Successful regeneration after experimental stroke by granulocyte-colony stimulating factor is not further enhanced by constraint-induced movement therapy either in concurrent or in sequential combination therapy

Stroke

Volumn 43, Issue 1, 2012, Pages 185-192

  Diederich, Kai ^a   Quennet, Verena ^c   Bauer, Henrike ^c   Müller, Harald D ^c   Wersching, Heike ^a   Schäbitz, Wolf Rüdiger ^a,b   Minnerup, Jens ^a   Sommer, Clemens ^c  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b EVKB ^*  (Germany)

^c JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

CIMT; FAU; G CSF; receptor autoradiography; regeneration

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; DIZOCILPINE; GRANULOCYTE COLONY STIMULATING FACTOR; N METHYL DEXTRO ASPARTIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CLINICAL EFFECTIVENESS; CONSTRAINT INDUCED MOVEMENT THERAPY; CONTROLLED STUDY; ENZYME BINDING; LIGAND BINDING; MALE; MOTOR PERFORMANCE; MOVEMENT THERAPY; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RAT; REGENERATION; STROKE; TREATMENT RESPONSE;

ANIMALS; BRAIN; BRAIN ISCHEMIA; COMBINED MODALITY THERAPY; GRANULOCYTE COLONY-STIMULATING FACTOR; MALE; PHYSICAL THERAPY MODALITIES; RATS; RATS, WISTAR; RECOVERY OF FUNCTION; REGENERATION; STROKE;

EID: 84855340458     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.111.622159     Document Type: Article

References (22)

1. Chen R, Cohen LG, Hallett M. Nervous system reorganization following injury. Neuroscience. 2002;4:761-773. (Pubitemid 34603248)
2. Taub E, Uswatte G, Elbert T. New treatments in neurorehabilitation founded on basic research. Nat Rev Neurosci. 2002;3:228-236. (Pubitemid 135706592)
3. Maurer MH, Schäbitz WR, Schneider A. Old friends in new constellations-the hematopoetic growth factors G-CSF, GM-CSF, and EPO for the treatment of neurological diseases. Curr Med Chem. 2008;15: 1407-1411. (Pubitemid 351997791)
4. Zhao C, Wang J, Zhao S, Nie Y. Constraint-induced movement therapy enhanced neurogenesis and behavioral recovery after stroke in adult rats. Tohoku J Exp Med. 2009;218:301-308.
5. Schneider A, Krüger C, Steigleder T, Weber D, Pitzer C, Laage R, et al. The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis. J Clin Invest. 2005;115: 2083-2098. (Pubitemid 41134150)
6. Schneider A, Wysocki R, Pitzer C, Krüger C, Laage R, Schwab S, Bach A, Schäbitz WR. An extended window of opportunity for G-CSF treatment in cerebral ischemia. BMC Biol. 2006;4:36.
7. Müller HD, Hanumanthiah K, Diederich K, Schwab S, Schäbitz W-R, Sommer C. BDNF but not forced arm use improves long-term outcome after photothrombotic stroke and transiently upregulates binding densities of excitatory glutamate receptors in the rat brain. Stroke. 2008;39: 1012-1021. (Pubitemid 351619554)
8. Koerner IP, Brambrink AM. Brain protection by anesthetic agents. Curr Opin Anaesthesiol. 2006;19:481-486. (Pubitemid 44386048)
9. Shanina EV, Redecker C, Reinecke S, Schallert T, Witte OW. Long-term effects of sequential cortical infarcts on scar size, brain volume and cognitive function. Behav Brain Res. 2005;158:69-77. (Pubitemid 40174712)
10. Paxinos G, Watson C. The Rat Brain, 7th ed. London: Elsevier Inc; 2007.
11. Kozlowski DA, Jampes DC, Schallert T. Use-dependent exaggeration of neuronal injury following unilateral sensorimotor cortex lesions. J Neurosci. 1996;16:4776-4786. (Pubitemid 26251072)
12. Schäbitz W-R, Berger C, Kollmar R, Seitz M, Tanay E, Kiessling M, et al. Effect of brain-derived neurotrophic factor treatment and forced arm use on functional motor recovery after small cortical ischemia. Stroke. 2004;35:992-997. (Pubitemid 38419816)
13. England TJ, Gibson CL, Bath PM. Granulocyte-colony stimulating factor in experimental stroke and its effects on infarct size and functional outcome: a systematic review. Brain Res Rev. 2009;62:71-82.
14. Minnerup J, Sevimli S, Schäbitz WR. Granulocyte-colony stimulating factor for stroke treatment: mechanisms of action and efficacy in preclinical studies. Exp Transl Stroke Med. 2009;1:2.
15. Minnerup J, Heidrich J, Wellmann J, Rogalewski A, Schneider A, Schäbitz WR. Meta-analysis of the efficacy of granulocyte-colony stimulating factor in animal models of focal cerebral ischemia. Stroke. 2008; 39:1855-1861.
16. Kolb B, Morshead C, Gonzalez C, Kim M, Gregg C, Shingo T, et al. Growth factor-stimulated generation of new cortical tissue and functional recovery after stroke damage to the motor cortex of rats. J Cereb Blood Flow Metab. 2007;27:983-997. (Pubitemid 46659027)
17. Sprigg N, Bath PM, Zhao L, Willmot MR, Gray LJ, Walker MF, et al. Granulocyte-colony-stimulating factor mobilizes bone marrow stem cells in patients with subacute ischemic stroke: the Stem cell Trial of recovery EnhanceMent after Stroke (STEMS) pilot randomized, controlled trial (ISRCTN 16784092). Stroke. 2006;37:2979-2982.
18. Müller HD, Kollmar R, Schwab S, Schäbitz WR, Sommer C. Neuroprotective effect of G-CSF is associated with maintained ligand binding to GABAA receptors in the ischemic cortical penumbra [Abstract]. Acta Neuropathol. 2003;106:393.
19. Sommer C, Fahrner A, Kiessling M. [3H]Muscimol binding to GABAA receptors is upregulated in CA1 neurons of the gerbil hippocampus in the ischemia tolerant state. Stroke. 2002;33:1698-1705. (Pubitemid 34619981)
20. Buchkremer-Ratzmann I, August M, Hagemann G, Witte OW. Electrophysiological transcortical diaschisis after cortical photothrombosis in rat brain. Stroke. 1996;27:1105-1111. (Pubitemid 26177614)
21. Biegon A, Fry PA, Paden CM, Alexandrovich A, Tsenter J, Shohami E. Dynamic changes in N-methyl-D-aspartate receptors after closed head injury in mice: implications for treatment of neurological and cognitive deficits. Proc Natl Acad Sci USA. 2004;101:5117-5122. (Pubitemid 38469212)
22. Dhawan J, Benveniste H, Nawrocky M, Smith SD, Biegon A. Transient focal ischemia results in persistent and widespread neuroinflammation and loss of glutamate NMDA receptors. Neuroimage. 2010;51:599-605.