MLH1-deficient HCT116 colon tumor cells exhibit resistance to the cytostatic and cytotoxic effect of the poly(A) polymerase inhibitor cordycepin (3'-deoxyadenosine) in vitro

Oncology Letters

Volumn 3, Issue 2, 2012, Pages 441-444

  Imesch, Patrick ^a   Goerens, Anouk ^a   Fink, Daniel ^a   Fedier, André ^a  

^a UNIVERSITÄTSSPITAL ZÜRICH   (Switzerland)

Author keywords

Apoptosis; Cordycepin; DNA mismatch repair; Drug resistance; mRNA polyadenylation; Proliferation

Indexed keywords

ANTINEOPLASTIC AGENT; CORDYCEPIN; DNA; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; POLYNUCLEOTIDE ADENYLYLTRANSFERASE; PROTEIN MLH1; PROTEIN P21;

APOPTOSIS; ARTICLE; CANCER RESISTANCE; CELL PROLIFERATION; COLON TUMOR; CONTROLLED STUDY; CYTOSTASIS; CYTOTOXICITY; DNA DAMAGE; DRUG EFFECT; DRUG SENSITIVITY; HUMAN; HUMAN CELL; MISMATCH REPAIR; POLYADENYLATION; PROTEIN CLEAVAGE; TUMOR CELL; UPREGULATION;

EID: 84855211941     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2011.504     Document Type: Article

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