Expression, localization, and phosphorylation of Akt1 in benign and malignant thyroid lesions

Endocrine Pathology

Volumn 22, Issue 4, 2011, Pages 206-211

  Krześlak, Anna ^a   Pomorski, Lech ^b   Lipińska, Anna ^a  

^a UNIVERSITY OF LODZ   (Poland)

^b MEDICAL UNIVERSITY OF LODZ   (Poland)

Author keywords

Akt1 expression; Localization; Phosphorylation; Thyroid cancer

Indexed keywords

AKT1 PROTEIN; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ARTICLE; CANCER CLASSIFICATION; CANCER LOCALIZATION; CELL LYSATE; CONTROLLED STUDY; CYTOPLASM; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; FEMALE; FRACTIONATION; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOPRECIPITATION; ISOLATION PROCEDURE; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; THYROID ADENOMA; THYROID FOLLICULAR CARCINOMA; THYROID TUMOR; TUMOR DIFFERENTIATION; WESTERN BLOTTING;

BLOTTING, WESTERN; CARCINOMA, PAPILLARY, FOLLICULAR; CELL FRACTIONATION; CYTOPLASM; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; MALE; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; STATISTICS, NONPARAMETRIC; THYROID NEOPLASMS;

EID: 84855289224     PISSN: 10463976     EISSN: 15590097     Source Type: Journal    
DOI: 10.1007/s12022-011-9177-4     Document Type: Article

References (18)

1. P Hou D Liu Y Shan S Hu K Studeman S Condouris Y Wang A Trink AK El-Naggar G Tallini V Vasko M Xing 2007 Genetic alterations and their relationship in the phosphatidylinositol 3-kinase/Akt pathway in thyroid cancer Clin Cancer Res 13 1161 1170 17317825 10.1158/1078-0432.CCR-06-1125 1:CAS:528:DC%2BD2sXhvF2hsLc%3D (Pubitemid 46424056)
2. M Shinohara YJ Chung M Saji MD Ringel 2007 AKT in thyroid tumorigenesis and progression Endocrinology 148 942 947 16946008 10.1210/en.2006-0937 1:CAS:528:DC%2BD2sXitlWgu7c%3D
3. M Xing 2010 Genetic alteration in the phosphatidylinositol-3 kinase/Akt pathway in thyroid cancer Thyroid 20 697 706 20578891 10.1089/thy.2010.1646 1:CAS:528:DC%2BC3cXosFarsbg%3D
4. BD Manning LC Cantley 2007 AKT/PKB signaling: navigating downstream Cell 129 1261 1274 17604717 10.1016/j.cell.2007.06.009 1:CAS:528:DC%2BD2sXotV2hs7g%3D (Pubitemid 46962095)
5. RW Matheny ML Adamo 2009 Current perspectives on Akt Akt-ivation and Akt-ions Exp Mol Biol 234 1264 1270 10.3181/0904-MR-138 1:CAS:528: DC%2BD1MXhtlOitrfP
6. M Noguchi V Ropars C Roumestand F Suizu 2007 Proto-oncogene TCL1: more than just a coactivator for Akt FASEB J 21 2273 2284 17360849 10.1096/fj.06-7684com 1:CAS:528:DC%2BD2sXptFKhtLg%3D (Pubitemid 47230657)
7. MR Easton H Cho K Roovers DW Shineman M Mizrani MS Forman VM-Y Lee M Shablocs R de Jong T Oltrsdorf T Ludwig A Efsrtiadis MJ Birnbaum 2005 Role of Akt3/protein kinase B in attainment normal brain size Mol Cell Biol 25 1869 1878 15713641 10.1128/MCB.25.5.1869-1878.2005 1:CAS:528:DC%2BD2MXhvFGqt7Y%3D (Pubitemid 40280150)
8. H Cho J Mu JK Kim JL Thorvaldsen Q Chu EB Crenshow KH Keastner MS Bartolomei GI Hulman MJ Birnbaum 2001 Insuline resistance and a diabetes mellitus like syndrom in mice lacking the protein kinase Akt2 (PKB beta) Science 292 1728 1731 11387480 10.1126/science.292.5522.1728 1:CAS:528: DC%2BD3MXkt1Slu7k%3D (Pubitemid 32506248)
9. H Cho JL Thorvaldsen Q Chu F Feng MJ Birnbaum 2001 Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice J Biol Chem 276 38349 38352 11533044 10.1074/jbc.C100462200 1:CAS:528:DC%2BD3MXnvVens70%3D
10. MD Ringel N Hayre J Saito B Sounier E Schuppert H Burch V Bernet KD Burman LD Kohn M Saji 2001 Overexpression and overactivation of Akt in thyroid carcinoma Cancer Res 61 6105 6111 11507060 1:CAS:528:DC%2BD3MXmt12ktLo%3D (Pubitemid 32762546)
11. V Vasko M Saji E Hardy M Kruhlak A Larin V Savchenko M Miyakawa O Isozaki H Murakami T Tsushima KD Burman C De Micco MD Ringel 2004 Akt activation and localization correlate with tumour invasion and oncogene expression in thyroid cancer J Med Genet 41 161 170 14985374 10.1136/jmg.2003.015339 1:CAS:528:DC%2BD2cXjtFCgsr8%3D (Pubitemid 38333792)
12. YR Chin A Toker 2009 Function of Akt/PKB signaling to cell motility, invasion and tumor stroma in cancer Cell Signal 21 470 476 19110052 10.1016/j.cellsig.2008.11.015 1:CAS:528:DC%2BD1MXhvF2rtbk%3D
13. M Miyakawa T Tsushima H Murakami K Wakai O Isozaki K Takano 2003 Increased expression of phosphorylated p70S6 kinase and Akt in papillary thyroid cancer tissues Endocr J 50 77 83 12733712 10.1507/endocrj.50.77 1:CAS:528:DC%2BD3sXjtFelsLg%3D (Pubitemid 36305850)
14. E Sozopoulos H Litsiou G Voutsinas N Mitsiades N Anagnostakis T Tseva E Patsouris S Tseleni-Balafouta 2010 Mutational and immunohistochemical study of the PI3K/Akt pathway in papillary thyroid carcinoma in Greece Endocr Pathol 21 90 100 20186503 10.1007/s12022-010-9112-0 1:CAS:528:DC%2BC3cXltlyrt7w%3D
15. M Yoeli-Lerner GK Yiu I Rabinovitz P Erhardt S Jauliac A Toker 2005 Akt blocks breast cancer cell motility and invasion trough the transcription factor NFAT Mol Cell 20 539 550 16307918 10.1016/j.molcel.2005.10.033 1:CAS:528:DC%2BD2MXht12msrzM (Pubitemid 41668639)
16. HY Irie RV Pearline D Grueneberg M Hsia P Ravichandran N Kothari S Natesan JS Brugge 2005 Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition J Cell Biol 171 1023 1034 16365168 10.1083/jcb.200505087 1:CAS:528:DC%2BD2MXhtlCjsr7N (Pubitemid 41815834)
17. JN Hutchinson J Jin RD Cardiff JR Woodgett WJ Muller 2004 Activation of Akt1 (PKB-α) can accelerated ErbB-2 mediated mammary tumorigenesis but suppresses tumor invasion Cancer Res 64 3171 3178 15126356 10.1158/0008-5472. CAN-03-3465 1:CAS:528:DC%2BD2cXjs1eht7o%3D (Pubitemid 38581419)
18. CS Kim VV Vasko Y Kato M Kruhlak M Saji SY Cheng MD Ringel 2005 AKT activation promotes metastasis in a mouse model of follicular thyroid carcinoma Endocrinology 146 4456 4463 16002527 10.1210/en.2005-0172 1:CAS:528: DC%2BD2MXhtVGmurfF (Pubitemid 41324044)