International perspective on the diagnosis of death

British Journal of Anaesthesia

Volumn 108, Issue SUPPL. 1, 2012, Pages

  Gardiner, D ^a   Shemie, S ^b   Manara, A ^c   Opdam, H ^d  

^a NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

^b MONTREAL CHILDREN S HOSPITAL   (Canada)

^c FRENCHAY HOSPITAL   (United Kingdom)

^d AUSTIN HOSPITAL   (Australia)

Author keywords

brain death; cardiopulmonary arrest; death; diagnosis; resuscitation orders

Indexed keywords

APNEA INDEX; ARTIFICIAL VENTILATION; AUSTRALIA; AUTOPSY; BLOOD PRESSURE MONITORING; BRAIN CIRCULATION; BRAIN DEATH; BRAIN FUNCTION; BREATHING; CADAVER; CANADA; CARDIOPULMONARY INSUFFICIENCY; CARDIOVASCULAR FUNCTION; CAUSE OF DEATH; COMA; CONSCIOUSNESS; CONVENTIONAL ANGIOGRAPHY; DEATH; DOPPLER ECHOGRAPHY; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAPHY; ELECTROCARDIOGRAPHY MONITORING; ELECTROENCEPHALOGRAM; ELECTROENCEPHALOGRAPHY; EYE MOVEMENT; HEART FAILURE; HEART MUSCLE ISCHEMIA; HUMAN; MAGNETIC RESONANCE ANGIOGRAPHY; PERSISTENT VEGETATIVE STATE; PHILOSOPHY; PHYSICIAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RELIGION; RESUSCITATION; REVIEW; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; STETHOSCOPE; SYSTEMATIC REVIEW (TOPIC); UNITED KINGDOM;

EID: 84855251220     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aer397     Document Type: Review

References (108)

1. Shemie SD. Clarifying the paradigm for the ethics of donation and transplantation: was 'dead' really so clear before organ donation? Philos Ethics Humanit Med 2007; 2: 18
2. Sweet WH. Brain death. N Engl J Med 1978; 299: 410-12 (Pubitemid 9009394)
3. Bernat JL, Culver CM, Gert B. Defining death in theory and practice. Hastings Cent Rep 1982; 12: 5-8
4. Lamb D. Death, Brain Death and Ethics. London: Croom Helm, 1985
5. Pallis C, Harley DH. ABC of Brainstem Death. London: BMJ Publishing Group, 1996
6. Machado C. Brain Death: A Reappraisal. New York: Springer, 2007
7. Posner JB, Plum F. Brain Death. In: Plum and Posner's Diagnosis of Stupor and Coma. Oxford: Oxford University Press, 2007; 331-40
8. Academy of Medical Royal Colleges. A Code of Practice for the Diagnosis and Confirmation of Death. London: Academy of Medical Royal Colleges, 2008. Available from http://www.aomrc.org.uk/publications/reports-guidance.html (accessed 1 April 2011)
9. Bernat JL, Capron AM, Bleck TP, et al. The circulatory-respiratory determination of death in organ donation. Crit Care Med 2010; 38: 963-70
10. The President's Council on Bioethics. Controversies in the Determination of Death: A White Paper by the President's Council on Bioethics. Washington: www.bioethics.gov, 2008. Available from http://bioethics.georgetown.edu/pcbe/ reports/death/(accessed 1 April 2011)
11. Shemie SD, Ross H, Pagliarello J, et al. Brain arrest: the neurological determination of death and organ donor management in Canada: organ donor management in Canada: recommendations of the forum on Medical Management to Optimize Donor Organ Potential. Can Med Assoc J 2006; 174: S13
12. Rosner F. The definition of death in Jewish Law. In: Youngner SJ, Arnold RM, Schapiro R, eds. The Definition of Death: Contemporary Controversies. Baltimore: Johns Hopkins University Press, 1999; 210-21
13. Bernat JL. Brain Death. In: Ethical Issues in Neurology. Philadelphia: Lippincott Williams & Wilkins, 2008; 253-86
14. Harvey. Exercitatio Anatomica de Motu Cordis et Sanguinis in Animalibus 1628. Available from http://www.fordham.edu/halsall/mod/1628harvey-blood.html (accessed 1 April 2011)
15. Bondeson J. Buried Alive: The Terrifying History of Our Most Primal Fear. London: W.W. Norton, 2002
16. Guernsey. Real and apparent death. In: Homeopathic Domestic Practice. New York: William Radde, 1853; 493-514. Available from http://books.google.co.uk/ ebooks/reader?id=ZDXXwnGXA1YC&printsec=frontcover&output=reader (accessed 1 April 2011)
17. Powner DJ, Ackerman BM, Grenvik A. Medical diagnosis of death in adults: historical contributions to current controversies. Lancet 1996; 348: 1219-23 (Pubitemid 26361612)
18. Australian Museum. Stethoscopes. Available from http://australianmuseum. net.au/Stethoscopes/ (accessed 4 March 2011)
19. Mollaret P, Goulon M. Le coma dépassé depassed coma (mémoire préliminaire). Rev Neurol (Paris) 1959; 101: 3-15
20. Wijdicks EFM. Brain Death. Philadelphia: Lippincott Williams & Wilkins, 2001
21. A definition of irreversible coma. Report of the Ad Hoc Committee of the Harvard Medical School to Examine the Definition of Brain Death. J Am Med Assoc 1968; 205: 337-40
22. Machado C, Korein J, Ferrer Y, et al. The Declaration of Sydney on human death. J Med Ethics 2007; 33: 699-703
23. Diagnosis of brain death. Statement issued by the honorary secretary of the Conference of Medical Royal Colleges and their Faculties in the United Kingdom on 11 October 1976. Br Med J 1976; 6045: 1187-8
24. Diagnosis of death. Memorandum issued by the honorary secretary of the Conference of Medical Royal Colleges and their Faculties in the United Kingdom on 15 January 1979. Br Med J 1979; 6159: 332
25. Barber JB. Guidelines for the determination of death. J Am Med Assoc 1981; 246: 2184
26. President's Commission. Defining Death: A Report on the Medical, Legal and Ethical Issues in the Determination of Death. Washington: President's Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research, 1981. Available from http://bioethics.georgetown.edu/pcbe/ reports/past-commissions/defining-death.pdf (accessed 1 April 2011)
27. Intensive Care Society and British Transplantation Society. Organ Donation After Circulatory Death: Report of a Consensus Meeting. London, 2010. Available from http://www.scottishintensivecare.org.uk/BTS-and-ICS-DCD- Consensus-statement.pdf (accessed 1 April 2011)
28. Posner JB, Plum F. Pathophysiology of signs and symptoms of coma. In: Plum and Posner's Diagnosis of Stupor and Coma. Oxford: Oxford University Press, 2007; 3-37
29. Green MB, Wikler D. Brain death and personal identity. Philos Public Aff 1980; 9: 105-33
30. Parfit D. Reasons and Persons. Oxford: Oxford University Press, 1984
31. Australian and New Zealand Intensive Care Society. The ANZICS Statement on Death and Organ Donation, 3rd Edn. Carlton South: Australian and New Zealand Intensive Care Society, 2008. Available from http://www.anzics.com.au/death-and- organdonation (accessed 1 April 2011)
32. University of Warwick and Joint Royal Colleges Ambulance Liaison Committee. Recognition of Life Extinct by Ambulance Clinicians. Warwick, 2006. Available from http://www.library.nhs.uk/Emergency/ViewResource.aspx?resID= 261611 (accessed 4 April 2011)
33. Moss J, Rockoff M. EEG monitoring during cardiac arrest and resuscitation. J Am Med Assoc 1980; 244: 2750
34. Steen PA, Gisvold SE, Milde JH, et al. Nimodipine improves outcome when given after complete cerebral ischemia in primates. Anesthesiology 1985; 62: 406-14 (Pubitemid 15111321)
35. Clute HL, Levy WJ. Electroencephalographic changes during brief cardiac arrest in humans. Anesthesiology 1990; 73: 821-5 (Pubitemid 20380921)
36. Losasso TJ, Muzzi DA, Meyer FB, Sharbrough FW. Electroencephalographic monitoring of cerebral function during asystole and successful cardiopulmonary resuscitation. Anesth Analg 1992; 75: 1021-4
37. Park GR. Editorial: Death and its diagnosis by doctors. Br J Anaesth 2004; 92: 625-8 (Pubitemid 38578747)
38. National Health and Medical Research Council. National Protocol for Donation after Cardiac Death. Canberra: National Protocol for Donation after Cardiac Death, 2010. Available from http://www.donatelife.gov.au/Media/docs/ DCD%20Protocol-September%202010-0e4e2c3d-2ef5-4dff-b7ef-af63d0bf6a8a-0.pdf (accessed 2 August 2011)
39. Shemie SD, Baker AJ, Knoll G, et al. National recommendations for donation after cardiocirculatory death in Canada: donation after cardiocirculatory death in Canada. Can Med Assoc J 2006; 175: S1
40. Institute of Medicine. Non-Heart-Beating Organ Transplantation: Practice and Protocols. Washington: National Academy Press, 2000.
41. Dhanani S, Hornby L, Ward R, Shemie S. Variability in the determination of death after cardiac arrest: a review of guidelines and statements. J Intensive Care Med Advance Access published on August 12, 2011, doi: 10.1177/0885066610396993.
42. DeVita MA. The death watch: certifying death using cardiac criteria. Prog Transplant 2001; 11: 58-66
43. Boucek MM, Mashburn C, Dunn SM, et al. Pediatric heart transplantation after declaration of cardiocirculatory death. N Engl J Med 2008; 359: 709-14
44. Curfman GD, Morrissey S, Drazen JM. Cardiac transplantation in infants. N Eng J Med 2008; 359: 749-50
45. Bernat JL. The boundaries of organ donation after circulatory death. N Engl J Med 2008; 359: 669-71
46. Bruzzone P. Ethical and legal issues in donation after cardiac death in Italy. Transplant Proc 2010; 42: 1046-7
47. Maleck WH, Piper SN, Triem J, Boldt J, Zittel FU. Unexpected return of spontaneous circulation after cessation of resuscitation (Lazarus phenomenon). Resuscitation 1998; 39: 125-8 (Pubitemid 29023404)
48. Hornby K, Hornby L, Shemie SD. A systematic review of autoresuscitation after cardiac arrest. Crit Care Med 2010; 38: 1246-53
49. BBC News. Patients Wrongly Certified Dead: 25th May 2008. Available from http://news.bbc.co.uk/1/hi/uk/7419652.stm (accessed 4 April 2011)
50. Gardiner D, Riley B. Non-heart-beating organ donation-solution or a step too far? Anaesthesia 2007; 62: 431-3 (Pubitemid 46915691)
51. Bell MDD. Non-heart beating organ donation: in urgent need of intensive care. Br J Anaesth 2008; 100: 738
52. Gawande A, Truog R, Annas G, Caplan G. Perspective roundtable: organ donation after cardiac death. N Eng J Med 2008. Available from http://gawande.com/documents/2009NEJMDonationafterCardiacDeath.pdf (accessed 4 April 2011)
53. Rix BA. Brain death, ethics, and politics in Denmark. In: Youngner SJ, Arnold RM, Schapiro R, eds. The Definition of Death: Contemporary Controversies. Baltimore: Johns Hopkins University Press, 1999; 227-38
54. Gardiner D. Report on the 4th International Meeting on Transplantation from Non-Heart Beating Donors: London 15-16 May 2008. J Int Care Soc 2008; 9: 206
55. Manara AR. The use of circulatory criteria to diagnose death after unsuccessful cardiopulmonary resuscitation. Resuscitation 2010; 81: 781-3
56. Capron AM. The bifurcated legal standard for determining death: does it work? In: Youngner SJ, Arnold RM, Schapiro R, eds. The Definition of Death: Contemporary Controversies. Baltimore: Johns Hopkins University Press, 1999; 117-36
57. Truog RD, Miller FG. The dead donor rule and organ transplantation. N Engl J Med 2008; 359: 674-5
58. Veatch RM. Donating hearts after cardiac death-reversing the irreversible. N Engl J Med 2008; 359: 672-3
59. Academy of Medical Royal Colleges. A Code of Practice for the Diagnosis of Brain Stem Death. London: Department of Health, 1998. Available from http://www.uktransplant.org.uk/ukt/how-to-become-a-donor/questions/answers/ further-info/dh-gov-uk-04035462.pdf (accessed 1 April 2011)
60. Canadian Neurocritical Care Group. Guidelines for the diagnosis of brain death. Can J Neurol Sci 1999; 26: 64-6
61. Executive Summary: A Review of the Literature on the Determination of Brain Death. Canadian Council for Donation and Transplantation, 2003. Available from http://www.ccdt.ca/english/publications/lit-pdfs/Brain-Death-Short-Lit- Review.pdf (accessed 1 April 2011)
62. Wijdicks EFM. Clinical diagnosis and confirmatory testing of brain death in adults. In: Brain Death. Philadelphia: Lippincott Williams & Wilkins, 2001; 61-90
63. Wijdicks EF, Varelas PN, Gronseth GS, Greer DM. Evidence-based guideline update: determining brain death in adults: report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2010; 74: 1911-8
64. Mohandas A, Chou SN. Brain death. A clinical and pathological study. J Neurosurg 1971; 35: 211
65. Yoshioka T, Sugimoto H, Uenishi M, et al. Prolonged hemodynamic maintenance by the combined administration of vasopressin and epinephrine in brain death: a clinical study. Neurosurgery 1986; 18: 565
66. Ogata J, Imakita M, Yutani C, Miyamoto S, Kikuchi H. Primary brainstem death: a clinico-pathological study. Br Med J 1988; 51: 646
67. Shewmon DA. Chronic 'brain death': meta-analysis and conceptual consequences. Neurology 1998; 51: 1538
68. Plum F. Clinical standards and technological confirmatory tests in diagnosing brain death. In: Youngner SJ, Arnold RM, Schapiro R, eds. The Definition of Death: Contemporary Controversies. Baltimore: Johns Hopkins University Press, 1999; 34-65
69. Abe T. Against brain death in Japan. In: Potts M, Byrne PA, Nilges RG, eds. Beyond Brain Death. Dordrecht: Kluwer Academic Publishers, 2000; 191-9
70. Roberts DJ, MacCulloch KA, Versnick EJ, Hall RI. Should ancillary brain blood flow analyses play a larger role in the neurological determination of death? Can J Anaesth 2010; 57: 927-35
71. Webb AC, Samuels OB. Reversible brain death after cardiopulmonary arrest and induced hypothermia. Crit Care Med 2011; 39: 1538-42
72. Streat S. 'Reversible brain death'-is it true, confounded, or 'not proven'? Crit Care Med 2011; 39: 1601-3
73. White.Woman's waking after brain death raises many questions about organ donation: 27th May 2008. Available from http://www.lifesitenews.com/news/ archive/ldn/2008/may/08052709 (accessed 25 April 2011)
74. Associated Press. Illinois man believed to be brain dead wakes up: 26th November 2010. Available from http://www.dailyherald.com/article/20101126/news/ 101129682/ (accessed 25 April 2011)
75. Vieru T. Communicating with brain dead patients possible: 21st September 2010. Available from http://news.softpedia.com/news/Communicating-With-Brain- Dead-Patients-Possible-157389. shtml (accessed 25 April 2011)
76. Celizic M. Pronounced dead, man takes 'miraculous' turn: 24th March 2008. Available from http://today.msnbc.msn.com/id/23775873/ns/today-today-people// (accessed 7 April 2011)
77. Wijdicks EFM. The case against confirmatory tests for determining brain death in adults. Neurology 2010; 75: 77-83
78. Wijdicks EFM. Brain death worldwide: accepted fact but no global consensus in diagnostic criteria. Neurology 2002; 58: 20-5 (Pubitemid 34041932)
79. Young GB, Lee D. A critique of ancillary tests for brain death. Neurocrit Care 2004; 1: 499-508 (Pubitemid 41278341)
80. Wilms G, Vancalenbergh F, Demaerel P, Dubois B. Angiographic confirmation of brain death after decompressive craniectomy for posttraumatic brain oedema. JBR-BTR 2009; 92: 78-9
81. Heran MKS, Heran NS. Potential ancillary tests in the evaluation of brain death: the value of cerebral blood flow assessment. Canadian Council for Donation and Transplantation, 2006. Available from http://www.ccdt.ca/english/ publications/backgroundpdfs/Potential-Ancillary-Tests.pdf
82. Heran MK, Heran NS, Shemie SD. A review of ancillary tests in evaluating brain death. Can J Neurol Sci 2008; 35: 409-19
83. Zuckier LS, Kolano J. Radionuclide studies in the determination of brain death: criteria, concepts, and controversies. Semin Nucl Med 2008; 38: 262-73 (Pubitemid 351726330)
84. Sethi NK, Sethi PK. Brainstem death: implications in India. J Assoc Physicians India 2003; 51: 910-1 (Pubitemid 41279875)
85. Young PJ, Matta BF. Anaesthesia for organ donation in the brainstem dead-why bother? Anaesthesia 2000; 55: 105-6 (Pubitemid 30092983)
86. Hill DJ. Brain stem death: a United Kingdom anaesthetist's view. In: Potts M, Byrne PA, Nilges RG, eds. Beyond Brain Death. Dordrecht: Kluwer Academic Publishers, 2000; 159-69
87. Jorgensen EO. Spinal man after brain death. The unilateral extension-pronation reflex of the upper limb as an indication of brain death. Acta Neurochirurgica (Wien) 1973; 28: 259-73
88. Jain S, DeGeorgia M. Brain death-associated reflexes and automatisms. Neurocrit Care 2005; 3: 122-6 (Pubitemid 41325108)
89. Laskey W, Schondorf R, Polosa C. Intersegmental connections and interactions of myelinated somatic and visceral afferents with sympathetic preganglionic neurons in the unanesthetized spinal cat. J Auton Nerv Syst 1979; 1: 69-75
90. Freire-Maia L, Azevedo AD. The autonomic nervous system is not a purely efferent system. Med Hypotheses 1990; 32: 91-9 (Pubitemid 20194630)
91. Furness JB. The organisation of the autonomic nervous system: peripheral connections. Auton Neurosci 2006; 130: 1-5 (Pubitemid 44750858)
92. Mathias CJ. Orthostatic hypotension and paroxysmal hypertension in humans with high spinal cord injury. Prog Brain Res 2006; 152: 231-43
93. Inskip JA, Ramer LM, Ramer MS, Krassioukov AV. Autonomic assessment of animals with spinal cord injury: tools, techniques and translation. Spinal Cord 2008; 47: 2-35
94. Daniel PM. The blood supply of the hypothalamus and pituitary gland. Br Med Bull 1966; 22: 202
95. Tien RD. Sequence of enhancement of various portions of the pituitary gland on gadolinium-enhanced MR images: correlation with regional blood supply. Am J Roentgenol 1992; 158: 651-4
96. Nussey S, Whitehead S. The pituitary gland. In: Endocrinology: An Integrated Approach. Oxford: BIOS Scientific Publishers, 2001. Available from http://www.ncbi.nlm.nih.gov/books/NBK27/#A1297 (accessed 25 April 2011)
97. Lechan RM, Toni R. Functional anatomy of the hypothalamus and pituitary. www.endotext.org, 2008. Available from http://www.endotext.org/neuroendo/ neuroendo3b/neuroendo3b-2.htm (accessed 25 April 2011)
98. Wennervirta J, Salmi T, Hynynen M, et al. Entropy is more resistant to artifacts than bispectral index in brain-dead organ donors. Int Care Med 2007; 33: 133-6 (Pubitemid 46115480)
99. McKeown DW, Bonser RA, Kellum JA. Management of the heartbeating brain-dead organ donor. Br J Anaesth 2012; 108 (Suppl. 1): i96-i107.
100. Arnold RM, Youngner SJ. The dead donor rule: should we stretch it, bend it, or abandon it? Kennedy Inst Ethics J 1993; 3: 263-78
101. Truog RD, Robinson WM. Role of brain death and the dead-donor rule in the ethics of organ transplantation. Crit Care Med 2003; 31: 2391-6 (Pubitemid 37100844)
102. Veatch RM. Abandon the dead donor rule or change the definition of death? Kennedy Inst Ethics J 2004; 14: 261-76 (Pubitemid 39406903)
103. Fost N. Reconsidering the dead donor rule: is it important that organ donors be dead? Kennedy Inst Ethics J 2004; 14: 249-60 (Pubitemid 39406902)
104. Zamperetti N, Bellomo R, Defanti CA, Latronico N. Irreversible apnoeic coma 35 yr later. Towards a more rigorous definition of brain death? Int Care Med 2004; 30: 1715-22 (Pubitemid 39297173)
105. Singer P. Rethinking Life and Death: The Collapse of Our Traditional Ethics. Oxford: Oxford University Press, 1995
106. Campbell CS. Fundamentals of Life and Death: Christian Fundamentalism and Medical Science. In: Youngner SJ, Arnold RM, Schapiro R, eds. The Definition of Death: Contemporary Controversies. Baltimore: Johns Hopkins University Press, 1999; 194-209
107. Schone-Seifert B. Defining death in Germany: brain death and its discontents. In: Youngner SJ, Arnold RM, Schapiro R, eds. The Definition of Death: Contemporary Controversies. Baltimore: Johns Hopkins University Press, 1999; 257-71
108. Lock MM. Twice Dead: Organ Transplants and the Reinvention of Death. Berkeley: University of California Press, 2002