Tiam1, overexpressed in most malignancies, is a novel tumor biomarker

Molecular Medicine Reports

Volumn 5, Issue 1, 2012, Pages 48-53

  Chen, Bin ^a   Ding, Yi ^b   Liu, Feiye ^b   Ruan, Jian ^b   Guan, Jian ^b   Huang, Jing ^b   Ye, Xianghua ^b   Wang, Shuang ^b   Zhang, Gong ^b   Zhang, Xiangmei ^b   Liang, Zhao ^b   Luo, Rongcheng ^b   Chen, Longhua ^b  

^a GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND   (China)

^b SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

Hepatocellular carcinoma; T lymphoma invasion and metastasis 1; Tissue microarray; Tumor biomarker

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; MESSENGER RNA; TIAM1 PROTEIN; TUMOR MARKER; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ARTICLE; B CELL LYMPHOMA; BLADDER CARCINOMA; BREAST CANCER; CELL PROLIFERATION; COLON CARCINOMA; CONTROLLED STUDY; DIAGNOSTIC VALUE; FEMALE; HEPATOMA CELL; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LIVER CELL; LIVER CELL CARCINOMA; LUNG CANCER; MAJOR CLINICAL STUDY; MALE; NASOPHARYNX CARCINOMA; OVARY CANCER; PROSTATE CARCINOMA; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TISSUE MICROARRAY;

CARCINOMA, HEPATOCELLULAR; CELL LINE; GENE EXPRESSION REGULATION, NEOPLASTIC; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS; MICROARRAY ANALYSIS; RNA, MESSENGER; TUMOR MARKERS, BIOLOGICAL;

EID: 84855241571     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2011.612     Document Type: Article

References (27)

1. Habets GG, van der Kammen RA, Jenkins NA, Gilbert DJ, Copeland NG, Hagemeijer A and Collard JG: The invasion-inducing TIAM1 gene maps to human chromosome band 21q22 and mouse chromosome 16. Cytogenet Cell Genet 70: 48-51, 1995.
2. Habets GG, van der Kammen RA, Stam JC, Michiels F and Collard JG: Sequence of the human invasion-inducing TIAM1 gene, its conservation in evolution and its expression in tumor cell lines of different tissue origin. Oncogene 10: 1371-1376, 1995.
3. Habets GG, Scholtes EH, Zuydgeest D, van der Kammen RA, Stam JC, Berns A and Collard JG: Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins. Cell 77: 537-549, 1994. (Pubitemid 24153994)
4. Van Leeuwen FN, van der Kammen RA, Habets GG and Collard JG: Oncogenic activity of Tiam1 and Rac1 in NIH3T3 cells. Oncogene 11: 2215-2221, 1995. (Pubitemid 26008397)
5. Stam JC, Sander EE, Michiels F, van Leeuwen FN, Kain HE, van der Kammen RA and Collard JG: Targeting of Tiam1 to the plasma membrane requires the cooperative function of the N-terminal pleckstrin homology domain and an adjacent protein interaction domain. J Biol Chem 272: 28447-28454, 1997. (Pubitemid 27517792)
6. Harlan JE, Hajduk PJ, Yoon HS and Fesik SW: Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate. Nature 371: 168-170, 1994. (Pubitemid 24284017)
7. Musacchio A, Gibson T, Rice P, Thompson J and Saraste M: The PH domain: a common piece in the structural patchwork of signalling proteins. Trends Biochem Sci 18: 343-348, 1993. (Pubitemid 23258292)
8. Qi Y, Huang B, Yu L, Wang Q, Lan G and Zhang Q: Prognostic value of Tiam1 and Rac1 overexpression in nasopharyngeal carcinoma. ORL J Otorhinolaryngol Relat Spec 71: 163-171, 2009.
9. Engers R, Mueller M, Walter A, Collard JG, Willers R and Gabbert HE: Prognostic relevance of Tiam1 protein expression in prostate carcinomas. Br J Cancer 95: 1081-1086, 2006. (Pubitemid 44606836)
10. Minard ME, Kim LS, Price JE and Gallick GE: The role of the guanine nucleotide exchange factor Tiam1 in cellular migration, invasion, adhesion and tumor progression. Breast Cancer Res Treat 84: 21-32, 2004. (Pubitemid 38388857)
11. Liu L, Wu DH and Ding YQ: Tiam1 gene expression and its significance in colorectal carcinoma. World J Gastroenterol 11: 705-707, 2005. (Pubitemid 40220762)
12. Minard ME, Ellis LM and Gallick GE: Tiam1 regulates cell adhesion, migration and apoptosis in colon tumor cells. Clin Exp Metastasis 23: 301-313, 2006.
13. Zhao L, Liu Y, Sun X, He M and Ding Y: Overexpression of T lymphoma invasion and metastasis 1 predict renal cell carcinoma metastasis and overall patient survival. J Cancer Res Clin Oncol 137: 393-398, 2011.
14. Buchsbaum RJ, Connolly BA and Feig LA: Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascade. Mol Cell Biol 22: 4073-4085, 2002. (Pubitemid 34556578)
15. Buchsbaum RJ, Connolly BA and Feig LA: Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin. J Biol Chem 278: 18833-18841, 2003. (Pubitemid 36799265)
16. Sander EE, van Delft S, ten Klooster JP, Reid T, van der Kammen RA, Michiels F and Collard JG: Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase. J Cell Biol 143: 1385-1398, 1998. (Pubitemid 28559838)
17. Hordijk PL, ten Klooster JP, van der Kammen RA, Michiels F, Oomen LC and Collard JG: Inhibition of invasion of epithelial cells by Tiam1-Rac signaling. Science 278: 1464-1466, 1997. (Pubitemid 27509819)
18. Hamelers IH, Olivo C, Mertens AE, Pegtel DM, van der Kammen RA, Sonnenberg A and Collard JG: The Rac activator Tiam1 is required for (alpha)3(beta)1-mediated laminin-5 deposition, cell spreading, and cell migration. J Cell Biol 171: 871-881, 2005. (Pubitemid 41746588)
19. Woodcock SA, Rushton HJ, Castaneda-Saucedo E, Myant K, White GR, Blyth K, Sansom OJ and Malliri A: Tiam1-Rac signaling counteracts Eg5 during bipolar spindle assembly to facilitate chromosome congression. Curr Biol 20: 669-675, 2010.
20. Malliri A, Rygiel TP, van der Kammen RA, Song JY, Engers R, Hurlstone AF, Clevers H and Collard JG: The rac activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumor development. J Biol Chem 281: 543-548, 2006. (Pubitemid 43671217)
21. Buongiorno P, Pethe VV, Charames GS, Esufali S and Bapat B: Rac1 GTPase and the Rac1 exchange factor Tiam1 associate with Wnt-responsive promoters to enhance beta-catenin/TCF-dependent transcription in colorectal cancer cells. Mol Cancer 7: 73, 2008.
22. Pegtel DM, Ellenbroek SI, Mertens AE, van der Kammen RA, de Rooij J and Collard JG: The Par-Tiam1 complex controls persistent migration by stabilizing microtubule-dependent front-rear polarity. Curr Biol 17: 1623-1634, 2007. (Pubitemid 47503803)
23. Woodcock SA, Rooney C, Liontos M, Connolly Y, Zoumpourlis V, Whetton AD, Gorgoulis VG and Malliri A: SRC-induced disassembly of adherens junctions requires localized phosphorylation and degradation of the rac activator tiam1. Mol Cell 33: 639-653, 2009.
24. Bourguignon LY, Zhu H, Shao L and Chen YW: CD44 interaction with tiam1 promotes Rac1 signaling and hyaluronic acid-mediated breast tumor cell migration. J Biol Chem 275: 1829-1838, 2000. (Pubitemid 30060806)
25. Strumane K, Rygiel T, van der Valk M and Collard JG: Tiam1-deficiency impairs mammary tumor formation in MMTV-c-neu but not in MMTV-c-myc mice. J Cancer Res Clin Oncol 135: 69-80, 2009.
26. Gao Y, Dickerson JB, Guo F, Zheng J and Zheng Y: Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proc Natl Acad Sci USA 101: 7618-7623, 2004. (Pubitemid 38658078)
27. Ding Y, Chen B, Wang S, Zhao L, Chen J, Ding Y, Chen L and Luo R: Overexpression of Tiam1 in hepatocellular carcinomas predicts poor prognosis of HCC patients. Int J Cancer 124: 653-658, 2009.