Short-term statin treatment does not prevent ischemia and reperfusion-induced endothelial dysfunction in humans

Journal of Cardiovascular Pharmacology

Volumn 59, Issue 1, 2012, Pages 22-28

  Wouters, Constantijn W ^a   Wever, Kimberley E ^a   Bronckers, Inge ^a   Hopman, Maria T E ^a   Smits, Paul ^a   Thijssen, Dick H J ^a,b   Rongen, Gerard A ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

Author keywords

atorvastatin; ecto 5 nucleotidase; endothelial dysfunction; flow mediated dilation; ischemia and reperfusion injury; rosuvastatin

Indexed keywords

ATORVASTATIN; PLACEBO; ROSUVASTATIN;

ADULT; ARTICLE; BRACHIAL ARTERY; CONTROLLED STUDY; DISEASE ASSOCIATION; DOUBLE BLIND PROCEDURE; ENDOTHELIAL DYSFUNCTION; FEMALE; HEART PROTECTION; HUMAN; MALE; PLEIOTROPY; PREMEDICATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REPERFUSION INJURY; SHORT COURSE THERAPY; TREATMENT DURATION;

5'-NUCLEOTIDASE; ADOLESCENT; ADULT; BLOOD PRESSURE; BRACHIAL ARTERY; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; ENDOTHELIUM, VASCULAR; FEMALE; FLUOROBENZENES; HEART RATE; HEPTANOIC ACIDS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LIPIDS; MALE; MIDDLE AGED; PYRIMIDINES; PYRROLES; REAL-TIME POLYMERASE CHAIN REACTION; REPERFUSION INJURY; SULFONAMIDES; TIME FACTORS; VASODILATION; YOUNG ADULT;

EID: 84855354548     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/FJC.0b013e318232b1a4     Document Type: Article

References (51)

1. Lewis SJ, Moye LA, Sacks FM, et al. Effect of pravastatin on cardiovascular events in older patients with myocardial infarction and cholesterol levels in the average range. Results of the Cholesterol and Recurrent Events (CARE) trial. Ann Intern Med. 1998;129:681-689. (Pubitemid 28507140)
2. Pyorala K, Pedersen TR, Kjekshus J, et al. Cholesterol lowering with simvastatin improves prognosis of diabetic patients with coronary heart disease. A subgroup analysis of the Scandinavian Simvastatin Survival Study (4S); [see comments] [published erratum appears in Diabetes Care. 1997;20:1048]. Diabetes Care. 1997;20:614-620. (Pubitemid 27143424)
3. Sacks FM, Pfeffer MA, Moye LA, et al. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. N Engl J Med. 1996;335:1001-1009. (Pubitemid 26338729)
4. Downs JR, Clearfield M, Weis S, et al. Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study [see comments]. JAMA. 1998;279:1615-1622. (Pubitemid 28248586)
5. Osman L, Amrani M, Isley C, Yacoub MH, Smolenski RT. Stimulatory effects of atorvastatin on extracellular nucleotide degradation in human endothelial cells. Nucleosides Nucleotides Nucleic Acids. 2006;25:1125-1128. (Pubitemid 44651859)
6. Ledoux S, Laouari D, Essig M, et al. Lovastatin enhances ecto-5′-nucleotidase activity and cell surface expression in endothelial cells: implication of rhofamily GTPases. Circ Res. 2002;90:420-427. (Pubitemid 34633911)
7. Sanada S, Asanuma H, Minamino T, et al. Optimal windows of statin use for immediate infarct limitation: 5′-nucleotidase as another downstream molecule of phosphatidylinositol 3-kinase. Circulation. 2004;110:2143-2149. (Pubitemid 39372492)
8. Meijer P, Wouters CW, van den Broek PH, et al. Upregulation of ecto-5′-nucleotidase by rosuvastatin increases the vasodilator response to ischemia. Hypertension. 2010;56:722-727.
9. Urbich C, Dernbach E, Zeiher AM, et al. Double-edged role of statins in angiogenesis signaling. Circ Res. 2002;90:737-744. (Pubitemid 34640894)
10. Merla R, Ye Y, Lin Y, et al. The central role of adenosine in statin-induced ERK1/2, Akt, and eNOS phosphorylation. Am J Physiol Heart Circ Physiol. 2007;293:H1918-H1928. (Pubitemid 47367243)
11. Kolyada AY, Fedtsov A, Madias NE. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors upregulate inducible NO synthase expression and activity in vascular smooth muscle cells. Hypertension. 2001;38:1024-1029. (Pubitemid 34252800)
12. Hernandez-Perera O, Perez-Sala D, Navarro-Antolin J, et al. Effects of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthase in vascular endothelial cells. J Clin Invest. 1998;101:2711-2719. (Pubitemid 28294580)
13. Bolli R. Cardioprotective function of inducible nitric oxide synthase and role of nitric oxide in myocardial ischemia and preconditioning: an overview of a decade of research. J Mol Cell Cardiol. 2001;33:1897-1918. (Pubitemid 33097270)
14. Sack MN, Yellon DM. Insulin therapy as an adjunct to reperfusion after acute coronary ischemia: a proposed direct myocardial cell survival effect independent of metabolic modulation. J Am Coll Cardiol. 2003;41:1404-1407. (Pubitemid 36439004)
15. Bell RM, Yellon DM. Atorvastatin, administered at the onset of reperfusion, and independent of lipid lowering, protects the myocardium by up-regulating a pro-survival pathway. J Am Coll Cardiol. 2003;41:508-515. (Pubitemid 36164511)
16. Ludman A, Venugopal V, Yellon DM, et al. Statins and cardioprotection - more than just lipid lowering? Pharmacol Ther. 2009;122:30-43.
17. Meijer P, Oyen WJ, Dekker D, et al. Rosuvastatin increases extracellular adenosine formation in humans in vivo: a new perspective on cardiovascular protection. Arterioscler Thromb Vasc Biol. 2009;29:963-968.
18. Smits P, Williams SB, Lipson DE, et al. Endothelial release of nitric oxide contributes to the vasodilator effect of adenosine in humans. Circulation. 1995;92:2135-2141.
19. Kharbanda RK, Peters M, Walton B, et al. Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation. 2001;103:1624-1630. (Pubitemid 32246608)
20. Durante W, Johnson FK, Johnson RA. Arginase: a critical regulator of nitric oxide synthesis and vascular function. Clin Exp Pharmacol Physiol. 2007;34:906-911. (Pubitemid 47083958)
21. Hein TW, Zhang C, Wang W, et al. Ischemia-reperfusion selectively impairs nitric oxide-mediated dilation in coronary arterioles: counteracting role of arginase. FASEB J. 2003;17:2328-2330. (Pubitemid 39561482)
22. Mullen MJ, Kharbanda RK, Cross J, et al. Heterogenous nature of flow-mediated dilatation in human conduit arteries in vivo: relevance to endothelial dysfunction in hypercholesterolemia. Circ Res. 2001;88:145-151. (Pubitemid 32147301)
23. Loukogeorgakis SP, Williams R, Panagiotidou AT, et al. Transient limb ischemia induces remote preconditioning and remote postconditioning in humans by a K(ATP)-channel dependent mechanism. Circulation. 2007;116:1386-1395. (Pubitemid 47417565)
24. Liuni A, Luca MC, Gori T, et al. Rosuvastatin prevents conduit artery endothelial dysfunction induced by ischemia and reperfusion by a cyclooxygenase-2-dependent mechanism. J Am Coll Cardiol. 2010;55:1002-1006.
25. Katsiki N, Tziomalos K, Chatzizisis Y, et al. Effect of HMG-CoA reductase inhibitors on vascular cell apoptosis: beneficial or detrimental? Atherosclerosis. 2010;211:9-14.
26. Sakamoto T, Kojima S, Ogawa H, et al. Usefulness of hydrophilic vs lipophilic statins after acute myocardial infarction: subanalysis of MUSASHIAMI. Circ J. 2007;71:1348-1353. (Pubitemid 47378432)
27. Williams MR, Westerman RA, Kingwell BA, et al. Variations in endothelial function and arterial compliance during the menstrual cycle. J Clin Endocrinol Metab. 2001;86:5389-5395. (Pubitemid 33070265)
28. Doshi SN, Naka KK, Payne N, et al. Flow-mediated dilatation following wrist and upper arm occlusion in humans: the contribution of nitric oxide. Clin Sci (Lond). 2001;101:629-635. (Pubitemid 33135344)
29. Thijssen DH, Black MA, Pyke KE, et al. Assessment of flow-mediated dilation in humans: a methodological and physiological guideline. Am J Physiol Heart Circ Physiol. 2011;300:H2-H12.
30. Woodman RJ, Playford DA, Watts GF, et al. Improved analysis of brachial artery ultrasound using a novel edge-detection software system. J Appl Physiol. 2001;91:929-937. (Pubitemid 32681129)
31. Black MA, Cable NT, Thijssen DH, et al. Importance of measuring the time course of flow-mediated dilatation in humans. Hypertension. 2008;51:203-210. (Pubitemid 351159929)
32. Parker BA, Trehearn TL, Meendering JR. Pick your Poiseuille: normalizing the shear stimulus in studies of flow-mediated dilation. J Appl Physiol. 2009;107:1357-1359.
33. Thijssen DH, Dawson EA, Tinken TM, et al. Retrograde flow and shear rate acutely impair endothelial function in humans. Hypertension. 2009;53:986-992.
34. Pyke KE, Tschakovsky ME. Peak vs. total reactive hyperemia: which determines the magnitude of flow-mediated dilation? J Appl Physiol. 2007;102:1510-1519. (Pubitemid 46571047)
35. Schreiber-Deturmeny E, Bruguerolle B. Simultaneous high-performance liquid chromatographic determination of caffeine and theophylline for routine drug monitoring in human plasma. J Chromatogr B Biomed Appl. 1996;677:305-312. (Pubitemid 26105999)
36. Kilian JG, Nakhla S, Griffith K, et al. Reperfusion injury in the human forearm is mild and not attenuated by short-term ischaemic preconditioning. Clin Exp Pharmacol Physiol. 2005;32:86-90. (Pubitemid 40314474)
37. Loukogeorgakis SP, Panagiotidou AT, Broadhead MW, et al. Remote ischemic preconditioning provides early and late protection against endothelial ischemia-reperfusion injury in humans: role of the autonomic nervous system. J Am Coll Cardiol. 2005;46:450-456. (Pubitemid 41040285)
38. Loukogeorgakis SP, van den Berg MJ, Sofat R, et al. Role of NADPH oxidase in endothelial ischemia/reperfusion injury in humans. Circulation. 2010;121:2310-2316.
39. Loukogeorgakis SP, Panagiotidou AT, Yellon DM, et al. Postconditioning protects against endothelial ischemia-reperfusion injury in the human forearm. Circulation. 2006;113:1015-1019. (Pubitemid 43879477)
40. Okorie MI, Bhavsar DD, Ridout D, et al. Postconditioning protects against human endothelial ischaemia-reperfusion injury via subtype-specific KATP channel activation and is mimicked by inhibition of the mitochondrial permeability transition pore. Eur Heart J. 2011;32:1266-1274.
41. Devan AE, Umpierre D, Harrison ML, et al. Endothelial ischemia-reperfusion injury in humans: association with age and habitual exercise. Am J Physiol Heart Circ Physiol. 2011;300:H813-H819.
42. Gori T, Sicuro S, Dragoni S, et al. Sildenafil prevents endothelial dysfunction induced by ischemia and reperfusion via opening of adenosine triphosphate-sensitive potassium channels: a human in vivo study. Circulation. 2005;111:742-746. (Pubitemid 40250634)
43. Gori T, Di SG, Sicuro S, et al. Nitroglycerin protects the endothelium from ischaemia and reperfusion: human mechanistic insight. Br J Clin Pharmacol. 2007;64:145-150. (Pubitemid 47063243)
44. Gori T, Grotti S, Dragoni S, et al. Assessment of vascular function: flow-mediated constriction complements the information of flow-mediated dilatation. Heart. 2010;96:141-147.
45. Weissgerber TL, Davies GA, Tschakovsky ME. Low flow-mediated constriction occurs in the radial but not the brachial artery in healthy pregnant and nonpregnant women. J Appl Physiol. 2010;108:1097-1105.
46. Thijssen DH, van Bemmel MM, Bullens LM, et al. The impact of baseline diameter on flow-mediated dilation differs in young and older humans. Am J Physiol Heart Circ Physiol. 2008;295:H1594-H1598.
47. Thijssen DH, Dawson EA, Black MA, et al. Heterogeneity in conduit artery function in humans: impact of arterial size. Am J Physiol Heart Circ Physiol. 2008;295:H1927-H1934.
48. Inaba Y, Chen JA, Bergmann SR. Prediction of future cardiovascular outcomes by flow-mediated vasodilatation of brachial artery: a meta-analysis. Int J Cardiovasc Imaging. 2010;26:631-640.
49. Green DJ, Jones H, Thijssen D, et al. Flow-mediated dilation and cardiovascular event prediction: does nitric oxide matter? Hypertension. 2011.
50. Vallbracht-Israng KB, Morguet A, Schwimmbeck PL. Correlation of epicardial and systemic flow-mediated vasodilation in patients with atypical angina but no evidence of atherosclerotic disease. Can J Cardiol. 2007;23:1054-1060. (Pubitemid 351166032)
51. Anderson TJ, Uehata A, Gerhard MD, et al. Close relation of endothelial function in the human coronary and peripheral circulations. J Am Coll Cardiol. 1995;26:1235-1241.