Relationship of prepulse inhibition to temperament and character in healthy Japanese subjects

Neuroscience Research

Volumn 72, Issue 2, 2012, Pages 187-193

  Takahashi, Hidetoshi ^a,b   Iwase, Masao ^b   Yasuda, Yuka ^b,c   Ohi, Kazutaka ^b,c   Fukumoto, Motoyuki ^b,c   Iike, Naomi ^b   Yamamori, Hidenaga ^b,c   Nakahachi, Takayuki ^b   Ikezawa, Koji ^b   Azechi, Michiyo ^b   Canuet, Leonides ^b   Ishii, Ryouhei ^b   Kazui, Hiroaki ^b   Hashimoto, Ryota ^b,c,d   Takeda, Masatoshi ^b  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (Japan)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d OSAKA UNIVERSITY   (Japan)

Author keywords

Acoustic startle response; Asian subjects; Character; Prepulse inhibition; Sensorimotor gating; Temperament

Indexed keywords

ADULT; ARTICLE; AUDITORY STIMULATION; CHARACTER; CIGARETTE SMOKING; ELECTROMYOGRAPHY; FEMALE; HUMAN; HUMAN EXPERIMENT; JAPANESE; MALE; NORMAL HUMAN; ORBICULARIS OCULI MUSCLE; PREPULSE INHIBITION; PRIORITY JOURNAL; PSYCHOLOGICAL RATING SCALE; SCORING SYSTEM; SEX DIFFERENCE; SIGNAL NOISE RATIO; STARTLE REFLEX; TEMPERAMENT; TEMPERAMENT AND CHARACTER INVENTORY;

ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; CHARACTER; ELECTROMYOGRAPHY; FEMALE; HUMANS; MALE; MIDDLE AGED; SCHIZOPHRENIA; SENSORY GATING; STARTLE REACTION; TEMPERAMENT; YOUNG ADULT;

EID: 84855345706     PISSN: 01680102     EISSN: 18728111     Source Type: Journal    
DOI: 10.1016/j.neures.2011.10.009     Document Type: Article

References (88)

1. Abel K., Waikar M., Pedro B., Hemsley D., Geyer M. Repeated testing of prepulse inhibition and habituation of the startle reflex: a study in healthy human controls. J. Psychopharmacol. 1998, 12(4):330-337.
2. Abel K.M., Jolley S., Hemsley D.R., Geyer M.A. The influence of schizotypy traits on prepulse inhibition in young healthy controls. J. Psychopharmacol. 2004, 18(2):181-188.
3. Al-Halabí S., Herrero R., Sáiz P.A., García-Portilla M.P., Errasti J.M., Corcoran P., Bascarán M.T., Bousoño M., Lemos S., Bobes J. A cross-cultural comparison between Spain and the USA: temperament and character distribution by sex and age. Psychiatry Res. 2011, 186(2-3):397-401.
4. Ando J., Ono Y., Yoshimura K., Onoda N., Shinohara M., Kanba S., Asai M. The genetic structure of Cloninger's seven-factor model of temperament and character in a Japanese sample. J. Pers. 2002, 70(5):583-609.
5. Anokhin A.P., Heath A.C., Myers E., Ralano A., Wood S. Genetic influences on prepulse inhibition of startle reflex in humans. Neurosci. Lett. 2003, 353(1):45-48.
6. Boeker H., Kleiser M., Lehman D., Jaenke L., Bogerts B., Northoff G. Executive dysfunction, self, and ego pathology in schizophrenia: an exploratory study of neuropsychology and personality. Compr. Psychiatry 2006, 47(1):7-19.
7. Blumenthal T.D., Noto J.V., Fox M.A., Franklin J.C. Background noise decreases both prepulse elicitation and inhibition of acoustic startle blink responding. Biol. Psychol. 2006, 72(2):173-179.
8. Bora E., Veznedaroglu B. Temperament and character dimensions of the relatives of schizophrenia patients and controls: the relationship between schizotypal features and personality. Eur. Psychiatry 2007, 22(1):27-31.
9. Braff D., Stone C., Callaway E., Geyer M., Glick I., Bali L. Prestimulus effects on human startle reflex in normals and schizophrenics. Psychophysiology 1978, 15(4):339-343.
10. Braff D.L., Geyer M.A., Swerdlow N.R. Human studies of prepulse inhibition of startle: normal subjects, patient groups, and pharmacological studies. Psychopharmacology (Berl.) 2001, 156(2-3):234-258.
11. Braff D.L., Light G.A. The use of neurophysiological endophenotypes to understand the genetic basis of schizophrenia. Dialogues Clin. Neurosci. 2005, 7(2):125-135.
12. Brändström S., Richter J., Przybeck T. Distributions by age and sex of the dimensions of temperament and character inventory in a cross-cultural perspective among Sweden, Germany, and the USA. Psychol. Rep. 2001, 89(3):747-758.
13. Brandstrom S., Schlette P., Przybeck T.R., Lundberg M., Forsgren T., Sigvardsson S., Nylander P.O., Nilsson L.G., Cloninger R.C., Adolfsson R. Swedish normative data on personality using the Temperament and Character Inventory. Compr. Psychiatry 1998, 39(3):122-128.
14. Cadenhead K.S., Geyer M.A., Braff D.L. Impaired startle prepulse inhibition and habituation in patients with schizotypal personality disorder. Am. J. Psychiatry 1993, 150(12):1862-1867.
15. Cadenhead K.S., Swerdlow N.R., Shafer K.M., Diaz M., Braff D.L. Modulation of the startle response and startle laterality in relatives of schizophrenic patients and in subjects with schizotypal personality disorder: evidence of inhibitory deficits. Am. J. Psychiatry 2000, 157(10):1660-1668.
16. Calvo de Padilla M., Padilla E., Gonzalez Aleman G., Bourdieu M., Guerrero G., Strejilevich S., Escobar J.I., Svrakic N., Cloninger C.R., de Erausquin G.A. Temperament traits associated with risk of schizophrenia in an indigenous population of Argentina. Schizophr. Res. 2006, 83(2-3):299-302.
17. Campbell L.E., Hughes M., Budd T.W., Cooper G., Fulham W.R., Karayanidis F., Hanlon M.C., Stojanov W., Johnston P., Case V., Schall U. Primary and secondary neural networks of auditory prepulse inhibition: a functional magnetic resonance imaging study of sensorimotor gating of the human acoustic startle response. Eur. J. Neurosci. 2007, 26(8):2327-2333.
18. Cloninger C.R. A systematic method for clinical description and classification of personality variants. A proposal. Arch. Gen. Psychiatry 1987, 44(6):573-588.
19. Cloninger C.R., Svrakic D.M., Przybeck T.R. A psychobiological model of temperament and character. Arch. Gen. Psychiatry 1993, 50(12):975-990.
20. Comings D.E., Gonzales N., Saucier G., Johnson J.P., MacMurray J.P. The DRD4 gene and the spiritual transcendence scale of the character temperament index. Psychiatr. Genet. 2000, 10(4):185-189.
21. Cortés M.J., Valero J., Gutiérrez-Zotes J.A., Hernández A., Moreno L., Jariod M., Martorell L., Vilella E., Labad A. Psychopathology and personality traits in psychotic patients and their first-degree relatives. Eur. Psychiatry 2009, 24(7):476-482.
22. Daneluzzo E., Stratta P., Rossi A. The contribution of temperament and character to schizotypy multidimensionality. Compr. Psychiatry 2005, 46(1):50-55.
23. Evans L.H., Gray N.S., Snowden R.J. Prepulse inhibition of startle and its moderation by schizotypy and smoking. Psychophysiology 2005, 42(2):223-231.
24. First M.B., Spitzer R.L., Gibbon M., Williams J.B.W. Structured Clinical Interview for DSM-IV Axis I Disorders, Research Version, Non-patients Edition (SCID-I/NP) 1997, Biometrics Research Dept, New York State Psychiatric Institute, New York.
25. Franklin J.C., Bowker K.B., Blumenthal T.D. Anxiety and prepulse inhibition of acoustic startle in a normative sample: the importance of signal-to-noise ratio. Pers. Individ. Differ. 2009, 46(3):369-373.
26. Franklin J.C., Moretti N.A., Blumenthal T.D. Impact of stimulus signal-to-noise ratio on prepulse inhibition of acoustic startle. Psychophysiology 2007, 44(2):339-342.
27. George T.P., Termine A., Sacco K.A., Allen T.M., Reutenauer E., Vessicchio J.C., Duncan E.J. A preliminary study of the effects of cigarette smoking on prepulse inhibition in schizophrenia: involvement of nicotinic receptor mechanisms. Schizophr. Res. 2006, 87(1-3):307-315.
28. Gillespie N.A., Cloninger C.R., Heath A.C., Martin N.G. The genetic and environmental relationship between Cloninger's dimensions of temperament and character. Pers. Individ. Differ. 2003, 35(8):1931-1946.
29. Gonzalez-Torres M.A., Inchausti L., Ibáñez B., Aristegui M., Fernández-Rivas A., Ruiz E., Fernandez E., Bayón C. Temperament and character dimensions in patients with schizophrenia, relatives, and controls. J. Nerv. Ment. Dis. 2009, 197(7):514-519.
30. Greenwood T.A., Braff D.L., Light G.A., Cadenhead K.S., Calkins M.E., Dobie D.J., Freedman R., Green M.F., Gur R.E., Gur R.C., Mintz J., Nuechterlein K.H., Olincy A., Radant A.D., Seidman L.J., Siever L.J., Silverman J.M., Stone W.S., Swerdlow N.R., Tsuang D.W., Tsuang M.T., Turetsky B.I., Schork N.J. Initial heritability analyses of endophenotypic measures for schizophrenia: the consortium on the genetics of schizophrenia. Arch. Gen. Psychiatry 2007, 64(11):1242-1250.
31. Guillem F., Bicu M., Semkovska M., Debruille J.B. The dimensional symptom structure of schizophrenia and its association with temperament and character. Schizophr. Res. 2002, 56(1-2):137-147.
32. Ham B.J., Kim Y.H., Choi M.J., Cha J.H., Choi Y.K., Lee M.S. Serotonergic genes and personality traits in the Korean population. Neurosci. Lett. 2004, 354(1):2-5.
33. Hamer D. The God Gene: How Faith is Hardwired into Our Genes 2004, Doubleday, New York, NY, USA.
34. Hasenkamp W., Norrholm S.D., Green A., Lewison B., Boshoven W., Keyes M., Duncan E. Differences in startle reflex and prepulse inhibition in European-Americans and African-Americans. Psychophysiology 2008, 45(5):876-882.
35. Hashimoto R., Ohi K., Yasuda Y., Fukumoto M., Yamamori H., Takahashi H., Iwase M., Okochi T., Kazui H., Saitoh O., Tatsumi M., Iwata N., Ozaki N., Kamijima K., Kunugi H., Takeda M. Variants of the RELA gene are associated with schizophrenia and their startle responses. Neuropsychopharmacology 2011, 36(9):1921-1931.
36. Hazlett E.A., Buchsbaum M.S., Haznedar M.M., Singer M.B., Germans M.K., Schnur D.B., Jimenez E.A., Buchsbaum B.R., Troyer B.T. Prefrontal cortex glucose metabolism and startle eyeblink modification abnormalities in unmedicated schizophrenia patients. Psychophysiology 1998, 35(2):186-198.
37. Hazlett E.A., Buchsbaum M.S., Zhang J., Newmark R.E., Glanton C.F., Zelmanova Y., Haznedar M.M., Chu K.W., Nenadic I., Kemether E.M., Tang C.Y., New A.S., Siever L.J. Frontal-striatal-thalamic mediodorsal nucleus dysfunction in schizophrenia-spectrum patients during sensorimotor gating. Neuroimage 2008, 42(3):1164-1177.
38. Hokyo A., Kanazawa T., Uenishi H., Tsutsumi A., Kawashige S., Kikuyama H., Glatt S.J., Koh J., Nishimoto Y., Matsumura H., Motomura N., Yoneda H. Habituation in prepulse inhibition is affected by a polymorphism on the NMDA receptor 2B subunit gene (GRIN2B). Psychiatr. Genet. 2010, 20(5):191-198.
39. Hong L.E., Wonodi I., Stine O.C., Mitchell B.D., Thaker G.K. Evidence of missense mutations on the neuregulin 1 gene affecting function of prepulse inhibition. Biol. Psychiatry 2008, 63(1):17-23.
40. Hori H., Noguchi H., Hashimoto R., Nakabayashi T., Saitoh O., Murray R.M., Okabe S., Kunugi H. Personality in schizophrenia assessed with the Temperament and Character Inventory (TCI). Psychiatry Res. 2008, 160(2):175-183.
41. Jovanovic T., Szilagyi S., Chakravorty S., Fiallos A.M., Lewison B.J., Parwani A., Schwartz M.P., Gonzenbach S., Rotrosen J.P., Duncan E.J. Menstrual cycle phase effects on prepulse inhibition of acoustic startle. Psychophysiology 2004, 41(3):401-406.
42. Kaasinen V., Maguire R.P., Kurki T., Brück A., Rinne J.O. Mapping brain structure and personality in late adulthood. Neuroimage 2005, 24(2):315-322.
43. Kijima N., Saito R., Takeuchi M., Yoshino A., Ono Y., Kato M., Kitamura T. Cloninger's seven-factor model of temperament and character and Japanese version of Temperament and Character Inventory (TCI). Arch. Psychiatr. Diagn. Clin. Eval. 1996, 7(3):379-399. (in Japanese).
44. Kijima N., Tanaka E., Suzuki N., Higuchi H., Kitamura T. Reliability and validity of the Japanese version of the Temperament and Character Inventory. Psychol. Rep. 2000, 86(3 Pt 1):1050-1058.
45. Kumari V., Aasen I., Sharma T. Sex differences in prepulse inhibition deficits in chronic schizophrenia. Schizophr. Res. 2004, 69(2-3):219-235.
46. Kumari V., Antonova E., Geyer M.A., Ffytche D., Williams S.C., Sharma T. A fMRI investigation of startle gating deficits in schizophrenia patients treated with typical or atypical antipsychotics. Int. J. Neuropsychopharmacol. 2007, 10(4):463-477.
47. Kumari V., Antonova E., Zachariah E., Galea A., Aasen I., Ettinger U., Mitterschiffthaler M.T., Sharma T. Structural brain correlates of prepulse inhibition of the acoustic startle response in healthy humans. Neuroimage 2005, 26(4):1052-1058.
48. Kumari V., Checkley S.A., Gray J.A. Effect of cigarette smoking on prepulse inhibition of the acoustic startle reflex in healthy male smokers. Psychopharmacology (Berl.) 1996, 128(1):54-60.
49. Kumari V., Das M., Zachariah E., Ettinger U., Sharma T. Reduced prepulse inhibition in unaffected siblings of schizophrenia patients. Psychophysiology 2005, 42(5):588-594.
50. Kumari V., Fannon D., Geyer M.A., Premkumar P., Antonova E., Simmons A., Kuipers E. Cortical grey matter volume and sensorimotor gating in schizophrenia. Cortex 2008, 44(9):1206-1214.
51. Kumari V., Gray J.A., Geyer M.A., ffytche D., Soni W., Mitterschiffthaler M.T., Vythelingum G.N., Simmons A., Williams S.C., Sharma T. Neural correlates of tactile prepulse inhibition: a functional MRI study in normal and schizophrenic subjects. Psychiatry Res. 2003, 122(2):99-113.
52. Kumari V., Soni W., Sharma T. Influence of cigarette smoking on prepulse inhibition of the acoustic startle response in schizophrenia. Hum. Psychopharmacol. 2001, 16(4):321-326.
53. Kumari V., Toone B., Gray J.A. Habituation and prepulse inhibition of the acoustic startle reflex: effects of smoking status and psychosis-proneness. Pers. Individ. Differ. 1997, 23(2):183-191.
54. Kunugi H., Tanaka M., Hori H., Hashimoto R., Saitoh O., Hironaka N. Prepulse inhibition of acoustic startle in Japanese patients with chronic schizophrenia. Neurosci. Res. 2007, 59(1):23-28.
55. Li T., Ma X., Sham P.C., Sun X., Hu X., Wang Q., Meng H., Deng W., Liu X., Murray R.M., Collier D.A. Evidence for association between novel polymorphisms in the PRODH gene and schizophrenia in a Chinese population. Am. J. Med. Genet. B: Neuropsychiatr. Genet. 2004, 129B(1):13-15.
56. Liu H., Heath S.C., Sobin C., Roos J.L., Galke B.L., Blundell M.L., Lenane M., Robertson B., Wijsman E.M., Rapoport J.L., Gogos J.A., Karayiorgou M. Genetic variation at the 22q11 PRODH2/DGCR6 locus presents an unusual pattern and increases susceptibility to schizophrenia. Proc. Natl. Acad. Sci. U. S. A. 2002, 99(6):3717-3722.
57. Lorenzi C., Serretti A., Mandelli L., Tubazio V., Ploia C., Smeraldi E. 5-HT 1A polymorphism and self-transcendence in mood disorders. Am. J. Med. Genet. B: Neuropsychiatr. Genet. 2005, 137(1):33-35.
58. Matsuoka K., Uno M., Kasai K., Koyama K., Kim Y. Estimation of premorbid IQ in individuals with Alzheimer's disease using Japanese ideographic script (Kanji) compound words: Japanese version of National Adult Reading Test. Psychiatry Clin. Neurosci. 2006, 60(3):332-339.
59. McGhie A., Chapman J. Disorders of attention and perception in early schizophrenia. Br. J. Med. Psychol. 1961, 34:103-116.
60. Miettunen J., Veijola J., Lauronen E., Kantojärvi L., Joukamaa M. Sex differences in Cloninger's temperament dimensions - a meta-analysis. Compr. Psychiatry 2007, 48(2):161-169.
61. Moriwaki M., Kishi T., Takahashi H., Hashimoto R., Kawashima K., Okochi T., Kitajima T., Furukawa O., Fujita K., Takeda M., Iwata N. Prepulse inhibition of the startle response with chronic schizophrenia: a replication study. Neurosci. Res. 2009, 65(3):259-262.
62. Nilsson K.W., Damberg M., Ohrvik J., Leppert J., Lindström L., Anckarsäter H., Oreland L. Genes encoding for AP-2beta and the serotonin transporter are associated with the personality character spiritual acceptance. Neurosci. Lett. 2007, 411(3):233-237.
63. Pélissolo A., Lépine J.P. Normative data and factor structure of the Temperament and Character Inventory (TCI) in the French version. Psychiatry Res. 2000, 94(1):67-76.
64. Petrovsky N., Quednow B.B., Ettinger U., Schmechtig A., Mössner R., Collier D.A., Kühn K.U., Maier W., Wagner M., Kumari V. Sensorimotor gating is associated with CHRNA3 polymorphisms in schizophrenia and healthy volunteers. Neuropsychopharmacology 2010, 35(7):1429-1439.
65. Quednow B.B., Kühn K.U., Mössner R., Schwab S.G., Schuhmacher A., Maier W., Wagner M. Sensorimotor gating of schizophrenia patients is influenced by 5-HT2A receptor polymorphisms. Biol. Psychiatry 2008, 64(5):434-437.
66. Quednow B.B., Schmechtig A., Ettinger U., Petrovsky N., Collier D.A., Vollenweider F.X., Wagner M., Kumari V. Sensorimotor gating depends on polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase, but not on neuregulin-1 Arg38Gln genotype: a replication study. Biol. Psychiatry 2009, 66(6):614-620.
67. Quednow B.B., Wagner M., Mössner R., Maier W., Kühn K.U. Sensorimotor gating of schizophrenia patients depends on Catechol O-methyltransferase Val158Met polymorphism. Schizophr. Bull. 2010, 36(2):341-346.
68. Quednow B.B., Ettinger U., Mössner R., Rujescu D., Giegling I., Collier D.A., Schmechtig A., Kühn K.U., Möller H.J., Maier W., Wagner M., Kumari V. The schizophrenia risk allele C of the TCF4 rs9960767 polymorphism disrupts sensorimotor gating in schizophrenia spectrum and healthy volunteers. J. Neurosci. 2011, 31(18):6684-6691.
69. Rissling A.J., Dawson M.E., Schell A.M., Nuechterlein K.H. Effects of cigarette smoking on prepulse inhibition, its attentional modulation, and vigilance performance. Psychophysiology 2007, 44(4):627-634.
70. Roussos P., Giakoumaki S.G., Adamaki E., Anastasios G., Nikos R.K., Bitsios P. The association of schizophrenia risk d-amino acid oxidase polymorphisms with sensorimotor gating, working memory and personality in healthy males. Neuropsychopharmacology 2011, 36(8):1677-1688.
71. Roussos P., Giakoumaki S.G., Adamaki E., Bitsios P. The influence of schizophrenia-related neuregulin-1 polymorphisms on sensorimotor gating in healthy males. Biol. Psychiatry 2011, 69(5):479-486.
72. Roussos P., Giakoumaki S.G., Bitsios P. The dopamine D(3) receptor Ser9Gly polymorphism modulates prepulse inhibition of the acoustic startle reflex. Biol. Psychiatry 2008, 64(3):235-240.
73. Roussos P., Giakoumaki S.G., Bitsios P. A risk PRODH haplotype affects sensorimotor gating, memory, schizotypy, and anxiety in healthy male subjects. Biol. Psychiatry 2009, 65(12):1063-1070.
74. Roussos P., Giakoumaki S.G., Rogdaki M., Pavlakis S., Frangou S., Bitsios P. Prepulse inhibition of the startle reflex depends on the catechol O-methyltransferase Val158Met gene polymorphism. Psychol. Med. 2008, 38(11):1651-1658.
75. Simons R.F., Giardina B.D. Reflex modification in psychosis-prone young adults. Psychophysiology 1992, 29(1):8-16.
76. Smith M.J., Cloninger C.R., Harms M.P., Csernansky J.G. Temperament and character as schizophrenia-related endophenotypes in non-psychotic siblings. Schizophr. Res. 2008, 104(1-3):198-205.
77. Svrakic D.M., Whitehead C., Przybeck T.R., Cloninger C.R. Differential diagnosis of personality disorders by the seven-factor model of temperament and character. Arch. Gen. Psychiatry 1993, 50(12):991-999.
78. Swerdlow N.R., Weber M., Qu Y., Light G.A., Braff D.L. Realistic expectations of prepulse inhibition in translational models for schizophrenia research. Psychopharmacology (Berl.) 2008, 199(3):331-388.
79. Swerdlow N.R., Auerbach P., Monroe S.M., Hartston H., Geyer M.A., Braff D.L. Men are more inhibited than women by weak prepulses. Biol. Psychiatry 1993, 34(4):253-260.
80. Swerdlow N.R., Filion D., Geyer M.A., Braff D.L. " Normal" personality correlates of sensorimotor, cognitive, and visuospatial gating. Biol. Psychiatry 1995, 37(5):286-299.
81. Swerdlow N.R., Hartman P.L., Auerbach P.P. Changes in sensorimotor inhibition across the menstrual cycle: implications for neuropsychiatric disorders. Biol. Psychiatry 1997, 41(4):452-460.
82. Swerdlow N.R., Sprock J., Light G.A., Cadenhead K., Calkins M.E., Dobie D.J., Freedman R., Green M.F., Greenwood T.A., Gur R.E., Mintz J., Olincy A., Nuechterlein K.H., Radant A.D., Schork N.J., Seidman L.J., Siever L.J., Silverman J.M., Stone W.S., Tsuang D.W., Tsuang M.T., Turetsky B.I., Braff D.L. Multi-site studies of acoustic startle and prepulse inhibition in humans: initial experience and methodological considerations based on studies by the Consortium on the Genetics of Schizophrenia. Schizophr. Res. 2007, 92(1-3):237-251.
83. Swerdlow N.R., Talledo J.A., Braff D.L. Startle modulation in Caucasian-Americans and Asian-Americans: a prelude to genetic/endophenotypic studies across the 'Pacific Rim'. Psychiatr. Genet. 2005, 15(1):61-65.
84. Swerdlow N.R., Wasserman L.C., Talledo J.A., Casas R., Bruins P., Stephany N.L. Prestimulus modification of the startle reflex: relationship to personality and physiological markers of dopamine function. Biol. Psychol. 2002, 62(1):17-26.
85. Takahashi H., Iwase M., Canuet L., Yasuda Y., Ohi K., Fukumoto M., Iike N., Nakahachi T., Ikezawa K., Azechi M., Kurimoto R., Ishii R., Yoshida T., Kazui H., Hashimoto R., Takeda M. Relationship between prepulse inhibition of acoustic startle response and schizotypy in healthy Japanese subjects. Psychophysiology 2010, 47(5):831-837.
86. Takahashi H., Iwase M., Ishii R., Ohi K., Fukumoto M., Azechi M., Ikezawa K., Kurimoto R., Canuet L., Nakahachi T., Iike N., Tagami S., Morihara T., Okochi M., Tanaka T., Kazui H., Yoshida T., Tanimukai H., Yasuda Y., Kudo T., Hashimoto R., Takeda M. Impaired prepulse inhibition and habituation of acoustic startle response in Japanese patients with schizophrenia. Neurosci. Res. 2008, 62(3):187-194.
87. Turner R.M., Hudson I.L., Butler P.H., Joyce P.R. Brain function and personality in normal males: a SPECT study using statistical parametric mapping. Neuroimage 2003, 19(3):1145-1162.
88. Urgesi C., Aglioti S.M., Skrap M., Fabbro F. The spiritual brain: selective cortical lesions modulate human self-transcendence. Neuron 2010, 65(3):309-319.