Synthesis of new 1,2,4-triazoles as anti-inflammatory and anti-nociceptive agents

Pharmaceutical Chemistry Journal

Volumn 45, Issue 7, 2011, Pages 433-439

  Upmanyu, N ^a   Gupta, J K ^b   Shah, K ^b   Mishra, P ^b  

^a DR H S GOUR UNIVERSITY   (India)

^b GLA Group   (India)

Author keywords

1,2,4 Triazoles; anti inflammatory activity; anti nociceptive activity; cyclization

Indexed keywords

1,2,4 TRIAZOLE DERIVATIVE; 2 (4 BENZYLPIPERAZIN 1 YL) N [3 MERCAPTO 5 (4 METHYLPHENYL) 4H 1,2,4 TRIAZOL 4 YL]ACETAMIDE; 4 METHYLBENZOIC ACID; ANTIINFLAMMATORY AGENT; ANTINOCICEPTIVE AGENT; CARRAGEENAN; INDOMETACIN; N [3 MERCAPTO 5 (4 METHYLPHENYL) 4H 1,2,4 TRIAZOL 4 YL] 2 MORPHOLIN 4 YLACETAMIDE; N [3 MERCAPTO 5 (4 METHYLPHENYL) 4H 1,2,4 TRIAZOL 4 YL] 2 PIPERIDIN 1 YLACETAMIDE; PETHIDINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTINOCICEPTION; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG SYNTHESIS; ELECTROCHEMICAL ANALYSIS; FAST ATOM BOMBARDMENT MASS SPECTROMETRY; FEMALE; HOT PLATE TEST; INFRARED SPECTROSCOPY; MALE; MOUSE; NONHUMAN; PAW EDEMA; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; WATER IMMERSION;

EID: 84855277510     PISSN: 0091150X     EISSN: 15739031     Source Type: Journal    
DOI: 10.1007/s11094-011-0649-0     Document Type: Article

References (15)

1. R. Kharb, P. C. Sharma, and M. S. Yar, J. Enz. Inhib. Med. Chem., 26(1), 1-21 (2010).
2. L. Navidpour, H. Shafaroodi, K. Abdi, et al., Bioorg. Med. Chem., 14, 2507-2717 (2006).
3. G. Turan-Zitounia, M. Sývacýa, F. Kýlýc, et al., Eur. J. Med. Chem., 36, 685-689 (2001).
4. G. Turan-Zitouni, Z. A. Kaplancýklý, M. T. Yýldýz, et al., Eur. J. Med. Chem., 40, 607-613 (2005).
5. I. R. Ezabadi, C. Camoutsis, P. Zoumpoulakis, et al., Bioorg. Med. Chem., 16, 1150-1161 (2008).
6. B. S. Holla, B. Veerendra, M. K. Shivananda, et al., Eur. J. Med. Chem., 38, 759-767 (2003).
7. N. Demirbaş, R. Ugurluoglu, and A. Demirbaş, Bioorg. Med. Chem., 10, 3717-3723 (2002).
8. M. Shiradkar, G. V. S. Kumar, V. Dasari, et al., Eur. J. Med. Chem., 42, 807-816 (2007).
9. I. Küçükgüzel, Ş. G. Küçü kgüzel, S. Rollas, et al., Il Farmaco, 59, 893-901(2004).
10. J. L. Romine, S. W. Martin, V. K. Gribkoff, et al., J. Med. Chem., 45 (14), 2942-2952 (2002).
11. M. Kritsanida, A. Mouroutsou, P. Marakos, et al., Il Farmaco, 57, 253-257(2002).
12. D. J. Ecobichon, The Basis of Toxicology Testing, CRC Press, New York (1997).
13. C. A. Winter, E. A. Risley and G. W. Nuss, Proc. Soc. Exp. Biol. Med., 111, 544-547 (1962).
14. N. B. Eddy and D. Leimbach, J. Pharmacol. Exp. Ther., 107, 385-393 (1953).
15. J. Ben-Bassat, E. Peretz, and F. G. Sulman, Arch.Int. Pharmacodyn., 122, 434-447 (1959).