell subsets and intimal and adventitial B cells in atherosclerosis. Curr Opin Lipidol 22: 373-379.
9. Lied GA, Berstad A, (2011) Functional and clinical aspects of the B-cell-activating factor (BAFF): a narrative review. Scand J Immunol 73: 1-7.
10. Mackay F, Browning JL, (2002) BAFF: a fundamental survival factor for B cells. Nat Rev Immunol 2: 465-475.
11. Brink R, (2006) Regulation of B cell self-tolerance by BAFF. Semin Immunol 18: 276-283.
12. Thompson JS, Bixler SA, Qian F, Vora K, Scott ML, et al. (2001) BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF. Science 293: 2108-2111.
13. Miller DJ, Hayes CE, (1991) Phenotypic and genetic characterization of a unique B lymphocyte deficiency in strain A/WySnJ mice. Eur J Immunol 21: 1123-1130.
14. Sasaki Y, Casola S, Kutok JL, Rajewsky K, Schmidt-Supprian M, (2004) TNF family member B cell-activating factor (BAFF) receptor-dependent and-independent roles for BAFF in B cell physiology. J Immunol 173: 2245-2252.
15. Rekhter MD, Gordon D, (1995) Active proliferation of different cell types, including lymphocytes, in human atherosclerotic plaques. Am J Pathol 147: 668-677.
16. Mallat Z, Taleb S, Ait-Oufella H, Tedgui A, (2009) The role of adaptive T cell immunity in atherosclerosis. J Lipid Res 50 (Suppl): S364-369.
17. Kolbus D, Ramos OH, Berg KE, Persson J, Wigren M, et al. (2010) CD8+ T cell activation predominate early immune responses to hypercholesterolemia in Apoe(/) mice. BMC Immunol 11: 58.
18. Cybulsky MI, Iiyama K, Li H, Zhu S, Chen M, et al. (2001) A major role for VCAM-1, but not ICAM-1, in early atherosclerosis. J Clin Invest 107: 1255-1262.
19. Ou R, Zhang M, Huang L, Flavell RA, Koni PA, et al. (2008) Regulation of immune response and inflammatory reactions against viral infection by VCAM-1. J Virol 82: 2952-2965.
20. Hansson GK, Holm J, Kral JG, (1984) Accumulation of IgG and complement factor C3 in human arterial endothelium and atherosclerotic lesions. Acta Pathol Microbiol Immunol Scand A 92: 429-435.
21. Yla-Herttuala S, Palinski W, Butler SW, Picard S, Steinberg D, et al. (1994) Rabbit and human atherosclerotic lesions contain IgG that recognizes epitopes of oxidized LDL. Arterioscler Thromb 14: 32-40.
22. Parums D, Mitchinson MJ, (1981) Demonstration of immunoglobulin in the neighbourhood of advanced atherosclerotic plaques. Atherosclerosis 38: 211-216.
23. Litinskiy MB, Nardelli B, Hilbert DM, He B, Schaffer A, et al. (2002) DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL. Nat Immunol 3: 822-829.
24. Rahman ZS, Rao SP, Kalled SL, Manser T, (2003) Normal induction but attenuated progression of germinal center responses in BAFF and BAFF-R signaling-deficient mice. J Exp Med 198: 1157-1169.
25. Galkina E, Ley K, (2009) Immune and inflammatory mechanisms of atherosclerosis (*). Annu Rev Immunol 27: 165-197.
26. Tedgui A, Mallat Z, (2006) Cytokines in atherosclerosis: pathogenic and regulatory pathways. Physiol Rev 86: 515-581.
27. Ramos CL, Huo Y, Jung U, Ghosh S, Manka DR, et al. (1999) Direct demonstration of P-selectin- and VCAM-1-dependent mononuclear cell rolling in early atherosclerotic lesions of apolipoprotein E-deficient mice. Circ Res 84: 1237-1244.
28. Steiner O, Coisne C, Cecchelli R, Boscacci R, Deutsch U, et al. (2010) Differential roles for endothelial ICAM-1, ICAM-2, and VCAM-1 in shear-resistant T cell arrest, polarization, and directed crawling on blood-brain barrier endothelium. J Immunol 185: 4846-4855.
29. de Chaisemartin L, Goc J, Damotte D, Validire P, Magdeleinat P, et al. (2011) Characterization of chemokines and adhesion molecules associated with T cell presence in tertiary lymphoid structures in human lung cancer. Cancer Res.
30. Hortelano S, Lopez-Fontal R, Traves PG, Villa N, Grashoff C, et al. (2010) ILK mediates LPS-induced vascular adhesion receptor expression and subsequent leucocyte trans-endothelial migration. Cardiovasc Res 86: 283-292.
31. Hyun YM, Chung HL, McGrath JL, Waugh RE, Kim M, (2009) Activated integrin VLA-4 localizes to the lamellipodia and mediates T cell migration on VCAM-1. J Immunol 183: 359-369.
32. Galkina E, Ley K, (2007) Vascular adhesion molecules in atherosclerosis. Arterioscler Thromb Vasc Biol 27: 2292-2301.
33. Nishimura S, Manabe I, Nagasaki M, Eto K, Yamashita H, et al. (2009) CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med 15: 914-920.
34. Ng LG, Sutherland AP, Newton R, Qian F, Cachero TG, et al. (2004) B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells. J Immunol 173: 807-817.
35. Sutherland AP, Ng LG, Fletcher CA, Shum B, Newton RA, et al. (2005) BAFF augments certain Th1-associated inflammatory responses. J Immunol 174: 5537-5544.
36. Chan T, Pek EA, Huth K, Ashkar AA, (2011) CD4(+) T-cells are important in regulating macrophage polarization in C57BL/6 wild-type mice. Cell Immunol 266: 180-186.
37. Sung B, Na HS, Kim YI, Yoon YW, Han HC, et al. (1998) Supraspinal involvement in the production of mechanical allodynia by spinal nerve injury in rats. Neurosci Lett 246: 117-119.
38. Cid MC, Kleinman HK, Grant DS, Schnaper HW, Fauci AS, et al. (1994) Estradiol enhances leukocyte binding to tumor necrosis factor (TNF)-stimulated endothelial cells via an increase in TNF-induced adhesion molecules E-selectin, intercellular adhesion molecule type 1, and vascular cell adhesion molecule type 1. J Clin Invest 93: 17-25.
39. Micha R, Imamura F, Wyler von Ballmoos M, Solomon DH, Hernan MA, et al. (2011) Systematic Review and Meta-Analysis of Methotrexate Use and Risk of Cardiovascular Disease. Am J Cardiol.
40. Townsend MJ, Monroe JG, Chan AC, (2010) B-cell targeted therapies in human autoimmune diseases: an updated perspective. Immunol Rev 237: 264-283.
41. Sanz I, Lee FE, (2010) B cells as therapeutic targets in SLE. Nat Rev Rheumatol 6: 326-337.
42. Davidson A, (2010) Targeting BAFF in autoimmunity. Curr Opin Immunol 22: 732-739.
43. Navarra SV, Guzman RM, Gallacher AE, Hall S, Levy RA, et al. (2011) Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial. Lancet 377: 721-731.
44. Kanellakis P, Agrotis A, Kyaw TS, Koulis C, Ahrens I, et al. (2011) High-mobility group box protein 1 neutralization reduces development of diet-induced atherosclerosis in apolipoprotein e-deficient mice. Arterioscler Thromb Vasc Biol 31: 313-319.
45. Livak KJ, Schmittgen TD, (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408.