The nuclear receptor constitutive active/androstane receptor arrests DNA-damaged human hepatocellular carcinoma Huh7 cells at the G2/M phase

Molecular Carcinogenesis

Volumn 51, Issue 2, 2012, Pages 206-212

  Kamino, Hiroki ^a   Negishi, Masahiko ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Adriamycin; CAR; G2 M arrest; Huh7; Nuclear receptor

Indexed keywords

1,4 BIS(3,5 DICHLORO 2 PYRIDYLOXY)BENZENE; ANDROSTANE DERIVATIVE; CELL NUCLEUS RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR; CYCLIN G2; DIMETHYL SULFOXIDE; DOXORUBICIN;

ARTICLE; CELL CYCLE ARREST; CELL VIABILITY; CONTROLLED STUDY; DNA DAMAGE; FLUORESCENCE ACTIVATED CELL SORTING; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION;

BASE SEQUENCE; CARCINOMA, HEPATOCELLULAR; CELL DIVISION; CELL LINE, TUMOR; DNA DAMAGE; DNA PRIMERS; FLOW CYTOMETRY; G2 PHASE; HUMANS; LIVER NEOPLASMS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

EID: 84855251193     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.20783     Document Type: Article

References (16)

1. Honkakoski P, Zelko I, Sueyoshi T, Negishi M. The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene. Mol Cell Biol 1998; 18: 5652-5658.
2. Sueyoshi T, Kawamoto T, Zelko I, Honkakoski P, Negishi M. The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6. J Biol Chem 1999; 274: 6043-6046.
3. Kodama S, Negishi M. Phenobarbital confers its diverse effects by activating the orphan nuclear receptor CAR. Drug Metab Rev 2006; 38: 75-87.
4. Urquhart BL, Tirona RG, Kim RB. Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: Implications for inter-individual variability in response to drugs. J Clin Pharmacol 2007; 47: 566-578.
5. Kodama S, Koike C, Negishi M, Yamamoto Y. Nuclear receptors CAR and PXR cross talk with FoxO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes. Mol Cell Biol 2004; 24: 7931-7940.
6. Kakizaki S, Yamazaki Y, Takizawa D, Negishi M. New insights on the xenobiotic-sensing nuclear receptors in liver diseases-CAR and RXR. Curr Drug Metab 2008; 9: 614-621.
7. Yamamoto Y, Moore R, Goldsworthy TL, Negishi M, Maronpot RR. The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice. Cancer Res 2004; 64: 7197-7200.
8. Yamamoto Y, Moore R, Flavell RA, Lu B, Negishi M. Nuclear receptor CAR repressed TNFα-induced cell death by interacting with the anti-apoptotic GADD45B. PLoS ONE 2010; 5: e10121.
9. Jin S, Antinore MJ, Lung FD, et al. The Gadd 45 inhibition of Cdc2 kinase correlates with Gadd45-mediated growth suppression. Biol Chem 2000; 275: 16602-16608.
10. Zhan Q, Antinore MJ, Wang XW, et al. Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45. Oncogene 1999; 18: 2892-2900.
11. Vairapandi M, Balliet AG, Hoffman B, Liebermann DA. GADD45 and GADD45 are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress. J Cell Physiol 2002; 192: 327-338.
12. Zhu N, Shao Y, Xu L, Yu L, Sun L. Gadd45-α and Gadd45-γ utilize p38 and JNK signaling pathways to induce cell cycle G2/M arrest in Hep-G2 hepatoma cells. Mol Biol Rep 2009; 36: 2075-2085.
13. Horne MC, Goolsby GL, Donaldson KL, Tran D, Neubaur M, Wahl AF. Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression. J Biol Chem 1996; 271: 6050-6061.
14. Horne MC, Donaldson KL, Goolsby GL, et al. Cyclin G2 is up-regulated during growth inhibition and B cell antigen receptor-mediated cell cycle arrest. J Biol Chem 1997; 272: 12650-12661.
15. Kim Y, Shintani S, Kohno Y, Zhang R, Wong DT. Cyclin G2 dysregulation in human oral cancer. Cancer Res 2004; 64: 8980-8986.
16. Phillips JM, Yamamoto Y, Negishi M, Maronpot RR, Goodman JI. Orphan nuclear receptor constitutive active/androstane receptor-mediated alterations in DNA methylation during phenobarbital promotion of liver tumorigenesis. Toxicol Sci 2007; 96: 72-82.