Intracellular acidosis and pH regulation in central respiratory chemoreceptors

Journal of Health Care for the Poor and Underserved

Volumn 22, Issue 4 SUPPL., 2011, Pages 174-186

  Marutha Ravindran, C R ^a   Bayne, James N ^a   Bravo, Sara C ^a   Busby, Theo ^a   Crain, Charles N ^a   Escobedo, John A ^a   Gresham, Kenneth ^a   O'Grady, Brian J ^a   Rios, Lourdes ^a   Roy, Shashwata ^a   Gdovin, Matthew J ^a  

^a UNIVERSITY OF TEXAS AT SAN ANTONIO   (United States)

Author keywords

Carbon dioxide; Chemoreceptors; Ph; Respiration

Indexed keywords

ANIMAL; ARTICLE; BRAIN STEM; BREATHING; CHEMORECEPTOR; HEALTH CARE DISPARITY; HUMAN; HYPERCAPNIA; INFANT; LARVA; PATHOPHYSIOLOGY; PH; PHOTOLYSIS; PHYSIOLOGY; RESPIRATORY ACIDOSIS;

ACIDOSIS, RESPIRATORY; ANIMALS; BRAIN STEM; CHEMORECEPTOR CELLS; HEALTHCARE DISPARITIES; HUMANS; HYDROGEN-ION CONCENTRATION; HYPERCAPNIA; INFANT; LARVA; PHOTOLYSIS; RESPIRATION;

EID: 84855278453     PISSN: 10492089     EISSN: 15486869     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Jiaquan Xu, Kochanek KD, Murphy SL, et al. Deaths: final data for 2007. Hyattsville, MD: National Center for Health Statistics, 2010 May; 58(19).
2. MacDorman MF, Mathews TJ. Behind international rankings of infant mortality: how the United States compares with Europe. Hyattsville, MD: National Center for Health Statistics, 2009.
3. National Center for Health Statistics Health, United States, 2008 with special feature on the health of young adults. Hyattsville, MD: National Center for Health Statistics, 2009.
4. Mathews TJ, MacDorman MR Infant mortality statistics from the 2006 period linked birth/infant death data set. National Vital Statistics Reports. 2010;58(17).
5. Hyattsville, MD: National Center for Health Statistics, 2010.
6. Hoffman HJ, Damus K, Hillman L, et al. Risk factors for SIDS. Results of the National Institute of Child Health and Human Development SIDS Cooperative Epidemiological Study. Ann NY Acad Sci. 1988;533:13-30.
7. Filiano JJ, Kinney HC. A perspective on neuropathologic findings in victims of the sudden infant death syndrome: the triple-risk model. Biol Neonate. 1994;65(3-4):194-7. (Pubitemid 24118004)
8. Kinney HC, Thach BT. The sudden infant death syndrome. N Engl J Med. 2009 Aug. 20; 361(8):795-805.
9. Nattie EE, Li A, Coates EL. Central chemoreceptor location and the ventrolateral medulla. In: Trouth CO, Millis RM, Kiwull-Schone HF, et al. Ventral brainstem mechanisms and control of respiration and blood pressure. New York, NY: Marcel Dekker, Inc., 1995;131-50.
10. 2 chemosensitivity. Respir Physiol Neurobiol. 2005 Nov. 15; 149(1-3):165-79. (Pubitemid 41406219)
11. Nottingham S, Leiter JC, Wages P, et al. Developmental changes in intracellular pH regulation in medullary neurons of the rat. Am J Physio Regul Integr Comp Physiol. 2001 Dec; 281(6):R1940-51.
12. Zhao J, Gonzalez F, Mu D. Apnea of prematurity: from cause to treatment. Eur J Pediatr. 2011 Feb. 8.
13. Kinney HC, Thatch BT. The sudden infant death syndrome. N Engl J Med 2009;361:795-805.
14. Panigrahy A, Filiano J, Sleeper LA, et al. Decreased serotonergic receptor binding in rhombic lip-derived regions of the medulla oblongata in the sudden infant death syndrome. J Neuropathol Exp Neurol. 2000 May; 59(5):377-84. (Pubitemid 30257567)
15. Shannon DC, Kelly DH, O'Connell K. Abnormal regulation of ventilation in infants at risk for sudden-infant-death syndrome. N Eng J Med. 1977 Oct. 6; 297(14):747-50. (Pubitemid 8201635)
16. Nattie EE, Kinney HC. Nicotine, serotonin, and sudden infant death syndrome. Am J Respir Crit Care Med. 2002 Dec. 15;166(12 Pt 1):1530):1530-1.
17. Nattie EE, Li A, Richerson GB, et al. Medullary serotonergic neurones and adjacent neurones that express neurokinin-1 receptors are both involved in chemoreception in vivo. J Physiol. 2004;556. 1:235-53. (Pubitemid 38515181)
18. Torgerson CS, Gdovin MJ, Kogo N, et al. Depth profiles of pH and P02 in the in vitro brainstem preparation of the tadpole Rana catesbeiana. Respir Physiol. 1997 Jun; 108(3):205-13. (Pubitemid 27304204)
19. Funk GD, Feldman JL. Generation of respiratory rhythm and pattern in mammals: insights from developmental studies. Curr Opin Neurobiol. 1995 Dec; 5(6):778-85. (Pubitemid 26042628)
20. Galante RJ, Kubin L, Fishman AP, et al. Role of chloride-mediated inhibition in respiratory rhythmogenesis in an in vitro brainstem of tadpole, Rana catesbeiana. J Physiol. 1996 Apr. 15;492(Pt 2):545):545-58. (Pubitemid 26137762)
21. Torgerson C, Gdovin M, Remmers J. Ontogeny of central chemoreception during Active gill and lung ventilation in an in vitro brainstem preparation of Rana catesbeiana. J Exp Biol. 1997;200(Pt 15): 2063):2063-72. (Pubitemid 27324656)
22. Putnam RW. Intracellular pH regulation of neurons in chemosensitive and nonchemosensitive areas of brain slices. Respir Physiol. 2001 Dec; 129(1-2):37-56. (Pubitemid 33103918)
23. 2 chemoreception in developing bullfrogs: anomalous response to acetazolamide. J Appl Physiol. 2003 Mar; 94(3):1204-12. Epub 2002 Nov. 15. (Pubitemid 36232039)
24. Richerson GB. Serotonergic neurons as carbon dioxide sensors that maintain pH homeostasis. Nat Rev Neurosci. 2004 Jun; 5(6):449-61. (Pubitemid 38715512)
25. Gdovin MJ, Jackson VV, Zamora DA, et al. Effect of prevention of lung inflation on metamorphosis and respiration in the developing bullfrog tadpole, Rana catesbeiana. J Exp Zool A Comp Exp Biol. 2006 Apr. 1; 305(4):335-47.
26. Kinkead R, Bach KB, Johnson SM, et al. Plasticity in respiratory motor control: intermittent hypoxia and hypercapnia activate opposing serotonergic and noradrenergic modulatory systems. Comp Biochem Physiol A Mol Integr Physiol. 2001 Sep; 130(2):207-18. (Pubitemid 32822859)
27. Kinkead R, Belzile O, Gulemetova R. Serotonergic modulation of respiratory motor output during tadpole development. J Appl Physiol. 2002 Sep; 93(3):936-46. (Pubitemid 34919666)
28. Belzile O, Gulemetova R, Kinkead R. Role of 5HT2A/C receptors in serotonergic modulation of respiratory motor output during tadpole development. Respir Physiol Neurobiol. 2002 Nov. 19; 133(3):277-82. (Pubitemid 35300240)
29. Montandon G, Bairam A, Kinkead R. Long-term consequences of neonatal caffeine on ventilation, occurrence of apneas, and hypercapnic chemoreflex in male and female rats. Pediatr Res. 2006 Apr; 59(4 Pt 1):519):519-24. (Pubitemid 43740049)
30. Montandon G, Kinkead R, Bairam A. Disruption of adenosinergic modulation of ventilation at rest and during hypercapnia by neonatal caffeine in young rats: role of adenosine A (1) and A (2A) receptors. Am J Physiol Regul Integr Comp Physiol. 2007 Apr; 292(4):R1621-31. Epub 2006 Nov. 30. (Pubitemid 46557827)
31. Montandon G, Bairam A, Kinkead R. Neonatal caffeine induces sex-specific developmental plasticity of the hypoxic respiratory chemoreflex in adult rats. Am J Physiol Regul Integr Comp Physiol. 2008 Sep; 295(3) R922-34. Epub 2008 Jul. 2.
32. Wang JL, Wu ZH, Pan BX, et al. Adenosine Al receptors modulate the discharge activities of inspiratory and biphasic expiratory neurons in the medial region of Nucleus Retrofacialis of neonatal rat in vitro. Neurosci Lett. 2005 Apr. 29; 379(1):27-31. Epub 2005 Jan 11.
33. 2 chemoreception: chemosensitivity in the ventral medulla of developing bullfrogs. Amer J Physiol Regul Integr Comp Physiol. 2003 Dec; 285(6):R1461-72. (Pubitemid 37464406)
34. Paterson DS, Trachtenberg FL, Thompson EG, et al. Multiple serotonergic brainstem abnormalities in sudden infant death syndrome. JAMA. 2006 Nov. 1; 296(17):2124-32. (Pubitemid 44664707)
35. Audero E, Coppi E, Mlinar B, et al. Sporadic autonomic dysregulation and death associated with excessive serotonin autoinhibition. Science. 2008 Jul. 4; 321(5885):130-3. (Pubitemid 351956249)
36. Taylor AC, Kollros JJ. Stages in the normal development of Rana pipiens larvae. Anat Rec. 1946 Jan; 94:7-13.
37. Gdovin MJ, Zamora DA, Marutha Ravindran CR, et al. Employing a pH sensitive fluorophore to measure intracellular pH in the in vitro brainstem preparation of rana catesbeiana. Open Zoo J. 2009;2:117-23.
38. Gdovin MJ, Torgerson CS, Remmers JE. The Actively breathing tadpole brainstem preparation as a model for the development of respiratory pattern generation and central chemoreception. Comp Biochem Physiol A Mol Integr Physiol. 1999;124:275-86.
39. Gdovin MJ, Torgerson CS, Remmers JE. Neurorespiratory pattern of gill and lung ventilation in the decerebrate spontaneously breathing tadpole. Respir Physiol. 1998 Aug; 113(2):135-46. (Pubitemid 29028010)
40. +/ nigericin for calibrating BCECF. I. Estimating steady-state intracellular pH. Am J Physiol. 1996 Oct; 271(4 Pt 1):C1131-45.
41. +/ nigericin for calibrating BCECE II. Intracellular pH dependence of the correction. Am J Physiol. 1996 Oct;271(4 Pt 1):C1146-56.
42. Thomas JA, Buchsbaum RN, Zimniak A, et al. Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ. Biochemistry. 1979 May 29; 18(11):2210-8. (Pubitemid 9191034)
43. West NH, Topor ZL, Van Vliet BN. Hypoxemic threshold for lung ventilation in the toad. Respir Physiol. 1987 Dec; 70(3):377-90. (Pubitemid 18045507)
44. Goldstein JI, Mok JM, Simon CM, et al. Intracellular pH regulation in neurons from chemosensitive and nonchemosensitive regions of Helix aspersa. Am J Physiol Regul Integr Comp Physiol. 2000 Aug; 279(2):R414-23.
45. + channels. Am J Physiol Cell Physiol. 2003 Jan; 284(1):C145-55. Epub 2002 Sep. 18. (Pubitemid 35470634)
46. Filosa JA, Dean JB, Putnam RW. Role of intracellular and extracellular pH in the chemosensitive response of rat locus coeruleus neurones. J Physiol. 2002 Jun. 1;541(Pt 2):493):493-509. (Pubitemid 35190215)
47. Rotman B, Papermaster BW. Membrane properties of living mammalian cells as studied by enzymatic hydrolysis of fluorogenic esters. Proc Natl Acad Sci USA. 1966 Jan; 55(1):134-41.