Detection of intranasally delivered bone marrow-derived mesenchymal stromal cells in the lesioned mouse brain: A cautionary report

Stem Cells International

Volumn , Issue , 2011, Pages

  Chartoff, Elena H ^a   Damez Werno, Diane ^a   Sonntag, Kai C ^a   Hassinger, Linda ^a   Kaufmann, Daniel E ^b   Peterson, Jesse ^a   McPhie, Donna ^a   Cataldo, Anne M ^a   Cohen, Bruce M ^a  

^a MCLEAN HOSPITAL   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENHANCED GREEN FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOFLUORESCENCE IMAGING; BRAIN DAMAGE; CELL CULTURE; CELL ULTRASTRUCTURE; COLORIMETRY; CONTROLLED STUDY; CORPUS STRIATUM; FLUORESCENCE ANALYSIS; HEMATOPOIETIC STEM CELL; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MOUSE; NONHUMAN; OLFACTORY BULB; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENIC MOUSE; WILD TYPE;

MUS; MUS MUSCULUS;

EID: 84855274940     PISSN: None     EISSN: 16879678     Source Type: Journal    
DOI: 10.4061/2011/586586     Document Type: Article

References (43)

1. Grove J. E., Bruscia E., Krause D. S., Plasticity of bone marrow-derived stem cells Stem Cells 2004 22 4 487 500 (Pubitemid 39014565)
2. Pittenger M. F., Mackay A. M., Beck S. C., Jaiswal R. K., Douglas R., Mosca J. D., Moorman M. A., Simonetti D. W., Craig S., Marshak D. R., Multilineage potential of adult human mesenchymal stem cells Science 1999 284 5411 143 147 (Pubitemid 29282067)
3. Brazelton T. R., Rossi F. M. V., Keshet G. I., Blau H. M., From marrow to brain: expression of neuronal phenotypes in adult mice Science 2000 290 5497 1775 1779 (Pubitemid 32004810)
4. Jiang Y., Jahagirdar B. N., Reinhardt R. L., Schwartz R. E., Keene C. D., Ortiz-Gonzalez X. R., Reyes M., Lenvik T., Lund T., Blackstad M., Du J., Aldrich S., Lisberg A., Low W. C., Lergaespada D. A., Verfaillie C. M., Pluripotency of mesenchymal stem cells derived from adult marrow Nature 2002 418 6893 41 49 (Pubitemid 34742565)
5. Mezey E., Chandross K. J., Harta G., Maki R. A., McKercher S. R., Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow Science 2000 290 5497 1779 1782 (Pubitemid 32004811)
6. Woodbury D., Schwarz E. J., Prockop D. J., Black I. B., Adult rat and human bone marrow stromal cells differentiate into neurons Journal of Neuroscience Research 2000 61 4 364 370 (Pubitemid 30620221)
7. Check E., Stem-cell paper corrected Nature 2007 447 7146 763 (Pubitemid 46920115)
8. Neuhuber B., Gallo G., Howard L., Kostura L., Mackay A., Fischer I., Reevaluation of in vitro differentiation protocols for bone marrow stromal cells: disruption of actin cytoskeleton induces rapid morphological changes and mimics neuronal phenotype Journal of Neuroscience Research 2004 77 2 192 204 (Pubitemid 38859404)
9. Azizi S. A., Stokes D., Augelli B. J., DiGirolamo C., Prockop D. J., Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino ratssimilarities to astrocyte grafts Proceedings of the National Academy of Sciences of the United States of America 1998 95 7 3908 3913 (Pubitemid 28173227)
10. Coyne T. M., Marcus A. J., Reynolds K., Black I. B., Woodbury D., Disparate host response and donor survival after the transplantation of mesenchymal or neuroectodermal cells to the intact rodent brain Transplantation 2007 84 11 1507 1516 (Pubitemid 350294727)
11. Moloney T. C., Dockery P., Windebank A. J., Barry F. P., Howard L., Dowd E., Survival and immunogenicity of mesenchymal stem cells from the green fluorescent protein transgenic rat in the adult rat brain Neurorehabilitation and Neural Repair 2010 24 7 645 656
12. Terada N., Hamazaki T., Oka M., Hoki M., Mastalerz D. M., Nakano Y., Meyer E. M., Morel L., Petersen B. E., Scott E. W., Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion Nature 2002 416 6880 542 545 (Pubitemid 34288856)
13. Ying Q. L., Nichols J., Evans E. P., Smith A. G., Changing potency by spontaneous fusion Nature 2002 416 6880 545 548 (Pubitemid 34288857)
14. Kurozumi K., Nakamura K., Tamiya T., Kawano Y., Ishii K., Kobune M., Hirai S., Uchida H., Sasaki K., Ito Y., Kato K., Honmou O., Houkin K., Date I., Hamada H., Mesenchymal stem cells that produce neurotrophic factors reduce ischemic damage in the rat middle cerebral artery occlusion model Molecular Therapy 2005 11 1 96 104 (Pubitemid 40012003)
15. Levy Y. S., Bahat-Stroomza M., Barzilay R., Burshtein A., Bulvik S., Barhum Y., Panet H., Melamed E., Offen D., Regenerative effect of neural-induced human mesenchymal stromal cells in rat models of Parkinson's disease Cytotherapy 2008 10 4 340 352 (Pubitemid 351983158)
16. Venkataramana N. K., Kumar S. K. V., Balaraju S., Radhakrishnan R. C., Bansal A., Dixit A., Rao D. K., Das M., Jan M., Gupta P. K., Totey S. M., Open-labeled study of unilateral autologous bone-marrow-derived mesenchymal stem cell transplantation in Parkinson's disease Translational Research 2010 155 2 62 70
17. Balin B. J., Broadwell R. D., Salcman M., El-Kalliny M., Avenues for entry of peripherally administered protein to the central nervous system in mouse, rat, and squirrel monkey The Journal of Comparative Neurology 1986 251 2 260 280 (Pubitemid 16027854)
18. Illum L., Transport of drugs from the nasal cavity to the central nervous system European Journal of Pharmaceutical Sciences 2000 11 1 1 18 (Pubitemid 30410839)
19. Liu X. F., Fawcett J. R., Thorne R. G., DeFor T. A., Frey W. H., Intranasal administration of insulin-like growth factor-I bypasses the blood-brain barrier and protects against focal cerebral ischemic damage Journal of the Neurological Sciences 2001 187 1-2 91 97 (Pubitemid 32618661)
20. Mathison S., Nagilla R., Kompella U. B., Nasal route for direct delivery of solutes to the central nervous system: fact or fiction? Journal of Drug Targeting 1998 5 6 415 441 (Pubitemid 28499678)
21. Thorne R. G., Pronk G. J., Padmanabhan V., Frey W. H., Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration Neuroscience 2004 127 2 481 496 (Pubitemid 38950662)
22. Lemiale F., Kong W. P., Akyrek L. M., Ling X., Huang Y., Chakrabarti B. K., Eckhaus M., Nabel G. J., Enhanced mucosal immunoglobulin A response of intranasal adenoviral vector human immunodeficiency virus vaccine and localization in the central nervous system Journal of Virology 2003 77 18 10078 10087 (Pubitemid 37122089)
23. Damjanovic D., Zhang X., Mu J., Fe Medina M., Xing Z., Organ distribution of transgene expression following intranasal mucosal delivery of recombinant replication-defective adenovirus gene transfer vector Genetic Vaccines and Therapy 2008 6, article no. 5
24. Danielyan L., Schfer R., von Ameln-Mayerhofer A., Buadze M., Geisler J., Klopfer T., Burkhardt U., Proksch B., Verleysdonk S., Ayturan M., Buniatian G. H., Gleiter C. H., Frey W. H., Intranasal delivery of cells to the brain European Journal of Cell Biology 2009 88 6 315 324
25. van Velthoven C. T. J., Kavelaars A., van Bel F., Heijnen C. J., Nasal administration of stem cells: a promising novel route to treat neonatal ischemic brain damage Pediatric Research 2010 68 5 419 422
26. Danielyan L., Schfer R., Von Ameln-Mayerhofer A., Bernhard F., Verleysdonk S., Buadze M., Lourhmati A., Klopfer T., Schaumann F., Schmid B., Koehle C., Proksch B., Weissert R., Reichardt H. M., van den Brandt J., Buniatian G. H., Schwab M., Gleiter C. H., Frey W. H., Therapeutic efficacy of intranasally delivered mesenchymal stem cells in a rat model of parkinson disease Rejuvenation Research 2011 14 1 3 16
27. Chen C. W. D., Boiteau R. M., Lai W. F. T., Barger S. W., Cataldo A. M., sAPP enhances the transdifferentiation of adult bone marrow progenitor cells to neuronal phenotypes Current Alzheimer Research 2006 3 1 63 70
28. Brazelton T. R., Blau H. M., Optimizing techniques for tracking transplanted stem cells in vivo Stem Cells 2005 23 9 1251 1265 (Pubitemid 41504913)
29. Jackson K. A., Snyder D. S., Goodell M. A., Skeletal muscle fiber-specific green autofluorescence: potential for stem cell engraftment artifacts Stem Cells 2004 22 2 180 187 (Pubitemid 38282633)
30. Soleimani M., Nadri S., A protocol for isolation and culture of mesenchymal stem cells from mouse bone marrow Nature Protocols 2009 4 1 102 106
31. Sauer H., Oertel W. H., Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: a combined retrograde tracing and immunocytochemical study in the rat Neuroscience 1994 59 2 401 415 (Pubitemid 24098798)
32. Paxinos G., Franklin K. B. J., The Mouse Brain in Stereotaxic Coordinates 2001 San Diego, Calif, USA Academic Press
33. Schnell S. A., Staines W. A., Wessendorf M. W., Reduction of lipofuscin-like autofluorescence in fluorescently labeled tissue Journal of Histochemistry Cytochemistry 1999 47 6 719 730 (Pubitemid 29244510)
34. Fujikawa D. G., Zhao S., Ke X., Shinmei S. S., Allen S. G., Mild as well as severe insults produce necrotic, not apoptotic, cells: evidence from 60-min seizures Neuroscience Letters 2010 469 3 333 337
35. Billinton N., Knight A. W., Seeing the wood through the trees: a review of techniques for distinguishing green fluorescent protein from endogenous autofluorescence Analytical Biochemistry 2001 291 2 175 197 (Pubitemid 32373153)
36. Coyne T. M., Marcus A. J., Woodbury D., Black I. B., Marrow stromal cells transplanted to the adult brain are rejected by an inflammatory response and transfer donor labels to host neurons and glia Stem Cells 2006 24 11 2483 2492 (Pubitemid 44674309)
37. Long Y., Yang K. Y., Bone marrow derived cells for brain repair: recent findings and current controversies Current Molecular Medicine 2003 3 8 719 725 (Pubitemid 37536877)
38. Gilissen E. P., Jacobs R. E., Mcguinness E. R., Allman J. M., Topographical localization of lipofuscin pigment in the brain of the aged fat-tailed dwarf lemur (Cheirogaleus medius) and grey lesser mouse lemur (Microcebus murinus): comparison to iron localization American Journal of Primatology 1999 49 2 183 193 (Pubitemid 29404987)
39. Vaishnav R. A., Getchell M. L., Huang L., Hersh M. A., Stromberg A. J., Getchell T. V., Cellular and molecular characterization of oxidative stress in olfactory epithelium of harlequin mutant mouse Journal of Neuroscience Research 2008 86 1 165 182
40. Muotri A. R., Nakashima K., Toni N., Sandler V. M., Gage F. H., Development of functional human embryonic stem cell-derived neurons in mouse brain Proceedings of the National Academy of Sciences of the United States of America 2005 102 51 18644 18648 (Pubitemid 43011279)
41. Priller J., Persons D. A., Klett F. F., Kempermann G., Kreutzberg G. W., Dirnagl U., Neogenesis of cerebellar Purkinje neurons from gene-marked bone marrow cells in vivo Journal of Cell Biology 2001 155 5 733 738 (Pubitemid 34286225)
42. Wernig M., Benninger F., Schmandt T., Rade M., Tucker K. L., Bssow H., Beck H., Brstle O., Functional integration of embryonic stem cell-derived neurons in vivo Journal of Neuroscience 2004 24 22 5258 5268 (Pubitemid 38725409)
43. Bobis S., Jarocha D., Majka M., Mesenchymal stem cells: characteristics and clinical applications Folia Histochemica et Cytobiologica 2006 44 4 215 230 (Pubitemid 44696963)