CD147-targeting siRNA inhibits cell-matrix adhesion of human malignant melanoma cells by phosphorylating focal adhesion kinase

Journal of Dermatology

Volumn 39, Issue 1, 2012, Pages 63-67

  Nishibaba, Rie ^a   Higashi, Yuko ^a   Su, Juan ^b   Furukawa, Tatsuhiko ^a   Kawai, Kazuhiro ^a   Kanekura, Takuro ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

^b CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

CD147; cell matrix adhesion; focal adhesion kinase; integrin 1; malignant melanoma

Indexed keywords

BETA1 INTEGRIN; CD147 ANTIGEN; COLLAGEN TYPE 1; COLLAGEN TYPE 4; FOCAL ADHESION KINASE; SMALL INTERFERING RNA;

ARTICLE; CELL ADHESION; CELL STRUCTURE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EXTRACELLULAR MATRIX; GENE SILENCING; HUMAN; HUMAN CELL; MELANOMA; MELANOMA CELL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

ANTIGENS, CD147; ANTIGENS, CD29; CELL ADHESION; CELL LINE, TUMOR; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; FOCAL ADHESION PROTEIN-TYROSINE KINASES; GENE SILENCING; HUMANS; MELANOMA; NEOPLASM INVASIVENESS; PHOSPHORYLATION; RNA, SMALL INTERFERING;

EID: 84855342991     PISSN: 03852407     EISSN: 13468138     Source Type: Journal    
DOI: 10.1111/j.1346-8138.2011.01304.x     Document Type: Article

References (26)

1. Kanekura T, Miyauchi T, Tashiro M, Muramatsu T,. Basigin, a new member of the immunoglobulin superfamily: genes in different mammalian species, glycosylation changes in the molecule from adult organs and possible variation in the N-terminal sequences. Cell Struct Funct 1991; 16: 23-30.
2. Kanekura T, Chen X, Kanzaki T,. Basigin (CD147) is expressed on melanoma cells and induces tumor cell invasion by stimulating production of matrix metalloproteinase by fibroblasts. Int J Cancer 2002; 99: 520-528. (Pubitemid 34461604)
3. Chen X, Lin J, Kanekura T, et al. A small interfering CD147-targeting RNA inhibited the proliferation, invasiveness, and metastatic activity of malignant melanoma. Cancer Res 2006; 66: 11323-11330. (Pubitemid 46009963)
4. Bordador LC, Li X, Toole B, et al. Expression of EMMPRIN by oral squamous cell carcinoma. Int J Cancer 2000; 85: 347-352. (Pubitemid 30030407)
5. Polette M, Gilles C, Marchand V, et al. Tumor collagenase stimulatory factor (TCSF) expression and localization in human lung and breast cancers. J Histochem Cytochem 1997; 45: 703-709. (Pubitemid 27224703)
6. Nabeshima K, Iwasaki H, Koga K, et al. Emmprin (basigin/CD147): matrix metalloproteinase modulator and multifunctional cell recognition molecule that plays a critical role in cancer progression. Pathol Int 2006; 56: 359-367. (Pubitemid 43886799)
7. Su J, Chen X, Kanekura T,. A CD147-targeting siRNA inhibits the proliferation, invasiveness, and VEGF production of human malignant melanoma cells by down-regulating glycolysis. Cancer Lett 2009; 273: 140-147.
8. Kanekura T, Chen X,. CD147/basigin promotes progression of malignant melanoma and other cancers. J Dermatol Sci 2010; 57: 149-154.
9. Guo W, Giancotti FG,. Integrin signaling during tumour progression. Nat Rev Mol Cell Biol 2004; 5: 816-826.
10. Kuphal S, Bauer R, Bosserhoff AK,. Integrin signaling in malignant melanoma. Cancer Metastasis Rev 2005; 24: 195-222. (Pubitemid 40922795)
11. Hood JD, Cheresh DA,. Role of integrins in cell invasion and migration. Nat Rev Cancer 2002; 2: 91-100. (Pubitemid 37328796)
12. Cary LA, Guan JL,. Focal adhesion kinase in integrin-mediated signaling. Front Biosci 1999; 4: D102-D113.
13. Mitra SK, Hanson DA, Schlaepfer DD,. Focal adhesion kinase: in command and control of cell motility. Nat Rev Mol Cell Biol 2005; 6: 56-68. (Pubitemid 40064899)
14. Dai JY, Dou KF, Wang CH, et al. The interaction of HAb18G/CD147 with integrin alpha6 beta1 and its implications for the invasion potential of human hepatoma cells. BMC Cancer 2009; 9: 337.
15. Friedl P, Wolf K,. Tumor-cell invasion and migration: diversity and escape mechanism. Nat Rev Cancer 2003; 3: 362-374. (Pubitemid 37328856)
16. Pellinen T, Ivaska J,. Integrin traffic. J Cell Sci 2006; 119: 3723-3731. (Pubitemid 44614425)
17. Caswell PT, Norman JC,. Integrin trafficking and the control of cell migration. Traffic 2006; 7: 14-21.
18. Mon NN, Ito S, Senga T, Hamaguchi M,. FAK signaling in neoplastic disorders: a linkage between inflammation and cancer. Ann NY Acad Sci 2006; 1086: 199-212. (Pubitemid 47084387)
19. Curtin KD, Meinertzhagen IA, Wyman RJ,. Basigin (EMMPRIN/CD147) interacts with integrin to affect cellular architecture. J Cell Sci 2005; 118: 2649-2660. (Pubitemid 40932890)
20. Angers-Loustau A, Cote JF, Charest A, et al. Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblasts. J Cell Biol 1999; 144: 1019-1031. (Pubitemid 29238975)
21. Yu DH, Qu CK, Henegariu O, Lu X, Feng GS,. Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration, and focal adhesion. J Biol Chem 1998; 273: 21125-21131. (Pubitemid 28385400)
22. Manes S, Mira E, Gomez-Mouton C, Zhao ZJ, Lacalle RA, Martinez-A C,. Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility. Mol Cell Biol 1999; 19: 3125-3135. (Pubitemid 29144557)
23. Lu Z, Jiang G, Blume-Jensen P, Hunter T,. Epidermal growth factor-induced tumor cell invasion and metastasis initiated by dephosphorylation and downregulation of focal adhesion kinase. Mol Cell Biol 2001; 21: 4016-4031. (Pubitemid 32476463)
24. Cary LA, Han DC, Polte TR, Hanks SK, Guan JL,. Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migration. J Cell Biol 1998; 140: 211-221. (Pubitemid 28070908)
25. Qian AR, Zhang W, Cao JP, et al. Downregulation of CD147 expression alters cytoskeleton architecture and inhibits gelatinase production and SAPK pathway in human hepatocellular carcinoma cells. J Exp Clin Cancer Res 2008; 27: 50.
26. Tang J, Wu YM, Zhao P, Yang XM, Jiang JL, Chen ZN,. Overexpression of HAb18G/CD147 promotes invasion and metastasis via alpha3 beta1 integrin mediated FAK-paxillin and FAK-PI3K-Ca2+ pathways. Cell Mol Life Sci 2008; 65: 2933-2942.