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Volumn 32, Issue 1, 2012, Pages 177-189

Mechanisms of glutamate efflux at the blood-brain barrier: Involvement of glial cells

Author keywords

astrocytes; blood brain barrier; coculture; excitatory amino acid transporters; glutamate; in vitro model

Indexed keywords

ANION CHANNEL; EXCITATORY AMINO ACID TRANSPORTER; GLUTAMIC ACID;

EID: 84855349051     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2011.121     Document Type: Article
Times cited : (55)

References (43)
  • 1
    • 0033964471 scopus 로고    scopus 로고
    • Acidic amino acid clearance from CSF in the neonatal versus adult rat using ventriculo-cisternal perfusion
    • DOI 10.1046/j.1471-4159.2000.740770.x
    • Al-Sarraf H, Preston JE, Segal MB (2000) Acidic amino acid clearance from CSF in the neonatal versus adult rat using ventriculo-cisternal perfusion. J Neurochem 74:770-6 (Pubitemid 30053750)
    • (2000) Journal of Neurochemistry , vol.74 , Issue.2 , pp. 770-776
    • Al-Sarraf, H.1    Preston, J.E.2    Segal, M.B.3
  • 3
    • 2342471420 scopus 로고    scopus 로고
    • The blood-brain barrier: An overview: Structure, regulation, and clinical implications
    • DOI 10.1016/j.nbd.2003.12.016, PII S0969996103002833
    • Ballabh P, Braun A, Nedergaard M (2004) The blood-brain barrier: an overview: structure, regulation, and clinical implications. Neurobiol Dis 16:1-13 (Pubitemid 38569790)
    • (2004) Neurobiology of Disease , vol.16 , Issue.1 , pp. 1-13
    • Ballabh, P.1    Braun, A.2    Nedergaard, M.3
  • 4
    • 33846217457 scopus 로고    scopus 로고
    • Transporters for L-glutamate: An update on their molecular pharmacology and pathological involvement
    • DOI 10.1038/sj.bjp.0706949, PII 0706949
    • Beart PM,O' Shea RD (2007) Transporters for L-glutamate: an update on their molecular pharmacology and pathological involvement. Br J Pharmacol 150:5-17 (Pubitemid 46094664)
    • (2007) British Journal of Pharmacology , vol.150 , Issue.1 , pp. 5-17
    • Beart, P.M.1    O'Shea, R.D.2
  • 5
    • 0029884574 scopus 로고    scopus 로고
    • Glutamate is transported across the rat blood-brain barrier by a sodium-independent system
    • DOI 10.1016/0304-3940(96)12635-5
    • Benrabh H, Lefauconnier JM (1996) Glutamate is transported across the rat blood-brain barrier by a sodium-independent system. Neurosci Lett 210:9-12 (Pubitemid 26176845)
    • (1996) Neuroscience Letters , vol.210 , Issue.1 , pp. 9-12
    • Benrabh, H.1    Lefauconnier, J.M.2
  • 6
    • 84982337275 scopus 로고
    • Amino Acid and protein metabolism-VI cerebral compartments of glutamic acid metabolism
    • Berl S, Lajtha A, Waelsch H (1961) Amino Acid and protein metabolism-VI cerebral compartments of glutamic acid metabolism. J Neurochem 7:186-97
    • (1961) J Neurochem , vol.7 , pp. 186-197
    • Berl, S.1    Lajtha, A.2    Waelsch, H.3
  • 7
    • 0034659742 scopus 로고    scopus 로고
    • Prolonged synaptic currents and glutamate spillover at the parallel fiber to stellate cell synapse
    • Carter AG, Regehr WG (2000) Prolonged synaptic currents and glutamate spillover at the parallel fiber to stellate cell synapse. J Neurosci 20:4423-34 (Pubitemid 30396607)
    • (2000) Journal of Neuroscience , vol.20 , Issue.12 , pp. 4423-4434
    • Carter, A.G.1    Regehr, W.G.2
  • 9
    • 67651100897 scopus 로고    scopus 로고
    • Closing the gap between the in-vivo and in-vitro blood-brain barrier tightness
    • Cohen-Kashi Malina K, Cooper I, Teichberg VI (2009) Closing the gap between the in-vivo and in-vitro blood-brain barrier tightness. Brain Res 1284:12-21
    • (2009) Brain Res , vol.1284 , pp. 12-21
    • Cohen-Kashi Malina, K.1    Cooper, I.2    Teichberg, V.I.3
  • 10
    • 12344337754 scopus 로고    scopus 로고
    • Localization of brain endothelial luminal and abluminal transporters with immunogold electron microscopy
    • DOI 10.1602/neurorx.2.1.27
    • Cornford EM, Hyman S (2005) Localization of brain endothelial luminal and abluminal transporters with immunogold electron microscopy. NeuroRx 2:27-43 (Pubitemid 40128024)
    • (2005) NeuroRx , vol.2 , Issue.1 , pp. 27-43
    • Cornford, E.M.1    Hyman, S.2
  • 11
    • 0035001341 scopus 로고    scopus 로고
    • Glutamate uptake
    • DOI 10.1016/S0301-0082(00)00067-8, PII S0301008200000678
    • Danbolt NC (2001) Glutamate uptake. Prog Neurobiol 65: 1-105 (Pubitemid 32479155)
    • (2001) Progress in Neurobiology , vol.65 , Issue.1 , pp. 1-105
    • Danbolt, N.C.1
  • 13
    • 0033949264 scopus 로고    scopus 로고
    • Primary cultures of brain microvessel endothelial cells: A valid and flexible model to study drug transport through the blood-brain barrier in vitro
    • DOI 10.1016/S1385-299X(00)00020-9, PII S1385299X00000209
    • Franke H, Galla H, Beuckmann CT (2000) Primary cultures of brain microvessel endothelial cells: a valid and flexible model to study drug transport through the blood-brain barrier in vitro. Brain Res Brain Res Protoc 5:248-56 (Pubitemid 30440753)
    • (2000) Brain Research Protocols , vol.5 , Issue.3 , pp. 248-256
    • Franke, H.1    Galla, H.-J.2    Beuckmann, C.T.3
  • 14
    • 0030657941 scopus 로고    scopus 로고
    • Neuronal soluble factors differentially regulate the expression of the GLT1 and GLAST glutamate transporters in cultured astroglia
    • Gegelashvili G, Danbolt NC, Schousboe A (1997) Neuronal soluble factors differentially regulate the expression of the GLT1 and GLAST glutamate transporters in cultured astroglia. J Neurochem 69:2612-5 (Pubitemid 27495450)
    • (1997) Journal of Neurochemistry , vol.69 , Issue.6 , pp. 2612-2615
    • Gegelashvili, G.1    Danbolt, N.C.2    Schousboe, A.3
  • 15
    • 0030840881 scopus 로고    scopus 로고
    • High affinity glutamate transporters: Regulation of expression and activity
    • Gegelashvili G, Schousboe A (1997) High affinity glutamate transporters: regulation of expression and activity. Mol Pharmacol 52:6-15 (Pubitemid 27318612)
    • (1997) Molecular Pharmacology , vol.52 , Issue.1 , pp. 6-15
    • Gegelashvili, G.1    Schousboe, A.2
  • 17
    • 0141643089 scopus 로고    scopus 로고
    • Blood-mediated scavenging of cerebrospinal fluid glutamate
    • DOI 10.1046/j.1471-4159.2003.01972.x
    • Gottlieb M, Wang Y, Teichberg VI (2003) Blood-mediated scavenging of cerebrospinal fluid glutamate. J Neuro-chem 87:119-26. (write to the Help Desk NCBI | NLM | NIH Department of Health & Human Services Privacy Statement | Freedom of Information Act | Disclaimer) (Pubitemid 37210646)
    • (2003) Journal of Neurochemistry , vol.87 , Issue.1 , pp. 119-126
    • Gottlieb, M.1    Wang, Y.2    Teichberg, V.I.3
  • 18
    • 70349582346 scopus 로고    scopus 로고
    • The blood-brain barrier and glutamate
    • Hawkins RA (2009) The blood-brain barrier and glutamate. Am J Clin Nutr 90:8675-745
    • (2009) Am J Clin Nutr , vol.90 , pp. 8675-745
    • Hawkins, R.A.1
  • 19
    • 31544481841 scopus 로고    scopus 로고
    • Structure of the blood-brain barrier and its role in the transport of amino acids
    • Hawkins RA,O'Kane RL, Simpson IA, Vina JR (2006) Structure of the blood-brain barrier and its role in the transport of amino acids. J Nutr 136:218S-26S (Pubitemid 43156512)
    • (2006) Journal of Nutrition , vol.136 , Issue.1
    • Hawkins, R.A.1    O'Kane, R.L.2    Simpson, I.A.3    Vina, J.R.4
  • 20
    • 33745873475 scopus 로고    scopus 로고
    • Astrocyte control of synaptic transmission and neurovascular coupling
    • DOI 10.1152/physrev.00049.2005
    • Haydon PG, Carmignoto G (2006) Astrocyte control of synaptic transmission and neurovascular coupling. Physiol Rev 86:1009-31 (Pubitemid 44033387)
    • (2006) Physiological Reviews , vol.86 , Issue.3 , pp. 1009-1031
    • Haydon, P.G.1    Carmignoto, G.2
  • 22
    • 0032818545 scopus 로고    scopus 로고
    • Blood-brain barrier produces significant efflux of L-aspartic acid but not D-aspartic acid: In vivo evidence using the brain efflux index method
    • DOI 10.1046/j.1471-4159.1999.0731206.x
    • Hosoya K, Sugawara M, Asaba H, Terasaki T (1999) Blood-brain barrier produces significant efflux of L-aspartic acid but not D-aspartic acid: in vivo evidence using the brain efflux index method. J Neurochem 73: 1206-11 (Pubitemid 29395480)
    • (1999) Journal of Neurochemistry , vol.73 , Issue.3 , pp. 1206-1211
    • Hosoya, K.-I.1    Sugawara, M.2    Asaba, H.3    Terasaki, T.4
  • 23
    • 0035576934 scopus 로고    scopus 로고
    • Molecular physiology and pathophysiology of tight junctions in the blood -brain barrier
    • DOI 10.1016/S0166-2236(00)02004-X, PII S016622360002004X
    • Huber JD, Egleton RD, Davis TP (2001) Molecular physiology and pathophysiology of tight junctions in the blood-brain barrier. Trends Neurosci 24:719-25 (Pubitemid 33097539)
    • (2001) Trends in Neurosciences , vol.24 , Issue.12 , pp. 719-725
    • Huber, J.D.1    Egleton, R.D.2    Davis, T.P.3
  • 24
    • 0022764679 scopus 로고
    • Swine in cardiovascular research
    • Hughes HC (1986) Swine in cardiovascular research. Lab Anim Sci 36:348-50
    • (1986) Lab Anim Sci , vol.36 , pp. 348-350
    • Hughes, H.C.1
  • 25
    • 0022004262 scopus 로고
    • High-affinity transport of glutamate in rat brain microvessels
    • DOI 10.1016/0014-4886(85)90216-X
    • Hutchison HT, Eisenberg HM, Haber B (1985) High-affinity transport of glutamate in rat brain microvessels. Exp Neurol 87:260-9 (Pubitemid 15174399)
    • (1985) Experimental Neurology , vol.87 , Issue.2 , pp. 260-269
    • Hutchison, H.T.1    Eisenberg, H.M.2    Haber, B.3
  • 26
    • 0032903788 scopus 로고    scopus 로고
    • Effect of ammonia and methionine sulfoximine on myoinositol transport in cultured astrocytes
    • DOI 10.1023/A:1020928029845
    • Isaacks RE, Bender , Kim CY, Shi YF, Norenberg MD (1999) Effect of ammonia and methionine sulfoximine on myo-inositol transport in cultured astrocytes. Neurochem Res 24:51-9 (Pubitemid 29067776)
    • (1999) Neurochemical Research , vol.24 , Issue.1 , pp. 51-59
    • Isaacks, R.E.1    Bender, A.S.2    Kim, C.Y.3    Shi, Y.F.4    Norenberg, M.D.5
  • 28
    • 2542491081 scopus 로고    scopus 로고
    • Glutamine-induced free radical production in cultured astrocytes
    • DOI 10.1002/glia.20003
    • Jayakumar AR, Rama Rao KV, Schousboe A, Norenberg MD (2004) Glutamine-induced free radical production in cultured astrocytes. Glia 46:296-301 (Pubitemid 38679209)
    • (2004) GLIA , vol.46 , Issue.3 , pp. 296-301
    • Jayakumar, A.R.1    Rao, K.V.R.2    Schousboe, A.3    Norenberg, M.D.4
  • 30
    • 0031958583 scopus 로고    scopus 로고
    • Glutamine transport by the blood-brain barrier: A possible mechanism for nitrogen removal
    • Lee WJ, Hawkins RA, Vina JR, Peterson DR (1998) Glutamine transport by the blood-brain barrier: a possible mechanism for nitrogen removal. Am J Physiol 274:C1101-7
    • (1998) Am J Physiol , vol.274
    • Lee, W.J.1    Hawkins, R.A.2    Vina, J.R.3    Peterson, D.R.4
  • 31
    • 0035282612 scopus 로고    scopus 로고
    • Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18
    • DOI 10.1038/35065084
    • Lin CI, Orlov I, Ruggiero AM, Dykes-Hoberg M, Lee A, Jackson M, Rothstein JD (2001) Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18. Nature 410:84-8 (Pubitemid 32225840)
    • (2001) Nature , vol.410 , Issue.6824 , pp. 84-88
    • Lin, C.-I.G.1    Orlov, I.2    Rugglero, A.M.3    Dykes-Heberg, M.4    Lee, A.5    Jackson, M.6    Rothstein, J.D.7
  • 32
  • 33
    • 0039967156 scopus 로고    scopus 로고
    • Na(+)-dependent glutamate transporters (EAAT1, EAAT2, and EAAT3) of the blood-brain barrier. A mechanism for glutamate removal
    • O'Kane RL, Martinez-Lopez I, DeJoseph MR, Vina JR, Hawkins RA (1999) Na(+)-dependent glutamate transporters (EAAT1, EAAT2, and EAAT3) of the blood-brain barrier. A mechanism for glutamate removal. J Biol Chem 274:31891-5
    • (1999) J Biol Chem , vol.274 , pp. 31891-5
    • O'Kane, R.L.1    Martinez-Lopez, I.2    Dejoseph, M.R.3    Vina, J.R.4    Hawkins, R.A.5
  • 34
    • 0031751209 scopus 로고    scopus 로고
    • Molecular biology of mammalian plasma membrane amino acid transporters
    • Palacin M, Estevez R, Bertran J, Zorzano A (1998) Molecular biology of mammalian plasma membrane amino acid transporters. Physiol Rev 78:969-1054 (Pubitemid 28491947)
    • (1998) Physiological Reviews , vol.78 , Issue.4 , pp. 969-1054
    • Palacin, M.1    Estevez, R.2    Bertran, J.3    Zorzano, A.4
  • 35
    • 0031744792 scopus 로고    scopus 로고
    • Pharmacological characterization of swelling-induced D-[3H]as-partate release from primary astrocyte cultures
    • Rutledge EM, Aschner M, Kimelberg HK (1998) Pharmacological characterization of swelling-induced D-[3H]as-partate release from primary astrocyte cultures. Am J Physiol 274:C1511-20
    • (1998) Am J Physiol , vol.274
    • Rutledge, E.M.1    Aschner, M.2    Kimelberg, H.K.3
  • 38
    • 0023434082 scopus 로고
    • Evidence for an alanine, serine, and cysteine system of transport in isolated brain capillaries
    • Tayarani I, Lefauconnier JM, Roux F, Bourre JM (1987) Evidence for an alanine, serine, and cysteine system of transport in isolated brain capillaries. J Cereb Blood Flow Metab 7:585-91
    • (1987) J Cereb Blood Flow Metab , vol.7 , pp. 585-591
    • Tayarani, I.1    Lefauconnier, J.M.2    Roux, F.3    Bourre, J.M.4
  • 39
    • 58149460241 scopus 로고    scopus 로고
    • Homeostasis of glutamate in brain fluids: An accelerated brain-to-blood efflux of excess glutamate is produced by blood glutamate scavenging and offers protection from neuropathologies
    • Teichberg VI, Cohen-Kashi-Malina K, Cooper I, Zlotnik A (2009) Homeostasis of glutamate in brain fluids: an accelerated brain-to-blood efflux of excess glutamate is produced by blood glutamate scavenging and offers protection from neuropathologies. Neuroscience 158: 301-8
    • (2009) Neuroscience , vol.158 , pp. 301-308
    • Teichberg, V.I.1    Cohen-Kashi-Malina, K.2    Cooper, I.3    Zlotnik, A.4
  • 40
    • 0029888341 scopus 로고    scopus 로고
    • Cloning and functional characterization of a system ASC-like Na+-dependent neutral amino acid transporter
    • Utsunomiya-Tate N, Endou H, Kanai Y (1996) Cloning and functional characterization of a system ASC-like Na+-dependent neutral amino acid transporter. J Biol Chem 271:14883-90
    • (1996) J Biol Chem , vol.271 , pp. 14883-90
    • Utsunomiya-Tate, N.1    Endou, H.2    Kanai, Y.3
  • 42
    • 65849424920 scopus 로고    scopus 로고
    • Pharmacological "cross-inhibition" of connexin hemi-channels and swelling activated anion channels
    • Ye ZC, Oberheim N, Kettenmann H, Ransom BR (2009) Pharmacological "cross-inhibition" of connexin hemi-channels and swelling activated anion channels. Glia 57:258-69
    • (2009) Glia , vol.57 , pp. 258-269
    • Ye, Z.C.1    Oberheim, N.2    Kettenmann, H.3    Ransom, B.R.4
  • 43
    • 0033486004 scopus 로고    scopus 로고
    • A novel method to determine the localization of high and low-affinity GABA transporters to the luminal and antiluminal membranes of brain capillary endothelial cells
    • Zhang Y, Liu G (1999) A novel method to determine the localization of high and low-affinity GABA transporters to the luminal and antiluminal membranes of brain capillary endothelial cells. Brain Res Brain Res Protoc 4:288-94
    • (1999) Brain Res Brain Res Protoc , vol.4 , pp. 288-294
    • Zhang, Y.1    Liu, G.2


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