The vertebrate brain, evidence of its modular organization and operating system: Insights into the brain's basic units of structure, function, and operation and how they influence neuronal signaling and behavior

Frontiers in Behavioral Neuroscience

Volumn , Issue JUNE, 2011, Pages

  Baslow, Morris H ^a  

^a NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

Author keywords

Behavior; Brain; Cognition; Language; Learning; Memory; Neurons; Signaling

Indexed keywords

N ACETYLASPARTIC ACID; N ACETYLASPARTYLGLUTAMIC ACID;

ASTROCYTE; BEHAVIOR; BRAIN FUNCTION; BRAIN METABOLISM; BRAIN NERVE CELL; BRAIN REGION; CANAVAN DISEASE; CELL COMMUNICATION; COGNITION; DENDRITE; ENDOTHELIUM CELL; ENERGY METABOLISM; GENE MUTATION; HUMAN; HYDROLYSIS; INBORN ERROR OF METABOLISM; NEUROTRANSMISSION; NONHUMAN; OLIGODENDROGLIA; REVIEW; SYNAPSE;

EID: 84855229009     PISSN: 16625153     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnbeh.2011.00005     Document Type: Review

References (32)

1. Agre, P., King, L. S., Yasui, M., Guggino, W. B., Ottersen, O. P., Fujiyoshi, Y., Engel, A., and Neilsen, S. (2002). Aquaporin water channels-from atomic structure to clinical medicine. J. Physiol. 542, 3-16.
2. Ai, H., Rybak, J., Menzel, R., and Itoh, T. (2009). Response characteristics of vibration-sensitive interneurons related to Johnston's organ in the honeybee, Apis mellifera. J. Comp. Neurol. 515, 145-160.
3. Anand, B. K., Chhina, G. S., Sharma, K. N., Dua, S., and Singh, B. (1964). Activity of single neurons in the hypothalamic feeding centers: effect of glucose. Am. J. Physiol. 207, 1146-1154.
4. Barbieri, M. (2009). A short history of biosemiotics. Biosemiotics 2, 221-245.
5. Baslow, M. H. (1999a). The existence of molecular water pumps in the nervous system. A review of the evidence. Neurochem. Int. 34, 77-90.
6. Baslow, M. H. (1999b). Molecular water pumps and the etiology of Canavan disease; a case of the sorcerer's apprentice. J. Inherit. Metab. Dis. 22, 99-101.
7. Baslow, M. H. (2000). Functions of N-acetyl-L-aspartate and N-acetyl-L-aspartylglutamate in the vertebrate brain. Role in glial cell-specific signaling. J. Neurochem. 75, 453-459.
8. Baslow, M. H. (2002). Evidence supporting a role for N-acetyl-L-aspartate as a molecular water pump in myelinated neurons in the central nervous system. An analytical review. Neurochem. Int. 40, 295-300.
9. Baslow, M. H. (2007). "N-acetylaspartate and N-acetylaspartylglutamate," in Handbook of Neurochemistry and Molecular Neurobiology, 3rd Edn, Vol. 6, Amino Acids and Peptides in the Nervous System, ed. A. Lajtha (New York, NY: Springer Science), 305-346.
10. Baslow, M. H. (2009). The languages of neurons: an analysis of coding mechanisms by which neurons communicate, learn and store information. Entropy 11, 782-797.
11. Baslow, M. H. (2010a). Biosemiosis and the cellular basis of mind. How the oxidation of glucose by individual neurons in brain results in meaningful communications and in the emergence of "mind". Biosemiotics, 4, 1-15.
12. Baslow, M. H. (2010b). A novel key-lock mechanism for inactivating amino acid neurotransmitters during transit across extracellular space. Amino Acids 38, 51-55.
13. Baslow, M. H. (2010c). Evidence that the tri-cellular metabolism of N-acetylaspartate functions as the brain's "operating system": how NAA metabolism supports meaningful intercellular frequency-encoded communications. Amino Acids 39, 1139-1145.
14. Baslow, M. H. (2010d). The nature of neuronal words and language. Nat. Sci. 2, 205-211.
15. Baslow, M. H., and Guilfoyle, D. N. (2006). Functions of N-acetylaspartate and N-acetylaspartylglutamate in brain: evidence of a role in maintenance of higher brain integrative activities of information processing and cognition. Adv. Exp. Med. Biol. 576, 95-112.
16. Baslow, M. H., and Guilfoyle, D. N. (2007). Using proton magnetic resonance imaging and spectroscopy to understand brain "activation". Brain Lang. 102, 153-164.
17. Baslow, M. H., Suckow, R. F., Gaynor, K., Bhakoo, K. K., Marks, N., Saito, M., Saito, M., Duff, K., Matsuoka, Y., and Berg, M. (2003). Brain damage results in downregulation of N-acetylaspartate as a neuronal osmolyte. Neuromolecular Med. 3, 95-103.
18. Boltshauser, E., Schmitt, B., Wevers, R. A., Engelke, U., Burlina, A. B., and Burlina, A. P. (2004). Follow-up of a child with hypoacetylaspartia. Neuropediatrics 35, 255-258.
19. Di Lorenzo, P. M., Leshchinskiy, S., Moroney, D. N., and Ozdoba, J. M. (2009). Making time count: functional evidence for temporal coding of taste sensation. Behav. Neurosci. 123, 14-25.
20. Djurfeldt, M., Ekeberg, O., and Lansner, A. (2008). Large-scale modeling a tool for conquering the complexity of the brain. Front. Neuroinform. 2:1. doi: 10.3389/neuro.11.001.2008
21. Eyherabide, H. G., Rokem, A., Herz, A. V. M., and Samengo, I. (2009). Bursts generate a non-reducible spike-pattern code. Front. Neurosci. 3:1. doi: 10.3389/ neuro.01002.2009
22. Gilbertson, T. A., Avenet, P., Kinnamon, S. C., and Roper, S. D. (1992). Proton currents through amiloride-sensitive Na channels in hamster taste cells. J. Gen. Physiol. 100, 803-824.
23. Gillary, H. L. (1966). Stimulation of the salt receptor of the blowfly. II. Temperature. J. Gen. Physiol. 50, 351-357.
24. Lee, C. R., and Rice, M. E. (2008). Hydrogen peroxide increases the excitability of substantia nigra pars reticulata GABAergic neurons. Society for Neuroscience Meeting, November 16, 2008, Program 179.2, Poster No. QQ37.
25. Martin, E., Capone, A., Schneider, J., Hennig, J., and Thiel, T. (2001). Absence of N-acetylaspartate in the human brain: impact on neurospectroscopy? Ann. Neurol. 49, 518-521.
26. Matalon, R., Michals, K., Sebasta, D., Deanching, M., Gashkoff, P., and Casanova, J. (1988). Aspartoacylase deficiency and N-acetylaspartic aciduria in patients with Canavan disease. Am. J. Med. Genet. 29, 463-471.
27. Merivee, E., Renou, M., Mand, M., Luik, A., Heidemaa, M., and Ploomi, A. (2004). Electrophysiological responses to salts from antennal chaetoid taste sensilla of the ground beetle Pterostichus aethiops. J. Insect Physiol. 50, 1001-1013.
28. Meunier, D., Lambiotte, R., Fornito, A., Ersche, K. D., and Bullmore, E. T. (2009). Hierarchical modularity in human brain functional networks. Front. Neuroinform. 3:37. doi: 10.3389/ neuro.11.037.2009
29. Rash, J. E., Duffy, H. S., Dudek, F. E., Bilhartz, B. L., Whalen, L. R., and Yasumura, T. (1997). Grid-mapped freeze-fracture analysis of gap junctions in gray and white matter of adult rat central nervous system, with evidence for a "panglial syncytium" that is not coupled to neurons. J. Comp. Neurol. 388, 265-292.
30. Takahashi, S., and Sakurai, Y. (2009). Sub-millisecond firing synchrony of closely neighboring pyramidal neurons in hippocampal CA1 of rats during delayed non-matching to sample task. Front. Neural Circuits 3:9. doi: 10.3389/neuro.04.009.2009
31. Taube, J. S. (2010). Interspike interval analyses reveal irregular firing patterns at short, but not long, intervals in rat head direction cells. J. Neurophysiol. 104, 1635-1648.
32. Wiame, E., Tyteca, D., Pierrot, N., Collard, F., Amyere, M., Noel, G., Desmedt, J., Nassogne, M-C., Vikkula, M.,Octave, J-N., Vincent, M-F., Courtoy, P. J., Boltshauser, E., and Van Schaftingen, E. (2010). Molecular identification of aspartate N-acetyltransferase and its mutation in hypoacetylaspartia. Biochem. J.425, 127-136.