Rifaximin is effective for the treatment of Clostridium difficile - Associated diarrhea: Results of an open-label pilot study

Gastroenterology Research and Practice

Volumn , Issue , 2011, Pages

  Rubin, David T ^a   Sohi, Sunana ^a   Glathar, Matthew ^a   Thomas, Tojo ^a   Yadron, Nicole ^a   Surma, Bonnie L ^a  

^a UNIVERSITY OF CHICAGO MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METRONIDAZOLE; RIFAXIMIN; VANCOMYCIN;

ABSENCE OF SIDE EFFECTS; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLOSTRIDIUM DIFFICILE INFECTION; DRUG EFFICACY; DRUG SAFETY; FECES ANALYSIS; FEMALE; HUMAN; MALE; RECURRENT DISEASE; TREATMENT OUTCOME;

EID: 84855254075     PISSN: 16876121     EISSN: 1687630X     Source Type: Journal    
DOI: 10.1155/2011/106978     Document Type: Article

References (29)

1. McMaster-Baxter N. L., Musher D. M., Clostridium difficile: recent epidemiologic findings and advances in therapy Pharmacotherapy 2007 27 7 1029 1039 (Pubitemid 46986690)
2. Muto C. A., Pokrywka M., Shutt K., Mendelsohn A. B., Nouri K., Posey K., Roberts T., Croyle K., Krystofiak S., Patel-Brown S., Pasculle A. W., Paterson D. L., Saul M., Harrison L. H., A large outbreak of Clostridium difficile -associated disease with an unexpected proportion of deaths and colectomies at a teaching hospital following increased fluoroquinolone use Infection Control and Hospital Epidemiology 2005 26 3 273 280 (Pubitemid 40445086)
3. Loo V. G., Poirier L., Miller M. A., Oughton M., Libman M. D., Michaud S., Bourgault A. M., Nguyen T., Frenette C., Kelly M., Vibien A., Brassard P., Fenn S., Dewar K., Hudson T. J., Horn R., René P., Monczak Y., Dascal A., A predominantly clonal multi-institutional outbreak of Clostridium difficile associated diarrhea with high morbidity and mortality New England Journal of Medicine 2005 353 23 2442 2449 (Pubitemid 41770165)
4. Ricciardi R., Rothenberger D. A., Madoff R. D., Baxter N. N., Increasing prevalence and severity of Clostridium difficile colitis in hospitalized patients in the United States Archives of Surgery 2007 142 7 624 631 (Pubitemid 47080440)
5. McFarland L. V., Beneda H. W., Clarridge J. E., Raugi G. J., Implications of the changing face of Clostridium difficile disease for health care practitioners American Journal of Infection Control 2007 35 4 237 253 (Pubitemid 46670518)
6. McDonald L. C., Killgore G. E., Thompson A., Owens R. C., Kazakova S. V., Sambol S. P., Johnson S., Gerding D. N., An epidemic, toxin gene-variant strain of Clostridium difficile New England Journal of Medicine 2005 353 23 2433 2441 (Pubitemid 41770164)
7. Warny M., Pepin J., Fang A., Killgore G., Thompson A., Brazier J., Frost E., McDonald L. C., Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe Lancet 2005 366 9491 1079 1084 (Pubitemid 41338761)
8. Drudy D., Harnedy N., Fanning S., Hannan M., Kyne L., Emergence and control of fluoroquinolone-resistant, toxin A-negative, toxin B-positive Clostridium difficile Infection Control and Hospital Epidemiology 2007 28 8 932 940 (Pubitemid 47218272)
9. Barbut F., Gariazzo B., Bonné L., Lalande V., Burghoffer B., Luiuz R., Petit J. -C., Clinical features of Clostridium difficile-associated infections and molecular characterization of strains: results of a retrospective study, 2000-2004 Infection Control and Hospital Epidemiology 2007 28 2 131 139 (Pubitemid 46374152)
10. Fekety R., Guidelines for the diagnosis and management of Clostridium difficile -associated diarrhea and colitis American Journal of Gastroenterology 1997 92 5 739 750
11. Mylonakis E., Ryan E. T., Calderwood S. B., Clostridium difficile -associated diarrhea: a review Archives of Internal Medicine 2001 161 4 525 533 (Pubitemid 32167517)
12. Oldfield E. C., Clostridium difficile -associated diarrhea: resurgence with a vengeance Reviews in Gastroenterological Disorders 2006 6 2 79 96
13. Musher D. M., Aslam S., Logan N., Nallacheru S., Bhaila I., Borchert F., Hamill R. J., Relatively poor outcome after treatment of Clostridium difficile colitis with metronidazole Clinical Infectious Diseases 2005 40 11 1586 1590 (Pubitemid 40720807)
14. Nair S., Yadav D., Corpuz M., Pitchumoni C. S., Clostridium difficile colitis: factors influencing treatment failure and relapsea prospective evaluation American Journal of Gastroenterology 1998 93 10 1873 1876 (Pubitemid 29071697)
15. Pépin J., Alary M. E., Valiquette L., Raiche E., Ruel J., Fulop K., Godin D., Bourassa C., Increasing risk of relapse after treatment of Clostridium difficile colitis in Quebec, Canada Clinical Infectious Diseases 2005 40 11 1591 1597 (Pubitemid 40720808)
16. Pépin J., Valiquette L., Gagnon S., Routhier S., Brazeau I., Outcomes of Clostridium difficile -associated disease treated with metronidazole or vancomycin before and after the emergence of NAP1/027 American Journal of Gastroenterology 2007 102 12 2781 2788 (Pubitemid 350179349)
17. Pelez T., Alcal L., Alonso R., Rodrguez-Créixems M., Garca-Lechuz J. M., Bouza E., Reassessment of clostridium difficile susceptibility to metronidazole and vancomycin Antimicrobial Agents and Chemotherapy 2002 46 6 1647 1650 (Pubitemid 34535177)
18. Hoover W. W., Gerlach E. H., Hoban D. J., Eliopoulos G. M., Pfaller M. A., Jones R. N., Antimicrobial activity and spectrum of rifaximin, a new topical rifamycin derivative Diagnostic Microbiology and Infectious Disease 1993 16 2 111 118 (Pubitemid 23090031)
19. Scarpignato C., Pelosini I., Experimental and clinical pharmacology of rifaximin, a gastrointestinal selective antibiotic Digestion 2006 73 1, supplement 13 27
20. Koo H. L., DuPont H. L., Current and future developments in travelers' diarrhea therapy Expert Review of Anti-Infective Therapy 2006 4 3 417 427 (Pubitemid 43905464)
21. Hecht D. W., Galang M. A., Sambol S. P., Osmolski J. R., Johnson S., Gerding D. N., In vitro activities of 15 antimicrobial agents against 110 toxigenic Clostridium difficile clinical isolates collected from 1983 to 2004 Antimicrobial Agents and Chemotherapy 2007 51 8 2716 2719 (Pubitemid 47206204)
22. Marchese A., Salerno A., Pesce A., Debbia E. A., Schito G. C., In vitro activity of rifaximin, metronidazole and vancomycin against Clostridium difficile and the rate of selection of spontaneously resistant mutants against representative anaerobic and aerobic bacteria, including ammonia-producing species Chemotherapy 2000 46 4 253 266 (Pubitemid 30428839)
23. Baker D. E., Rifaximin: a nonabsorbed oral antibiotic Reviews in Gastroenterological Disorders 2005 5 1 19 30 (Pubitemid 40443993)
24. DuPont H. L., Jiang Z.-D., Garey K., The oral nonsystemic antibiotic rifaximin prevents symptom recurrence in patients with recurrent Clostridium difficile -associated diarrhea Gastroenterology 2007 132 4, supplement 2 195
25. Johnson S., Schriever C., Galang M., Kelly C. P., Gerding D. N., Interruption of recurrent Clostridium difficile -associated diarrhea episodes by serial therapy with vancomycin and rifaximin Clinical Infectious Diseases 2007 44 6 846 848 (Pubitemid 46365312)
26. Berman A. L., Efficacy of rifaximin and vancomycin combination therapy in a patient with refractory Clostridium difficile -associated diarrhea Journal of Clinical Gastroenterology 2007 41 10 932 933 (Pubitemid 350307082)
27. David D. S., Addition of rifaximin emema resolves colitis associated with Clostridium difficile infection The American Journal of Gastroenterology 2007 102 supplement 2 S277
28. Boero M., Berti E., Morgando A., Verme G., Treatment for colitis caused by Clostridium difficile: results of a randomized open study of rifaximine vs. vancomycin Microbiologia Medica 1990 5 74 77
29. Teasley D. G., Olson M. M., Gebhard R. L., Gerding D. N., Peterson L. R., Schwartz M. J., Prospective randomised trial of metronidazole verus vancomycin for Clostridium-difficile -associated dirrhoea and colitis Lancet 1983 2 1043 1046 (Pubitemid 14235361)