Orally administered l-arginine and glycine are highly effective against acid reflux esophagitis in rats

Medical Science Monitor

Volumn 18, Issue 1, 2012, Pages

  Nagahama, Kenji ^a   Nishio, Hikaru ^a   Yamato, Masanori ^a   Takeuchi, Koji ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Acid reflux esophagitis; Amino acid; Dual effect; Pepsin; Rat model

Indexed keywords

ALANINE; ARGININE; GLUTAMINE; GLYCINE; INDOMETACIN; N(G) NITROARGININE METHYL ESTER; OMEPRAZOLE; PEPSTATIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; DISEASE SEVERITY; FORESTOMACH; MALE; NONHUMAN; PH; PYLORUS LIGATION; RAT; REFLUX ESOPHAGITIS;

EID: 84855295886     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: 10.12659/msm.882190     Document Type: Article

References (32)

1. Orlando RC: Pathogenesis of reflux esophagitis and Barrett's esophagus. Med Clin North Am, 2005; 89: 219-41
2. Hunt RH: Importance of pH control in the management of GERD. Arch Intern Med, 1999; 159: 649-57
3. Schubert ML, Peura DA: Control of gastric acid secretion in health and disease. Gastroenterology, 2008; 134: 1842-60
4. Bell NJ, Burget D, Howden CW et al: Appropriate acid suppression for the management of gastro-oesophageal reflux disease. Digestion, 1992; 51(Suppl.1): 59-67
5. Hamamoto N, Hashimoto T, Adachi K et al: Comparative study of nizatidine and famotidine for maintenance therapy of erosive esophagitis. J Gastroenterol Hepatol, 2005; 20: 281-86
6. Inatomi N, Nagaya H, Takami K et al: Effects of a proton pump inhibitor, AG-1749 (lansoprazole), on reflux esophagitis and experimental ulcers in rats. Jpn J Pharmacol, 1991; 55: 437-51
7. Nagahama K, Yamato M, Kato S, Takeuchi K: Protective effect of lafutidine, a novel H2 receptor antagonist on acid reflux esophagitis in rats through capsaicin-sensitive afferent neurons. J Pharmacol Sci, 2003; 93: 55-61
8. Roberts NB: Review article: human pepsins - their multiplicity, function and role in reflux disease. Aliment Pharmacol Ther, 2006; 24: 2-9.
9. Goldberg HI, Dodds WJ, Gee S et al: Role of acid and pepsin in acute experimental esophagitis. Gastroenterology, 1969; 56: 223-30
10. Nagahama K, Yamato M, Nishio H, Takeuchi K: Essential role of pepsin in pathogenesis of acid reflux esophagitis in rats. Dig Dis Sci, 2006; 51: 303-9
11. Okabe S, Takeuchi K, Takata Y et al: Effects of L-glutamine on various gastric lesions in rats and guinea pigs. Digestion, 1976; 14: 325-31
12. De Backer A, Haentjens P, Willems G: Hydrochloric acid. A trigger of cell proliferation in the esophagus of dogs. Dig Dis Sci, 1994; 9: 884-90
13. Hollwarth ME, Smith ME, Kvietys RP, Granger DN: Esophageal blood flow in the cat: Normal distribution and effects of acid perfusion. Gastroenterology, 1986; 90: 622-28
14. Jankowski J, Coghill G, Tregaskis B et al: Epidermal growth factor in the esophagus. Gut, 1992; 33: 1448-53
15. Lanas AI, Blas JM, Ortego J et al: Adaptationof esophageal mucosa to acid- and pepsin-induced damage: Role of nitric oxide and epidermal growth factor. Dig Dis Sci, 1997; 42: 1003-12
16. Konturek SJ, Konturek PC, Brzozowski T, Bubenik GA: Role of melatonin in upper gastrointestinal tract. J Physiol Pharmacol, 2007; 58: 23-52
17. Tack J: Review article: the role of bile and pepsin in the pathophysiology and treatment of gastro-oesophageal reflux disease. Aliment Pharmacol Ther, 2006; 24: 10-16
18. Wang C, Hunt RH: Precise role of acid in non-erosive reflux disease. Digestion, 2008; 78: 31-41
19. Orlando RC: Reflux esophagitis: overview. Scand J Gastroenterol, 1995; 30: 36-37
20. Orlando RC: Pathogenesis of gastroesophageal reflux disease. Am J Med Sci, 2003; 326: 274-78
21. Robert A, Nezamis IE, Lancaster C et al: Mild irritant prevent gastric necrosis through adaptive cytoprotection mediated by prostaglandins. Am J Physiol, 1983; 245: G113-21
22. Barnett K, Bell CJ, McKnight W et al: Role of cyclooxygenase-2 in modulating gastric acid secretion in the normal and inflamed rat stomach. Am J Physiol, 2000; 279: G1292-97
23. Takeeda M, Hayashi Y, Yamato M et al: Roles of endogenous prostaglandins and cyclooxygenase isozymes in mucosal defense of inflamed rat stomach. J Physiol Pharmacol, 2004; 55: 193-205
24. Poplawski C, Sosnowski D, Szaflarska-Popławska A et al: Role of bile acids, prostaglandins and COX inhibitors in chronic esophagitis in a mouse model. World J Gastroenterol, 2006; 12: 1739-42
25. Yamato M, Nagahama K, Kotani T et al: Biphasic effect of prostaglandin E2 on a rat model of esophagitis mediated by EP1 receptors: Relation to pepsin secretion. Digestion, 2005; 72: 109-18
26. Takeuchi K, Ohuchi T, Kato S, Okabe S: Cytoprotective action of L-arginine against HC1-induced gastric injury in rats: involvement of nitric oxide? Jpn J Pharmacol, 1993; 61: 13-21
27. Moncada S, Palmer RM, Higgs EA: Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev, 1991; 43: 109-42
28. Laine L, Takeuchi K, Tarnawski A: Gastric mucosal defense and cytoprotection: bench to bedside. Gastroenterology, 2008; 135: 41-60
29. Ozel SK, Dagli TE, Yuksel M et al: The roles of free oxygen radicals, nitric oxide, and endothelin in caustic injury of rat esophagus. J Pediatr Surg, 2004; 39: 1381-85
30. Ishiyama F, Iijima K, Asanuma K et al: Exogenous luminal nitric oxide exacerbates esophagus tissue damage in a reflux esophagitis model of rats. Scand J Gastroenterol, 2009; 44: 527-37
31. Ito Y, Okuda S, Ohkawa F et al: Dual role of nitric oxide in gastric hypersecretion in distended stomach: Inhibition of acid secretion and stimulation of pepsin secretion. Life Sci, 2008; 83: 886-92
32. Castell DO, Murray JA, Tutuian R et al: The pathophysiology of gastrooesophageal reflux disease: oesophageal manifestations. Aliment Pharmacol Ther, 2004; 20(Suppl.9): 14-25